A new In Situ Oxidized 2D Layered MnBi2Te4 Cathode for High-Performance Aqueous Zinc-Ion Battery.

Recently, aqueous zinc ion batteries (AZIBs) with the superior theoretical capacity, high safety, low prices, and environmental protection, have emerged as a contender for advanced energy storage. However, challenges related to cathode materials, such as dissolution, instability, and structural collapse, have hindered the progress of AZIBs. Here, a novel AZIB is constructed using an oxidized 2D layered MnBi2Te4 cathode for the first time. The oxidized MnBi2Te4 cathode with large interlayer spacing and low energy barrier for zinc ion diffusion at 240 °C, exhibited impressive characteristics, including a high reversibility capacity of 393.1 mAh g-1 (0.4 A g-1), outstanding rate performance, and long cycle stability. Moreover, the corresponding aqueous button cell also exhibits excellent electrochemical performance. To demonstrate the application in practice in the realm of flexible wearable electronics, a quasi-solid-state micro ZIB (MZIB) is constructed and shows excellent flexibility and high-temperature stability (the capacity does not significantly degrade when the temperature reaches 100 °C and the bending angle exceeds 150°). This research offers effective tactics for creating high-performance cathode materials for AZIBs.

Bioinspired Dual-Mode Stretchable Strain Sensor Based on Magnetic Nanocomposites for Strain/Magnetic Discrimination.

Recently, flexible stretchable sensors have been gaining attention for their excellent adaptability for electronic skin applications. However, the preparation of stretchable strain sensors that achieve dual-mode sensing while still retaining ultra-low detection limit of strain, high sensitivity, and low cost is a pressing task. Herein, a high-performance dual-mode stretchable strain sensor (DMSSS) based on biomimetic scorpion foot slit microstructures and multi-walled carbon nanotubes (MWCNTs)/graphene (GR)/silicone rubber (SR)/Fe3 O4 nanocomposites is proposed, which can accurately sense strain and magnetic stimuli. The DMSSS exhibits a large strain detection range (≈160%), sensitivity up to 100.56 (130-160%), an ultra-low detection limit of strain (0.16% strain), and superior durability (9000 cycles of stretch/release). The sensor can accurately recognize sign language movement, as well as realize object proximity information perception and whole process information monitoring. Furthermore, human joint movements and micro-expressions can be monitored in real-time. Therefore, the DMSSS of this work opens up promising prospects for applications in sign language pose recognition, non-contact sensing, human-computer interaction, and electronic skin.

Bioinspired Engineering of Fillable Gradient Structure into Flexible Capacitive Pressure Sensor Toward Ultra-High Sensitivity and Wide Working Range.

Tactile sensing is required for electronic skin and intelligent robots to function properly. However, the dielectric layer's poor structural compressibility in conventional pressure sensors results in a limited pressure sensing range and low sensitivity. To solve this issue, a flexible pressure sensor with a crocodile-inspired fillable gradient structure is provided. The fillable gradient structure and grooves in the pressure sensor accommodate the deformed microstructure that permits the enhancement of the media layer compressibility via COMSOL finite element simulation and optimization. The pressure sensor exhibits a high sensitivity of up to 0.97 k Pa-1 (0-4 kPa), a wide pressure detection range (7 Pa-380 kPa), and outstanding repeatability. The sensor can detect Morse code, robotic grabbing, and human motion monitoring. As a result, flexible sensors with a bionic fillable gradient structure pave the way for wearable devices and offer a novel method for achieving highly precise tactile perception.

Rh Phenotype and Allele Frequencies Among 88,856 Patients in China.

BACKGROUND: This study was performed to provide information on the frequencies of Rh antigens, alleles, and phenotypes from our region in Tianjin, China. METHODS: This observational study was conducted on patients from January 2018 to March 2021 using a fully automated system for ABO and Rh typing of blood cells. The phenotypes of C, c, E, and e were detected by the slide method. The data were collected and calculations done to determine the antigen, phenotypes and allele frequencies. RESULTS: Four hundred thirty-three cases of Rh (D) negative phenotype were confirmed in 88,856 patients. Of the four Rh antigens (C, c, E, e) that were phenotyped by serological methods, the "e" antigen was found to have the highest frequency (99.74%). The most common Rh negative phenotype observed was ccdee, followed by Ccdee. The prevalence of Rh phenotypes ccdEe, CCdee, CcdEe, CCdEe, ccdEE were found to be rare in our population with percentages of 0.0473%, 0.018%, 0.018%, 0.0034%, and 0.0011%, respectively. CONCLUSIONS: Knowledge of red cell antigen phenotype frequencies in a population is helpful in terms of their ethnic distribution. We have determined the prevalence of Rh antigens and Rh phenotypes in China. The Rh blood group distribution in this population was different from that in other populations.

Identification and Blood Transfusion of Rare B(A) Blood Group.

BACKGROUND: To study serologic and gene characteristics of the B(A) blood group of one patient in Tianjin, China. To investigate the blood transfusion for patients with B(A) blood group. METHODS: ABO subgroups were identified by standard serologic techniques in ABO typing discrepancy sample from one patient at the Tianjin Medical University General Hospital. DNA (deoxyribonucleic acid) was collected from his sample and PCR (polymerase chain reaction) was used to sequence exons 6 and 7. PCR products were sequenced to identify ABO subgroups and the B(A) allele. Molecular genotyping of the ABO gene was performed by DNA sequencing of exons 6 and 7 of the ABO gene. RESULTS: The patient's red cells showed mixed field agglutination reaction (MF) with anti-A and weak reaction (W+) with anti-H. However, it has strong agglutination reaction with anti-B. The patient's serum showed the presence of anti-A antibody, while it can't react with B cell. The serological characteristics of the patient's red cells were similar to AxB subtype. Variation sites were confirmed at 261delG, 297 A>G, 526 C>G, 640 A>G, 657 C>T, 703 G>A, 796 C>A, 803 G>C, 930 G>A in exon 6 and 7 of the ABO gene. The sequence was similar to B101 except for nt640 (A>G). Genotyping indicated that the specimen was B(A)04. CONCLUSIONS: Molecular genotyping confirmed the ABO status as B(A)04. The B(A) blood group is associated with a complicated serologic phenotype and DNA detection is necessary for this atypical phenotype sample. To ensure the safety of transfusion, this study developed an emergency transfusion procedure for patients with B(A) type.

Logic Design and Power Optimization of Floating-Point Multipliers.

Under IEEE-754 standard, for the current situation of excessive time and power consumption of multiplication operations in single-precision floating-point operations, the expanded boothwallace algorithm is used, and the partial product caused by booth coding is rounded and predicted with the symbolic expansion idea, and the partial product caused by single-precision floating-point multiplication and the accumulation of partial products are optimized, and the flowing water is used to improve the throughput. Based on this, a series of verification and synthesis simulations are performed using the SMIC-7 nm standard cell process. It is verified that the new single-precision floating-point multiplier can achieve a smaller power share compared to the conventional single-precision floating-point multiplier.

Influence of the Initial Neutrophils to Lymphocytes and Platelets Ratio on the Incidence and Severity of Sepsis-Associated Acute Kidney Injury: A Double Robust Estimation Based on a Large Public Database.

Background: Acute kidney injury (AKI) is a frequent consequence of sepsis and has been linked to poor prognosis. In critically ill patients, the ratio of neutrophils to lymphocytes and platelets (N/LP) has been confirmed as an inflammation-related marker connected with the development of renal dysfunction. However, the effect of the N/LP ratio on the initiation and development of AKI in patients with sepsis remained unclear. The purpose of this study was to determine if the N/LP ratio on intensive care unit (ICU) admission was associated with the occurrence of sepsis-associated AKI (S-AKI) and severe AKI. Methods: Adult septic patients from the Medical Information Mart for Intensive Care-IV database were screened and classified into three categories (low, middle, or high) based on their N/LP ratio quartiles. The Cox proportional hazard and competing risk models were used to determine the risk of S-AKI in various N/LP groups, whilst the logistic regression model and restricted cubic splines (RCS) analysis were employed to investigate the link between N/LP ratios and the occurrence of severe AKI. Finally, we did a doubly robust estimation, a subgroup analysis, and a sensitivity analysis to determine the findings' robustness. Results: We categorized 485, 968, and 485 septic patients into three groups based on their N/LP ratios: low, intermediate, and high. According the Cox proportional hazard model, the hazard rate (95% CI) for those in the middle and high N/LP groups on the incidence of S-AKI were 1.30(1.07, 1.58) and 1.27(1.02, 1.59), respectively, as compared to those in the low N/LP group. And the Fine-Gray proportional subdistribution hazards model indicated that mortality was not a substantial competing risk for S-AKI. Additionally, multivariate logistic regression revealed that the risk of severe AKI increased 1.83 fold in the high group compared to the low group. The RCS result also suggested that the probability of severe AKI rose significantly when N/LP > 9.5. The consistency of these findings was confirmed using doubly robust estimation. However, subgroup and sensitivity analyses revealed that the association between N/LP and the incidence of S-AKI, severe AKI varied considerably between different populations and diagnostic criteria. Conclusion: A raised initial N/LP level may induce the development of S-AKI and severe AKI within 7 days after ICU admission in septic patients. These influences were enhanced in elder, male, septic shock, and those with poor health condition. Furthermore, high NLP was more strongly connected to the risk of S-AKI and severe AKI in sepsis patients on the urine output-based AKI criteria than on the serum creatinine-based criteria.

Preparation of porous Co3O4 and its response to ethanol with low energy consumption.

Co3O4 is a promising p-type semiconductor for ethanol detection. In this work, ethanol detection sensors were fabricated with nanostructured Co3O4, which exhibited higher selectivity and lower operating temperature. The Co3O4 was synthesised using ZIF-67 as a sacrificial precursor. The T400-Co3O4 that was obtained by calcining ZIF-67 at 400 °C showed the best sensing performance. Its response to 100 ppm ethanol vapor was 221.99 at a low optimal operating temperature (200 °C). Moreover, T400-Co3O4 achieved a low detection limit (1 ppm), remarkable repeatability, and higher selectivity compared to ammonia, carbon monoxide, acetone, hydrogen, methane, methanol, and nitrogen dioxide. The enhanced sensing performance was mainly attributed to three factors: (1) the adsorption/desorption of active adsorbed oxygen molecules (e.g. O- and O2-) and abundant oxygen vacancies, which increased the number of active sites; (2) the catalytic activity of Co3+, which greatly increased the reaction route and decreased the activation energy; and (3) the effective diffusion of gas molecules, which increased the effect of collisions between gas molecules and the material surface. This work provides an effective means to fabricate sensitive ethanol gas sensors with low energy consumption.

[Progress of intensive care unit delirium research from 2010 to 2020: analysis based on knowledge visualization].

OBJECTIVE: To explored the progress of intensive care unit (ICU) delirium between 2010 and 2020 based on knowledge visualization analysis. METHODS: The literatures related to ICU delirium included in Web of Sciences (WOS) and China National Knowledge Infrastructure (CNKI) databases from 2010 to 2020 were collected. A bibliometric analysis was performed. The growth trend was showed by Excel 2019 software. The information about country, institution and author were extracted by VOSviewer 1.6.15 for generating cooperative network, to find the main research power and each cooperative relation. At the same time, Citespace 5.0.R1 was used to analyze those high frequency keywords and bursting keywords and build the map of co-citation reference, in order to explore the evolution of research in the field of ICU delirium and the hotspots about this field in recent 10 years. RESULTS: A total of 1 102 Chinese journal articles and 2 422 English "Articles" or "Reviews" from 2010 to 2020 were collected preliminarily, and the number of published literatures increased steadily. In the respect of quality, the impact factors of most articles were concentrated between 2 and 3, and the literatures with impact factor over 5 accounted for 27.9% (337/1 209). According to the knowledge visualization analysis, the United States published most of the related articles (total 1 152) in this field, while the England and Canada ranked second and third respectively, totaling 220 and 204. In terms of the distribution of research institutions, the Vanderbilt University School of Medicine was not only far ahead in the number of publication (n = 149), but more importantly, top three high-impact authors located in this institution. The amount of domestic publications was lower than developed countries, however, the burst index, which reflected the sudden increase, ranked first (7.09), suggesting that the interest and investment of Chinese researchers was increasing recently. The most productive institution in China was Capital Medical University School of Nursing with totaling 23 articles. Wu Ying, who published most Chinese papers (n = 14), belongs to this institution. However, it was a pity that there was no large scientific community be constructed in China, and the cooperation between institutions was deficient. By generating the co-occuring keyword mapping, the research hotpots mainly focused on the prevention, treatment and prevention of delirium in mechanically ventilated patients, the effect of dexmedetomidine and exploring the risk factor of ICU delirium. Finally, the results of co-citation reference analysis showed that Cluster 4 (risk assessment) was still in the process of development, in hence it was the frontier in this domain. CONCLUSIONS: There was a big gap between China and leading countries in the field of ICU delirium research. The main research power was located in the United States, and the trending of future studies mainly focus on delirium-related risk assessment.

Sandwich magnetically imprinted immunosensor for electrochemiluminescence ultrasensing diethylstilbestrol based on enhanced luminescence of Ru@SiO2 by CdTe@ZnS quantum dots.

A molecularly imprinted magnetic sensor with electroluminescent tags (MIP-ECL sensor) was developed for ultrasensing diethylstilbestrol (DES). A strategy is exploited to enhance ECL emission of the [Ru(bpy)3]2 +-tripropyl amine (TPrA) system by CdTe@ZnS quantum-dots (QDs) through energy transfer. Magnetically molecularly imprinted nanoparticles (MMIPs NPs) based on Fe3O4@SiO2 carriers are artificial, easily reproducible, and could replace easily inactivated first antibodies for capturing more DES molecules. Functionalized bio-conjugates of single antibody-CdTe@ZnS (Ab-CdTe@ZnS) are for the first time loaded on signal labels of Ru(bpy)32 +-doped silica nanocomposites (Ru@SiO2) for signal amplification. The final bio-conjugated signal probes are denoted as Ab-DES/CdTe@ZnS-Ru@SiO2. MMIPs beads that have captured antigens are bio-conjugated with antibody-labeled luminescent probes by specific immunoreactive reaction, and then the luminescent immunocomplex generates ECL signal on the magnetic electrode. The logarithm of ECL intensities depend linearly on the logarithm of DES concentrations in the range from 4.8 × 10- 4 to 36.0 nM with a detection limit of 0.025 pM. This novel assay is much more sensitive than other MIP sensors, and achieves lower cost and more enhanced stability than other immunosensors. The sensor is significantly potential and has been applied to DES detection in actual environment.

GHSR deficiency exacerbates cardiac fibrosis: role in macrophage inflammasome activation and myofibroblast differentiation.

AIMS: Sustained activation of ß-adrenergic signalling induces cardiac fibrosis, which marks progression to heart failure. GHSR (growth hormone secretagogue receptor) is the receptor for ghrelin, which is an orexigenic gastric hormone with newly defined cardiovascular effects. The present study determined the effects of GHSR deficiency in a mouse model of isoproterenol (ISO)-induced cardiac fibrosis and examined the underlying mechanism. METHODS AND RESULTS: Histochemical studies showed that GHSR deficiency exacerbated cardiac fibrosis. Quantitative RT-PCR, western blotting, and immunofluorescence staining demonstrated that cardiac fibroblasts isolated from GHSR-/- mice exhibited increased expression of marker genes for myofibroblast trans-differentiation (α-SMA, SM22, and calponin) upon transforming growth factor-ß treatment compared to wild-type mice. RNA-sequencing of heart transcriptomes revealed that differentially expressed genes in GHSR-/- hearts were enriched in such biological processes as extracellular matrix organization, inflammatory response, lipid metabolism, cell cycle, migration, and adhesion. Particularly, GHSR deficiency increased Wnt/ß-catenin pathway activation in ISO-induced myocardial fibrosis. In addition, loss of GHSR in macrophages instigated inflammasome activation with increased cleavage and release of interleukin-18. CONCLUSION: These results for the first time demonstrated that GHSR deficiency aggravated ISO-induced cardiac fibrosis, suggesting that GHSR was a potential target for the intervention of cardiac fibrosis.

Nickel-Catalyzed Transformation of Diazoacetates to Alkyl Radicals Using Alcohol as a Hydrogen Source.

A nickel-catalyzed transformation of diazoacetates to α-carbonyl methylene radicals has been disclosed in the presence of hyperoxide using ethanol as a hydrogen source and solvent. This strategy is successfully applied in the formation of indolin-2-ones or 1,4-dicarbonyl compounds from acrylamides or enamides in moderate to good yields. These reactions undergo radical addition onto C-C double bonds followed by a cyclization/oxidation or an oxidation/hydrolysis process, respectively.

Layered hydroxide nickel benzoates: hydrothermal synthesis, structure characterization, and exfoliation reaction.

This paper introduces two hydrothermally synthesized layered hydroxide nickel benzoates with the layered basic metal salt structures of basal spacings of 1.71 and 1.48 nm and their exfoliation reactions. These inorganic-organic hybrid layered compounds were characterized with XRD, FTIR, TG-DTA, SEM, SAED, and TEM. The 1.71 nm layered phase is a low temperature stable phase and has lattice parameters of a=0.7017(1)nm, b=0.3495(0)nm, c=1.763(7)nm, α=γ=90°, and ß=101.6(6)°. The 1.48 nm layered phase is a high temperature stable phase and has lattice parameters of a=0.6277(2)nm, b=0.3678(2)nm, c=1.514(1)nm, α=γ=90°, and ß=97.35(0)°. The benzoate anions in the interlayer space are coordinated to Ni(II) with unidentate and bidentate binding modes in the 1.71 nm layered phase, and with only bidentate binding mode in the 1.48 nm layered phase. These hybrid layered phases were exfoliated into their nanosheets in organic solvents, which gave a new category of inorganic-organic hybrid nanosheets. The exfoliation reactions are dependent on the structures and chemical compositions of the hybrid layered phases, as well as the molecule structures of the organic solvents used in the exfoliation.

Investigations on copper-titanate intercalation materials for amperometric sensor.

Copper-based titanate intercalation electrode materials (referred as Cu-TO) were achieved by electrochemical reduction of the intercalated cupric ions that were ion exchanged on the layer structured titanate films by using n-propylamine as an exfoliating agent. The copper-based titanate intercalation electrode materials were characterized by X-ray diffraction (XRD), electrochemical techniques and inductive coupled plasma-atomic emission spectroscopy (ICP-AES). These copper-based titanate materials were exploited to fabricate the enzymeless glucose sensors, and their assay performances to glucose were evaluated by conventional electrochemical techniques. Cyclic voltammetry (CV) and chronoamperometry (I-t) revealed a high sensitivity, fast response, excellent stability, and good reproducibility in the glucose determination at +0.55 V. Under optimal conditions, the electrocatalytic response of the sensor was proportional to the glucose concentration in the range of 2.5x10(-7) M to 8.0x10(-3) M with a detection limit of 5.0x10(-8) M (signal-to-noise=3). Moreover, the intercalated copper electrode materials exhibited high stability and improved selectivity for glucose compared with the more apparently accessible copper. This work also provides a simply controlled test-bed for electrochemical functionalization of layered titanate for sensor applications.

An organically templated cobalt-vanadium oxide with beta cage units: hydrothermal synthesis and x-ray structural characterization of (C(2)H(10)N(2))[Co(2)(C(2)O(4))V(4)O(12)].

A novel organically templated cobalt-vanadium oxalate, (C(2)H(10)N(2))[Co(2)(C(2)O(4))V(4)O(12)], was synthesized under mild hydrothermal conditions and characterized by single-crystal/powder X-ray diffraction, infrared spectroscopy, and thermogravimetric analysis. The compound crystallizes in an orthorhombic system with space group Cmcm and cell parameters a = 11.527(2) A, b = 9.9476(18) A, c = 14.780(3) A. The compound possesses 3-dimensional topologies with sodalite analogue structure and is constructed by C(2)O(4)-incorporated beta cage units. On the basis of the results of TG/DTA analyses, the structure is thermally stable up to approximately 573 K.