A Strongly Ambiphilic Ferrocene-Based Cyclic (Alkyl)(amino)carbene - Specific Decomposition to an Enamine by a 1,2-Phenyl Shift.

The recently described crystalline cyclic (alkyl)(amino)carbene with a 1,1'-ferrocenylene (fc) backbone fc(CPh2-C-NMes) (A, Mes = mesityl) is highly reactive due to its particularly pronounced ambiphilicity and is thermally not stable in solution due to an intramolecular insertion of the divalent carbon atom into a methyl C-H bond of the Mes substituent. The closely related congener fc(CPh2-C-N-p-C6H4-tBu) (1) cannot undergo such an insertion reaction. Nevertheless, 1 is too short-lived for isolation due to a rapid 1,2-shift of a phenyl group, furnishing the isomeric cyclic enamine fc[C(Ph)=C(Ph)-N-p-C6H4-tBu] (1') in a specific decomposition process unprecedented for CAACs. Trapping of 1 was possible with carbon monoxide, elemental selenium and with [CuBr(SMe2)], respectively affording the aminoketene 1=C=O, the selenoamide 1=Se and the homoleptic CuI complex [Cu(1)2][CuBr2]. 1 is an even stronger ambiphile than A according to NMR spectroscopic data. Similar to A, 1 does not react with H2, because the experimentally observed intramolecular process is kinetically more favourable according to DFT results.

Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods.

Ibuprofen (IBP), the 29th most prescribed drug in the United States in 2019, is a widely used nonsteroidal anti-inflammatory drug (NSAID) comprising two enantiomers, (R)-IBP and (S)-IBP, collectively known as (RS)-IBP. This critical review examines analytical techniques for the enantioselective separation and determination of IBP enantiomers, crucial for pharmaceutical and clinical applications. The review focuses on state-of-the-art methods, including chromatographic techniques including high-performance liquid chromatography, gas chromatography, liquid chromatography-tandem mass spectrometry, and some other techniques. This review addresses pharmacokinetics, pharmacology, and side effects of each enantiomer, ensuring safe drug usage. By consolidating diverse analytical methods and their applicability in different matrices, this review serves as a valuable resource for researchers, analysts, and practitioners in pharmaceutical analysis, pharmacology, and clinical studies.

Enantiomeric Analysis of Chiral Drugs Using Mass Spectrometric Methods: A Comprehensive Review.

Chirality plays a crucial role in the drug development process, influencing fundamental chemical and biochemical processes and significantly affecting our daily lives. This review provides a comprehensive examination of mass spectrometric (MS) methods for the enantiomeric analysis of chiral drugs. It thoroughly investigates MS-hyphenated techniques, emphasizing their critical role in achieving enantioselective analysis. Furthermore, it delves into the intricate chiral recognition mechanisms inherent in MS, elucidating the fundamental principles that govern successful chiral separations. By critically assessing the obstacles and potential benefits associated with each MS-based method, this review offers valuable insights for researchers navigating the complexities of chiral analysis. Both qualitative and quantitative approaches are explored, presenting a comparative analysis of their strengths and limitations. This review is aimed at significantly enhancing the understanding of chiral MS methods, serving as a crucial resource for researchers and practitioners engaged in enantioselective studies.

Stereoselective analysis of chiral pesticides: a review.

Chiral organic pollutants, including pesticides, herbicides, medicines, flame retardants, and polycyclic musk, represent a significant threat to both the environment and human health. The presence of asymmetric centers in the structure of chiral pesticides introduces stereoisomers with distinct distributions, fates, biomagnification capacities, and cytotoxicities. In aquatic environments, pesticides, as persistent/pseudo-persistent compounds, have been detected in substantial quantities, posing severe risks to non-target species and, ultimately, public health through water supply and food exposures. In response to this environmental challenge, stereoselective analytical methods have gained prominence for the identification of pesticide/drug enantiomers in recent years. This review examines the environmental impact of chiral pesticides, emphasizing the distinct biological activities and distribution patterns of their stereoisomers. By highlighting the advancements in liquid chromatography for enantiomeric analysis, the review aims to underscore the urgent need for a comprehensive understanding of these pollutants to facilitate informed remediation strategies and ensure the safer dispersal of chiral organic pollutants in the environment, thereby addressing the potential risks they pose to ecosystems and human health. Future research should focus on developing sustainable and efficient methodologies for the precise analysis of stereoisomers in complex matrices, particularly in sewage water, emphasizing the importance of sewage processing plants in ensuring water quality.

Palladium-Catalyzed C(sp3)-H Biarylation of 8-Methyl Quinolines with Cyclic Diaryliodonium Salts to Access Functionalized Biaryls and Fluorene Derivatives.

Herein, we have developed the cyclic diaryliodonium salts as biarylating agents in the C(sp3)-H functionalization using 8-methyl quinoline as the intrinsic directing group. The oxidant-free reaction produces a vast array of the biarylated products with iodo functionality that can be further functionalized. Additionally, intramolecular C(sp3)-H functionalization in a stepwise manner under palladium-catalyzed conditions produced the fluorene derivatives in excellent yields.

Copper-catalyzed cascade reaction of tryptamines with diazo compounds to access hexahydropyrroloindoline derivatives.

A domino reaction sequence of cyclopropanation/ring-opening/iminium cyclization of tryptamine derivatives with donor-acceptor diazo compounds is developed to furnish pyrroloindolines, creating three consecutive stereogenic centers in a single step. The copper-catalyzed reaction provides pyrroloindolines at room-temperature with good substrate scope.

Chemical characteristics and oxidative potential of indoor and outdoor PM2.5 in densely populated urban slums.

A significant proportion of population in metropolitan cities in India live in slums which are highly dense and crowded informal housing settlements with poor environmental conditions including high exposure to air pollution. Recent studies report that toxicity is induced by oxidative processes, mediated by the water-soluble PM chemical components leading to reactive oxygen species production thereby causing inflammatory disorders. Hence, for the first time, this study assessed the chemical characteristics and oxidative potential (OP) of indoor and outdoor PM2.5 in two slums in Mumbai, India. Daily gravimetric PM2.5 was measured in ∼40 homes each in a low- and a high-traffic slum and analysed for 18 water-soluble elements and organic carbon (WSOC). Subsequently, OP was assessed through the Dithiothreitol (DTT) assay. Average WSOC was similar in indoor and outdoor environments while the water-soluble concentrations of total elements ranged 4.5-6.5 µg/m3 indoors and 6.4-19.2 µg/m3 outdoors, with S, Ca, K, Na and Zn being the most abundant elements. Spatial distributions of indoor concentrations were influenced by outdoor sources such as local traffic emissions for Cd, Fe, Al and Zn. The influence of outdoor-origin particles was enhanced in homes reporting high air exchange rates. OP was higher outdoors than indoors in both low-traffic slum (0.04-0.51 nmol min-1m-3 outdoors and 0.02-0.38 nmol min-1m-3 indoors) and high-traffic slum (0.03-1.06 nmol min-1m-3 outdoors and 0.04-0.77 nmol min-1m-3 indoors). Outdoor and indoor OP was also more influenced by outdoor road dust showing significant correlation with tracer elements Cu and Al (r ≥ 0.45; p < 0.05). Similar to OP, the non-carcinogenic health risk associated with indoor PM2.5 were also higher in high-traffic slum (Hazard Index, HI = 1.60) than in low-traffic slum (HI = 0.43). Overall, this study shows that the indoor PM2.5 and its chemical constituents in Mumbai slums are primarily of outdoor origin with higher toxicity and non-carcinogenic health risk in high-traffic slums.

Dicarbofunctionalization of unactivated alkenes by palladium-catalyzed domino Heck/intermolecular direct hetero arylation with heteroarenes.

A palladium-catalyzed domino Heck/intermolecular direct hetero arylation sequence of unactivated alkenes was developed, providing 1,2,3-triazole containing bisheterocycles bearing all-carbon quaternary centers with yields of 25-90%. The protocol was extended to 1,3,4-oxadiazoles as well. The installed triazole was further exploited for late-stage functionalizations, and the mechanistic studies indicate the involvement of C-H activation.

De novo genome assembly and comparative annotation reveals metabolic versatility in cellulolytic bacteria from cropland and forest soils.

Cellulose, the most abundant polysaccharide in nature, is a rich source of renewable energy and sustains soil nutrients. Among the microorganisms known to degrade cellulose, bacteria are less studied compared to fungi. In the present work, we have investigated the culturable bacteria actively involved in cellulose degradation in forest and crop field soils. Based on clear zone formation and enzyme activity assay, we identified 7 bacterial strains positive for cellulose degradation. Of these, two most efficient strains (Bacillus cereus strains BHU1 and BHU2) were selected for whole genome sequencing, annotation, and information regarding GC content, number of genes, total subsystems, starch, and cellulose degradation pathways. Average nucleotide identity (ANI) showed more than 90% similarity between both the strains (BHU1 and BHU2) and with B. cereus ATCC 14579. Both the strains have genes and enzyme families like endoglucanase and ß-glucosidase as evident from whole genome sequence. Cellulase containing gene families (GH5, GH8, GH1), and many other carbohydrate-degrading enzymes, were present in both the bacterial strains. Taken together, the results suggest that the strains were efficient in cellulose degradation, and can be used for energy generation and production of value-added product.

Late stage functionalization of heterocycles using hypervalent iodine(iii) reagents.

Late stage functionalization (LSF) through direct X-H manipulations (X = C, N) enables synthetic chemists to accelerate the diversification of natural products, agrochemicals and pharmaceuticals allowing rapid access to novel bioactive molecules without resorting to arduous de novo synthesis. LSF does not only allow tapping of the hitherto unexplored chemical space but also renders the synthetic sequence more straightforward, atom economical and cost-effective. In this regard, the recent decade has witnessed the emergence of hypervalent iodine(iii) reagents as a powerful synthetic tool owing to their easy availability, mild reaction conditions, remarkable oxidizing properties and high functional group tolerance. Iodine(iii) reagents have tremendous applications in the regio- and chemo-selective late-stage functionalization of a diverse variety of heterocycles through an exciting range of transformations, such as oxidative amination, cross-dehydrogenative coupling (CDC), fluoroalkylation, azidation, halogenation and oxidation. The present review, classified according to the types of synthetic methods involved, encompasses all these recent developments in the field of transition-metal-free iodine(iii)-catalyzed/mediated direct functionalizations of heterocycles with representative examples and insightful mechanistic discussions.

Genotoxic effects of PM10 and PM2.5 bound metals: metal bioaccessibility, free radical generation, and role of iron.

The present study was undertaken to examine the possible genotoxicity of ambient particulate matter (PM10 and PM2.5) in Pune city. In both size fractions of PM, Fe was found to be the dominant metal by concentration, contributing 22% and 30% to the total mass of metals in PM10 and PM2.5, respectively. The speciation of soluble Fe in PM10 and PM2.5 was investigated. The average fraction of Fe3+ and Fe2+ concentrations in PM2.5 was 80.6% and 19.3%, respectively, while in PM2.5 this fraction was 71.1% and 29.9%, respectively. The dominance of Fe(III) state in both PM fractions facilitates the generation of hydroxyl radicals (·OH), which can damage deoxyribose nucleic acid (DNA), as was evident from the gel electrophoresis study. The DNA damage by ·OH was supported through the in silico density functional theory (DFT) method. DFT results showed that C8 site of guanine (G)/adenine (A) and C6 site of thymine (T)/cytosine (C) would be energetically more favorable for the attack of hydroxyl radicals, when compared with the C4 and C5 sites. The non-standard Watson-Crick base pairing models of oxidative products of G, A, T and C yield lower-energy conformations than canonical dA:dT and dG:dC base pairing. This study may pave the way to understand the structural consequences of base-mediated oxidative lesions in DNA and its role in human diseases.

Chemical fractionation and health risk assessment of particulate matter-bound metals in Pune, India.

The present study deals with the assessment of sequential extraction of particulate matter (PM)-bound metals and the potential health risks associated with them in a growing metropolitan city (Pune) of India. The average mass concentration of both PM2.5-10 and PM2.5 exceeded the National Ambient Air Quality Standards. Significant seasonal variation in mass concentration was found for both size fractions of PM with higher values in winter season and lower in monsoon. Chemical species of the studied trace metals in PM exhibited significant differences, due to difference in sources of pollution. Metals such as Cd, Pb, and Cr in both size fractions and Zn and Co in fine fraction were more efficiently extracted in mobile fractions showing their mobile nature while Ni and Fe showed reduced mobility. Fe showed the highest concentrations among all the analyzed elements in both coarse (PM2.5-10) and fine (PM2.5) PM, while Cd showed least concentration in both size fractions. PCA identified industrial emissions, vehicular activity, coal combustion, diesel exhaust, waste incineration, electronic waste processing, constructional activities, soil, and road dust as probable contributors responsible for the metallic fraction of PM. All the metals showed varying contamination in PM samples. The contamination was higher for fine particles than coarse ones. The average global contamination factor was found to be 27.0-34.3 in coarse and fine PM, respectively. The hazard quotient (HQ) estimated for Cd, Co, and Ni (both total and easily accessible concentrations) exceeded the safe level (HQ = 1), indicating that these metals would result in non-carcinogenic health effects to the exposed population. The HQ ranged from 9.1 × 10-5 for Cu (coarse) to 8.3 for Ni (fine) PM. The cancer risk for Cd, Ni, and Cr in both sized PM were much higher than the acceptable limits of USEPA.

Expression of polyQ aggregates in Malpighian tubules leads to degeneration in Drosophila melanogaster.

BACKGROUND: Polyglutamine (polyQ) disorders are caused by expanded CAG (Glutamine) repeats in neurons in the brain. The expanded repeats are also expressed in the non-neuronal cells, however, their contribution to disease pathogenesis is not very well studied. In the present study, we have expressed a stretch of 127 Glutamine repeats in Malpighian tubules (MTs) of Drosophila melanogaster as these tissues do not undergo ecdysone induced histolysis during larval to pupal transition at metamorphosis. RESULTS: Progressive degeneration, which is the hallmark of neurodegeneration is also observed in MTs. The mutant protein forms inclusion bodies in the nucleus resulting in expansion of the nucleus and affect chromatin organization which appear loose and open, eventually resulting in DNA fragmentation and blebbing. A virtual absence of tubule lumen was observed followed by functional abnormalities. As development progressed, severe abnormalities affecting pupal epithelial morphogenesis processes were observed resulting in complete lethality. Distribution of heterogeneous RNA binding protein (hnRNP), HRB87F, Wnt/wingless and JNK signaling and expression of Relish was also found to be affected. Expression of resistance genes following polyQ expression was up regulated. CONCLUSION: The present study gives an insight into the effects of polyQ aggregates in non-neuronal tissues.

Long-term Follow-up of Trigeminal Neuralgia Patients treated with Percutaneous Balloon Compression Technique: A Retrospective Analysis.

BACKGROUND: Trigeminal neuralgia (TN) refers to sharp, lancinating pain in the areas supplied by trigeminal nerve. Both pharmacological and surgical lines of treatments are available for the treatment of TN. Percutaneous balloon compression (PBC) is one such surgical technique that is usually advocated for the treatment of TN occurring in elderly patients. Hence, we aim to evaluate the follow-up results of the TN patients treated by the PBC technique. MATERIALS AND METHODS: A total of 400 patients were selected for the study who had undergone surgical treatment of TN by percutaneous balloon decompression technique. All the postoperative follow-up records of the patients, clinical history, and complication records of the patients were studied and evaluated. RESULTS: Of all the patients included in the study, 353 patients showed improvement clinically after PBC therapy. Out 400, 180 were males and 220 were females. Postoperative complications of the patients during their follow-up were also recorded and it was observed that the most common complication arising after treatment with this technique included facial numbness, masseter muscle weakness, paresthesia, diplopia, and corneal anesthesia. CONCLUSION: One of the most common neuralgic pains affecting the face is the pain of TN. Although numerous lines of treatment options are available for its treatment, all these have one or the other drawbacks. From our results, we can conclude that PBC technique offers more advantages than other surgical modalities and, therefore, should be preferred over other techniques of treatment.

Marginal Adaptation Evaluation of Biodentine and MTA Plus in "Open Sandwich" Class II Restorations.

PURPOSES: This study aimed at evaluation of two different commercially available calcium silicate materials (Biodentine and mineral trioxide aggregate [MTA] Plus) used as dentin substitute. MATERIALS AND METHODS: Sixty Class II cavities were prepared in extracted mandibular third molars, with margins extending 1 mm below the cementum-enamel junction. The samples were divided into three groups on the basis of dentin substitute used: resin modified glass ionomer cement, Biodentine, and MTA Plus. Cavities were restored with composite resins in an "open sandwich" technique. The samples were subjected to alternate aging in phosphate buffered saline and cyclic loading. Marginal adaptation was evaluated in terms of "continuous margin" at the gingival margin, using a low vacuum scanning electron microscope. Statistical analysis was done with two-way analysis of variance with Holm-Sidak's correction for multiple comparisons. RESULTS: The glass ionomer group and Biodentine group presented an overall 83% and 91% of continuous margins, with no difference between them. MTA Plus showed least values of continuous margins. Granular deposits were seen over the surface of Biodentine and MTA Plus. CONCLUSIONS: Biodentine and resin-modified glass ionomer cement, when used as a dentin substitute under composite restorations in open sandwich technique, gave satisfactory marginal adaptation values. CLINICAL SIGNIFICANCE: Contemporary calcium silicate materials can be used as dentin substitute materials in "open sandwich" Class II restorations. This study evaluates the marginal adaptation of Biodentine, MTA Plus, and resin modified glass ionomer cement used as dentin substitutes and reports better adaptation obtained with Biodentine and glass ionomer cement.

The effect of climate and meteorological changes on particulate matter in Pune, India.

This paper presents the distinctiveness of particulate matter (PM) mass concentrations (PM10, PM2.5, and PM10-2.5) and meteorological effect in Pune city during 2011-2012. The PM samples were collected using Mini-Vol TAS air sampler (Airmetrics Co. Inc., 5 l min(-1) flow rate). The meteorological parameters were also measured during the study period. The analysis of 24-h average PM10, PM2.5, and PM10-2.5 concentrations showed the maximum during winter (267.2-67.2, 180.6-55.6, 138.9-11.7 µg m(-3)) followed by summer (236.1-55.5, 138.8-27.7, 125-13.8 µg m(-3)) and post-monsoon (153.3-82.3, 138.9-41.7, 41.7-14.4 µg m(-3)) and showed the lowest concentration during monsoon (98.9-27.8, 83.3-13.9, 40.0-6.0 µg m(-3)) seasons in the entire study. PM10 comprised a vast fraction of PM2.5 (61% of PM2.5), while the estimated PM2.5/PM10 ratios for monsoon, post-monsoon, winter, and summer seasons were ranged between 0.5 and 0.9, 0.51 and 0.91, 0.3 and 0.9, and 0.3 and 0.8, respectively. The 7-day back trajectories analysis for whole year shows that the air masses transported to Pune were mixed mainland-maritime such as from southwesterly, north, northwest. Chemometric analysis was applied as a tool to evaluate and predict the particulate mass concentration from available meteorological data. To achieve this, a calibration model was developed by partial least squares regression (PLSR) method and was further used to predict the PM concentrations based on meteorological data. On predicting the PM concentration from local meteorological data, the model performance and quality was found very good in case of PM10 compared to PM2.5.

Variation in oxidative potential of fine particulate matter and its association with chemical constituents at a regional site in India.

Fine particulate matter (PM2.5) constituents are greatly affected by site-specific emission sources and are one of the main reasons for oxidative stress that leads to cardiovascular ailments. This study investigated the temporal, seasonal, and episodic variations in the oxidative potential (OP) of PM2.5 and its association with chemical components. Additionally, we have also examined the effect of filter substrates on OP. Dithiothreitol (DTT) and ascorbic acid (AA) acellular assays were used to estimate the formation of reactive oxygen species (ROS) in PM2.5 samples collected over a year from a regional site in India. PM2.5 morphology and functional groups were also analyzed. Results showed that OPDTTv was at the highest in winter (2.56 ± 0.84 nmol min-1 m-3) and at the lowest during monsoon (0.79 ± 0.65 nmol min-1 m-3). OPAAv exhibited the highest activity in post-monsoon (0.09 ± 0.04 nmol min-1 m-3) and least in summer (0.05 ± 0.04 nmol min-1 m-3). Biomass burning (BB) and open-field burning of crop residue during the rabi and kharif harvesting seasons were associated with significantly elevated PM2.5 toxicity, which is indicative of the contribution of combustion-derived particles. OPDTTv and OPAAv levels from BB in post-monsoon were 21 % and 67 % higher than the levels observed during BB in summer. Flaky irregular agglomerates and porous structures were observed during the BB period. Fourier-transformed infrared spectroscopy revealed that traffic-emitted organic hydrocarbons CH functional group was dominant across the season. Further, chemical species such as organics (OC and EC fractions) and ions (SO42-, NH4+, Cl-, NO3-) were found to be significantly associated with OP. Among the three filter substrates, the Teflon showed higher OP variability for both assays. This study emphasizes the impact of regional toxic aerosols across seasons and during episodic events. It contributes to our understanding of the toxicity of ambient PM2.5, which is crucial for developing targeted air-quality management strategies.

To Study the Distress, Anxiety, Depression, and Sleep Effects of the COVID-19 Pandemic on Essential Workers.

Essential care workers like police personnel, social workers, and office and administrative staff of health institutions are also at increased risk of coronavirus disease 2019 (COVID-19) exposure along with healthcare workers. The present study aims to estimate the distress, anxiety, depression, and sleep impact of COVID-19 pandemic on essential workers through an online survey. This cross-sectional study (included 369 participants) was conducted in Chandigarh through an online survey using three psychological scales: Peritraumatic Distress Inventory (PDI), Insomnia Severity Index, and Depression Anxiety Stress Scale. Three-hundred-sixty-nine frontline warriors from hospital and community settings were included in the study. The respondents include police personnel (274; 73.66%), office staff (24; 6.45%), social workers (53; 14.24%), and media staff (21; 5.65%). Maximum distress was reported by media/transport officials on duty (85.7%). The majority of them scored high (>14), and slightly less than one-fourth (23.8%) scored significantly abnormal (>23) on PDI. About 42.9% reported moderate insomnia, 52.4% exhibited severe anxiety, and 33.3% of media/transport participants reported severe depression. Psychological morbidity is high in media/transport and social workers working in the community during the COVID-19 pandemic.

Finite element analysis (FEA) of stress distribution in platform-switched short dental implants.

The distribution of stress on short platform switched dental implants is of interest. Hence, the mandibular posterior molar area was modelled using a three-dimensional finite element method (FEM) with a continuous 1.5 mm cortical bone thickness and an inner cancellous bone core. The implants used in the study were 5 mm long, 4.5 mm wide and 3.5 mm wide at the abutments. 120 N of force was applied in both the vertical and oblique (20° and 35°) directions to create a realistic simulation. ANSYS Workbench was generated for each model. Von Mises stress was assessed in the cortical and cancellous bones at varying depths. Ten noded tetrahedron elements with three degrees of freedom per node were employed to interpret translations on the x, y, and z axes. The stress-based biomechanical behaviour of platform switched short osseo-integrated implants varied across all 5 positions in FEM simulations, based on the depth of implant placement, the direction of applied force, and the shape of the bone. Data shows that opposite forces to the vertical forces caused more damage. Thus, the implantation of subcrestal implants resulted in reduced stress on the cortical and cancellous bone.

Radioactive elements in wastewater and potable water: Sources, effects, and methods of analysis and removal.

Radioactive effluents, originating from nuclear power plants, medical-nuclear applications, and various extraction industries worldwide, present a significant and dangerous contamination challenge. The concentrations of radioactive substances in wastewater, surface water, and potable water vary widely depending on the source and location. For example, cesium-137 levels in wastewater from nuclear facilities can range from 0.1 to 10 Bq/L, while tritium concentrations in surface water near nuclear plants can reach up to 100 Bq/L. Regulatory guidelines, like the maximum contaminant level of 0.185 Bq/L for combined radium-226 and radium-228 in drinking water, are critical for ensuring safety and environmental protection. Specifically, in Fukushima, Japan, cesium-137 levels in surface water range from 0.1 to 10 Bq/L due to the nuclear accident. In contrast, regions with natural uranium deposits, like parts of the United States, have reported radium-226 concentrations in potable water up to 1 Bq/L. These variations highlight the necessity for focused monitoring and evaluation to protect water quality and community health. Among various methods, Gamma spectrometry and inductively coupled plasma mass spectrometry are precise for radionuclide quantification, scintillation detectors, and ion exchange, and adsorption techniques efficiently remove radioactive substances from water. This critical review examines the sources, adverse effects, and analysis and remediation strategies for various radioactive elements in wastewater. By thoroughly evaluating the origins and potential dangers associated with radioactive effluents, this report emphasizes the urgent need for rigorous monitoring and effective treatment practices to maintain the integrity of water resources and ecosystems. PRACTITIONER POINTS: Comprehensive analysis of the radioactive elements frequently found in wastewater and drinking water. Assess the negative effects of radioactive elements in water systems. Examine the treatment methods used to eliminate radioactive pollutants from water sources. Outline effective methods and tactics for addressing and controlling radioactive contamination occurrences. Analyze the latest advancements in technology, regulatory enhancements, and optimal methods to guarantee the safety of drinking water and the sustainable handling of radioactive substances in wastewater.