Relation with HOMA-IR and thyroid hormones in obese Turkish women with metabolic syndrome.

The aim of this study was to investigate the relationship between insulin resistance and thyroid function in obese pre- and postmenopausal women with or without metabolic syndrome (MetS). 141 obese women were divided into two groups, HOMA-IR<2.7 and HOMA-IR>2.7, to evaluate relation with HOMA-IR and fatness, hormone and blood parameters. They were then divided into four groups as pre- and postmenopausal with or without MetS. Various fatness, hormone and blood parameters were examined. Statistically significant difference was found in weight, body mass index (BMI), waist circumference, fat%, fasting insulin, TSH, FT3, FT4, FSH, Anti-microsomal antibody (ANTIM) and triglycerides levels in HOMA-IR<2.7 and HOMA-IR>2.7 obese Turkish women. This study showed that age, weight, BMI, waist circumference, fat%, fasting insulin, FT3, ANTIM, FSH, LH, total cholesterol, triglycerides, HDL, HOMA-IR, systolic and diastolic blood pressure levels were related in preand post menopausal status in obese women with or without MetS. Obesity may influence the levels of thyroid hormones and increases the risk of MetS in women. Postmenopausal status with MetS is associated with an increased TSH, FT3 and FT4 levels and HOMA-IR in obese women. Strong relation was observed with MetS and TSH and FT3 levels.

[Reliability and validity of Turkish form of Endicott Work Productivity Scale]. / Endicott Iste Uretkenlik Olçegi'nin (EIUO) Türk Toplumunda Geçerlilik ve Güvenilirliginin Degerlendirilmesi.

OBJECTIVE: The Endicott Work Productivity Scale (EWPS) is a brief self-report questionnaire designed to enable investigators to obtain a sensitive measure of work productivity. The purpose of the study was to investigate reliability and validity of the Turkish form of EWPS. METHOD: The study was performed with two separate groups; a patient group (n=74) and a community sample (n=107). Through the adaptation process the original form was translated into Turkish, and translated back into English. Statistical tests about construct validity, the concurrent validity, the test re-test reliability and internal consistency were performed. RESULTS: The internal consistency coefficient (Cronbach's alpha) was >.90 for both groups. The correlations of the individual items with the EWPS total scores ranged between.32 and.75. EWPS and HAM-D scores of the patient group was positively correlated (r =.52 and r =.62). The CGI scores correlation was.64 and SF-36 social functioning subscale was correlated negatively (r= -.43). The correlations of the test-retest scores of EWPS were.76. There was a significant mean difference between the total scores of patient and the community groups. CONCLUSION: The Turkish form of EWPS was found to be valid and reliable. The findings concerning the reliability and the validity of the EWPS indicate that this instrument can be used in the studies that will be conducted in Turkey.