Transition-metal free C3-amidation of quinoxalin-2(1H)-ones using Selectfluor as a mild oxidant.

A practical and efficient synthetic route to construct a variety of 3-amidated quinoxalin-2(1H)-ones was developed via transition-metal free direct oxidative amidation of quinoxalin-2(1H)-ones with amidates using Selectfluor reagent as a mild oxidant. This protocol features mild reaction conditions, operational simplicity, broad substrate scope, and good to excellent yields.

Comparison of the effects of micro-osteoperforation and corticision on the rate of orthodontic tooth movement in rats.

OBJECTIVE: To investigate the effects of flapless micro-osteoperforation and corticision on the rate of orthodontic tooth movement in rats. MATERIALS AND METHODS: Forty-five 8-week-old male Sprague-Dawley rats were divided into the following groups: micro-osteoperforation and orthodontic force (MOP + F), corticision and orthodontic force (C + F), and orthodontic force only (F, control). The left maxillary first molars were pulled forward with a force of 50 g. Flapless surgical interventions were conducted in the MOP + F and C + F groups. The total duration of the experiment was 6 weeks. Alveolar bone density and the number of osteoclasts were evaluated using microcomputed tomography and histologic examination, respectively. RESULTS: The tooth movement distance was significantly higher in both experimental groups than in the control group. Bone density and bone mineral density decreased in the MOP + F and C + F groups. The number of osteoclasts in the MOP + F and C + F groups was significantly higher than in the control group F. CONCLUSION: The two minimally invasive flapless surgical interventions increased bone remodeling and osteoclast activity and induced faster orthodontic tooth movement for at least 2 weeks in rats. No differences were observed between the outcome of flapless micro-osteoperforation and corticision in the rats.

A preliminary report of a disposable electrical non-fiberoptic endoscope in thoracoscopic surgery.

PURPOSE: Conventional thoracoscopic surgery requires a camera connected to optic fibers and rigid rod lens to ensure the provision of adequate light and quality of real-time images in the operative field. However, the camera, the connected optic fibers and rigid rod lens are not disposable due to cost, which is a concern as regards potential contamination of patients. To decrease such contamination, we designed a disposable device of extremely low cost which we tested in thoracoscopic surgery in animals. DESCRIPTION: A complementary metal-oxide-semiconductor is used for obtaining real-time image at a refresh rate of 30 frames per second. A circumferential light was added by a light emitting diode. We connected wires to a universal serial bus adapter, with which the device can negotiate with a computer so as to control signal retrieval and adjustment of the light as well as focus. The device was designed to be as compact as possible. The contour resembled a conventional thoracoscope, but with no optic fibers and rigid rod lens included. EVALUATION: We used the devices to perform routine thoracoscopic surgical procedures, including wedge resection of the lung, lobectomy, esophagectomy, pericardiotomy and pleural biopsy in two 40-kg pigs under general anesthesia. The operating techniques were not altered while using this device. CONCLUSION: This disposable, electrical non-fiberoptic endoscope has the potential to be easily and safely used in routine thoracoscopic surgery at a minimal cost. Further clinical evaluation will be required to demonstrate the utility in human patients.