Lifetime familiarity cue effects for autobiographical memory.

Recollecting an autobiographical memory requires a cue to initiate processes related to accessing and then elaborating on a past personal experience. Prior work has shown that the familiarity of a cue can influence the autobiographical memory retrieval process. Extending this work, we tested how familiarity accrued from cumulative lifetime exposures associated with the cue-as well as associated semantic knowledge-can affect how we access and remember autobiographical memories. In Experiment 1, we measured reaction times to access and report memories in response to cue words. In Experiment 2 we examined the details with which participants described memories in response to cue words. For both experiments, participants provided estimates of lifetime exposure and semantic knowledge for each cue. In Experiment 1, we found a cue's lifetime exposure, independent of semantic knowledge, led to quicker memory access. In Experiment 2, we found the lifetime exposure and semantic knowledge of a cue interactively affected the specificity of a described autobiographical memory. These results provide new evidence that the amount of lifetime exposure associated with a cue, both independently and interactively with semantic knowledge, influences how autobiographical memories are accessed and described.Clinical trial This was not a clinical trial.Trial Registration Number (TRN) N/A.

Involuntary memory signals in the medial temporal lobe.

We highlight recent progress in neuroimaging and neuropsychological research on memory mechanisms in the medial temporal lobe that speaks to the involuntary nature of memory retrieval processes. We suggest that evidence form these studies supports Barzykowski and Moulin's proposal that memory signals involved in experiences of familiarity and déjà vu can be generated in the absence of retrieval intentionality.

Feeling-of-knowing experiences breed curiosity.

A central tenet in theoretical work on metacognition is that retrieval experiences during memory search can exert control over behaviour. States of curiosity, which reflect motivational tendencies to seek out information, may play a critical role in this control function. We conducted two experiments to address this idea, focusing on links between feeling-of knowing (FOK) experiences, memory-search duration, and subsequent information-seeking behaviour. We administered an episodic FOK paradigm that probed memory for previously studied face-name pairs, and subsequently provided an opportunity to select limited pairs for restudy. This set-up allowed us to test whether current search duration and subsequent restudy choices are biased towards items with high FOK ratings. Results revealed a positive relationship between FOK ratings and the response times of these judgements. We observed a similar positive relationship between FOK ratings and subsequent item selection for restudy. Moreover, experimental manipulations of FOK ratings based on familiarity of the face cues also had parallel effects. Our findings suggest that metacognitive experiences during unsuccessful retrieval from episodic memory can induce states of curiosity that shape behaviour beyond the immediate retrieval context. Curiosity may act as a bond to ensure that memory gaps identified through unsuccessful retrieval adaptively guide future learning.

Global matching and fluency attribution in familiarity assessment.

In the integrative memory model proposed by Bastin et al., familiarity is thought to arise from attribution of fluency signals. We suggest that, from a computational and anatomical perspective, this conceptualization converges with a global-matching account of familiarity assessment. We also argue that consideration of global matching and evidence accumulation in decision making could help further our understanding of the proposed attribution system.

Perirhinal cortex automatically tracks multiple types of familiarity regardless of task-relevance.

Perirhinal cortex (PrC) has long been implicated in familiarity assessment for objects and corresponding concepts. However, extant studies have focused mainly on changes in familiarity induced by recent exposure in laboratory settings. There is an increasing appreciation of other types of familiarity signals, in particular graded familiarity accumulated throughout one's lifetime. In prior work (Duke et al., 2017, Cortex, 89, 61-70), PrC has been shown to track lifetime familiarity ratings when participants make related judgements. A theoretically important characteristic of familiarity is its proposed automaticity. Support for automaticity comes from a documented impact of recent stimulus exposure on behavioral performance, and on PrC signals, under conditions in which this exposure is not task relevant. In the current fMRI study, we tested whether PrC also tracks lifetime familiarity of object concepts automatically, and whether this type of familiarity influences behavior even when it is not task relevant. During scanning, neurotypical participants (N = 30, age range 18-40, 7 males) provided animacy judgements about concrete object concepts presented at differing frequencies in an initial study phase. In a subsequent test phase, they made graded judgements of recent or lifetime familiarity. Behavioral performance showed sensitivity to lifetime familiarity even when it was not relevant for the task at hand. Across five sets of fMRI analyses, we found that PrC consistently tracked recent and lifetime familiarity of object concepts regardless of the task performed. Critically, while several other temporal-lobe regions also showed isolated familiarity effects, none of them tracked familiarity with the same consistency. These findings demonstrate that PrC automatically tracks multiple types of familiarity. They support models that assign a broad role in the representation of information about object concepts to this structure.

Deficits in recent but not lifetime familiarity in amnestic mild cognitive impairment.

People with amnestic mild cognitive impairment (aMCI) repeat questions, seemingly without any sense of familiarity (i.e., recognition of prior occurrence without recollection of episodic context). Accumulation of neurofibrillary tau in preclinical Alzheimer's disease begins in perirhinal cortex, a medial temporal lobe region linked to familiarity. Both observations would predict impaired familiarity assessment in aMCI; however, the extant evidence is mixed. To reveal familiarity impairments, it may be necessary to minimize the influence of recollection. In the current study, older adults with aMCI and healthy controls were administered two tasks on which a well-characterized patient (NB) with selective familiarity impairments due to surgical left temporal lobe excision sparing the hippocampus showed abnormal performance: frequency judgments for words exposed to in a recent study phase and judgments of cumulative lifetime familiarity for object concepts denoted by words. We also administered a process dissociation procedure (PDP) task that previously revealed spared familiarity in aMCI. We predicted that familiarity would be spared in aMCI on the PDP task, but impaired when assessed by frequency judgments for recent laboratory exposures and lifetime familiarity judgments. Familiarity was spared on the PDP task, but was impaired when probed with frequency judgments for recently exposed words in aMCI. Lifetime familiarity was also not impaired in aMCI. These results highlight the benefits of studying familiarity under conditions that minimize recollection and the value of frequency judgments in revealing familiarity deficits, and suggest that perirhinal cortex may not be necessary for accessing familiarity accumulated over a lifetime of experience.

Late positive complex in event-related potentials tracks memory signals when they are decision relevant.

The Late Positive Complex (LPC) is an Event-Related Potential (ERP) consistently observed in recognition-memory paradigms. In the present study, we investigated whether the LPC tracks the strength of multiple types of memory signals, and whether it does so in a decision dependent manner. For this purpose, we employed judgements of cumulative lifetime exposure to object concepts, and judgements of cumulative recent exposure (i.e., frequency judgements) in a study-test paradigm. A comparison of ERP signatures in relation to degree of prior exposure across the two memory tasks and the study phase revealed that the LPC tracks both types of memory signals, but only when they are relevant to the decision at hand. Another ERP component previously implicated in recognition memory, the FN400, showed a distinct pattern of activity across conditions that differed from the LPC; it tracked only recent exposure in a decision-dependent manner. Another similar ERP component typically linked to conceptual processing in past work, the N400, was sensitive to degree of recent and lifetime exposure, but it did not track them in a decision dependent manner. Finally, source localization analyses pointed to a potential source of the LPC in left ventral lateral parietal cortex, which also showed the decision-dependent effect. The current findings highlight the role of decision making in ERP markers of prior exposure in tasks other than those typically used in studies of recognition memory, and provides an initial link between the LPC and the previously suggested role of ventral lateral parietal cortex in memory judgements.