Exploring prospects of deliberation in intractable natural resource management conflicts.

Deliberative processes are increasingly advocated as means to handle intractable natural resource management (NRM) conflicts. Research shows that disputing actors can deliberate and achieve higher degrees of mutual understanding and working agreements under ideal conditions, but the transferability of these findings to real-world intractable NRM conflicts can be questioned. This paper explores the possibilities of designing and realizing deliberation and its expected outcomes in real-world NRM conflicts. We used recommended design principles to set up deliberative processes in two intractable mining conflicts involving indigenous peoples in Northern Sweden and assessed the actors' communication and outcomes using frame analysis. The results show that the recommended design principles are hard, but not impossible, to fully implement in intractable NRM conflicts. Both conflicts proved difficult to deliberate and resolve in the sense of reaching agreements. However, the findings suggest that deliberation, as well as meta-consensus, or structured disagreement, is possible to achieve in settings with favorable conditions, e.g. good and established inter-group relations prior to the conflict. In the absence of these conditions, where relations were hostile and shaped by historical and institutional injustices, deliberation was not achieved. In both cases, polarization among the participants remained, or increased, in spite of the deliberative activities. The study highlights the importance of understanding deliberation as embedded in place specific historical and institutional contexts which shape both process and outcomes in powerful ways. More efforts should focus on alternative, or complementary, ways to handle intractable NRM conflicts, including how contested experiences of history, institutions and Indigenous rights can be addressed.

Competing pathways to sustainability? Exploring conflicts over mine establishments in the Swedish mountain region.

Natural resource (NR) exploitation often gives rise to conflict. While most actors intend to manage collectively used places and their NRs sustainably, they may disagree about what this entails. This article accordingly explores the origin of NR conflicts by analysing them in terms of competing pathways to sustainability. By comparing conflicts over mine establishments in three places in northern Sweden, we specifically explore the role of place-based perceptions and experiences. The results indicate that the investigated conflicts go far beyond the question of metals and mines. The differences between pathways supporting mine establishment and those opposing it refer to fundamental ideas about human-nature relationships and sustainable development (SD). The study suggests that place-related parameters affect local interpretations of SD and mobilisation in ways that explain why resistance and conflict exist in some places but not others. A broader understanding of a particular conflict and its specific place-based trajectory may help uncover complex underlying reasons. However, our comparative analysis also demonstrates that mining conflicts in different places share certain characteristics. Consequently, a site-specific focus ought to be combined with attempts to compare, or map, conflicts at a larger scale to improve our understanding of when and how conflicts evolve. By addressing the underlying causes and origins of contestation, this study generates knowledge needed to address NR management conflicts effectively and legitimately.

Day-by-day symptom relief after corticosteroid injection for trigger digit: a randomized controlled study of two techniques.

This prospective randomized controlled study compared two injection techniques for trigger digit: either dorsal to the tendons in the proximal phalanx (PP group) or anterior to the tendons at the A1 pulley level (A1 group) in 106 patients. The primary outcome was the number of days to total relief of pain, stiffness and triggering, as recorded by the patients on visual analogue scales day-by-day for 6 weeks. The median number of days to complete symptom relief was 9 days in the PP group and 11 days in the A1 group for pain, 11 days and 15 days for stiffness and 21 and 20 days for triggering, respectively. Ninety-one per cent of all patients did not require any additional treatment, but 11 patients in both groups reported some remaining symptoms at 6 weeks. This study did not detect any significant difference between the two injection techniques, but provides detailed data of the rate and order of symptomatic relief after corticosteroid injection for this common condition.Level of evidence: I.

siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle.

Type 2 diabetes is associated with defects in insulin signaling and the resulting abnormal glucose and lipid metabolism. The complexity of insulin signaling cascades is highlighted by the existence of multiple isoforms of target proteins implicated in metabolic and gene-regulatory events. We utilized siRNA to decipher the specific role of predominant insulin receptor substrates and Akt isoforms expressed in human skeletal muscle. Gene silencing revealed specialized roles of insulin signaling cascades to metabolic endpoints. IRS-1 and Akt2 were required for myoblast differentiation and glucose metabolism, whereas IRS-2 and Akt1 were dispensable. A key role of IRS-2 and Akt1 in lipid metabolism was revealed, highlighting reciprocal relationships between metabolic pathways. Unraveling the isoform-specific regulation of glucose and lipid metabolism by key elements along insulin signaling cascades through siRNA-mediated gene silencing in human tissues will facilitate the discovery of novel targets for the treatment of diabetes and related metabolic disorders.

Who should manage protected areas in the Swedish mountain region? A survey approach to co-management.

This article investigates attitudes towards co-management of protected areas in Sweden, at the national, county and local level. In Sweden, protected areas are still primarily designated and managed hierarchically-a practice increasingly contested by people living close to them, including indigenous Sámi reindeer herders whose economic activities are located within protected areas. The general view could, on the contrary, be anticipated to be pro-state since protected areas are considered to be of national interest. For democratic reasons, however, the opinions of the whole population should be considered. In order to measure both local and general views, this study is based on a two-sample survey of 8868 respondents. The objectives are to map and explain attitudes regarding who should manage protected areas in Sweden, and to test the usefulness of a multi-level quantitative method. Such an approach is unusual in co-management literature that is empirically mainly based on local case studies. The explanatory ambition sets out to test three hypotheses drawn from common-pool resource theory; resource dependency, common understanding, and trust. Perhaps surprisingly, the results show that a considerable majority of the respondents (at all levels) wish to see self- or co-management. All three hypotheses are important to understand attitudes toward the management of protected areas, but not always in the way that the theory anticipates.