Alternatives of mesenchymal stem cell-derived exosomes as potential therapeutic platforms.

With outstanding therapeutic potential in the tissue regeneration and anti-inflammation, mesenchymal stem cell-derived exosomes (MSC-EXOs) have emerged as a prominent therapeutic in recent. However, poor production yield and reproducibility have remained as significant challenges of their practical applications. To surmount these challenges, various alternative materials with stem cell-like functions, have been recently investigated, however, there has been no comprehensive analysis in these alternatives so far. Here, we discuss the recent progress of alternatives of MSC-EXOs, including exosomes and exosome-like nanovesicles from various biological sources such as plants, milk, microbes, and body fluids. Moreover, we extensively compare each alternative by summarizing their unique functions and mode of actions to suggest the expected therapeutic target and future directions for developing alternatives for MSC-EXOs.

Beyond Metallic Electrode: Spontaneous Formation of Fluidic Electrodes from Operational Liquid in Highly Functional Droplet-Based Electricity Generator.

The droplet-based electricity generator (DEG) has facilitated efficient droplet energy harvesting, yet diversifying its applications necessitates the incorporation of various to the DEG. This study first proposes a methodology for advancing the DEG by substituting its conventional metallic electrode with electrically conductive water electrode (WE), which is spontaneously generated during the operation of the DEG with operating liquid. Due to the inherent conductive and fluidic nature of water, the introduction of the WE maintains the electrical output performance of the DEG while imparting functionalities such as high transparency and flexibility. So, the resultant WE applied DEG (WE-DEG) exhibits high optical transmittance (≈99%) and retains its electricity-generating capability under varying deformations, including bending and stretching. This innovation expands the versatility of the DEG, and especially, a sun-raindrop dual-mode energy harvester is demonstrated by hybridizing the WE-DEG and photovoltaic (PV) cell. This hybridization effectively addresses the weather-dependent limitations inherent in each energy harvester and enhances the temperature-induced inefficiencies typically observed in PV cells, thereby enhancing the overall efficiency. The introduction of the WE will be poised to catalyze new developments in DEG research, paving the way for broader applicability and enhanced efficiency in droplet energy harvesting technologies.

A Liquid Triboelectric Series.

The triboelectric series is a generally accepted method for describing the triboelectric effect. It provides a way to control the double face of the ubiquitous triboelectric effect: causes of unpredictable accidents and the resultant surface charge as energy sources. However, previous studies have been biased in solids despite being observed in liquids (liquid-solid contact electrification). Therefore, a liquid triboelectric series is necessary to be established to manipulate the liquid triboelectric effect according to the appropriate goal. In this study, a liquid triboelectric series is first established to describe the triboelectric properties of each liquid when contact electrification occurs with a solid surface. The liquid triboelectric series covers electrolytes, organic solvents, oxidants, and higher sugar alcohols. Common chemical groups can be derived from the liquid triboelectric series that hydroxyl groups enhance, and benzene groups suppress the liquid triboelectric effect. The results are demonstrated by the amplified efficiency of an energy harvester and particle contamination after surface washing. This study will play a pivotal role in understanding the liquid-solid contact electrification phenomenon and providing new perspectives on the applications of the liquid triboelectric effect.

Advancing Energy Harvesting Efficiency from a Single Droplet: A Mechanically Guided 4D Printed Elastic Hybrid Droplet-Based Electricity Generator.

A droplet possesses the ubiquity and potential to harvest a vast amount of energy. To exploit droplets effectively, a novel output enhancement strategy that can coexist and create synergy with the recently studied droplet-based electricity generator (DEG) and material/surface structure modification must be investigated. In this study, a mechanical buckling-based 4D printed elastic hybrid droplet-based electricity generator (HDEG) consisting of a DEG and solid-solid triboelectric nanogenerator (S-S TENG) is first presented. During the electricity generation process of the DEG by droplet impact, the HDEG structure, which is merged via a simple 4D printing technique, permits the conversion of dissipated energy into elastic energy, resulting in an S-S TENG output. The HDEG outputs are naturally integrated owing to the simultaneous activation of a single droplet, resulting in an approximately 30% improvement over the output of a single DEG. Internal and external parametric studies are performed as HDEG design guidelines. The HDEG exhibits a 25% better energy supply performance than that of a single DEG, demonstrating its applicability as a power source. This research proposes the way toward a hybrid system that efficiently harvests energy from ubiquitous droplets.

Increased Interfacial Area between Dielectric Layer and Electrode of Triboelectric Nanogenerator toward Robustness and Boosted Energy Output.

Given the operation conditions wherein mechanical wear is inevitable, modifying bulk properties of the dielectric layer of a triboelectric nanogenerator (TENG) has been highlighted to boost its energy output. However, several concerns still remain in regards to the modification due to high-cost materials and cumbersome processes being required. Herein, we report TENG with a microstructured Al electrode (TENG_ME) as a new approach to modifying bulk properties of the dielectric layer. The microstructured Al electrode is utilized as a component of TENG to increase the interfacial area between the dielectric layer and electrode. Compared to the TENG with a flat Al electrode (TENG_F), the capacitance of TENG_ME is about 1.15 times higher than that of TENG_F, and the corresponding energy outputs of a TENG_ME are 117 µA and 71 V, each of which is over 1.2 times higher than that of the TENG_F. The robustness of TENG_ME is also confirmed in the measurement of energy outputs changing after sandpaper abrasion tests, repetitive contact, and separation (more than 105 cycles). The results imply that the robustness and long-lasting performance of the TENG_ME could be enough to apply in reliable auxiliary power sources for electronic devices.

A Spherical Hybrid Triboelectric Nanogenerator for Enhanced Water Wave Energy Harvesting.

Water waves are a continuously generated renewable source of energy. However, their random motion and low frequency pose significant challenges for harvesting their energy. Herein, we propose a spherical hybrid triboelectric nanogenerator (SH-TENG) that efficiently harvests the energy of low frequency, random water waves. The SH-TENG converts the kinetic energy of the water wave into solid⁻solid and solid⁻liquid triboelectric energy simultaneously using a single electrode. The electrical output of the SH-TENG for six degrees of freedom of motion in water was investigated. Further, in order to demonstrate hybrid energy harvesting from multiple energy sources using a single electrode on the SH-TENG, the charging performance of a capacitor was evaluated. The experimental results indicate that SH-TENGs have great potential for use in self-powered environmental monitoring systems that monitor factors such as water temperature, water wave height, and pollution levels in oceans.

One-Step Fabrication of Transparent and Flexible Nanotopographical-Triboelectric Nanogenerators via Thermal Nanoimprinting of Thermoplastic Fluoropolymers.

Using thermal nanoimprinting, a novel transparent and flexible nanotopographical triboelectric nanogenerator (TENG), with simultaneous nanoreplication and integration of the contact layer with the electrode layer, is first demonstrated. It is expected that the present rapid one-step fabrication methodology well give "disposability" to the TENG with extremely reduced manufacturing costs, which may allay commercialization concerns.