Identification of Two Novel QTL for Fusarium Head Blight Resistance in German Wheat Cultivar Centrum.

Fusarium head blight (FHB) is a devastating disease that occurs in warm and humid environments. The German wheat 'Centrum' has displayed moderate to high levels of FHB resistance in the field for many years. In this study, an F6:8 recombinant inbred line (RIL) population derived from cross 'Centrum' × 'Xinong 979' was evaluated for FHB response following point inoculation in five environments. The population and parents were genotyped using the GenoBaits Wheat 16 K Panel. Stable quantitative trait loci (QTL) associated with FHB resistance in 'Centrum' were mapped on chromosome arms 2DS and 5BS. The most effective QTL, located in 2DS, was identified as a new chromosome region represented by a 1.4 Mb interval containing 17 candidate genes. Another novel QTL was mapped in chromosome arm 5BS of a 5BS to 7BS translocation chromosome. In addition, two environmentally sensitive QTL were mapped on chromosome arms 2BL from 'Centrum' and 5AS from 'Xinong 979'. Polymorphisms of flanking phenotypic variance explained (PVE) markers (allele-specific quantitative PCR [AQP]) AQP-6 for QFhb.nwafu-2DS and 16K-13073 for QFhb.nwafu-5BS were validated in a panel of 217 cultivars and breeding lines. These markers could be useful for marker-assisted selection (MAS) of FHB resistance and provide a starting point for fine mapping and marker-based cloning of the resistance genes.

Ruthenium/TiO2 -Catalyzed Hydrogenolysis of Polyethylene Terephthalate: Reaction Pathways Dominated by Coordination Environment.

Polyethylene terephthalate (PET) hydrogenolysis can produce benzene, toluene, and xylene (BTX), where the selectivity control is challenging. We report a reaction pathway dictated by the Ru coordination environment by examining the binding geometries of adsorbates on differently coordinated Ru centers and their evolution during PET hydrogenolysis. A BTX yield of 77 % was obtained using a Ru/TiO2 with a Ru coordination number of ca. 5.0 where edge/corner sites are dominant, while more gas and saturated products were formed for Ru/TiO2 containing primarily terrace sites. Density functional theory and isotopic labelling revealed that under-coordinated Ru edge sites favor "upright" adsorption of aromatic adsorbates while well-coordinated Ru sites favor "flat-lying" adsorption, where the former mitigates ring hydrogenation and opening. This study demonstrates that reaction pathways can be directed through controlled reactant/intermediate binding via tuning of the Ru coordination environment for efficient conversion of PET to BTX.

Effector gene silencing mediated by histone methylation underpins host adaptation in an oomycete plant pathogen.

The relentless adaptability of pathogen populations is a major obstacle to effective disease control measures. Increasing evidence suggests that gene transcriptional polymorphisms are a strategy deployed by pathogens to evade host immunity. However, the underlying mechanisms of transcriptional plasticity remain largely elusive. Here we found that the soybean root rot pathogen Phytophthora sojae evades the soybean Resistance gene Rps1b through transcriptional polymorphisms in the effector gene Avr1b that occur in the absence of any sequence variation. Elevated levels of histone H3 Lysine27 tri-methylation (H3K27me3) were observed at the Avr1b locus in a naturally occurring Avr1b-silenced strain but not in an Avr1b-expressing strain, suggesting a correlation between this epigenetic modification and silencing of Avr1b. To genetically test this hypothesis, we edited the gene, PsSu(z)12, encoding a core subunit of the H3K27me3 methyltransferase complex by using CRISPR/Cas9, and obtained three deletion mutants. H3K27me3 depletion within the Avr1b genomic region correlated with impaired Avr1b gene silencing in these mutants. Importantly, these mutants lost the ability to evade immune recognition by soybeans carrying Rps1b. These data support a model in which pathogen effector transcriptional polymorphisms are associated with changes in chromatin epigenetic marks, highlighting epigenetic variation as a mechanism of pathogen adaptive plasticity.

Spatial pattern of the population casualty rate caused by super typhoon Lekima and quantification of the interactive effects of potential impact factors.

BACKGROUND: Typhoons greatly threaten human life and property, especially in China. Therefore, it is important to make effective policy decisions to minimize losses associated with typhoons. METHODS: In this study, the GeoDetector method was used to quantify the determinant powers of natural and socioeconomic factors, and their interactions, on the population casualty rate of super typhoon Lekima. The local indicator of spatial association (LISA) method was followed to explore the spatial pattern of the population casualty rate under the influence of the identified dominant factors. RESULTS: Both natural and socioeconomic factors were found to have significantly impacted the population casualty rate due to super typhoon Lekima. Among the selected factors, maximum precipitation was dominant factor (q = 0.56), followed by maximum wind speed (q = 0.45). In addition, number of health technicians (q = 0.35) and number of health beds (q = 0.27) have a strong influence on the population casualty rate. Among the interactive effects of 12 influencing factors, the combined effects of maximum precipitation and ratio of brick-wood houses, the maximum precipitation and ratio of steel-concrete houses, maximum precipitation and number of health technicians were highest (q = 0.72). Furthermore, high-risk areas with very high casualty rates were concentrated in the southeastern part of Zhejiang and northern Shandong Provinces, while lower-risk areas were mainly distributed in northern Liaoning and eastern Jiangsu provinces. CONCLUSIONS: These results contribute to the development of more specific policies aimed at safety and successful property protection according to the regional differences during typhoons.

Spatiotemporal evolution of global population ageing from 1960 to 2017.

BACKGROUND: Population ageing is an increasingly severe global issue. And this has been posing challenges for public health policies and medical resource allocation There are various features of population ageing in different regions worldwide. METHODS: All data were obtained from the health data of World Bank Open Data. Quantile linear regression was used to subtly measure the common variation tendency and strength of the global ageing rate and ageing population. The Bayesian space-time hierarchy model (BSTHM) was employed to assess the detailed spatial temporal evolution of ageing rate and ageing population in global 195 countries and regions. RESULTS: Annual growth of the ageing (65 and above) rate occurred on six continents: Europe (0.1532%), Oceania (0.0873%), Asia (0.0834%), South America (0.0723%), North America (0.0673%) and Africa (0.0069%). The coefficient of variation of the global ageing rate increased from 0.54 in 1960 to 0.69 in 2017. The global ageing rate and ageing population increased over this period, correlating positively with their quantiles. Most countries (37/39) in Europe belong to the top level with regard to the ageing rate, including the countries with the greatest degree of ageing-Sweden, Germany, Austria, Belgium and the UK-whose spatial relative risks of ageing are 3.180 (3.113-3.214), 3.071 (3.018-3.122), 2.951 (2.903-3.001), 2.932 (2.880-2.984) and 2.917 (2.869-2.967), respectively. Worldwide, 44 low ageing areas which were distributed mainly in Africa (26 areas) and Asia (15 areas) experienced a decreasing trend of ageing rates. The local trends of ageing population in the 195 areas increased. CONCLUSIONS: The differentiation of global population ageing is becoming increasingly serious. Globally, all 195 areas showed an increasing local ageing trend in absolute terms, although there were 44 low-ageing areas that experienced a decreasing local trend of ageing rate. The statistical results may provide some baseline reference for developing public health policies in various countries or regions, especially in less-developed areas.

Spatial-temporal heterogeneity of hand, foot and mouth disease and impact of meteorological factors in arid/ semi-arid regions: a case study in Ningxia, China.

BACKGROUND: The incidence of hand, foot and mouth disease (HFMD) varies over space and time and this variability is related to climate and social-economic factors. Majority of studies on HFMD were carried out in humid regions while few have focused on the disease in arid/semi-arid regions, more research in such climates would potentially make the mechanism of HFMD transmission clearer under different climate conditions. METHODS: In this paper, we explore spatial-temporal distribution of HFMD in Ningxia province, which has an arid/semi-arid climate in northwest China. We first employed a Bayesian space-time hierarchy model (BSTHM) to assess the spatial-temporal heterogeneity of the HFMD cases and its relationship with meteorological factors in Ningxia from 2009 to 2013, then used a novel spatial statistical software package GeoDetector to test the spatial-temporal heterogeneity of HFMD risk. RESULTS: The results showed that the spatial relative risks in northern part of Ningxia were higher than those in the south. The highest temporal risk of HFMD incidence was in fall season, with a secondary peak in spring. Meteorological factors, such as average temperature, relative humidity, and wind speed played significant roles in the spatial-temporal distribution of HFMD risk. CONCLUSIONS: The study provide valuable information on HFMD distribution in arid/semi-arid areas in northwest China and facilitate understanding of the concentration of HFMD.

Space-time heterogeneity of hand, foot and mouth disease in children and its potential driving factors in Henan, China.

BACKGROUND: Hand, foot and mouth disease (HFMD) has become a substantial threat recently. However few studies have quantified spatiotemporal heterogeneity of HFMD and detected spatiotemporal interactive effect of potential driving factors on this disease. METHODS: Using GeoDetector and Bayesian space-time hierarchy model, we characterized the epidemiology of HFMD in Henan, one of the largest population provinces in China, from 2012 to 2013, and quantified the impacts of potential driving factors. RESULTS: Notably, 21.43 and 24.60% counties were identified as hot and cold spots, respectively. Spatially, the hotspots were mainly clustered in regions where the economic level was high. Temporally, the highest incidence period of HFMD was discovered to be in late spring and early summer. The impact of meteorological and socio-economic factors on the disease are significant, and this study found that a 1 °C rise in temperature was related to an increase of 4.09% in the HFMD incidence, a 1% increment in relative humidity was associated with a 1.77% increase of the disease, and a 1% increment in ratio of urban to rural population was associated with a 0.16% increase of the disease. CONCLUSION: Meteorological and socio-economic factors presented significantly association with HFMD incidence, high-risk mainly appeared in large cities and their adjacent regions in hot and humid season. These findings will be helpful for HFMD risk control and disease-prevention policies implementation.

Restructuring the interfacial active sites to generalize the volcano curves for platinum-cobalt synergistic catalysis.

Computationally derived volcano curve has become the gold standard in catalysis, whose practical application usually relies on empirical interpretations of composition or size effects by the identical active site assumption. Here, we present a proof-of-concept study on disclosing both the support- and adsorbate-induced restructuring of Pt-Co bimetallic catalysts, and the related interplays among different interfacial sites to propose the synergy-dependent volcano curves. Multiple characterizations, isotopic kinetic investigations, and multiscale simulations unravel that the progressive incorporation of Co into Pt catalysts, driven by strong Pt-C bonding (metal-support interfaces) and Co-O bonding (metal-adsorbate interfaces), initiates the formation of Pt-rich alloys accompanied by isolated Co species, then Co segregation to epitaxial CoOx overlayers and adjacent Co3O4 clusters, and ultimately structural collapse into amorphous alloys. Accordingly, three distinct synergies, involving lattice oxygen redox from Pt-Co alloy/Co3O4 clusters, dual-active sites engineering via Pt-rich alloy/CoOx overlayer, and electron coupling within exposed alloy, are identified and quantified for CO oxidation (gas-phase), ammonia borane hydrolysis (liquid-phase), and hydrogen evolution reaction (electrocatalysis), respectively. The resultant synergy-dependent volcano curves represent an advancement over traditional composition-/size-dependent ones, serving as a bridge between theoretical models and experimental observations in bimetallic catalysis.

Modification of low temperature-related hospital admissions for cardiovascular diseases by multiple green space indicators at multiple spatial scales: Evidence from Guangzhou, China.

BACKGROUND: Extreme temperatures have an adverse effect on the occurrence of cardiovascular diseases (CVDs). Previous literatures tend to discuss the modification of CVDs occurrence by green space under high temperature. Relatively less attention is paid to the modification under low temperature. The variation of different attributes and spatial scales of green space in affecting CVDs occurrence are also overlooked. METHODS: This study collected a total of 4364 first-time admission cases due to CVDs in a tertiary hospital in Guangzhou from 2012 to 2018, measured the scale of green space by greening rate (GR) and percentage of landscape (PLAND), the distribution of green space by patch density (PD), mean nearest neighbor distance (ENN_MN) and largest patch index (LPI), and the accessibility of green space by green patch accessibility index (GPAI). Using the time stratified case crossover design method, the modification of low temperature-related CVDs occurrence by the above green space indicators is evaluated in an area with a radius of 100-1000 m which is further divided at an interval of 100 m. RESULTS: We found high GR, high PLAND, high PD, low ENN_MN, high LPI, and low GPAI corresponds to low risk of CVDs occurrence, the optimal modification scale of each green space indicator, which is radius corresponding to the maximum risk difference between high and low indicator subgroups, is around 800 m (GR), 600 m (PLAND and PD), 500 m (GPAI), and 300 m (LPI and ENN_MN), respectively. As the temperature decreases further, the health benefit from low GPAI at the optimal scale is weakened, whereas the benefits from the others are strengthened. CONCLUSIONS: Low temperature related CVDs occurrence risk can be modified by multiple green space indicators, and these modifications have spatial scale effect. Our findings have important theoretical and practical significance for the formulation and implementation of local green space policies.

Associations between Different Ozone Indicators and Cardiovascular Hospital Admission: A Time-Stratified Case-Crossover Analysis in Guangzhou, China.

Epidemiological studies reported that ozone (O3) is associated with cardiovascular diseases. However, only few of these studies examined the impact of multiple O3 indicators on cardiovascular hospital admissions. This study aimed to explore and compare the impacts of different O3 indicators on cardiovascular hospital admissions in Guangzhou, China. Based upon the data on daily cardiovascular hospital admissions, air pollution, and meteorological factors in Guangzhou from 2014 to 2018, a time-stratified case-crossover design model was used to analyze the associations between different O3 indicators and cardiovascular hospital admissions. Moreover, the sensitivities of different age and gender groups were analyzed for the whole year and different seasons (i.e., warm and cold). During the warm season, for the single-pollutant model, the odds ratio (OR) value of cardiovascular hospital admissions was 1.0067 (95% confidence interval (CI): 1.0037, 1.0098) for every IQR increase in MDA8 O3 at a lag of five days. The effect of O3 on people over 60 year was stronger than that on the 15-60 years age group. Females were more sensitive than males to O3 exposure. These results provided valuable references for further scientific research and environmental improvement in Guangzhou. Given that short-term O3 exposure poses a threat to human health, the government should therefore pay attention to prevention and control policies to reduce and eliminate O3 pollution and protect human health.

Comparison of the association between different ozone indicators and daily respiratory hospitalization in Guangzhou, China.

Background: Epidemiological studies have widely proven the impact of ozone (O3) on respiratory mortality, while only a few studies compared the association between different O3 indicators and health. Methods: This study explores the relationship between daily respiratory hospitalization and multiple ozone indicators in Guangzhou, China, from 2014 to 2018. It uses a time-stratified case-crossover design. Sensitivities of different age and gender groups were analyzed for the whole year, the warm and the cold periods. We compared the results from the single-day lag model and the moving average lag model. Results: The results showed that the maximum daily 8 h average ozone concentration (MDA8 O3) had a significant effect on the daily respiratory hospitalization. This effect was stronger than for the maximum daily 1 h average ozone concentration (MDA1 O3). The results further showed that O3 was positively associated with daily respiratory hospitalization in the warm season, while there was a significantly negative association in the cold season. Specifically, in the warm season, O3 has the most significant effect at lag 4 day, with the odds ratio (OR) equal to 1.0096 [95% confidence intervals (CI): 1.0032, 1.0161]. Moreover, at the lag 5 day, the effect of O3 on the 15-60 age group was less than that on people older than 60 years, with the OR value of 1.0135 (95% CI: 1.0041, 1.0231) for the 60+ age group; women were more sensitive than men to O3 exposure, with an OR value equal to 1.0094 (95% CI: 0.9992, 1.0196) for the female group. Conclusion: These results show that different O3 indicators measure different impacts on respiratory hospitalization admission. Their comparative analysis provided a more comprehensive insight into exploring associations between O3 exposure and respiratory health.

Temporal and Spatial Heterogeneity of PM2.5 Related to Meteorological and Socioeconomic Factors across China during 2000-2018.

In recent years, air pollution caused by PM2.5 in China has become increasingly severe. This study applied a Bayesian space-time hierarchy model to reveal the spatiotemporal heterogeneity of the PM2.5 concentrations in China. In addition, the relationship between meteorological and socioeconomic factors and their interaction with PM2.5 during 2000-2018 was investigated based on the GeoDetector model. Results suggested that the concentration of PM2.5 across China first increased and then decreased between 2000 and 2018. Geographically, the North China Plain and the Yangtze River Delta were high PM2.5 pollution areas, while Northeast and Southwest China are regarded as low-risk areas for PM2.5 pollution. Meanwhile, in Northern and Southern China, the population density was the most important socioeconomic factor affecting PM2.5 with q values of 0.62 and 0.66, respectively; the main meteorological factors affecting PM2.5 were air temperature and vapor pressure, with q values of 0.64 and 0.68, respectively. These results are conducive to our in-depth understanding of the status of PM2.5 pollution in China and provide an important reference for the future direction of PM2.5 pollution control.

A Health Impact and Economic Loss Assessment of O3 and PM2.5 Exposure in China From 2015 to 2020.

China is in a critical air quality management stage. Rapid industrial development and urbanization has resulted in non-ignorable air pollution, which seriously endangers human health. Assessment of the health impacts and economic losses of air pollution is essential for the prevention and control policy formulation. Based on ozone (O3) and fine particulate matter concentration (PM2.5) monitoring data in 331 Chinese cities from 2015 to 2020, this study evaluated the health effects and the corresponding economic losses of O3 and PM2.5 pollution on three health endpoints. The ratio of population exposed to O3 levels that exceeded the Chinese Ambient Air Quality Standards (CAAQS) increased from 13.35% in 2015 to 14.15% in 2020, which resulted in 133,415 (2015) - 156,173 (2020) all-cause deaths, 88,941 (2015) - 104,051 (2020) cardiovascular deaths, and 28,614 (2015) - 33,456 (2020) respiratory deaths. The ratio of population exposed to PM2.5 levels that exceeded the CAAQS decreased, but in many regions, especially in North China and the Yangtze River Delta, the PM2.5 concentration remained high. By 2020, nearly half of the population in China was still exposed to PM2.5 levels that exceeded the CAAQS, and the corresponding economic losses reached CNY 3.46 and 3.05 billion, respectively. These results improved the understanding of the spatial-temporal variation trends of major air pollutants at city scale in China, and emphasize the continued coordination urgently needed for controlling O3 and PM2.5 following the implementation of the 2013 policy to mitigate air pollution to protect human health.

Short-term health impacts related to ozone in China before and after implementation of policy measures: A systematic review and meta-analysis.

This paper presents a meta-analysis of the impacts of short-term exposure to ozone (O3) on three health endpoints: all-cause, cardiovascular, and respiratory mortality in China. All relevant studies from January 1990 to December 2021 were searched from four databases. After screening, 30 studies were included for the meta-analysis. The results showed that a significant rise of 0.41 % (95 % confidence interval (CI): 0.35 %-0.48 %) in all-cause, 0.60 % (95 % CI: 0.51 %-0.68 %) in cardiovascular and 0.45 % (95 % CI: 0.28 %-0.62 %) in respiratory mortality for each 10 µg m-3 increase in the maximum daily 8 h average O3 concentration (MDA8 O3). Moreover, results stratified by heterogeneous time periods before and after implementing a policy measure in 2013, showed that the pooled effects for all-cause and respiratory mortality before were greater than those after, while the pooled effects for cardiovascular mortality before 2013 were slightly smaller than those after. The finding that short-term exposure to O3 was positively related to the three health endpoints was validated by means of a sensitivity analysis. Furthermore, we did not observe any publication bias. Our results present an updated and better understanding of the relationship between short-term exposure to O3 and the three health endpoints, while providing a reference for further assessment of the impact of short-term O3 exposure on human health.

Determinant Powers of Socioeconomic Factors and Their Interactive Impacts on Particulate Matter Pollution in North China.

Severe air pollution has significantly impacted climate and human health worldwide. In this study, global and local Moran's I was used to examine the spatial autocorrelation of PM2.5 pollution in North China from 2000-2017, using data obtained from Atmospheric Composition Analysis Group of Dalhousie University. The determinant powers and their interactive effects of socioeconomic factors on this pollutant are then quantified using a non-linear model, GeoDetector. Our experiments show that between 2000 and 2017, PM2.5 pollution globally increased and exhibited a significant positive global and local autocorrelation. The greatest factor affecting PM2.5 pollution was population density. Population density, road density, and urbanization showed a tendency to first increase and then decrease, while the number of industries and industrial output revealed a tendency to increase continuously. From a long-term perspective, the interactive effects of road density and industrial output, road density, and the number of industries were amongst the highest. These findings can be used to develop the effective policy to reduce PM2.5 pollution, such as, due to the significant spatial autocorrelation between regions, the government should pay attention to the importance of regional joint management of PM2.5 pollution.

Spatiotemporal variations in the incidence of bacillary dysentery and long-term effects associated with meteorological and socioeconomic factors in China from 2013 to 2017.

Bacillary dysentery is a global public health problem that exhibits manifest spatiotemporal heterogeneity. However, long-term variations and regional determinant factors remain unclear. In this study, the Bayesian space-time hierarchy model was used to identify the long-term spatiotemporal heterogeneity of the incidence of bacillary dysentery and quantify the associations of meteorological factors with the incidence of bacillary dysentery in northern and southern China from 2013 to 2017. GeoDetector was used to quantify the determinant powers of socioeconomic factors in the two regions. The results showed that the incidence of bacillary dysentery peaked in summer (June to August), indicating temporal seasonality. Geographically, the hot spots (high-risk areas) were distributed in northwestern China (Xinjiang, Gansu, and Ningxia) and northern China (including Beijing, Tianjin, and Hebei), whereas the cold spots (low-risk areas) were concentrated in southeastern China (Jiangsu, Zhejiang, Fujian, and Guangdong). Moreover, significant regional differences were found among the meteorological and socioeconomic factors. Average temperature was the dominant meteorological factor in both northern and southern China. In northern and southern China, a 1 °C increase in the average temperature led to an increase of 1.01% and 4.26% in bacillary dysentery risk, respectively. The dominant socioeconomic factors in northern and southern China were per capita gross domestic product and the number of health technicians, with q statistic values of 0.81 and 0.49, respectively. These findings suggest that hot, moist, and overcrowded environments or poor health conditions increase the risk of bacillary dysentery. This study provides suggestions and serves as a basis for surveillance efforts. Further, the suggestions may aid in the control of bacillary dysentery and in the implementation of disease prevention policies.

Spatial heterogeneity of the association between temperature and hand, foot, and mouth disease risk in metropolitan and other areas.

Interest in assessing the effects of temperature on hand, foot, and mouth disease (HFMD) has increased. However, little evidence is available on spatial heterogeneity in relationship to temperature and HFMD in metropolitan (capital city and municipal districts) and other areas where economic levels are significantly different. In this study, the Bayesian space-time hierarchy model was applied to identify the spatiotemporal heterogeneity of HFMD. GeoDetector was then used to quantify the determinant power of temperature to the disease in regions where the economic level has significant spatial heterogeneity. There was significant spatial heterogeneity in the influence of temperature on the incidence of HFMD in metropolitan and other areas. In metropolitan areas, where the disease risk is higher (hot spots), the HFMD incidence was higher alongside an increase in average temperature. However, in non-metropolitan areas, where the disease risk is lower (cold spots), there was an approximately S-shaped relationship between the temperature and the HFMD risk. More specifically, when the temperature was >25 °C, the HFMD incidence no longer increased monotonically with the increasing temperature. There was significant spatial heterogeneity in the effects of temperature on the HFMD incidence in metropolitan and non-metropolitan areas. This finding may serve as a suggestion and basis for the surveillance and control of this disease and it is conducive to the rational allocation of medical resources in different areas.

Spatiotemporal heterogeneity of PM2.5 and its relationship with urbanization in North China from 2000 to 2017.

Fine particulate matter (PM2.5) pollution is becoming an increasing global concern due to rapid urbanization and socioeconomic development, especially in North China. Although North China experiences poor air quality and high PM2.5 concentrations, their spatial heterogeneity and relationship with the relative spatial risks of air pollution have not been explored. Therefore, in this study, the temporal variation trends (slope values) of the PM2.5 concentrations in North China from 2000 to 2017 were first quantified using the unitary linear regression model, and the Bayesian space-time hierarchy model was introduced to characterize their spatiotemporal heterogeneity. The spatial lag model was then used to examine the determinant power of urbanization and other socioeconomic factors. Additionally, the correlation between the spatial relative risks (probability of a region becoming more/less polluted relative to the average PM2.5 concentrations of the study area), and the temporal variation trends of the PM2.5 concentrations were quantified using the bivariate local indicators of spatial association model. The results showed that the PM2.5 concentrations increased during 2000-2017, and peaked in 2007 and 2013. Spatially, the cities at high risk of PM2.5 pollution were mainly clustered in southeastern Hebei, northern Henan, and western Shandong where the slope values were low, as demonstrated by the value of Moran's I (-0.56). Moreover, urbanization and road density were both positively correlated with PM2.5 pollution, while the proportion of tertiary industry was negatively correlated. Furthermore, a notable increasing trend was observed in some cities, such as Tianjin, Zaozhuang, Qingdao, and Xinyang. These findings can contribute to the development of effective policies from the perspective of rapid urbanization to relieve and reduce PM2.5 pollution.

The Coupled Impact of Emergency Responses and Population Flows on the COVID-19 Pandemic in China.

Coronavirus disease 2019 (COVID-19) has spread around the world and requires effective control measures. Like the human-to-human transmission of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the distribution of COVID-19 was driven by population flow and required emergency response measures to slow down its spread and degrade the epidemic risk. The local epidemic risk of COVID-19 is a combination of emergency response measures and population flow. Because of the spatial heterogeneity, the different impacts of coupled emergency responses and population flow on the COVID-19 epidemic during the outbreak period and a control period are unclear. We examined and compared the impact of emergency response measures and population flow on China's epidemic risk after the Wuhan lockdown during the outbreak period and a control period. We found that the population flow out of Wuhan had a long-term impact on the epidemic's spread. In the outbreak period, a large population flow out of Wuhan led to nationwide migration mobility, which directly increased the epidemic in each province. Meanwhile, quick emergency responses mitigated the spread. Although low population flow to provinces far from Hubei delayed the outbreak in those provinces, relatively delayed emergency response increased the epidemic in the control period. Consequently, due to the strong transmission ability of the SARS-CoV-2 virus, no region correctly estimated the epidemic, and the relaxed emergency response raised the epidemic risks in the context of the outbreak.

Effects of temperature fluctuations on spatial-temporal transmission of hand, foot, and mouth disease.

Hand, foot, and mouth disease (HFMD), predominantly occurs among infants and children. Previous studies have shown that suitable, stable temperatures favor HFMD virus reproduction; however, temperature fluctuations also affect virus transmission, and there are, so far, no studies concerning the association between such fluctuations and the incidence of HFMD. The objective of this study was to map the spatial-temporal distribution of HFMD incidence and quantify the long-term effects of temperature fluctuations on HFMD incidence in children. HFMD cases in children under five, from January 2009 to December 2013, in Beijing, Tianjin, and Hebei provinces of China, were used in this study. The GeoDetector and Bayesian space-time hierarchy models were employed to explore the spatial-temporal association between temperature fluctuations and HFMD incidence. The results indicate that HFMD incidence had significant spatial stratified heterogeneity (GeoDetector q-statistic = 0.83, p < 0.05), and that areas with higher risk mainly appeared in metropolises and their adjacent regions. HFMD transmission was negatively associated with temperature fluctuations. A 1 °C increase in the standard deviation of maximum and minimum temperatures was associated with decreases of 8.22% and 11.87% in the risk of HFMD incidence, respectively. The study suggests that large temperature fluctuations affect virus growth or multiplication, thereby inhibiting the activity of the virus and potentially even leading to its extinction, and consequently affecting the spatial-temporal distribution of HFMD. The findings can serve as a reference for the practical control of this disease and offer help in the rational allocation of medical resources.