Single-photon ranging lidar based on multi-repetition-rate pulse train correlation and accumulation.

A single-photon lidar based on multi-repetition-rate pulse train correlation and accumulation is proposed, and a ranging experiment is conducted on a 32 m target. By accumulating the correlation ranging results of pulse trains with internal spacings of 80, 100, and 125 ns, the signal-to-noise ratio of the cross correlation function is improved by about three-fold, which enables our method to improve the ranging precisions by more than 20% compared with the single repetition-rate method, and the shorter the acquisition time, the more obvious the advantage will be. Experimental results show that at an acquisition time of 0.01 s, our method can still achieve a ranging precision of 2.59 cm, while the single repetition-rate method can no longer obtain effective ranging results at this time. This method will be of great significance for realizing high-speed, large-scale unambiguous single-photon lidar ranging.

Engineering exosomes derived from TNF-α preconditioned IPFP-MSCs enhance both yield and therapeutic efficacy for osteoarthritis.

BACKGROUND: The pathogenesis of osteoarthritis (OA) involves the progressive degradation of articular cartilage. Exosomes derived from mesenchymal stem cells (MSC-EXOs) have been shown to mitigate joint pathological injury by attenuating cartilage destruction. Optimization the yield and therapeutic efficacy of exosomes derived from MSCs is crucial for promoting their clinical translation. The preconditioning of MSCs enhances the therapeutic potential of engineered exosomes, offering promising prospects for application by enabling controlled and quantifiable external stimulation. This study aims to address these issues by employing pro-inflammatory preconditioning of MSCs to enhance exosome production and augment their therapeutic efficacy for OA. METHODS: The exosomes were isolated from the supernatant of infrapatellar fat pad (IPFP)-MSCs preconditioned with a pro-inflammatory factor, TNF-α, and their production was subsequently quantified. The exosome secretion-related pathways in IPFP-MSCs were evaluated through high-throughput transcriptome sequencing analysis, q-PCR and western blot analysis before and after TNF-α preconditioning. Furthermore, exosomes derived from TNF-α preconditioned IPFP-MSCs (IPFP-MSC-EXOsTNF-α) were administered intra-articularly in an OA mouse model, and subsequent evaluations were conducted to assess joint pathology and gait alterations. The expression of proteins involved in the maintenance of cartilage homeostasis within the exosomes was determined through proteomic analysis. RESULTS: The preconditioning with TNF-α significantly enhanced the exosome secretion of IPFP-MSCs compared to unpreconditioned MSCs. The potential mechanism involved the activation of the PI3K/AKT signaling pathway in IPFP-MSCs by TNF-α precondition, leading to an up-regulation of autophagy-related protein 16 like 1(ATG16L1) levels, which subsequently facilitated exosome secretion. The intra-articular administration of IPFP-MSC-EXOsTNF-α demonstrated superior efficacy in ameliorating pathological changes in the joints of OA mice. The preconditioning of TNF-α enhanced the up-regulation of low-density lipoprotein receptor-related protein 1 (LRP1) levels in IPFP-MSC-EXOsTNF-α, thereby exerting chondroprotective effects. CONCLUSION: TNF-α preconditioning constitutes an effective and promising method for optimizing the therapeutic effects of IPFP-MSCs derived exosomes in the treatment of OA.

Comut-viz: efficiently creating and browsing comutation plots online.

BACKGROUND: Comutation plot is a widely used visualization method to deliver a global view of the mutation landscape of large-scale genomic studies. Current tools for creating comutation plot are either offline packages that require coding or online web servers with varied features. When a package is used, it often requires repetitive runs of code to adjust a single feature that might only be a few clicks in a web app. But web apps mostly have limited capacity for customization and cannot handle very large genomic files. RESULTS: To improve on existing tools, we identified features that are most frequently adjusted in creating a plot and incorporate them in Comut-viz that interactively filters and visualizes mutation data as downloadable plots. It includes colored labels for numeric metadata, a preloaded palette for changing colors and two input boxes for adjusting width and height. It accepts standard mutation annotation format (MAF) files as input and can handle large MAF files with more than 200 k rows. As a front-end only app, Comut-viz guarantees privacy of user data and no latency in the analysis. CONCLUSIONS: Comut-viz is a highly responsive and extensible web app to make comutation plots. It provides customization for frequently adjusted features and accepts large genomic files as input. It is suitable for genomic studies with more than a thousand samples.

Phase control scheme of the coherent beam combining system for generating perfect vectorial vortex beams assisted by a Dammann vortex grating.

Based on Dammann vortex grating and adaptive gain stochastic parallel gradient descent algorithm, we theoretically proposed a phase control technology scheme of the coherent beam combining system for generating perfect vectorial vortex beams (VVBs). The simulated results demonstrate that the discrete phase locking for different types of VVBs (including vortex beams, vector beams, and generalized VVBs) can be successfully realized. The intensity distributions, polarization orientation, Pancharatnam phases, and beam widths of different |Hm,n〉 states with the obtained discrete phase distribution further prove that the generated beams are perfect VVBs. Subsequently, the phase aberration residual for different VVBs is evaluated using the normalized phase cosine distance function, and their values range from 0.01 to 0.08, which indicates the obtained discrete phase distribution is close to the ideal phase distribution. In addition, benefitting from the high bandwidth of involved devices in the proposed scheme, the influence of dynamic phase noise can be negligible. The proposed method could be beneficial to realize and switch flexible perfect VVBs in further applications.

High-aspect-ratio dielectric pillar with nanocavity backed by metal substrate in the infrared range.

We investigated absorption and field enhancements of shallow nanocavities on top of high-aspect-ratio dielectric pillars in the infrared range. The structure includes a high-aspect-ratio nanopillar array of high refractive index, with nano-cavities on top of the pillars, and a metal plane at the bottom. The enhancement factor of electric field intensity reaches 3180 in the nanocavities and peak absorption reaches 99%. We also investigated the finite-size effect of the presented structure to simulate real experiments. Due to its narrow absorption bandwidth 3.5 nm, it can work as a refractive index sensor with sensitivity 297.5 nm/RIU and figure of merit 85. This paves the way to directly control light field at the nanoscales in the infrared light range. The investigated nanostructure will find applications in multifunctional photonics devices such as chips for culturing cells, refractive index sensors, biosensors of single molecule detection and nonlinear sensors.

Generation of perfect vectorial vortex beams by employing coherent beam combining.

Based on coherent beam combining, we propose a method for generating the perfect vectorial vortex beams (VVBs) with a specially designed radial phase-locked Gaussian laser array, which is composed of two discrete vortex arrays with right-handed (RH) and left-handed (LH) circularly polarized states and in turn adjacent to each other. The simulation results demonstrate that the VVBs with correct polarization order and topological Pancharatnam charge are successfully generated. The diameter and thickness of generated VVBs independent of the polarization orders and topological Pancharatnam charges further prove that the generated VVBs are perfect. Propagating in free space, the generated perfect VVBs can be stable for a certain distance, even with half-integer orbital angular momentum. In addition, constant phases φ0 between the RH and LH circularly polarized laser arrays has no effect on polarization order and topological Pancharatnam charge but makes polarization orientation to rotate φ0/2. Moreover, perfect VVBs with elliptically polarized states can be flexibly generated only by adjusting the intensity ratio between the RH and LH circularly polarized laser array, and such perfect VVBs are also stable on beam propagation. The proposed method could provide a valuable guidance for high power perfect VVBs in future applications.

Reconfigurable coaxial single-photon LIDAR based on the SPAD array.

The single-photon avalanche diode (SPAD) array with time-to-digital converter (TDC) circuits on each pixel is an excellent candidate detector for imaging LIDAR systems. However, the low fill-factor of the SPAD array does not allow for efficient use of laser energy when directly adopted in a LIDAR system. Here, we design a reconfigurable coaxial single-photon LIDAR based on the SPAD array and diffractive optical elements (DOEs). We use the DOE and beam expander to shape the laser beam into a laser dot matrix. The total divergence angle of the DOE spot beam is strictly matched to the total field of view (FOV) angle of the SPAD array. Meanwhile, each focused beamlet is individually matched to every active area of the SPAD array detector, which increases the use of output energy about 100 times compared to the diffusion illumination system. Besides, the system uses the active area as the minimum pixel and can support sub-pixel scanning, resulting in higher resolution images. Through this coaxial structure, two different telescope systems after transceiver switching can be reconfigured for imaging targets at different distances. Based on our single-photon LIDAR system, we achieved 3D imaging of targets at 100 m and 180 m using two different telescope configurations.

High-resolution depth imaging with a small-scale SPAD array based on the temporal-spatial filter and intensity image guidance.

Currently single-photon avalanche diode (SPAD) arrays suffer from a small-scale pixel count, which makes it difficult to achieve high-resolution 3D imaging directly through themselves. We established a CCD camera-assisted SPAD array depth imaging system. Based on illumination laser lattice generated by a diffractive optical element (DOE), the registration of the low-resolution depth image gathered by SPAD and the high-resolution intensity image gathered by CCD is realized. The intensity information is used to guide the reconstruction of a resolution-enhanced depth image through a proposed method consisting of total generalized variation (TGV) regularization and temporal-spatial (T-S) filtering algorithm. Experimental results show that an increasement of 4 × 4 times for native depth image resolution is achieved and the depth imaging quality is also improved by applying the proposed method.

Unclonable Micro-Texture with Clonable Micro-Shape towards Rapid, Convenient, and Low-Cost Fluorescent Anti-Counterfeiting Labels.

An ideal anti-counterfeiting label not only needs to be unclonable and accurate but also must consider cost and efficiency. But the traditional physical unclonable function (PUF) recognition technology must match all the images in a database one by one. The matching time increases with the number of samples. Here, a new kind of PUF anti-counterfeiting label is introduced with high modifiability, low reagent cost (2.1 × 10-4 USD), simple and fast authentication (overall time 12.17 s), high encoding capacity (2.1 × 10623 ), and its identification software. All inorganic perovskite nanocrystalline films with clonable micro-profile and unclonable micro-texture are prepared by laser engraving for lyophilic patterning, liquid strip sliding for high throughput droplet generation, and evaporative self-assembling for thin film deposition. A variety of crystal film profile shapes can be used as "specificator" for image recognition, and the verification time of recognition technology based on this divide-and-conquer strategy can be decreased by more than 20 times.

Superacid-doped polyaniline as a soluble polymeric active electrolyte for supercapacitors.

Using polyaniline as a soluble electrochemically active additive in an electrolyte has the advantages of high pseudocapacitance and good cycle stability of polyaniline, however, the challenge is how to make polyaniline soluble in the electrolyte. In this study, we prepare a solution of polyaniline in N-methylpyrrolidone by protonating polyaniline with trifluoromethyl sulfonic acid. Spectroscopic and electrochemical results indicate that the weak binding interaction, between trifloromethyl sulfonate ions and protonated polyaniline chains, increases the solubility of trifloromethyl sulfonic acid doped polyaniline. An active electrolyte system composed of 15 mg mL-1 polyaniline and 0.4 M trifluoromethyl sulfonic acid in N-methylpyrrolidone is developed. With the active electrolyte and reduced graphene oxide as the electrodes, the fabricated supercapacitor shows a higher specific capacitance than the corresponding electric double-layer supercapacitors. Because the volume change and hydrolyzation of polyaniline, which are the main causes of the performance degradation in polyaniline-based supercapacitors, are avoided, the present supercapacitor exhibits an excellent cycle stability of 100% capacitance retention after 10 000 cycles. This work demonstrates the possibility of directly using a conductive polymer as an active electrolyte in supercapacitors with high cycle stability.

Nanowire-Seeded Growth of Single-Crystalline (010) ß-Ga2 O3 Nanosheets with High Field-Effect Electron Mobility and On/Off Current Ratio.

2D ß-Ga2 O3 nanosheets, as fundamental materials, have great potential in next generations of ultraviolet transparent electrodes, high-temperature gas sensors, solar-blind photodetectors, and power devices, while their synthesis and growth with high crystalline quality and well-controlled orientation have not been reported yet. The present study demonstrates how to grow single-crystalline ultrathin quasi-hexagonal ß-Ga2 O3 nanosheets with nanowire seeds and proposes a hierarchy-oriented growth mechanism. The hierarchy-oriented growth is initiated by epitaxial growth of a single-crystalline ( 2 - 01 ) ß-Ga2 O3 nanowire on a GaN nanocrystal and followed by homoepitaxial growth of quasi-hexagonal (010) ß-Ga2 O3 nanosheets. The undoped 2D (010) ß-Ga2 O3 nanosheet field effect transistor has a field-effect electron mobility of 38 cm2 V-1 s-1 and an on/off current ratio of 107 with an average subthreshold swing of 150 mV dec-1 . The from-nanowires-to-nanosheets technique paves a novel way to fabricate nanosheets, which has great impact on the field of nanomaterial synthesis and growth and the area of nanoelectronics as well.

Numerical investigation of narrowband infrared absorber and sensor based on dielectric-metal metasurface.

Metasurfaces are investigated intensively for biophotonics applications due to their resonant wavelength flexibly tuned in the near infrared region specially matching biological tissues. Here, we present numerically a metasurface structure combining dielectric resonance with surface plasmon mode of a metal plane, which is a perfect absorber with a narrow linewidth 10 nm wide and quality factor 120 in the near infrared regime. As a sensor, its bulk sensitivity and bulk figure of merit reach respectively 840 nm/RIU and 84/RIU, while its surface sensitivity and surface figure of merit are respectively 1 and 0.1/nm. For different types of adsorbate layers with the same thickness of 8 nm, its surface sensitivity and figure of merit are respectively 32.3 and 3.2/RIU. The enhanced electric field is concentrated on top of dielectric patch ends and in the patch ends simultaneously. Results show that the presented structure has high surface (and bulk) sensing capability in sensing applications due to its narrow linewidth and deep modulation depth. This could pave a new route toward dielectric-metal metasurface in biosensing applications, such as early disease detections and designs of neural stem cell sensing platforms.

Enhancing sodium ionic conductivity in tetragonal-Na3PS4 by halogen doping: a first principles investigation.

Tetragonal Na3PS4 (t-Na3PS4) has been demonstrated as a very promising candidate for a solid-state sodium-ion electrolyte with high Na ionic conductivity at ambient temperature. In this paper, we systematically investigated the Na ionic conductivity in pristine and halogen (F, Cl, Br, and I) doped tetragonal-Na3PS4 superionic conductors using first-principles calculations. The Na ionic conductivity of pristine t-Na3PS4 is calculated to be about 0.01 mS cm-1, while much higher Na ionic conductivities could be achieved by introducing Na ion vacancies via a halogen doping strategy. The calculated Na ionic conductivity of t-Na3PS4 doped with 1.56% Cl is 1.07 mS cm-1 at ambient temperature. Among different halogen-doped t-Na3PS4, Br-doped t-Na3PS4 shows the lowest activation energy and the highest Na ionic conductivity, which reaches 2.37 mS cm-1 at 300 K. The low activation energy and high Na ionic conductivity in Br-doped t-Na3PS4 are due to a relatively lower defect binding energy of the defect pair of halogen substitution and a Na ion vacancy. Our results suggest Br-doped t-Na3PS4 may serve as a very promising Na-ion solid-state superionic conductor.

Stress-Induced Cubic-to-Hexagonal Phase Transformation in Perovskite Nanothin Films.

The strong coupling between crystal structure and mechanical deformation can stabilize low-symmetry phases from high-symmetry phases or induce novel phase transformation in oxide thin films. Stress-induced structural phase transformation in oxide thin films has drawn more and more attention due to its significant influence on the functionalities of the materials. Here, we discovered experimentally a novel stress-induced cubic-to-hexagonal phase transformation in the perovskite nanothin films of barium titanate (BaTiO3) with a special thermomechanical treatment (TMT), where BaTiO3 nanothin films under various stresses are annealed at temperature of 575 °C. Both high-resolution transmission electron microscopy and Raman spectroscopy show a higher density of hexagonal phase in the perovskite thin film under higher tensile stress. Both X-ray photoelectron spectroscopy and electron energy loss spectroscopy does not detect any change in the valence state of Ti atoms, thereby excluding the mechanism of oxygen vacancy induced cubic-to-hexagonal (c-to-h) phase transformation. First-principles calculations show that the c-to-h phase transformation can be completed by lattice shear at elevated temperature, which is consistent with the experimental observation. The applied bending plus the residual tensile stress produces shear stress in the nanothin film. The thermal energy at the elevated temperature assists the shear stress to overcome the energy barriers during the c-to-h phase transformation. The stress-induced phase transformation in perovskite nanothin films with TMT provides materials scientists and engineers a novel approach to tailor nano/microstructures and properties of ferroelectric materials.

Discovering a First-Order Phase Transition in the Li-CeO2 System.

An in-depth understanding of (de)lithiation induced phase transition in electrode materials is crucial to grasp their structure-property relationships and provide guidance to the design of more desirable electrodes. By operando synchrotron XRD (SXRD) measurement and Density Functional Theory (DFT) based calculations, we discover a reversible first-order phase transition for the first time during (de)lithiation of CeO2 nanoparticles. The LixCeO2 compound phase is identified to possess the same fluorite crystal structure with FM3M space group as that of the pristine CeO2 nanoparticles. The SXRD determined lattice constant of the LixCeO2 compound phase is 0.551 nm, larger than that of 0.541 nm of the pristine CeO2 phase. The DFT calculations further reveal that the Li induced redistribution of electrons causes the increase in the Ce-O covalent bonding, the shuffling of Ce and O atoms, and the jump expansion of lattice constant, thereby resulting in the first-order phase transition. Discovering the new phase transition throws light upon the reaction between lithium and CeO2, and provides opportunities to the further investigation of properties and potential applications of LixCeO2.

Charge- and thickness-dependent inplane deformation of multilayer graphene thin films.

The charge- and thickness-dependent inplane deformation of multilayer graphene thin films in an electrolyte was studied by joint first-principles/continuum calculations (JFPCC) and the surface eigenstress model. At thermodynamic equilibrium, a multilayer graphene film exhibits initial deformation, which is asymmetric with respect to negative and positive charges, and the thickness-dependent minimal inplane C-C bond length occurs at the same positive charge of about 0.0381 × 10(20) |e| m(-2) for all studied films. The surface eigenstress model was further developed to take the charge-induced deformation into account, which yields analytical formulas. The analytical formulas describe the JFPCC results well for multilayer graphene thin films with a layer number larger than two, and are powerful and user friendly for understanding the charge and thickness dependent deformation in atomistic calculations and sophisticated experiments with multilayer graphene thin films.

Size- and temperature-dependent Young's modulus and size-dependent thermal expansion coefficient of thin films.

Nanomaterials possess a high surface/volume ratio and surfaces play an essential role in size-dependent material properties. In the present study, nanometer-thick thin films were taken as an ideal system to investigate the surface-induced size- and temperature-dependent Young's modulus and size-dependent thermal expansion coefficient. The surface eigenstress model was further developed with the consideration of thermal expansion, leading to analytic formulas of size- and temperature-dependent Young's modulus, and size-dependent thermal expansion coefficient of thin films. Molecular dynamics (MD) simulations on face-centered cubic (fcc) Ag, Cu, and Ni(001) thin films were conducted at temperatures ranging from 300 K to 600 K. The MD simulation results are perfectly consistent with the theoretical predictions, thereby verifying the theoretical approach. The newly developed surface eigenstress model will be able to attack similar problems in other types of nanomaterials.

Periodically Modulated Size-Dependent Elastic Properties of Armchair Graphene Nanoribbons.

First-principles calculations were conducted on armchair graphene nanoribbons (AGNRs) to simulate the elastic behavior of AGNRs with hydrogen-terminated and bare edges. The results show width-dependent elastic properties with a periodicity of three, which depends on the nature of edge. The edge eigenstress and eigendisplacement models are able to predict the width-dependent nominal Young's modulus and Poisson's ratio, while the Clar structure explains the crucial role of edges in the periodically modulated size-dependent elastic properties.

Nanoslit-microcavity-based narrow band absorber for sensing applications.

We propose an ultranarrow bandwidth perfect infrared absorber consisting of a metal periodic structured surface with nanoslits, a spacer dielectric, and a metal back plate. Its bandwidth and aborption are respectively about 8 nm and 95%. The thickness of the nanobars and the spacer, and the width of the nanoslits are primary factors determining the absorption performance. This structure not only has narrow bandwidth but also can obtain the giant electric field enhancement in the tiny volume of the nanoslits. Operated as a refractive index sensor, this structure has figure of merit as high as 25. It has potential in biomedical and sensing applications.

Metal-dielectric-metal based narrow band absorber for sensing applications.

We have investigated numerically the narrowband absorption property of a metal-dielectric-metal based structure which includes a top metallic nanoring arrays, a metal backed plate, and a middle dielectric spacer. Its absorption is up to 90% with linewidth narrower than 10 nm. This can be explained in terms of surface lattice resonance of the periodic structure. The spectrum with the sharp absorption dip, i.e. the lattice resonance, strongly depends on the refractive index of media surrounding the nanorings. This feature can be explored to devise a refractive index sensor, of which the bulk sensitivity factor is one order larger than that based on gap resonance mode, while the surface sensitivity factor can be two times larger. The proposed narrowband absorber has potential in applications of plasmonic biosensors.