Association between Hyperhomocysteinemia and Hypertensive Retinopathy in a Chinese Han Population.

Purpose/aim: In some diseases, hyperhomocysteinemia (HHcy) has been recognized as a risk factor. However, information on the correlation between HHcy and hypertensive retinopathy (HR) in the Chinese population is unclear. We, therefore, aimed to investigate this association.Materials and Methods: A total of 382 patients were collected and 126 individuals were excluded in this study. Finally, 128 patients with HR and 128 control subjects were enrolled sequentially. The association between HHcy and the occurrence of HR was determined by multivariate logistic regression analysis, including interaction and stratified analyses.Results: HHcy, cardiovascular disease, fasting blood glucose, creatinine, triglyceride, diabetes, smoking habits, drinking habits were significantly associated with HR (P < .05) in the univariate logistic regression analysis. Each increase of 1 µmol/L of homocysteine concentration was significantly correlated with a 9% increased risk of HR (odds ratio [OR] = 1.09, 95% confidence interval [CI]: 1.07-1.55, P < .05). Hierarchical analysis identified history of diabetes (OR = 7.38, P > .05), age ≥60 years (OR = 3.08, P > .05), male sex (OR = 1.04, P > .05), history of cardiovascular disease (OR = 7.88, P > .05), smoking habit (OR = 1.08, P > .05), and drinking habit (OR = 78.31, P > .05), as factors associated with HR, but not as independent risk factors for HR. Interaction analysis demonstrated no interaction between HHcy and HR.Conclusions: Within the Chinese Han population, HHcy is an independent risk factor for HR.

Indicating and predicting role of the horizontal C/D ratio in preclinical diabetic retinopathy associated with chronic angle-closure glaucoma.

AIM: To observe morphological optic disc characteristics in patients with preclinical diabetic retinopathy (DR) associated with chronic angle-closure glaucoma (CACG). METHODS: Twenty-two cases (43 eyes) of preclinical DR associated with CACG were enrolled in group A; 24 preclinical DR cases (46 eyes) were enrolled in group B; 26 CACG cases (51 eyes) were enrolled in group C; and 49 normal controls (49 eyes) were enrolled in group D. All underwent optical coherence tomography to measure the horizontal C/D ratio (HCDR), C/D area ratio (CDaR), vertical C/D ratio (VCDR), rim area (RA), cup volume (CV), disc area (DA) and average retinal nerve fiber layer (RNFL) thickness. RESULTS: The ages of groups A, B, C, and D were 67.60±3.36, 66.78±3.33, 65.98±3.83, and 67.54±3.17y, respectively. The HCDR values in groups A, B, and C were distinct relative to those in group D (P<0.0001, P<0.01, and P<0.05, respectively). The HCDR values in group A were higher compared with those in groups B (P<0.0001) and D (P<0.0001); while these values were virtually identical statistically between groups A and C (P>0.05). The CDaR values in group A were higher in comparison to those in groups B and D (P<0.0001 in both groups); while these values were virtually identical statistically between groups A and C (P>0.05). The RA values in group A were smaller relative to those in groups B and D (P<0.0001 in both groups); while groups A and C were not distinct statistically (P>0.05). The CV values in group A were greater in comparison to those in groups B and D (P<0.0001 in both groups); while groups A and C were not distinct statistically (P>0.05). DA was not distinct for comparisons of two groups among the four groups (P>0.05). HCDR value correlated with mean nasal RNFL thickness (r=-0.909, P<0.0001), mean superior RNFL thickness (r=-0.866, P<0.0001), mean inferior RNFL thickness (r=-0.650, P<0.001) and mean temporal RNFL thickness (r=-0.562, P<0.01) in group A. CONCLUSION: The HCDR was a sensitive morphological parameter in detecting structural visual disc changes in preclinical DR associated with CACG, which can reflect optic nerve damage caused jointly by CACG and diabetes. A higher HCDR may predict optic nerve atrophy.

Transcatheter hepatic arterial infusion chemotherapy vs sorafenib in the treatment of patients with hepatocellular carcinoma of Barcelona Clinic Liver Cancer stage C: a meta-analysis of Asian population.

OBJECTIVE: To compare the clinical efficacy and safety of transcatheter hepatic arterial infusion chemotherapy (HAIC) with those of sorafenib in the treatment of patients with hepatocellular carcinoma (HCC) of Barcelona Clinic Liver Cancer (BCLC) stage C. METHODS: Potentially relevant studies comparing the clinical efficacy and safety of HAIC with those of sorafenib were searched using Medline, PubMed, Embase, Cochrane Library, and Chinese databases (Wanfang Data and China National Knowledge Infrastructure). Overall survival rate (OSR), tumor response rate, disease control rate (DCR), and serious adverse events (SAEs) were compared and analyzed. Pooled ORs with 95% CIs were calculated using either the fixed-effects model or the random-effects model. All statistical analyses were conducted using Review Manager (version 5.3) from the Cochrane Collaboration. RESULTS: A total of 1,264 patients were included in this meta-analysis. The results of this study showed that HAIC was associated with significantly higher 1-, 2-, and 3-year OSRs than sorafenib (OR 1.88, 95% CI1-year: [1.27-2.78], P1-year=0.002; OR 2.15, 95% CI2-year: [1.06-4.37], P2-year=0.03; OR 7.90, 95% CI3-year: [2.12-29.42], P3-year=0.002). Compared to sorafenib, HAIC was associated with superior complete response (CR), partial response (PR), and objective response rate (ORR) (OR 3.90, 95% CICR: [1.89-8.03], P CR =0.0002; OR 3.47, 95% CIPR: [2.31-5.24], P PR <0.00001; OR 3.02, 95% CIOR: [2.05-4.45], P OR <0.0001). There was no statistically significant difference between HAIC and sorafenib in stable disease (SD), progressive disease (PD), DCR, and SAEs (OR 0.86, 95% CISD: [0.51-1.45], P SD =0.56; OR 0.62, 95% CIPD: [0.35-1.11], P PD =0.11; OR 0.53, 95% CISAE: [0.14-1.92], P SAE =0.33). CONCLUSION: This study showed that HAIC was associated with better efficacy than sorafenib in terms of OSR and tumor response. Therefore, HAIC can be considered as an alternative treatment option for patients with HCCs of BCLC stage C.

Plasma plasminogen activator inhibitor-1 is associated with end-stage proliferative diabetic retinopathy in the Northern Chinese Han population.

OBJECTIVE: To identify predictors of end-stage proliferative diabetic retinopathy (PDR) in a cohort of individuals with type 2 diabetes mellitus (T2DM) from the Northern Chinese Han population. METHODS: We investigated characteristics of 153 consecutive diabetic patients with end-stage PDR (62 males, 91 females), 123 consecutive PDR patients without end-stage PDR (48 males, 75 females), and 151 normal subjects (63 males, 88 females). Only one eye of each patient or healthy subject was included in this study. Univariate logistic regression models and multivariate logistic regression models were constructed to evaluate the predictors of end-stage PDR. RESULTS: In univariate analysis, systolic blood pressure, diastolic blood pressure, duration of diabetes, family history of T2DM, and plasminogen activator inhibitor-1 (PAI-1) were significently associated with end-stage PDR. After multivariate analysis, family history of T2DM, plasma PAI-1 levels, smoking, and duration of diabetes were four positive predictors associated with end-stage PDR. CONCLUSIONS: Higher plasma levels of PAI-1 were associated with end-stage PDR in the Northern Chinese Han population with T2DM.

Risk factors associated with retinal neovascularization of diabetic retinopathy in type 2 diabetes mellitus.

AIM: To evaluate the risk factors associated with retinal neovascularization of diabetic retinopathy in northern Chinese Han patients with type 2 diabetes mellitus (T2DM). METHODS: The clinical characteristics of 200 patients with proliferative diabetic retinopathy (PDR) and 100 age-matched healthy individuals were compared. The univariate and multivariate logistic regression analysis were performed in the patients with PDR. RESULTS: Fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), blood urea nitrogen (BUN), uric acid (UA), white blood cell count (WBC), absolute neutrophil count, hematocrit (HCT) and mean platelet volume (MPV) and mean platelet volume (MPV) were all significantly higher in patients with PDR than in the control group (P<0.05). The univariate and multivariate logistic regression analysis showed that risk factors independently associated with retinal neovascularization of DR were duration of diabetes mellitus (OR=1.112; P=0.000), BUN (OR=1.277; P=0.000), smoking (OR=3.967; P=0.000) and MPV (OR=2.472; P=0.000). On the other hand, panretinal photocoagulation was associated with reduced risk of retinal neovascularization (OR=0.983; P=0.000). CONCLUSION: Preventing and controlling T2DM in terms of risk factors, including duration of diabetes, BUN, smoking and MPV, might offer novel approaches to prevent or delay the onset of retinal neovascularization in patients with PDR.