RESUMO
For this study, a geothermal area around Izmir-Dikili, located in the western part of Turkey, was chosen as a measuring site and the radon concentrations of environmental samples were determined. Indoor radon monitoring was performed for 3 months in dwellings located in different part of the region using passive CR-39 nuclear track detectors. The radon concentrations of water samples drawn from wells, municipal supplies, village fountains and spas in the area were measured using a liquid scintillation detector (Packard Tri-Carb 2770 TR/SL, A-277001). Soil samples collected from each location were analysed and (226)Ra concentrations were determined using a gamma ray spectrometer connected to an HPGe detector. Annual effective doses from radon inhalation and ingestion were calculated.
Assuntos
Monitoramento de Radiação/métodos , Radônio/análise , Poluentes Radioativos do Ar/análise , Poluição do Ar em Ambientes Fechados/análise , Poluentes Radioativos do Solo/análise , Turquia , Poluentes Radioativos da Água/análiseRESUMO
This paper presents the indoor radon concentrations in dwellings located in the Dikili geothermal area in western Turkey. Indoor radon monitoring was performed for 3 mo using 121 detectors installed in the living rooms and bedrooms of 62 houses selected from the region. A passive time-integrating radon measuring technique was applied by using CR-39 solid-state nuclear track detectors. Average indoor radon levels for the houses varied from 31 to 280 Bq m(-3). Corresponding annual effective doses were calculated, and risks for lung cancer due to inhalation of indoor radon were estimated.
Assuntos
Poluição do Ar em Ambientes Fechados/análise , Poluição do Ar em Ambientes Fechados/estatística & dados numéricos , Fontes Termais , Neoplasias Pulmonares/epidemiologia , Neoplasias Induzidas por Radiação/epidemiologia , Proteção Radiológica/métodos , Radônio/análise , Medição de Risco/métodos , Habitação/estatística & dados numéricos , Humanos , Prevalência , Doses de Radiação , Monitoramento de Radiação/métodos , Fatores de Risco , Turquia/epidemiologiaRESUMO
OBJECTIVE: We compared in vitro relaxant effect of chloride channel modulators, such as 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) and anthracene-9-carboxylate (9-AC), and beta(2)-adrenergic agonists, such as ritodrine, in pregnant rat myometrium. METHODS: Isolated myometrial strips were obtained from eight pregnant rats, and the strips were mounted in organ baths for recording isometric tension. The effects of 10(-8)-10(-4) M ritodrine, 10(-6)-3 x 10(-4) M NPPB, and 10(-6)-10(-3) M 9-AC on spontaneous contractions were recorded. RESULTS: Ritodrine (10(-8)-10(-5) M) completely inhibited the amplitude and frequency of spontaneous contractions in myometrial strips isolated from pregnant rats in a concentration-dependent manner, but the relaxant effect of ritodrine at 10(-4) M concentration resulted in tachyphylaxis. The chloride channel blocker NPPB (10(-6)-3 x 10(-4) M) and the chloride transport inhibitor 9-AC (10(-5)-10(-3) M) decreased the amplitude of spontaneous myometrial contractions in a concentration-dependent manner; the maximum inhibition produced by the highest tested concentration of each drug was 43.8% and 42.1% of the original degree of spontaneous contractions, respectively. The frequency of myometrial contractions was significantly inhibited by NPPB and 9-AC beginning with the concentration of 10(-4) M. CONCLUSION: NPPB and 9-AC appear to be effective relaxants of pregnant rat myometrium. These effects of NPPB and 9-AC might be therapeutically advantageous in clinical management of preterm labor.