Intraosseous hibernoma: a case report and review of the literature.

Intraosseous hibernoma is a rare benign bone tumor, with only 4 cases reported in English literature. CASE REPORT: In this report, we describe a 42-year-old man with  no past medical history and right chest pain. Imaging studies showed an osteolytic lesion with fat attenuation lesion in the right fourth rib. The lesion was completely resected and microscopic study showed mildly thickened bone trabeculae and multivacuolated brown fat cells replacing the normal white fat and hematopoietic elements. The diagnostic of intraosseous hibernoma was made. CONCLUSION: Although it is rare, hibernoma should be included in the differential diagnosis of lipomatous  tumors.

Intraosseous hibernoma: a case report and review of the literature.

Intraosseous hibernoma is a rare benign bone tumor, with only 4 cases reported in English literature. CASE REPORT: In this report, we describe a 42-year-old man with  no past medical history and right chest pain. Imaging studies showed an osteolytic lesion with fat attenuation lesion in the right fourth rib. The lesion was completely resected and microscopic study showed mildly thickened bone trabeculae and multivacuolated brown fat cells replacing the normal white fat and hematopoietic elements. The diagnostic of intraosseous hibernoma was made. CONCLUSION: Although it is rare, hibernoma should be included in the differential diagnosis of lipomatous  tumors.

[Prognostic value of markers of aggressiveness of urinary bladder tumours evaluated by immunohistochemistry]. / Valeur pronostique des marqueurs d'agressivité des tumeurs vésicales évalués par immunohistochimie.

BACKGROUND: The study of some immunohistochemical markers provides an objective and reproducible prognostic evaluation of urinary bladder tumour. aims: study the expression of the following immunohistochemical markers in Tumours of the bladder: Proliferating Cell Nuclear Antigen (PCNA), Ki67 antigen (MIB1), the C-erbB2 proto- antigene, the tumor suppressor gene p53, the receptor for epidermal growth factor (EGF-R), the apoptosis suppressor gene bcl2, the carcinoembryonic antigen (CEA) and epithelial membrane antigen (EMA). methods: Study of retrospective series of 30 patients having tumours of the urinary bladder. results: The expression of PCNA with a cut-off value of 14% is correlated with recurrence (P = 0.010). The expression of PCNA with a cut-off value of 1% is correlated with tumour stage (P = 0.003). The expression of MIB1 with a cut-off value of 47% is correlated with recurrence (P = 0.010). The expression of MIB1 with a cut-off value of 47% is correlated with the tumour progression in stage and\or in grade (P = 0.007). The expression of C-erbB2 with a cutoff value of 28% is correlated in the tumour grade (P = 0.007). The other antibodies didn't demonstrate a prognostic value. CONCLUSION: MIb1 and PCNA being correlated with recurrence, they can be useful with the decision of the rhythm of the endoscopy. The correlation of C-erbB2 with the tumour grade could serve to better graduating bladder tumours.

Study of the hydrogen physisorption on adsorbents based on activated carbon by means of statistical physics formalism: modeling analysis and thermodynamics investigation.

An advanced statistical physics model has been applied to study the hydrogen adsorption isotherm on two modified types of activated carbon, namely granular coal activated carbon (AC (GC)) and coconut shell activated carbon (AC (CS)). This model is established with the statistical physics approach. It is a more general model including various parameters having a defined physico-chemical sense which were discussed at different temperatures. Hence new physic-chemical interpretations of the adsorption process of hydrogen are provided. The analysis of the hydrogen uptake capacities at saturation showed that the AC (GC) adsorbent displayed a high adsorption capacity (3.21 mg/g). This due to the contribution of the number of hydrogen molecules per site (1.27) associated with the receptor sites density (0.74 mg/g) and the number of formed layers (3.42). The modeling results suggested that the hydrogen adsorption occurred by non-parallel positions on the two tested adsorbents thus evincing that the adsorption cannot be other than a multi-molecular process. The calculated adsorption energies globally varied from 7.01 to 12.92 kJ/mol, confirming the physical nature of the adsorption process for both studied systems. The thermodynamic functions, namely internal energy, enthalpy and entropy were estimated to better analyze the hydrogen sorption process. In summary, the statistical physics analysis provided reliable concrete physico-chemical interpretations of hydrogen adsorption process on carbon-based adsorbents with various microstructures to develop a storage compounds with a suitable framework for a hydrogen storage structure.

New insights in the physicochemical investigation of the vitamin B12 nucleus using statistical physics treatment: interpretation of experiments and surface properties.

In this research paper, the equilibrium isotherms for the adsorption of cobalt(ii)nitrate and cobalt(ii)chloride on tetrakis(4-tolylphenyl)porphyrin (H2TTPP) were obtained at four temperatures for modeling analysis. The experimental data describing the adsorbed quantity of cobalt particles were measured using the quartz crystal microbalance (QCM) strategy. Then, statistical physics formalism was employed to interpret the complexation mechanism by applying the real gas law that contemplates the interaction between the adsorbate particles in the free state. Advanced models treated with the law of van der Waals were applied for the single and L.B.L adsorptions of Co2+ at various temperatures (288-318 K). The experimental adsorption data of CoCl2 on porphyrins were satisfactorily fitted with the monolayer equation, showing that the chlorine particles had no effect on the complexation system, while the nitrate particles were involved in the adsorption of Co(NO3)2 and contributed to the layer formation. The physicochemical parameters of statistical physics models were estimated and used to compare the complexation mechanisms of both adsorbates. The study of the cohesion pressure (a) and the co-volume (b) confirmed that cobalt chloride guaranteed more stability during the formation of the vitamin B12 nucleus. Deeper energetic analysis demonstrated that cobalt ions were complexed by ionic or covalent bonds in the case of cobalt chloride (complexation energy (-E 1/2) varies from -48.2 to -50.3), while a physisorption process took place in the case of cobalt nitrate ((-E 1) varies from -33.6 to -36.1), thus indicating that CoCl2-H2TTPP was the most stable complex. The statistical physics models were also used to investigate two thermodynamic functions that govern the adsorption mechanisms, namely, the configurational entropy and the Gibbs free enthalpy.

Physico-chemical study of complexation of silver ion (Ag+) by macrocyclic molecules (hexa-Helicenes) based on statistical physics theory: new description of a cancer drug.

In recent papers, it is found that the silver-[6]Helicene complex can be used as a cancer drug but the interaction silver-hexaHelicene has not yet proven. The idea of this paper is to investigate the complexation process of the [6]Helicene by the silver metal (Ag+) using three types of adsorbates. Indeed, the adsorption of silver chloride, silver nitrate and silver sulfide into the sensor films deposited on the QCM electrode are measured at three temperatures (293-333 K). Films of the [6]Helicene were deposited on the QCM resonators using spin coating method in order to obtain uniform and homogenous sensor surface. Experimental results indicated that the [6]Helicene can form a stable complex with the silver ion and that the AgCl is the appropriate adsorbate for the complexation achievement. Actually, an advanced modeling analysis by means of statistical physics adsorption models is applied to explore the new vision of the complextion system. The values of the models parameters are deduced from fitting the experimental data with the developed models. They result in confirming the experimental findings by comparing the complexation energies of the three examined systems. In particular, for the silver nitrate, the Van-der-Waals parameters explained the isotherms drop at high concentration through the lateral interactions between the adsorbates. The adsorption energies analysis showed the highest interaction AgCl-[6]Helicene. Density functional theory (DFT) simulations showed that chemical bonds take place during the adsorption of silver chloride on hexaHelicene which confirms that the [6]Helicene can function as a chiral molecular tweezer of the univalent cationic silver.