Detalhe da pesquisa
1.
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
Proc Natl Acad Sci U S A
; 114(23): E4676-E4685, 2017 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28533375
2.
Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.
J Biol Chem
; 290(31): 19287-306, 2015 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-26025364
3.
Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.
J Biol Chem
; 287(25): 21204-13, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22511757
4.
Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation.
Biochem Biophys Res Commun
; 426(1): 100-5, 2012 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22917535
5.
Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.
Autophagy
; 17(12): 4119-4140, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34024231
6.
FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16INK4a increase.
Aging Cell
; 19(11): e13226, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33156570
7.
Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease.
J Huntingtons Dis
; 8(1): 53-69, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30594931
8.
iPSC-based drug screening for Huntington's disease.
Brain Res
; 1638(Pt A): 42-56, 2016 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26428226
9.
Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells.
Stem Cell Reports
; 5(6): 1023-1038, 2015 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26651603
10.
Polyglutamine Disease Modeling: Epitope Based Screen for Homologous Recombination using CRISPR/Cas9 System.
PLoS Curr
; 62014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24761311
11.
Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells.
Cell Stem Cell
; 11(2): 253-63, 2012 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22748967
12.
Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells.
PLoS Curr
; 2: RRN1193, 2010 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21037797
13.
Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.
Neuron
; 67(2): 199-212, 2010 Jul 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-20670829
14.
Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models.
Chem Biol
; 17(11): 1189-200, 2010 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21095569
15.
Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury.
J Biol
; 7(7): 24, 2008 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-18803859