Detalhe da pesquisa
1.
TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation.
Cell
; 184(10): 2618-2632.e17, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33836156
2.
SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice.
J Virol
; 96(1): e0151121, 2022 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34668780
3.
Influenza A viruses limit NLRP3-NEK7-complex formation and pyroptosis in human macrophages.
EMBO Rep
; 21(12): e50421, 2020 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33180976
4.
Modeling SARS-CoV-2: Comparative Pathology in Rhesus Macaque and Golden Syrian Hamster Models.
Toxicol Pathol
; 50(3): 280-293, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35128980
5.
Enhanced immunostimulatory activity of cyclic dinucleotides on mouse cells when complexed with a cell-penetrating peptide or combined with CpG.
Eur J Immunol
; 45(4): 1170-9, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25581346
6.
Influenza A virus infection alters the resistance profile of gut microbiota to clinically relevant antibiotics.
Microbiol Spectr
; 12(1): e0363522, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38051056
7.
The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection.
Biochim Biophys Acta Mol Basis Dis
; 1870(5): 167193, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38648902
8.
The Relationship Between Laboratory Findings and Mortality in COVID-19 Patients Requiring Intensive Care.
Cureus
; 15(6): e41194, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37525784
9.
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.
Cell Host Microbe
; 31(10): 1668-1684.e12, 2023 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37738983
10.
A single respiratory tract infection early in life reroutes healthy microbiome development and affects adult metabolism in a preclinical animal model.
NPJ Biofilms Microbiomes
; 8(1): 51, 2022 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35780244
11.
RIG-I and TLR-7/8 agonists as combination adjuvant shapes unique antibody and cellular vaccine responses to seasonal influenza vaccine.
Front Immunol
; 13: 974016, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36426358
12.
Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera.
Nat Commun
; 13(1): 3921, 2022 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35798721
13.
Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariants.
Med
; 3(10): 705-721.e11, 2022 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36044897
14.
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19.
Life Sci Alliance
; 5(4)2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35012962
15.
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.
bioRxiv
; 2022 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36299428
16.
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.
Science
; 371(6532): 926-931, 2021 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33495306
17.
The N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized by convalescent and post-vaccination human sera.
medRxiv
; 2021 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33501468
18.
Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization.
medRxiv
; 2021 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34075384
19.
Respiratory tissue-associated commensal bacteria offer therapeutic potential against pneumococcal colonization.
Elife
; 92020 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33287959
20.
Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.
bioRxiv
; 2020 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33299999