Detalhe da pesquisa
1.
Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.
Mol Cell
; 77(3): 656-668.e5, 2020 02 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32004469
2.
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol Cell
; 80(3): 485-500.e7, 2020 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33027691
3.
Activation of the GLP-1 receptor by a non-peptidic agonist.
Nature
; 577(7790): 432-436, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31915381
4.
Structural and functional diversity among agonist-bound states of the GLP-1 receptor.
Nat Chem Biol
; 18(3): 256-263, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34937906
5.
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.
Nature
; 555(7694): 121-125, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29466332
6.
Glycosylation Improves the Proteolytic Stability of Exenatide.
Bioconjug Chem
; 34(6): 1014-1018, 2023 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37192432
7.
Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors.
Int J Mol Sci
; 23(15)2022 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35897648
8.
AM833 Is a Novel Agonist of Calcitonin Family G Protein-Coupled Receptors: Pharmacological Comparison with Six Selective and Nonselective Agonists.
J Pharmacol Exp Ther
; 377(3): 417-440, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33727283
9.
Chemical Synthesis and Characterization of a Nonfibrillating Glycoglucagon.
Bioconjug Chem
; 32(10): 2148-2153, 2021 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34494823
10.
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Proc Natl Acad Sci U S A
; 115(31): E7438-E7447, 2018 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30012612
11.
Protein kinase D and Gßγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2.
J Biol Chem
; 294(27): 10649-10662, 2019 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31142616
12.
Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism.
J Biol Chem
; 293(24): 9370-9387, 2018 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29717000
13.
Protein Kinase D and Gßγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane.
J Biol Chem
; 291(21): 11285-99, 2016 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27030010
14.
Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.
J Biol Chem
; 290(22): 13875-87, 2015 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-25878251
15.
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.
J Biol Chem
; 289(39): 27215-27234, 2014 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25118282
16.
The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.
Gastroenterology
; 147(6): 1417-28, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25194674
17.
Regulation of RGS5 GAP activity by GPSM3.
Mol Cell Biochem
; 405(1-2): 33-40, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25842189
18.
Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons.
J Biol Chem
; 288(36): 25689-25700, 2013 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23913690
19.
The involvement of the Wnt/ß-catenin signaling cascade in fibrosis progression and its therapeutic targeting by relaxin.
Biochem Pharmacol
; 223: 116130, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38490518
20.
The role of G protein-coupled receptor kinases in GLP-1R ß-arrestin recruitment and internalisation.
Biochem Pharmacol
; 222: 116119, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38461904