Polarization Engineering of Entangled Photons from a Lithium Niobate Nonlinear Metasurface.

Complex polarization states of photon pairs are indispensable in various quantum technologies. Conventional methods for preparing desired two-photon polarization states are realized through bulky nonlinear crystals, which can restrict the versatility and tunability of the generated quantum states due to the fixed crystal nonlinear susceptibility. Here we present a solution using a nonlinear metasurface incorporating multiplexed silica metagratings on a lithium niobate film of 300 nm thickness. We fabricate two orthogonal metagratings on a single substrate with an identical resonant wavelength, thereby enabling the spectral indistinguishability of the emitted photons, and we demonstrate in experiments that the two-photon polarization states can be shaped by the metagrating orientation. Leveraging this essential property, we formulate a theoretical approach for generating arbitrary polarization-entangled qutrit states by combining three metagratings on a single metasurface, allowing the encoding of the desired quantum states or information. Our findings enable miniaturized optically controlled quantum devices by using ultrathin metasurfaces as polarization-entangled photon sources.

Amplified Drug Delivery System with a Pair of Master Keys Triggering Precise Drug Release for Chemo-Photothermal Therapy.

A versatile drug delivery system (DDS) enabling highly effective and targeting oncotherapy has always been of great significance in medical research. In the development of a stimuli-responsive DDS, compared with a single-factor stimulation DDS, a multifactor activation DDS has higher therapeutic specificity between diseased and normal tissue, but there are challenges in drug-release efficiency and united targeting cancer therapy. Herein, a novel dual-microRNA (dual-miRNA)-mediated 1:N-amplified DDS is fabricated. The gold nanocage (AuNC) was synthesized and used as a carrier. A DNA bridge motif as a nanolock (DNA bridge nanolock) was designed and modified on the surface of AuNCs, which could seal the holes of AuNCs. Using the dual-miRNAs as a pair of master keys, through DNA strand migration and DNAzyme self-assembly, a cell endogenous substance Mg2+-dependent DNAzyme cyclic shear reaction could perform the function of the master keys to open multiple locks for the enhanced release of doxorubicin from the AuNCs. In addition, under near-infrared irradiation, via absorption of light and heat release, the AuNC is activated to perform the function of photothermal therapy. Thereby, the system achieves precise chemo-photothermal therapy. Using the in vitro and in vivo anti-tumor analysis, the DDS could be proved to present a novel design of enhanced and targeted drug-release system for highly effective cancer therapy.

High-flow nasal cannula versus conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia: a multicenter randomized controlled trial.

BACKGROUND: High-flow nasal cannula (HFNC) can improve ventilatory function in patients with acute COPD exacerbation. However, its effect on clinical outcomes remains uncertain. METHODS: This randomized controlled trial was conducted from July 2017 to December 2020 in 16 tertiary hospitals in China. Patients with acute COPD exacerbation with mild hypercapnia (pH ≥ 7.35 and arterial partial pressure of carbon dioxide > 45 mmHg) were randomly assigned to either HFNC or conventional oxygen therapy. The primary outcome was the proportion of patients who met the criteria for intubation during hospitalization. Secondary outcomes included treatment failure (intolerance and need for non-invasive or invasive ventilation), length of hospital stay, hospital cost, mortality, and readmission at day 90. RESULTS: Among 337 randomized patients (median age, 70.0 years; 280 men [83.1%]; median pH 7.399; arterial partial pressure of carbon dioxide 51 mmHg), 330 completed the trial. 4/158 patients on HFNC and 1/172 patient on conventional oxygen therapy met the criteria for intubation (P = 0.198). Patients progressed to NPPV in both groups were comparable (15 [9.5%] in the HFNC group vs. 22 [12.8%] in the conventional oxygen therapy group; P = 0.343). Compared with conventional oxygen therapy, HFNC yielded a significantly longer median length of hospital stay (9.0 [interquartile range, 7.0-13.0] vs. 8.0 [interquartile range, 7.0-11.0] days) and a higher median hospital cost (approximately $2298 [interquartile range, $1613-$3782] vs. $2005 [interquartile range, $1439-$2968]). There were no significant differences in other secondary outcomes between groups. CONCLUSIONS: In this multi-center randomized controlled study, HFNC compared to conventional oxygen therapy did not reduce need for intubation among acute COPD exacerbation patients with mild hypercapnia. The future studies should focus on patients with acute COPD exacerbation with respiratory acidosis (pH < 7.35). However, because the primary outcome rate was well below expected, the study was underpowered to show a meaningful difference between the two treatment groups. TRIAL REGISTRATION: NCT03003559 . Registered on December 28, 2016.

Dual Nanoislands on Ni/C Hybrid Nanosheet Activate Superior Hydrazine Oxidation-Assisted High-Efficiency H2 Production.

Clean hydrogen evolution through electrochemical water splitting underpins various innovative approaches to the pursuit of sustainable energy conversion technologies, but it is blocked by the sluggish anodic oxygen evolution reaction (OER). The hydrazine oxidation reaction (HzOR) has been considered as one of the most promising substitute for OER to improve the efficiency of hydrogen evolution reaction (HER). Herein, we construct novel dual nanoislands on Ni/C hybrid nanosheet array: one kind of island represents the part of bare Ni particle surface, while the other stands for the part of core-shell Ni@C structure (denoted as Ni-C HNSA), in which exposed Ni atoms and Ni-decorated carbon shell perform as active sites for HzOR and HER respectively. As a result, when the current density reaches 10 mA cm-2 , the working potentials are merely -37 mV for HER and -20 mV for HzOR. A two-electrode electrolyzer exhibits superb activity that only requires an ultrasmall cell voltage of 0.14 V to achieve 50 mA cm-2 .

[Antibiotic use in very low birth weight/extremely low birth weight infants in 15 hospitals in Jiangsu Province of China: a multicenter survey]. / 江苏省15家医院极低/è¶ ä½Žå‡ºç”Ÿä½“é‡å„¿æŠ—ç”Ÿç´ ä½¿ç”¨çŽ°çŠ¶è°ƒæŸ¥.

OBJECTIVES: To investigate the current status of antibiotic use in very low birth weight/extremely low birth weight infants in Jiangsu Province of China, and to provide a clinical basis for the quality and improvement of antibiotic management in the neonatal intensive care unit (NICU). METHODS: A retrospective analysis was performed on the data on general conditions and antibiotic use in the very low birth weight/extremely low birth weight infants who were admitted to 15 hospitals of Jiangsu Province from January 1, 2019 to December 31, 2020. A questionnaire containing 10 measures to reduce antibiotic use was designed to investigate the implementation of these intervention measures. RESULTS: A total of 1 920 very low birth weight/extremely low birth weight infants were enrolled, among whom 1 846 (96.15%) were treated with antibiotic, and the median antibiotic use rate (AUR) was 50/100 patient-days. The AUR ranged from 24/100 to 100/100 patient-days in the 15 hospitals. After adjustment for the confounding factors including gestational age, birth weight, and neonatal critical score, the Poisson regression analysis showed that there was a significant difference in the adjusted AUR (aAUR) among the hospitals (P<0.01). The investigation results showed that among the 10 measures to reduce antibiotic use, 8 measures were implemented in less than 50% of these hospitals, and the number of intervention measures implemented was negatively correlated with aAUR (rs=-0.564, P=0.029). CONCLUSIONS: There is a high AUR among the very low birth weight/extremely low birth weight infants in the 15 hospitals of Jiangsu Province, with a significant difference among hospitals. The hospitals implementing a relatively few measures to reduce antibiotic use tend to have a high AUR. It is expected to reduce AUR in very low birth weight/extremely low birth weight infants by promoting the quality improvement of antibiotic use management in the NICU.

Fluorescent-Raman Binary Star Ratio Probe for MicroRNA Detection and Imaging in Living Cells.

The expression of microRNAs (miRNAs) is critical in gene regulation and has been counted into disease diagnosis marks. Precise imaging and quantification of miRNAs could afford the important information for clinical diagnosis. Here, two smart binary star ratio (BSR) probes were designed and constructed, and miRNA triggered the connection of the binary star probes and the reciprocal changes of dual signals in living cells. This multifunctional probe integrates fluorescence and surface enhanced Raman scattering (SERS) imaging, with enzyme-free numerator signal amplification for dual-mode imaging and dual-signal quantitative analysis of miRNA. First, compared with the single-mode ratio imaging method, using fluorescence-SERS complementary ratio imaging, this probe enables more accurate imaging contrast for direct visualization signal changes in living cells. Multiscale information about the dynamic behavior of miRNA and the probe is acquired. Next, via SERS reverse signal ratio response and a novel enzyme-free numerator signal amplification, the amplified signal and reduced black value were achieved in the quantification of miRNA. More importantly, BSR probes showed good stability in cells and were successfully used for accurate tracing and quantification of miR-203 from MCF-7 cells. Therefore, the reported BSR probe is a potential tool for the reliable monitoring of biomolecule dynamics in living cells.

Ultrabroadband, compact, polarization independent and efficient metasurface-based power splitter on lithium niobate waveguides.

We propose a metasurface-based Lithium Niobate waveguide power splitter with an ultrabroadband and polarization independent performance. The design consists of an array of amorphous silicon nanoantennas that partially converts the input mode to multiple output modes creating multimode interference such that the input power is equally split and directed to two branching waveguides. FDTD simulation results show that the power splitter operates with low insertion loss (< 1dB) over a bandwidth of approximately 800 nm in the near-infrared range, far exceeding the O, E, S, C, L and U optical communication bands. The metasurface is ultracompact with a total length of 2.7 µm. The power splitter demonstrates a power imbalance of less than 0.16 dB for both fundamental TE and TM modes. Our simulations show that the device efficiency exhibits high tolerance to possible fabrication imperfections.

Artificial Heterointerfaces Achieve Delicate Reaction Kinetics towards Hydrogen Evolution and Hydrazine Oxidation Catalysis.

Electrochemical water splitting for H2 production is limited by the sluggish anode oxygen evolution reaction (OER), thus using hydrazine oxidation reaction (HzOR) to replace OER has received great attention. Here we report the hierarchical porous nanosheet arrays with abundant Ni3 N-Co3 N heterointerfaces on Ni foam with superior hydrogen evolution reaction (HER) and HzOR activity, realizing working potentials of -43 and -88 mV for 10 mA cm-2 , respectively, and achieving an industry-level 1000 mA cm-2 at 200 mV for HzOR. The two-electrode overall hydrazine splitting (OHzS) electrolyzer requires the cell voltages of 0.071 and 0.76 V for 10 and 400 mA cm-2 , respectively. The H2 production powered by a direct hydrazine fuel cell (DHzFC) and a commercial solar cell are investigated to inspire future practical applications. DFT calculations decipher that heterointerfaces simultaneously optimize the hydrogen adsorption free energy (ΔGH* ) and promote the hydrazine dehydrogenation kinetics. This work provides a rationale for advanced bifunctional electrocatalysts, and propels the practical energy-saving H2 generation techniques.

Plasmonic analogue of geometric diodes realizing asymmetric optical transmission.

Geometric diodes represent a relatively new class of diodes used in rectennas that rely on the asymmetry of a conducting thin film. Here, we numerically investigate a plasmonic analogue of geometric diodes to realize nanoscale optical asymmetric transmission. The device operates based on spatial symmetry breaking that relies on a unique property of surface plasmon polaritons (SPPs), namely, adiabatic nanofocusing. We show that the structure can realize on-chip asymmetric electromagnetic transmission with a total dimension of ∼2µm×6µm. We demonstrate a signal contrast of 0.7 and an asymmetric optical transmission ratio of 4.77 dB. We investigate the origin of the asymmetric transmission and show that it is due mainly to asymmetric out-coupling of SPPs to far-field photons. We highlight the role of evanescent field coupling of SPPs in undermining the asymmetric transmission efficiency and show that by adjusting the plasmonic waveguide dimensions, a signal contrast of 0.94 and an asymmetric optical transmission ratio of 5.18 dB can be obtained. Our work presents a new paradigm for on-chip nanoscale asymmetric optical transmission utilizing the unique properties of SPPs.

Thin-film perfect infrared absorbers over single- and dual-band atmospheric windows.

A thin-film perfect electromagnetic absorber with a tunable response in the infrared (IR) region is proposed using a metal-dielectric-metal configuration, which consists of a Ti top layer and a Ge spacer layer on a Ti substrate. The thin-film structure simplifies the absorber design by tuning the thicknesses of the two layers, which is suitable for large-scale fabrication by matured deposition technologies. The absorber supports perfect IR absorption with tunability from 3 µm to over 15 µm. Furthermore, the total thickness is much smaller than the wavelength, and the absorption has small iridescence. Based on this design, we demonstrated two samples with one supporting single-band absorption in the atmospheric absorption window (5-8 µm) and the other one supporting dual-band absorption in the two atmospheric transmission windows (3-5 and 8-13 µm). These absorption signatures can find applications in IR invisibility and radiative cooling.

Dynamic control of spontaneous emission rate using tunable hyperbolic metamaterials.

We numerically investigate the dynamic control over the spontaneous emission rate of quantum emitters using tunable hyperbolic metamaterials (HMMs). The dispersion of a metal-dielectric thin-film stack at a given frequency can undergo a topological transition from an elliptical to a hyperbolic dispersion by incorporating a tunable metal or dielectric film in the HMM. This transition modifies the local density of optical states of the emitter and, hence, its emission rate. In the visible range, we use an HMM consisting of TiN and ${{\rm Sb}_2}{{\rm S}_3}$Sb2S3 and show considerable tunability in the Purcell enhancement and quantum efficiency as ${{\rm Sb}_2}{{\rm S}_3}$Sb2S3 phase changes from amorphous to crystalline. Similarly, we show tunable Purcell enhancement in the telecommunication wavelength range using a ${\rm TiN}/{{\rm VO}_2}$TiN/VO2- HMM. Finally, tunable spontaneous emission rate in the mid-IR range is obtained using a ${\rm graphene}/{\rm MgF}_2$graphene/MgF2 HMM by modifying the graphene conductivity through changing its chemical potential. We show that using a metal nitride (for the visible and NIR HMMs) and a fluoride (for the mid-IR HMM) is important to get an appreciable change in the effective permittivity of the thin-film multilayer stack.

Effects of native defects and cerium impurity on the monoclinic BiVO4 photocatalyst obtained via PBE+U calculations.

In this article, we report a periodic density functional theory (DFT) investigation on the formation of the native defects and cerium doping in monoclinic BiVO4 (m-BiVO4) and their effect on the electronic structures, using the Perdew-Burke-Ernzerhof functionals corrected for on-site Coulombic interactions (PBE+U). From the point defect formation energies and transition levels, the Bivac (Bi vacancy), Vvac (V vacancy), Oint (O interstitial) and CeV (Ce doping on V site) defects in m-BiVO4 are identified as shallow acceptors. For Ce doping in m-BiVO4, the substitution of Bi by Ce is energetically favorable in the single positively charged state (Ce) under Bi/V-poor conditions, while the substitution of V by Ce is in the single negatively charged state (Ce) under O-rich conditions. The calculated electronic structures suggest that Ce degrades the activity by an unoccupied deep level in the gap region, mainly composed of Ce 4f orbitals, which makes this defect as the photogenerated electron-hole recombination center, in good agreement with the experimental results. For Ce, no localized state exists within the calculated band gap. Its formation energy is sensitive to the chemical potentials and Fermi energy, suggesting that the Bi/V-poor and O-rich conditions are desirable to eliminate the deep-level states and improve photocatalysis. Our results provide insights into enhancing the photocatalytic activity of m-BiVO4 for energy and environmental applications through the rational design of defect-controlled synthesis conditions.

The first-principles study of nH-VSn complex: impurity effects on p-type SnO monolayer.

As a rare typical p-channel layered oxide semiconductor, two-dimensional tin monoxide has attracted great attention due to its wide promising applications in nano-electronics. Using the first-principles calculation, we studied the effects of multi-hydrogen-tin/oxygen vacancy complex impurities on the electronic properties of the p-type monolayer SnO. The calculation results indicated that O vacancy (VO) is a donor and Sn vacancy (VSn) acts as a double acceptor. VSn should be the source of p-type in undoped SnO in an O-rich environment. When hydrogen is introduced, the more stable nH-VSn (n = 1, 2, and 3) complex defects can be formed. These complex impurities can affect the p-type SnO monolayer in the following three main ways: (i) the p-type H-VSn compensates the deeper acceptor level of VSn and enhances the majority carrier mobility. (ii) The more stable 2H-VSn neutralizes the p-type dopant nature of VSn and H-VSn. (iii) The 3H-VSn converts the defect to be an n-type dopant. Our results indicated that limitation of hydrogen is necessary for the preparation of high-quality p-type two-dimensional SnO, as a small amount of hydrogen produces positive effect on p-type SnO; however, the higher concentration of hydrogen is destructive to the p-type character of monolayer SnO.

Hybrid density functional studies of native defects and H impurities in wurtzite CdSe.

In this study, the formation energies and electronic properties of six native defects as well as H impurities in wurtzite (wz) CdSe are systematically investigated using hybrid density functional calculations. It is shown that native defects, including antisite CdSe and interstitial Cdi, may be sources of the unintentional n-type conductivity in CdSe under Se-poor conditions; meanwhile, the vacancy defect VSe is not a good donor. However, when the common H impurity is considered, it is suggested that both the substitutional impurity HSe and the interstitial impurity Hi are the dominant and effective origins of the unintentional n-type conductivity in Se-poor conditions. However, unintentional p-type conductivity in CdSe is challenging to form regardless of the growth conditions. Moreover, hybrid functional calculations of the electronic structures show that the six native point defects and the extrinsic impurities Hi and HSe will cause more or fewer changes in the band gap. Among all considered defects and impurities, it is found that only the interstitial defect Cdi introduces impurity levels into the band gap. In particular, the present hybrid functional calculations theoretically affirm that the vacancy defect VCd in CdSe can induce a 2 µB magnetic moment; however, other native defects will not introduce any magnetic moment.

Broadband infrared plasmonic metamaterial absorber with multipronged absorption mechanisms.

A broadband plasmonic metamaterial absorber with near perfect multiband absorption in the infrared region is designed using a metal-insulator-metal configuration and fabricated using photolithography. The metal-insulator-metal configuration consists of a Ti microdisk array, a SiO2 insulator spacer, and an Al bottom layer. The multiband absorption occurs with near perfect absorption at 4.8-7.5 µm and 9.7-10.5 µm. Ultra-broadband absorption in the mid-IR wavelength range between 3-14 µm is realized by adding a rough photoresist layer on top of the periodic microdisk structures. The multiband absorption is achieved through the combined mechanisms including plasmonic surface lattice resonance, gap plasmon resonance, Fabry-Perot cavity resonance, and the intrinsic phonon-polariton absorption of SiO2.

Quasi-rhombus metasurfaces as multimode interference couplers for controlling the propagation of modes in dielectric-loaded waveguides.

Metasurfaces can control the propagation of free space and guided modes by imparting a phase gradient and modifying the mode propagation properties. Here we propose a design to control optical signals in a dielectric-loaded waveguide using quasi-rhombus gradient plasmonic metasurface structure. The metasurface acts as a multimode interference coupler that can focus, route, and split the propagating field in UV-visible spectral range. The ability to gain full control on waveguided mode with minimal footprint can significantly impact miniaturization of optical devices and photonic integrated circuits.

Real-time in situ study of femtosecond-laser-induced periodic structures on metals by linear and nonlinear optics.

Femtosecond-laser surface structuring on metals is investigated in real time by both fundamental and second harmonic generation (SHG) signals. The onset of surface modification and its progress can be monitored by both the fundamental and SHG probes. However, the dynamics of femtosecond-laser-induced periodic surface structures (FLIPSSs) formation can only be revealed by SHG but not fundamental because of the higher sensitivity of SHG to structural geometry on metal. Our technique provides a simple and effective way to monitor the surface modification and FLIPSS formation thresholds and allows us to obtain the optimal FLIPSS for SHG enhancement.

Generation of continuously rotating polarization by combining cross-polarizations and its application in surface structuring.

In this study, we develop a simple but highly effective technique that generates a continuously varying polarization within a laser beam. This is achieved by having orthogonal linear polarizations on each side of the beam. By simply focusing such a laser beam, we can attain a gradually and continuously changing polarization within the entire Rayleigh range due to diffraction. To demonstrate this polarization distribution, we apply this laser beam onto a metal surface and create a continuously rotating laser induced periodic surface structure pattern. This technique provides a very effective way to produce complex surface structures that may potentially find applications, such as polarization modulators and metasurfaces.

First-principles study of Ga-vacancy induced magnetism in ß-Ga2O3.

First principles calculations based on density functional theory were performed to study the electronic structure and magnetic properties of ß-Ga2O3 in the presence of cation vacancies. We investigated two kinds of Ga vacancies at different symmetry sites and the consequent structural distortion and defect states. We found that both the six-fold coordinated octahedral site and the four-fold coordinated tetrahedral site vacancies can lead to a spin polarized ground state. Furthermore, the calculation identified a relationship between the spin polarization and the charge states of the vacancies, which might be explained by a molecular orbital model consisting of uncompensated O2- 2p dangling bonds. The calculations for the two vacancy systems also indicated a potential long-range ferromagnetic order which is beneficial for spintronics application.

A graphene-coupled Bi2WO6 nanocomposite with enhanced photocatalytic performance: a first-principles study.

An experimentally synthesized graphene/Bi2WO6 composite showed an enhancement of the visible-light photocatalytic activity, while the underlying mechanism is not known. Here, first-principles calculations based on density functional theory were performed to explore the various properties of the graphene/Bi2WO6(010) composite aiming at gaining insights into the mechanism of its photocatalytic activity. The stability, electronic properties, charge transfer, and visible-light response were investigated in detail on the Bi2WO6(010) surface coupled with graphene. An analysis of charge distribution and Bader charge shows that there is a strong covalent bonding between graphene and the Bi2WO6(010) surface. The covalent interaction induces a small bandgap in graphene. The interband transition of graphene and the surface states of the Bi2WO6(010) surface would cause the absorption spectrum of graphene/Bi2WO6(010) to cover the entire visible-light region and even the infrared-light region. The photogenerated electrons flow to graphene from the conduction band of Bi2WO6 under the built-in electric field and band edge potential well. Thus, graphene serves as a photogenerated electron collector and transporter which significantly reduces the probability of electron-hole recombination and increases catalytic reaction sites not only on the surface of graphene but on also the surface of Bi2WO6. The decrease of charge recombination is possibly responsible for the enhancement of the visible-light photocatalytic activity of the graphene/Bi2WO6(010) nanocomposite.