Pesquisa | BVS Violência e Saúde

1.

The crosstalk between DNA repair and immune responses.

Cimprich, Karlene A; Li, Guo-Min; Demaria, Sandra; Gekara, Nelson O; Zha, Shan; Chen, Qianming.

Mol Cell ; 83(20): 3582-3587, 2023 10 19.

Artigo em Inglês | MEDLINE | ID: mdl-37863025

2.

Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination.

Schvartzman, Juan-Manuel; Forsyth, Grace; Walch, Henry; Chatila, Walid; Taglialatela, Angelo; Lee, Brian J; Zhu, Xiaolu; Gershik, Steven; Cimino, Francesco V; Santella, Anthony; Menghrajani, Kamal; Ciccia, Alberto; Koche, Richard; Sánchez-Vega, Francisco; Zha, Shan; Thompson, Craig B.

Mol Cell ; 83(13): 2347-2356.e8, 2023 Jul 06.

Artigo em Inglês | MEDLINE | ID: mdl-37311462

3.

Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements.

Li, Zhiming; Duan, Shoufu; Hua, Xu; Xu, Xiaowei; Li, Yinglu; Menolfi, Demis; Zhou, Hui; Lu, Chao; Zha, Shan; Goff, Stephen P; Zhang, Zhiguo.

Nature ; 623(7987): 643-651, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37938774

4.

The plié by DNA-PK: dancing on DNA.

Zha, Shan; Shao, Zhengping; Zhu, Yimeng.

Mol Cell ; 81(4): 644-646, 2021 02 18.

Artigo em Inglês | MEDLINE | ID: mdl-33606972

5.

XRCC1 prevents toxic PARP1 trapping during DNA base excision repair.

Demin, Annie A; Hirota, Kouji; Tsuda, Masataka; Adamowicz, Marek; Hailstone, Richard; Brazina, Jan; Gittens, William; Kalasova, Ilona; Shao, Zhengping; Zha, Shan; Sasanuma, Hiroyuki; Hanzlikova, Hana; Takeda, Shunichi; Caldecott, Keith W.

Mol Cell ; 81(14): 3018-3030.e5, 2021 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-34102106

6.

DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis.

Shao, Zhengping; Flynn, Ryan A; Crowe, Jennifer L; Zhu, Yimeng; Liang, Jialiang; Jiang, Wenxia; Aryan, Fardin; Aoude, Patrick; Bertozzi, Carolyn R; Estes, Verna M; Lee, Brian J; Bhagat, Govind; Zha, Shan; Calo, Eliezer.

Nature ; 579(7798): 291-296, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-32103174

7.

The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection.

Billing, David; Horiguchi, Michiko; Wu-Baer, Foon; Taglialatela, Angelo; Leuzzi, Giuseppe; Nanez, Silvia Alvarez; Jiang, Wenxia; Zha, Shan; Szabolcs, Matthias; Lin, Chyuan-Sheng; Ciccia, Alberto; Baer, Richard.

Mol Cell ; 72(1): 127-139.e8, 2018 10 04.

Artigo em Inglês | MEDLINE | ID: mdl-30244837

8.

MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.

Hung, Putzer J; Johnson, Britney; Chen, Bo-Ruei; Byrum, Andrea K; Bredemeyer, Andrea L; Yewdell, William T; Johnson, Tanya E; Lee, Brian J; Deivasigamani, Shruthi; Hindi, Issa; Amatya, Parmeshwar; Gross, Michael L; Paull, Tanya T; Pisapia, David J; Chaudhuri, Jayanta; Petrini, John J H; Mosammaparast, Nima; Amarasinghe, Gaya K; Zha, Shan; Tyler, Jessica K; Sleckman, Barry P.

Mol Cell ; 71(2): 332-342.e8, 2018 07 19.

Artigo em Inglês | MEDLINE | ID: mdl-30017584

9.

Phosphorylation of DNA-PKcs at the S2056 cluster ensures efficient and productive lymphocyte development in XLF-deficient mice.

Zhu, Yimeng; Jiang, Wenxia; Lee, Brian J; Li, Angelina; Gershik, Steven; Zha, Shan.

Proc Natl Acad Sci U S A ; 120(25): e2221894120, 2023 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-37307443

10.

Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner.

Shao, Zhengping; Lee, Brian J; Zhang, Hanwen; Lin, Xiaohui; Li, Chen; Jiang, Wenxia; Chirathivat, Napon; Gershik, Steven; Shen, Michael M; Baer, Richard; Zha, Shan.

Proc Natl Acad Sci U S A ; 120(31): e2301972120, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37487079

11.

Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM.

Zhou, Yi; Lee, Ji-Hoon; Jiang, Wenxia; Crowe, Jennie L; Zha, Shan; Paull, Tanya T.

Mol Cell ; 65(1): 91-104, 2017 Jan 05.

Artigo em Inglês | MEDLINE | ID: mdl-27939942

12.

PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites.

Lin, Xiaohui; Jiang, Wenxia; Rudolph, Johannes; Lee, Brian J; Luger, Karolin; Zha, Shan.

Nucleic Acids Res ; 50(7): 3958-3973, 2022 04 22.

Artigo em Inglês | MEDLINE | ID: mdl-35349716

13.

DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice.

Wang, Xiaobin S; Menolfi, Demis; Wu-Baer, Foon; Fangazio, Marco; Meyer, Stefanie N; Shao, Zhengping; Wang, Yunyue; Zhu, Yimeng; Lee, Brian J; Estes, Verna M; Cupo, Olivia M; Gautier, Jean; Pasqualucci, Laura; Dalla-Favera, Riccardo; Baer, Richard; Zha, Shan.

Proc Natl Acad Sci U S A ; 118(38)2021 09 21.

Artigo em Inglês | MEDLINE | ID: mdl-34521752

14.

FATC Domain Deletion Compromises ATM Protein Stability, Blocks Lymphocyte Development, and Promotes Lymphomagenesis.

Milanovic, Maja; Shao, Zhengping; Estes, Verna M; Wang, Xiaobin S; Menolfi, Demis; Lin, Xiaohui; Lee, Brian J; Xu, Jun; Cupo, Olivia M; Wang, Dong; Zha, Shan.

J Immunol ; 206(6): 1228-1239, 2021 03 15.

Artigo em Inglês | MEDLINE | ID: mdl-33536256

15.

Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.

Jiang, Wenxia; Crowe, Jennifer L; Liu, Xiangyu; Nakajima, Satoshi; Wang, Yunyue; Li, Chen; Lee, Brian J; Dubois, Richard L; Liu, Chao; Yu, Xiaochun; Lan, Li; Zha, Shan.

Mol Cell ; 58(1): 172-85, 2015 Apr 02.

Artigo em Inglês | MEDLINE | ID: mdl-25818648

16.

Inhibition of DNA replication initiation by silver nanoclusters.

Tao, Yu; Aparicio, Tomas; Li, Mingqiang; Leong, Kam W; Zha, Shan; Gautier, Jean.

Nucleic Acids Res ; 49(9): 5074-5083, 2021 05 21.

Artigo em Inglês | MEDLINE | ID: mdl-33905520

17.

DNA-PKcs phosphorylation at the T2609 cluster alters the repair pathway choice during immunoglobulin class switch recombination.

Crowe, Jennifer L; Wang, Xiaobin S; Shao, Zhengping; Lee, Brian J; Estes, Verna M; Zha, Shan.

Proc Natl Acad Sci U S A ; 117(37): 22953-22961, 2020 09 15.

Artigo em Inglês | MEDLINE | ID: mdl-32868446

18.

CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining.

Wang, Xiaobin S; Zhao, Junfei; Wu-Baer, Foon; Shao, Zhengping; Lee, Brian J; Cupo, Olivia M; Rabadan, Raul; Gautier, Jean; Baer, Richard; Zha, Shan.

Proc Natl Acad Sci U S A ; 117(41): 25700-25711, 2020 10 13.

Artigo em Inglês | MEDLINE | ID: mdl-32989150

19.

Revisiting PARP2 and PARP1 trapping through quantitative live-cell imaging.

Zhang, Hanwen; Lin, Xiaohui; Zha, Shan.

Biochem Soc Trans ; 50(4): 1169-1177, 2022 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-35959996

20.

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo.

Shao, Zhengping; Lee, Brian J; Rouleau-Turcotte, Élise; Langelier, Marie-France; Lin, Xiaohui; Estes, Verna M; Pascal, John M; Zha, Shan.

Nucleic Acids Res ; 48(17): 9694-9709, 2020 09 25.

Artigo em Inglês | MEDLINE | ID: mdl-32890402

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