RESUMO
PURPOSE: Little research has examined the validity of using census data to determine an individual's socio-economic status (SES), as measured by race and educational level. This study assessed the accuracy of using aggregate level data from United States Census Block Groups in determining race and education SES indicators in a cohort of women from North Carolina. METHODS: The study analyzed patient data from the Carolina Mammography Registry and 1990 United States Census in 21 North Carolina counties. Women (n = 39,546) were geocoded to their census block group and their block group characteristics (surrogate measures) were validated with their self-reported values on race and education. An analysis was performed to explore whether using these surrogate measures would affect measured associations with the self-reported values. RESULTS: Whites were accurately identified (84.8%) more consistently than Blacks (14.1%) regardless of their urban/rural status. Women without a high school diploma or equivalent were accurately identified (56.2%) more often than those with higher education levels (45.9%). Analyses using the surrogate measures were significantly different than the true values according to chi-square statistics. CONCLUSIONS: Use of census data to derive SES indicators tends to be more accurate for the majority than the minority population. Researchers must be sensitive to the ecologic fallacy when using aggregate level data such as the census to determine individual level characteristics.
Assuntos
Negro ou Afro-Americano/estatística & dados numéricos , Censos , Doença Crônica/epidemiologia , Escolaridade , Indicadores Básicos de Saúde , População Branca/estatística & dados numéricos , Mama/citologia , Contagem de Células , Feminino , Humanos , Mamografia/estatística & dados numéricos , North Carolina/epidemiologia , Grupos Raciais , Sistema de Registros , Reprodutibilidade dos Testes , População Rural , Fatores Socioeconômicos , População UrbanaRESUMO
For patients with pyogenic lung abscesses who do not respond to medical therapy, thoracotomy with pulmonary resection is the widely-accepted treatment of choice. Six patients with lung abscess who failed to respond to conservative medical management were treated by percutaneous catheter drainage using small catheters (10 Fr or smaller). Five patients showed prompt clinical improvement and the sixth improved after a modification in antibiotic therapy. All patients recovered with radiographic resolution of the abscess and were well at followup periods from two months to two years. In such patients, percutaneous drainage with small catheters provides an excellent clinical result with minimal risk and trauma.
Assuntos
Drenagem/instrumentação , Abscesso Pulmonar/terapia , Adulto , Idoso , Antibacterianos/uso terapêutico , Cateterismo/instrumentação , Pré-Escolar , Humanos , Abscesso Pulmonar/diagnóstico por imagem , Masculino , RadiografiaRESUMO
The objective of this study was to evaluate how the introduction of radiologic studies affected the diagnostic workup for pancreatic cancer, from 1955 through 1979. For 961 patients diagnosed as having pancreatic cancer at three teaching hospitals, we reviewed medical records, autopsy reports, and death certificates for results from all radiologic studies, surgical and pathologic procedures, and for the final diagnosis. The number of radiologic studies per patient increased as new studies were introduced; 1.6 for 1955-1959, 3.5 for 1975-1979 (P less than 0.0001). Depending on the cutoff level chosen, the sensitivity of the overall radiologic diagnosis increased over time, 0.17-0.43 for 1955-1959, to 0.54-0.78 for 1975-1979; CT, US, and ERCP accounted for much of the increase. As newer radiologic studies are introduced, continued use of previously accepted studies should be carefully evaluated.
Assuntos
Adenocarcinoma/diagnóstico por imagem , Neoplasias Pancreáticas/diagnóstico por imagem , Adenocarcinoma/diagnóstico , Angiografia , Colangiografia , Colangiopancreatografia Retrógrada Endoscópica , Humanos , Neoplasias Pancreáticas/diagnóstico , Tomografia Computadorizada por Raios X , UltrassonografiaRESUMO
RATIONALE AND OBJECTIVES: Dilatation of fallopian tube remnants after ligation has been described but never systematically studied in post-ligation hysterosalpingograms (HSGs). This study describes the frequency and appearance of proximal tubal remnant dilatation as seen on HSGs in women with a history of bilateral tubal ligation (BTL). METHODS: A retrospective review of medical records and a subjective and objective evaluation of dilatation seen on HSGs included 68 consecutive women seen for pre-reanastomosis HSG. RESULTS: Among the 68 women, 44 (67%) had objectively measured dilatation on one or both tubes. Dilatation was present in both short and long tubal remnants. There were no measurable differences between women with and without presence of dilatation. Neither length nor dilatation of tubal remnant was associated with pregnancy outcome. CONCLUSIONS: Dilatation of the tubal remnant after bilateral tubal ligation is a common finding on HSG and can be accurately identified from the HSG by radiologists. Dilatation is not strictly related to length, and in our small sample with follow-up, was not associated with pregnancy outcome.
Assuntos
Doenças das Tubas Uterinas/diagnóstico por imagem , Complicações Pós-Operatórias/diagnóstico por imagem , Esterilização Tubária , Adolescente , Adulto , Distribuição de Qui-Quadrado , Diatrizoato de Meglumina , Dilatação Patológica/diagnóstico por imagem , Dilatação Patológica/epidemiologia , Doenças das Tubas Uterinas/epidemiologia , Feminino , Seguimentos , Humanos , Histerossalpingografia/métodos , Incidência , Complicações Pós-Operatórias/epidemiologia , Gravidez , Resultado da Gravidez , Reversão da Esterilização , Fatores de TempoRESUMO
OBJECTIVES: The authors compared the two most common presurgical tests now used for the preoperative staging of adenocarcinoma of the prostate, prostate-specific antigen (PSA) and magnetic resonance imaging (MRI). METHODS: One hundred consecutive radical retropubic prostatectomy patients were imaged at 1.5 Tesla before surgery with routine T1-weighted and T2-weighted transaxial images. The images were analyzed by two experienced radiologists for evidence of extracapsular disease. Radiologists rated each gland on a scale of 0 to 100 for the percentage likelihood of extracapsular disease based on its MRI appearance. Receiver operator characteristic (ROC) curves were plotted, and areas were calculated for the two radiologists and the preoperative PSA values. RESULTS: Comparison of the areas of the ROC curves generated from the two radiologists and those from the preoperative PSA values showed no statistical difference. CONCLUSIONS: In this series, radiologic interpretation of body coil MRI studies in those patients chosen for a radical retropubic prostatectomy was no better in staging adenocarcinoma of the prostate than simply using the preoperative PSA values.
Assuntos
Adenocarcinoma/patologia , Biomarcadores Tumorais/sangue , Imageamento por Ressonância Magnética , Antígeno Prostático Específico/sangue , Neoplasias da Próstata/patologia , Biópsia , Estudos de Avaliação como Assunto , Reações Falso-Positivas , Humanos , Metástase Linfática , Imageamento por Ressonância Magnética/métodos , Imageamento por Ressonância Magnética/estatística & dados numéricos , Masculino , Estadiamento de Neoplasias , Próstata/patologia , Curva ROCRESUMO
From January 1980 through June 1986, 199 percutaneous needle localizations for clinically occult breast lesions were performed at North Carolina Memorial Hospital. A retrospective analysis of the medical records, mammograms, operative notes, and pathology reports was undertaken to evaluate the success of this procedure. In our series, biopsy was prompted by abnormal calcifications in 27.1% of lesions, occult masses in 37.2%, and by a combination of occult masses and microcalcification in 35.7%. Overall, we had a yield of positive biopsies for cancer of 16.3%, with the yield improving from 12.3% in the earlier years of our study, to 18.7% in the latter years. Of the cancer cases detected, 89.7% were stage I. The localization procedure was successful in 95.9% of the cases. Analysis of our eight failures, along with a review of the literature, shows the major reasons for failure to be incomplete removal of areas with multiple calcifications, dislodgement of the needle, and problems resulting from lack of communication between the radiologist and surgeon. We conclude that the failure rate is low, the yield good, and needle localization a worthwhile procedure for localizing nonpalpable occult lesions.
Assuntos
Biópsia por Agulha , Neoplasias da Mama/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Doenças Mamárias/etiologia , Doenças Mamárias/patologia , Neoplasias da Mama/complicações , Calcinose/etiologia , Calcinose/patologia , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
A prospective study was conducted from 1977 through 1983, to determine the incidence of complications, particularly bleeding, after fine needle biopsy for suspected malignancy of the abdomen and pelvis. Hematocrits before and after the biopsy procedure, medical record follow-up, and review by a coagulation specialist were used to identify bleeders. We performed 395 biopsies on 360 patients. Thirteen percent of the patients had bothersome pain either during or after the biopsy. Hematocrit drops of 3% or more were found in 51 (12.7%) of the patients; nine were determined to be a direct result of the biopsy procedure. Our results and review of the literature suggest that there are complications, including delayed bleeding, yet few are life threatening. We caution, however, that adequate follow-up to identify bleeders is very important in patients having fine-needle biopsies of solid masses of the abdomen.
Assuntos
Neoplasias Abdominais/patologia , Biópsia por Agulha/efeitos adversos , Hemorragia Gastrointestinal/etiologia , Hematócrito , Humanos , Dor/etiologia , Estudos Prospectivos , Fatores de TempoRESUMO
The Acyclovir in Pregnancy Registry was established to gather data on prenatal exposure to acyclovir. Exposed pregnancies are tracked prospectively to ascertain exposure, risk factors, and pregnancy outcome. Through June 30, 1990, 312 acyclovir-exposed pregnancies had been reported and followed. Of these, 239 were exposed during the first trimester; outcomes included 24 spontaneous fetal losses, 47 induced abortions, 159 live births of infants without congenital abnormalities, and nine outcomes with congenital abnormalities. Among the 73 second- and third-trimester exposures, one infant was born with an abnormality. Exposures are also reported to the registry retrospectively, ie, after the outcome of pregnancy is known. Registry findings to date do not show an increase in the number of birth defects among the prospective reports when compared with that expected in the general population, and there is no consistent pattern of abnormalities among retrospective or prospective reports. These findings should provide some reassurance in counseling women following inadvertent prenatal exposure. The cases accumulated to date represent a sample of insufficient size for reaching reliable and definitive conclusions about the safety of acyclovir for pregnant women and their developing fetuses. Therefore, until further information is available, the Acyclovir in Pregnancy Registry Advisory Committee recommends following the 1989 Centers for Disease Control Sexually Transmitted Diseases Treatment Guidelines for the use of acyclovir in pregnancy, and encourages reporting of all prenatal exposures to the registry (1-800-722-9292, ext. 8465).
Assuntos
Aciclovir/efeitos adversos , Resultado da Gravidez , Sistema de Registros , Aciclovir/uso terapêutico , Feminino , Humanos , Gravidez , Estudos ProspectivosRESUMO
OBJECTIVE: Published screening mammography performance measures vary across countries. An inter-national study was undertaken to assess the comparability of two performance measures: the recall rate and positive predictive value (PPV). These measures were selected because they do not require identification of all cancers in the screening population, which is not always possible. SETTING: The screening mammography programs or data registries in 25 member countries of the International Breast Cancer Screening Network (IBSN). METHODS: In 1999 an assessment form was distributed to IBSN country representatives in order to obtain information on how screening mammography was performed and what specific data related to recall rates and PPV were collected. Participating countries were then asked to provide data to allow calculation of recall rates, PPV and cancer detection rates for screening mammography by age group for women screened in the period 1997-1999. RESULTS: Twenty-two countries completed the assessment form and 14 countries provided performance data. Differences in screening mammography delivery and data collection were evident. For most countries, recall rates were higher for initial than for subsequent mammograms. There was no consistent relationship of initial to subsequent PPV, although PPV generally decreased as the recall rate increased. Recall rates decreased with increasing age, while PPV increased as age increased. CONCLUSION: Similar patterns for mammography performance measures were evident across countries.However, the development of a more standardized approach to defining and collecting data would allow more valid international comparisons, with the potential to optimize mammography performance. At present, international comparisons of performance should be made with caution due to differences in defining and collecting mammography data.
Assuntos
Neoplasias da Mama/prevenção & controle , Mamografia/normas , Programas de Rastreamento/normas , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/epidemiologia , Bases de Dados Factuais , Feminino , Humanos , Valor Preditivo dos TestesRESUMO
In 105 knees, the roentgenographic classifications of hemophilic arthropathy of Arnold and Hilgartner, of Pettersson et al., and of a new system were compared. The amount of interobserver agreement (between two observers) was good for all three systems and, for all three, there was a good correlation between progressive severity of the lesion and decreasing function of the joint. The system of Pettersson et al. was better than that of Arnold and Hilgartner for grading severe arthropathy, but it was not better than the new, simplified system. The new system is a four-sign, 7-point classification, in contrast to the eight-sign, 13-point system of Pettersson et al.
Assuntos
Hemofilia A/complicações , Articulação do Joelho/diagnóstico por imagem , Adolescente , Adulto , Criança , Humanos , Artropatias/classificação , Artropatias/diagnóstico por imagem , RadiografiaRESUMO
RATIONALE AND OBJECTIVES: Screening mammography data can be reported on a breast-specific or woman-specific level, and much mammography data available for research is woman-specific. The purpose of this study was to determine if woman-specific screening mammography data are sufficient for research and reporting by measuring and comparing the accuracy of screening mammography on a breast-specific and on a woman-specific level. MATERIALS AND METHODS: Definitions for true-positive and false-positive mammography results were developed to distinguish between breast-specific and woman-specific calculations. The sensitivity, specificity, and positive predictive values of screening mammography were calculated on a breast-specific and on a woman-specific basis for the entire population of the Carolina Mammography Registry and for a randomly selected subset of the population. RESULTS: Only small differences were found in breast-specific versus woman-specific calculations of sensitivity, specificity, and positive predictive values for both the entire population and the smaller subset population. For both populations, woman-specific sensitivity and positive predictive values were slightly higher than the same breast-specific values, and woman-specific specificity was slightly lower. CONCLUSION: For research and reporting, woman-specific data are sufficient.
Assuntos
Doenças Mamárias/diagnóstico por imagem , Mamografia , Adulto , Idoso , Biópsia , Doenças Mamárias/patologia , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/patologia , Carcinoma Intraductal não Infiltrante/diagnóstico por imagem , Carcinoma Intraductal não Infiltrante/patologia , Diagnóstico Diferencial , Erros de Diagnóstico , Reações Falso-Positivas , Feminino , Humanos , Mamografia/normas , Mamografia/estatística & dados numéricos , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Sistema de Registros/estatística & dados numéricos , Reprodutibilidade dos Testes , Sensibilidade e EspecificidadeRESUMO
RATIONALE AND OBJECTIVES: We assessed the follow-up behavior of women who had abnormal results of screening mammograms taken on a mobile van. METHODS: A retrospective cohort study was conducted between 1988 and 1991 of all women served by a mobile mammography van in rural North Carolina. Compliance with radiologist recommendations for follow-up was assessed through review of patient records and mail surveys of patients with incomplete records. RESULTS: Compliance was 44% for negative or benign mammograms, 57% for indeterminate mammograms, and 62% for probably malignant or malignant mammograms. Women who had a previous mammogram or had a malignant finding were more likely to comply with follow-up recommendations (p < .0001) than women with normal or benign results and no history of mammography. Compliers and noncompliers did not differ with respect to family history of breast cancer or personal history of breast discomfort. CONCLUSION: Compliance with recommendations in this setting was lower than expected. This may be because rural women using mobile van mammography have limited access to the resources needed for appropriate follow-up. Further research is needed to examine explanations for poor compliance in this setting.
Assuntos
Mamografia/métodos , Unidades Móveis de Saúde , Cooperação do Paciente , Adulto , Idoso , Neoplasias da Mama/diagnóstico por imagem , Estudos de Coortes , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , North Carolina , População RuralRESUMO
RATIONALE AND OBJECTIVES: The Mammography Quality Standards Act requires practices to measure limited aspects of their performance. The authors conducted this study to calculate the differences in measurements of sensitivity and specificity due only to differences in the definitions used in the analysis. This included definitions for case inclusion. MATERIALS AND METHODS: Data from the New Mexico Mammography Project for January 1991 to December 1995 on 136,540 women who underwent screening mammography were analyzed. A starting definition was created for each performance measure. The components of the definition were varied, and estimates of sensitivity and specificity for the different definitions were calculated. RESULTS: Sensitivity was lower and specificity was higher when assessed on the basis of the results of all imaging performed in the screening work-up rather than on the initial screening examination alone. Sensitivity was higher and specificity was lower in women who did not undergo rather than in women who did recently undergo a previous examination. When the definition of a positive examination included cases that were recommended for short-term follow-up, the work-up sensitivity was slightly higher and the work-up specificity was considerably lower. Longer follow-up times for determining the diagnosis of cancer were associated with decreasing sensitivity, particularly when the follow-up period extended beyond 12 months. CONCLUSION: Variations in the operational definitions for measures of mammographic performance affect these estimates. To facilitate valid comparisons, reports need to be explicit regarding the definitions and methods used.
Assuntos
Mamografia/normas , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias da Mama/diagnóstico por imagem , Interpretação Estatística de Dados , Feminino , Seguimentos , Humanos , Programas de Rastreamento , Pessoa de Meia-Idade , Sensibilidade e EspecificidadeRESUMO
There are two common methods of obtaining high-quality screening mammography: screen-film mammography (more simply, mammography) using a dedicated unit, and xeromammography. We studied the accuracy of the two techniques in detecting breast cancer by a retrospective study, analysing accuracy of interpretation in cases where both mammography and xeromammography were performed. Seventy-six patients were considered with 86 biopsies and mammograms resulting in detection of 32 cancers and 54 benign lesions. There was no difference in accuracy of interpretation between mammography and xeromammography. The sensitivities were: mammography 0.91, xeromammography 0.88. The specificities were: mammography 0.63, xeromammography 0.75. We conclude that both modalities are comparable in detecting cancer when optimal technique and experienced personnel are used.
Assuntos
Neoplasias da Mama/diagnóstico por imagem , Mamografia , Xeromamografia , Adulto , Idoso , Humanos , Pessoa de Meia-Idade , Estudos RetrospectivosRESUMO
Better communications are essential in the new medical environment. Methods to make more efficient the throughput in an existing department, foster confidence of patients, and improve the communications and efficiency of referring physicians are needed. The most difficult and thus the driving component of the new communications environment is image transmission. Concepts of picture archiving and communications systems, or PACS, arising from digital technology make possible unique and ubiquitous solutions to image communications. Better quality control and improved interpretation throughout the system, including the offices of referring physicians, will be possible. Radiologists are in a position to mold this new medical industry.
Assuntos
Redes de Comunicação de Computadores , Sistemas Computacionais , Instalações de Saúde , Departamentos Hospitalares , Sistemas de Informação Hospitalar , Consultórios Médicos , Serviço Hospitalar de Radiologia , Sistemas de Informação em Radiologia , Intensificação de Imagem Radiográfica , Estados UnidosRESUMO
BACKGROUND: Most breast biopsies will be negative for cancer. Benign breast biopsy can cause changes in the breast tissue, but whether such changes affect the interpretive performance of future screening mammography is not known. METHODS: We prospectively evaluated whether self-reported benign breast biopsy was associated with reduced subsequent screening mammography performance using examination data from the mammography registries of the Breast Cancer Surveillance Consortium from January 2, 1996, through December 31, 2005. A positive interpretation was defined as a recommendation for any additional evaluation. Cancer was defined as any invasive breast cancer or ductal carcinoma in situ diagnosed within 1 year of mammography screening. Measures of mammography performance (sensitivity, specificity, and positive predictive value 1 [PPV1]) were compared both at woman level and breast level in the presence and absence of self-reported benign biopsy history. Referral to biopsy was considered a positive interpretation to calculate positive predictive value 2 (PPV2). Multivariable analysis of a correct interpretation on each performance measure was conducted after adjusting for registry, year of examination, patient characteristics, months since last mammogram, and availability of comparison film. Accuracy of the mammogram interpretation was measured using area under the receiver operating characteristic curve (AUC). All statistical tests were two-sided. RESULTS: A total of 2,007,381 screening mammograms were identified among 799,613 women, of which 14.6% mammograms were associated with self-reported previous breast biopsy. Multivariable adjusted models for mammography performance showed reduced specificity (odds ratio [OR] = 0.74, 95% confidence interval [CI] = 0.73 to 0.75, P < .001), PPV2 (OR = 0.85, 95% CI = 0.79 to 0.92, P < .001), and AUC (AUC 0.892 vs 0.925, P < .001) among women with self-reported benign biopsy. There was no difference in sensitivity or PPV1 in the same adjusted models, although unadjusted differences in both were found. Specificity was lowest among women with documented fine needle aspiration-the least invasive biopsy technique (OR = 0.58, 95% CI = 0.55 to 0.61, P < .001). Repeating the analysis among women with documented biopsy history, unilateral biopsy history, or restricted to invasive cancers did not change the results. CONCLUSIONS: Self-reported benign breast biopsy history was associated with statistically significantly reduced mammography performance. The difference in performance was likely because of tissue characteristics rather than the biopsy itself.
Assuntos
Biópsia , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/patologia , Mama/patologia , Mamografia , Programas de Rastreamento/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Área Sob a Curva , Detecção Precoce de Câncer , Feminino , Humanos , Modelos Logísticos , Pessoa de Meia-Idade , Análise Multivariada , Valor Preditivo dos Testes , Estudos Prospectivos , Curva ROC , Sensibilidade e Especificidade , Fatores de TempoRESUMO
Nuclear magnetic resonance (NMR) has been proposed to be the best diagnostic test for multiple sclerosis (MS). We performed a critical analysis of 13 papers evaluating the use of NMR in MS. Out of an ideal 17 criteria for validation and reproducibility, a top of 11 (65%) was the maximum found. Foremost deficiencies were a lack of blind analysis and inadequate patient samples. Thus the claim that NMR is the diagnostic tool of choice in MS remains to be proven.
Assuntos
Espectroscopia de Ressonância Magnética , Esclerose Múltipla/diagnóstico , HumanosRESUMO
Analysis of 320 cancers found in a screened population between August 1985 and May 1990 revealed 77 cancers that were "missed" at screening mammography. The missed lesions consisted of cancers incorrectly diagnosed after mammography (false-negative results) but visible in retrospect (n = 19); cancers correctly diagnosed after mammography but visible in retrospect on an earlier mammogram (n = 47); and cancers that went undetected by the first of two readers (n = 11). Missed lesions were categorized according to type of miss, reason for the miss, breast density, lesion features, and lesion location. The missed lesion were compared with 121 cancers that were correctly diagnosed at screening mammography. The missed cancers occurred in women with denser breasts (P = .046), were less likely to demonstrate malignant microcalcifications, and were more likely to demonstrate a developing opacity as an indication of cancer (P = .005). An understanding of the characteristics of missed lesions may be a valuable aid in increasing the sensitivity of screening mammography.