Detalhe da pesquisa
1.
Regulated dynamic subcellular GLUT4 localization revealed by proximal proteome mapping in human muscle cells.
J Cell Sci
; 136(23)2023 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38126809
2.
SAR exploration at the C-3 position of tetrahydro-ß-carboline sstr3 antagonists.
Bioorg Med Chem Lett
; 26(6): 1529-1535, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26898814
3.
A novel series of indazole-/indole-based glucagon receptor antagonists.
Bioorg Med Chem Lett
; 25(19): 4143-7, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26303893
4.
Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes.
Proc Natl Acad Sci U S A
; 108(13): 5378-83, 2011 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-21389266
5.
Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension.
bioRxiv
; 2024 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38895483
6.
The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.
J Pharmacol Exp Ther
; 344(2): 407-16, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23161216
7.
CHAC1 inactivation is effective to preserve muscle glutathione but is insufficient to protect against muscle wasting in cachexia.
PLoS One
; 18(4): e0283806, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37014882
8.
GLUT4 dynamic subcellular localization is controlled by AMP kinase activation as revealed by proximal proteome mapping in human muscle cells.
bioRxiv
; 2023 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37333333
9.
GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia.
Cell Rep
; 42(1): 111947, 2023 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36640326
10.
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance.
Nat Metab
; 5(4): 589-606, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37100997
11.
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.
Nat Commun
; 14(1): 4812, 2023 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37558654
12.
Neutralization of GDF15 Prevents Anorexia and Weight Loss in the Monocrotaline-Induced Cardiac Cachexia Rat Model.
Cells
; 11(7)2022 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35406637
13.
BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice.
Mol Metab
; 66: 101611, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36220546
14.
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle.
Cell Metab
; 4(1): 89-96, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16814735
15.
11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice.
J Exp Med
; 202(4): 517-27, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16103409
16.
Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core.
Bioorg Med Chem Lett
; 21(1): 76-81, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21147532
17.
Hypothalamic insulin signaling is required for inhibition of glucose production.
Nat Med
; 8(12): 1376-82, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-12426561
18.
Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity.
Nat Med
; 8(2): 179-83, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11821903
19.
Growth differentiation factor 15 neutralization does not impact anorexia or survival in lipopolysaccharide-induced inflammation.
iScience
; 24(6): 102554, 2021 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34189431
20.
Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding.
J Neurosci
; 29(21): 7015-22, 2009 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19474328