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Remote sensing (RS) image scene classification has obtained increasing attention for its broad application prospects. Conventional fully-supervised approaches usually require a large amount of manually-labeled data. As more and more RS images becoming available, how to make full use of these unlabeled data is becoming an urgent topic. Semi-supervised learning, which uses a few labeled data to guide the self-training of numerous unlabeled data, is an intuitive strategy. However, it is hard to apply it to cross-dataset (i.e., cross-domain) scene classification due to the significant domain shift among different datasets. To this end, semi-supervised domain adaptation (SSDA), which can reduce the domain shift and further transfer knowledge from a fully-labeled RS scene dataset (source domain) to a limited-labeled RS scene dataset (target domain), would be a feasible solution. In this paper, we propose an SSDA method termed bidirectional sample-class alignment (BSCA) for RS cross-domain scene classification. BSCA consists of two alignment strategies, unsupervised alignment (UA) and supervised alignment (SA), both of which can contribute to decreasing domain shift. UA concentrates on reducing the distance of maximum mean discrepancy across domains, with no demand for class labels. In contrast, SA aims to achieve the distribution alignment both from source samples to the associate target class centers and from target samples to the associate source class centers, with awareness of their classes. To validate the effectiveness of the proposed method, extensive ablation, comparison, and visualization experiments are conducted on an RS-SSDA benchmark built upon four widely-used RS scene classification datasets. Experimental results indicate that in comparison with some state-of-the-art methods, our BSCA achieves the superior cross-domain classification performance with compact feature representation and low-entropy classification boundary. Our code will be available at https://github.com/hw2hwei/BSCA.
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High-resolution satellite images can provide abundant, detailed spatial information for land cover classification, which is particularly important for studying the complicated built environment. However, due to the complex land cover patterns, the costly training sample collections, and the severe distribution shifts of satellite imageries caused by, e.g., geographical differences or acquisition conditions, few studies have applied high-resolution images to land cover mapping in detailed categories at large scale. To fill this gap, we present a large-scale land cover dataset, Five-Billion-Pixels. It contains more than 5 billion labeled pixels of 150 high-resolution Gaofen-2 (4 m) satellite images, annotated in a 24-category system covering artificial-constructed, agricultural, and natural classes. In addition, we propose a deep-learning-based unsupervised domain adaptation approach that can transfer classification models trained on labeled dataset (referred to as the source domain) to unlabeled data (referred to as the target domain) for large-scale land cover mapping. Specifically, we introduce an end-to-end Siamese network employing dynamic pseudo-label assignment and class balancing strategy to perform adaptive domain joint learning. To validate the generalizability of our dataset and the proposed approach across different sensors and different geographical regions, we carry out land cover mapping on five megacities in China and six cities in other five Asian countries severally using: PlanetScope (3 m), Gaofen-1 (8 m), and Sentinel-2 (10 m) satellite images. Over a total study area of 60,000 km2, the experiments show promising results even though the input images are entirely unlabeled. The proposed approach, trained with the Five-Billion-Pixels dataset, enables high-quality and detailed land cover mapping across the whole country of China and some other Asian countries at meter-resolution.
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Urbanization is the second largest mega-trend right after climate change. Accurate measurements of urban morphological and demographic figures are at the core of many international endeavors to address issues of urbanization, such as the United Nations' call for "Sustainable Cities and Communities". In many countries - particularly developing countries -, however, this database does not yet exist. Here, we demonstrate a novel deep learning and big data analytics approach to fuse freely available global radar and multi-spectral satellite data, acquired by the Sentinel-1 and Sentinel-2 satellites. Via this approach, we created the first-ever global and quality controlled urban local climate zones classification covering all cities across the globe with a population greater than 300,000 and made it available to the community (https://doi.org/10.14459/2021mp1633461). Statistical analysis of the data quantifies a global inequality problem: approximately 40% of the area defined as compact or light/large low-rise accommodates about 60% of the total population, whereas approximately 30% of the area defined as sparsely built accommodates only about 10% of the total population. Beyond, patterns of urban morphology were discovered from the global classification map, confirming a morphologic relationship to the geographical region and related cultural heritage. We expect the open access of our dataset to encourage research on the global change process of urbanization, as a multidisciplinary crowd of researchers will use this baseline for spatial perspective in their work. In addition, it can serve as a unique dataset for stakeholders such as the United Nations to improve their spatial assessments of urbanization.
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Aerial scene recognition is a fundamental visual task and has attracted an increasing research interest in the last few years. Most of current researches mainly deploy efforts to categorize an aerial image into one scene-level label, while in real-world scenarios, there often exist multiple scenes in a single image. Therefore, in this paper, we propose to take a step forward to a more practical and challenging task, namely multi-scene recognition in single images. Moreover, we note that manually yielding annotations for such a task is extraordinarily time- and labor-consuming. To address this, we propose a prototype-based memory network to recognize multiple scenes in a single image by leveraging massive well-annotated single-scene images. The proposed network consists of three key components: 1) a prototype learning module, 2) a prototype-inhabiting external memory, and 3) a multi-head attention-based memory retrieval module. To be more specific, we first learn the prototype representation of each aerial scene from single-scene aerial image datasets and store it in an external memory. Afterwards, a multi-head attention-based memory retrieval module is devised to retrieve scene prototypes relevant to query multi-scene images for final predictions. Notably, only a limited number of annotated multi-scene images are needed in the training phase. To facilitate the progress of aerial scene recognition, we produce a new multi-scene aerial image (MAI) dataset. Experimental results on variant dataset configurations demonstrate the effectiveness of our network. Our dataset and codes are publicly available.
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As remote sensing (RS) data obtained from different sensors become available largely and openly, multimodal data processing and analysis techniques have been garnering increasing interest in the RS and geoscience community. However, due to the gap between different modalities in terms of imaging sensors, resolutions, and contents, embedding their complementary information into a consistent, compact, accurate, and discriminative representation, to a great extent, remains challenging. To this end, we propose a shared and specific feature learning (S2FL) model. S2FL is capable of decomposing multimodal RS data into modality-shared and modality-specific components, enabling the information blending of multi-modalities more effectively, particularly for heterogeneous data sources. Moreover, to better assess multimodal baselines and the newly-proposed S2FL model, three multimodal RS benchmark datasets, i.e., Houston2013 - hyperspectral and multispectral data, Berlin - hyperspectral and synthetic aperture radar (SAR) data, Augsburg - hyperspectral, SAR, and digital surface model (DSM) data, are released and used for land cover classification. Extensive experiments conducted on the three datasets demonstrate the superiority and advancement of our S2FL model in the task of land cover classification in comparison with previously-proposed state-of-the-art baselines. Furthermore, the baseline codes and datasets used in this paper will be made available freely at https://github.com/danfenghong/ISPRS_S2FL.
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Automatic building extraction from optical imagery remains a challenge due to, for example, the complexity of building shapes. Semantic segmentation is an efficient approach for this task. The latest development in deep convolutional neural networks (DCNNs) has made accurate pixel-level classification tasks possible. Yet one central issue remains: the precise delineation of boundaries. Deep architectures generally fail to produce fine-grained segmentation with accurate boundaries due to their progressive down-sampling. Hence, we introduce a generic framework to overcome the issue, integrating the graph convolutional network (GCN) and deep structured feature embedding (DSFE) into an end-to-end workflow. Furthermore, instead of using a classic graph convolutional neural network, we propose a gated graph convolutional network, which enables the refinement of weak and coarse semantic predictions to generate sharp borders and fine-grained pixel-level classification. Taking the semantic segmentation of building footprints as a practical example, we compared different feature embedding architectures and graph neural networks. Our proposed framework with the new GCN architecture outperforms state-of-the-art approaches. Although our main task in this work is building footprint extraction, the proposed method can be generally applied to other binary or multi-label segmentation tasks.
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Existing techniques of 3-D reconstruction of buildings from SAR images are mostly based on multibaseline SAR interferometry, such as PSI and SAR tomography (TomoSAR). However, these techniques require tens of images for a reliable reconstruction, which limits the application in various scenarios, such as emergency response. Therefore, alternatives that use a single SAR image and the building footprints from GIS data show their great potential in 3-D reconstruction. The combination of GIS data and SAR images requires a precise registration, which is challenging due to the unknown terrain height, and the difficulty in finding and extracting the correspondence. In this paper, we propose a framework to automatically register GIS building footprints to a SAR image by exploiting the features representing the intersection of ground and visible building facades, specifically the near-range boundaries in the building polygons, and the double bounce lines in the SAR image. Based on those features, the two data sets are registered progressively in multiple resolutions, allowing the algorithm to cope with variations in the local terrain. The proposed framework was tested in Berlin using one TerraSAR-X High Resolution SpotLight image and GIS building footprints of the area. Comparing to the ground truth, the proposed algorithm reduced the average distance error from 5.91 m before the registration to -0.08 m, and the standard deviation from 2.77 m to 1.12 m. Such accuracy, better than half of the typical urban floor height (3 m), is significant for precise building height reconstruction on a large scale. The proposed registration framework has great potential in assisting SAR image interpretation in typical urban areas and building model reconstruction from SAR images.
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This paper addresses the problem of semi-supervised transfer learning with limited cross-modality data in remote sensing. A large amount of multi-modal earth observation images, such as multispectral imagery (MSI) or synthetic aperture radar (SAR) data, are openly available on a global scale, enabling parsing global urban scenes through remote sensing imagery. However, their ability in identifying materials (pixel-wise classification) remains limited, due to the noisy collection environment and poor discriminative information as well as limited number of well-annotated training images. To this end, we propose a novel cross-modal deep-learning framework, called X-ModalNet, with three well-designed modules: self-adversarial module, interactive learning module, and label propagation module, by learning to transfer more discriminative information from a small-scale hyperspectral image (HSI) into the classification task using a large-scale MSI or SAR data. Significantly, X-ModalNet generalizes well, owing to propagating labels on an updatable graph constructed by high-level features on the top of the network, yielding semi-supervised cross-modality learning. We evaluate X-ModalNet on two multi-modal remote sensing datasets (HSI-MSI and HSI-SAR) and achieve a significant improvement in comparison with several state-of-the-art methods.
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Optical remote sensing imagery is at the core of many Earth observation activities. The regular, consistent and global-scale nature of the satellite data is exploited in many applications, such as cropland monitoring, climate change assessment, land-cover and land-use classification, and disaster assessment. However, one main problem severely affects the temporal and spatial availability of surface observations, namely cloud cover. The task of removing clouds from optical images has been subject of studies since decades. The advent of the Big Data era in satellite remote sensing opens new possibilities for tackling the problem using powerful data-driven deep learning methods. In this paper, a deep residual neural network architecture is designed to remove clouds from multispectral Sentinel-2 imagery. SAR-optical data fusion is used to exploit the synergistic properties of the two imaging systems to guide the image reconstruction. Additionally, a novel cloud-adaptive loss is proposed to maximize the retainment of original information. The network is trained and tested on a globally sampled dataset comprising real cloudy and cloud-free images. The proposed setup allows to remove even optically thick clouds by reconstructing an optical representation of the underlying land surface structure.
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Human settlement extent (HSE) information is a valuable indicator of world-wide urbanization as well as the resulting human pressure on the natural environment. Therefore, mapping HSE is critical for various environmental issues at local, regional, and even global scales. This paper presents a deep-learning-based framework to automatically map HSE from multi-spectral Sentinel-2 data using regionally available geo-products as training labels. A straightforward, simple, yet effective fully convolutional network-based architecture, Sen2HSE, is implemented as an example for semantic segmentation within the framework. The framework is validated against both manually labelled checking points distributed evenly over the test areas, and the OpenStreetMap building layer. The HSE mapping results were extensively compared to several baseline products in order to thoroughly evaluate the effectiveness of the proposed HSE mapping framework. The HSE mapping power is consistently demonstrated over 10 representative areas across the world. We also present one regional-scale and one country-wide HSE mapping example from our framework to show the potential for upscaling. The results of this study contribute to the generalization of the applicability of CNN-based approaches for large-scale urban mapping to cases where no up-to-date and accurate ground truth is available, as well as the subsequent monitor of global urbanization.
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Aerial image classification is of great significance in the remote sensing community, and many researches have been conducted over the past few years. Among these studies, most of them focus on categorizing an image into one semantic label, while in the real world, an aerial image is often associated with multiple labels, e.g., multiple object-level labels in our case. Besides, a comprehensive picture of present objects in a given high-resolution aerial image can provide a more in-depth understanding of the studied region. For these reasons, aerial image multi-label classification has been attracting increasing attention. However, one common limitation shared by existing methods in the community is that the co-occurrence relationship of various classes, so-called class dependency, is underexplored and leads to an inconsiderate decision. In this paper, we propose a novel end-to-end network, namely class-wise attention-based convolutional and bidirectional LSTM network (CA-Conv-BiLSTM), for this task. The proposed network consists of three indispensable components: (1) a feature extraction module, (2) a class attention learning layer, and (3) a bidirectional LSTM-based sub-network. Particularly, the feature extraction module is designed for extracting fine-grained semantic feature maps, while the class attention learning layer aims at capturing discriminative class-specific features. As the most important part, the bidirectional LSTM-based sub-network models the underlying class dependency in both directions and produce structured multiple object labels. Experimental results on UCM multi-label dataset and DFC15 multi-label dataset validate the effectiveness of our model quantitatively and qualitatively.
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In this paper, we aim at tackling a general but interesting cross-modality feature learning question in remote sensing community-can a limited amount of highly-discriminative (e.g., hyperspectral) training data improve the performance of a classification task using a large amount of poorly-discriminative (e.g., multispectral) data? Traditional semi-supervised manifold alignment methods do not perform sufficiently well for such problems, since the hyperspectral data is very expensive to be largely collected in a trade-off between time and efficiency, compared to the multispectral data. To this end, we propose a novel semi-supervised cross-modality learning framework, called learnable manifold alignment (LeMA). LeMA learns a joint graph structure directly from the data instead of using a given fixed graph defined by a Gaussian kernel function. With the learned graph, we can further capture the data distribution by graph-based label propagation, which enables finding a more accurate decision boundary. Additionally, an optimization strategy based on the alternating direction method of multipliers (ADMM) is designed to solve the proposed model. Extensive experiments on two hyperspectral-multispectral datasets demonstrate the superiority and effectiveness of the proposed method in comparison with several state-of-the-art methods.
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The local climate zone (LCZ) scheme was originally proposed to provide an interdisciplinary taxonomy for urban heat island (UHI) studies. In recent years, the scheme has also become a starting point for the development of higher-level products, as the LCZ classes can help provide a generalized understanding of urban structures and land uses. LCZ mapping can therefore theoretically aid in fostering a better understanding of spatio-temporal dynamics of cities on a global scale. However, reliable LCZ maps are not yet available globally. As a first step toward automatic LCZ mapping, this work focuses on LCZ-derived land cover classification, using multi-seasonal Sentinel-2 images. We propose a recurrent residual network (Re-ResNet) architecture that is capable of learning a joint spectral-spatial-temporal feature representation within a unitized framework. To this end, a residual convolutional neural network (ResNet) and a recurrent neural network (RNN) are combined into one end-to-end architecture. The ResNet is able to learn rich spectral-spatial feature representations from single-seasonal imagery, while the RNN can effectively analyze temporal dependencies of multi-seasonal imagery. Cross validations were carried out on a diverse dataset covering seven distinct European cities, and a quantitative analysis of the experimental results revealed that the combined use of the multi-temporal information and Re-ResNet results in an improvement of approximately 7 percent points in overall accuracy. The proposed framework has the potential to produce consistent-quality urban land cover and LCZ maps on a large scale, to support scientific progress in fields such as urban geography and urban climatology.
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Hyperspectral dimensionality reduction (HDR), an important preprocessing step prior to high-level data analysis, has been garnering growing attention in the remote sensing community. Although a variety of methods, both unsupervised and supervised models, have been proposed for this task, yet the discriminative ability in feature representation still remains limited due to the lack of a powerful tool that effectively exploits the labeled and unlabeled data in the HDR process. A semi-supervised HDR approach, called iterative multitask regression (IMR), is proposed in this paper to address this need. IMR aims at learning a low-dimensional subspace by jointly considering the labeled and unlabeled data, and also bridging the learned subspace with two regression tasks: labels and pseudo-labels initialized by a given classifier. More significantly, IMR dynamically propagates the labels on a learnable graph and progressively refines pseudo-labels, yielding a well-conditioned feedback system. Experiments conducted on three widely-used hyperspectral image datasets demonstrate that the dimension-reduced features learned by the proposed IMR framework with respect to classification or recognition accuracy are superior to those of related state-of-the-art HDR approaches.
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In this paper we discuss the potential and challenges regarding SAR-optical stereogrammetry for urban areas, using very-high-resolution (VHR) remote sensing imagery. Since we do this mainly from a geometrical point of view, we first analyze the height reconstruction accuracy to be expected for different stereogrammetric configurations. Then, we propose a strategy for simultaneous tie point matching and 3D reconstruction, which exploits an epipolar-like search window constraint. To drive the matching and ensure some robustness, we combine different established hand-crafted similarity measures. For the experiments, we use real test data acquired by the Worldview-2, TerraSAR-X and MEMPHIS sensors. Our results show that SAR-optical stereogrammetry using VHR imagery is generally feasible with 3D positioning accuracies in the meter-domain, although the matching of these strongly hetereogeneous multi-sensor data remains very challenging.
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Currently, numerous remote sensing satellites provide a huge volume of diverse earth observation data. As these data show different features regarding resolution, accuracy, coverage, and spectral imaging ability, fusion techniques are required to integrate the different properties of each sensor and produce useful information. For example, synthetic aperture radar (SAR) data can be fused with optical imagery to produce 3D information using stereogrammetric methods. The main focus of this study is to investigate the possibility of applying a stereogrammetry pipeline to very-high-resolution (VHR) SAR-optical image pairs. For this purpose, the applicability of semi-global matching is investigated in this unconventional multi-sensor setting. To support the image matching by reducing the search space and accelerating the identification of correct, reliable matches, the possibility of establishing an epipolarity constraint for VHR SAR-optical image pairs is investigated as well. In addition, it is shown that the absolute geolocation accuracy of VHR optical imagery with respect to VHR SAR imagery such as provided by TerraSAR-X can be improved by a multi-sensor block adjustment formulation based on rational polynomial coefficients. Finally, the feasibility of generating point clouds with a median accuracy of about 2â¯m is demonstrated and confirms the potential of 3D reconstruction from SAR-optical image pairs over urban areas.
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Large-scale hydrodynamic models generally rely on fixed-resolution spatial grids and model parameters as well as incurring a high computational cost. This limits their ability to accurately forecast flood crests and issue time-critical hazard warnings. In this work, we build a fast, stable, accurate, resolution-invariant, and geometry-adaptive flood modeling and forecasting framework that can perform at large scales, namely FloodCast. The framework comprises two main modules: multi-satellite observation and hydrodynamic modeling. In the multi-satellite observation module, a real-time unsupervised change detection method and a rainfall processing and analysis tool are proposed to harness the full potential of multi-satellite observations in large-scale flood prediction. In the hydrodynamic modeling module, a geometry-adaptive physics-informed neural solver (GeoPINS) is introduced, benefiting from the absence of a requirement for training data in physics-informed neural networks (PINNs) and featuring a fast, accurate, and resolution-invariant architecture with Fourier neural operators. To adapt to complex river geometries, we reformulate PINNs in a geometry-adaptive space. GeoPINS demonstrates impressive performance on popular partial differential equations across regular and irregular domains. Building upon GeoPINS, we propose a sequence-to-sequence GeoPINS model to handle long-term temporal series and extensive spatial domains in large-scale flood modeling. This model employs sequence-to-sequence learning and hard-encoding of boundary conditions. Next, we establish a benchmark dataset in the 2022 Pakistan flood using a widely accepted finite difference numerical solution to assess various flood simulation methods. Finally, we validate the model in three dimensions - flood inundation range, depth, and transferability of spatiotemporal downscaling - utilizing SAR-based flood data, traditional hydrodynamic benchmarks, and concurrent optical remote sensing images. Traditional hydrodynamics and sequence-to-sequence GeoPINS exhibit exceptional agreement during high water levels, while comparative assessments with SAR-based flood depth data show that sequence-to-sequence GeoPINS outperforms traditional hydrodynamics, with smaller simulation errors. The experimental results for the 2022 Pakistan flood demonstrate that the proposed method enables high-precision, large-scale flood modeling with an average MAPE of 14.93 % and an average Mean Absolute Error (MAE) of 0.0610 m for 14-day water depth simulations while facilitating real-time flood hazard forecasting using reliable precipitation data.
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Objective: This study employs the Geographically and Temporally Weighted Regression (GTWR) model to assess the impact of meteorological elements and imported cases on dengue fever outbreaks, emphasizing the spatial-temporal variability of these factors in border regions. Methods: We conducted a descriptive analysis of dengue fever's temporal-spatial distribution in Yunnan border areas. Utilizing annual data from 2013 to 2019, with each county in the Yunnan border serving as a spatial unit, we constructed a GTWR model to investigate the determinants of dengue fever and their spatio-temporal heterogeneity in this region. Results: The GTWR model, proving more effective than Ordinary Least Squares (OLS) analysis, identified significant spatial and temporal heterogeneity in factors influencing dengue fever's spread along the Yunnan border. Notably, the GTWR model revealed a substantial variation in the relationship between indigenous dengue fever incidence, meteorological variables, and imported cases across different counties. Conclusion: In the Yunnan border areas, local dengue incidence is affected by temperature, humidity, precipitation, wind speed, and imported cases, with these factors' influence exhibiting notable spatial and temporal variation.
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Dengue , Dengue/epidemiologia , China/epidemiologia , Humanos , Análise Espaço-Temporal , Incidência , Surtos de Doenças , Regressão EspacialRESUMO
OBJECTIVES: To investigate the mechanism of electroacupuncture (EA) at "Neiguan" (PC6) in impro-ving myocardial electrical remodeling in rats with acute myocardial infarction (AMI) by enhancing transient outward potassium current. METHODS: A total of 30 male SD rats were randomly divided into control, model and EA groups, with 10 rats in each group. The AMI model was established by subcutaneous injection with isoprenaline (ISO, 85 mg/kg). EA was applied to left PC6 for 20 min, once daily for 5 days. Electrocardiogram (ECG) was recorded after treatment. TTC staining was used to observe myocardial necrosis. HE staining was used to observe the pathological morphology of myocardial tissue and measure the cross-sectional area of myocardium. Potassium ion-related genes in myocardial tissue were detected by RNA sequencing. The mRNA and protein expressions of Kchip2 and Kv4.2 in myocardial tissue were detected by real-time fluorescence quantitative PCR and Western blot, respectively. RESULTS: Compared with the control group, cardiomyocyte cross-sectional area in the model group was significantly increased (P<0.01), the ST segment was significantly elevated (P<0.01), and QT, QTc, QTd and QTcd were all significantly increased (P<0.05, P<0.01). After EA treatment, cardiomyocyte cross-sectional area was significantly decreased (P<0.01), the ST segment was significantly reduced (P<0.01), and the QT, QTc, QTcd and QTd were significantly decreased (P<0.01, P<0.05). RNA sequencing results showed that a total of 20 potassium ion-related genes co-expressed by the 3 groups were identified. Among them, Kchip2 expression was up-regulated most notablely in the EA group. Compared with the control group, the mRNA and protein expressions of Kchip2 and Kv4.2 in the myocardial tissue of the model group were significantly decreased (P<0.01, P<0.05), while those were increased in the EA group (P<0.01, P<0.05). CONCLUSIONS: EA may improve myocardial electrical remodeling in rats with myocardial infarction, which may be related to its functions in up-regulating the expressions of Kchip2 and Kv4.2.
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Remodelamento Atrial , Eletroacupuntura , Infarto do Miocárdio , Isquemia Miocárdica , Ratos , Masculino , Animais , Isquemia Miocárdica/terapia , Ratos Sprague-Dawley , Pontos de Acupuntura , Miocárdio/metabolismo , Infarto do Miocárdio/genética , Infarto do Miocárdio/terapia , Potássio/metabolismo , RNA Mensageiro/metabolismoRESUMO
Background: Clinical appearance and high-frequency ultrasound (HFUS) are indispensable for diagnosing skin diseases by providing internal and external information. However, their complex combination brings challenges for primary care physicians and dermatologists. Thus, we developed a deep multimodal fusion network (DMFN) model combining analysis of clinical close-up and HFUS images for binary and multiclass classification in skin diseases. Methods: Between Jan 10, 2017, and Dec 31, 2020, the DMFN model was trained and validated using 1269 close-ups and 11,852 HFUS images from 1351 skin lesions. The monomodal convolutional neural network (CNN) model was trained and validated with the same close-up images for comparison. Subsequently, we did a prospective and multicenter study in China. Both CNN models were tested prospectively on 422 cases from 4 hospitals and compared with the results from human raters (general practitioners, general dermatologists, and dermatologists specialized in HFUS). The performance of binary classification (benign vs. malignant) and multiclass classification (the specific diagnoses of 17 types of skin diseases) measured by the area under the receiver operating characteristic curve (AUC) were evaluated. This study is registered with www.chictr.org.cn (ChiCTR2300074765). Findings: The performance of the DMFN model (AUC, 0.876) was superior to that of the monomodal CNN model (AUC, 0.697) in the binary classification (P = 0.0063), which was also better than that of the general practitioner (AUC, 0.651, P = 0.0025) and general dermatologists (AUC, 0.838; P = 0.0038). By integrating close-up and HFUS images, the DMFN model attained an almost identical performance in comparison to dermatologists (AUC, 0.876 vs. AUC, 0.891; P = 0.0080). For the multiclass classification, the DMFN model (AUC, 0.707) exhibited superior prediction performance compared with general dermatologists (AUC, 0.514; P = 0.0043) and dermatologists specialized in HFUS (AUC, 0.640; P = 0.0083), respectively. Compared to dermatologists specialized in HFUS, the DMFN model showed better or comparable performance in diagnosing 9 of the 17 skin diseases. Interpretation: The DMFN model combining analysis of clinical close-up and HFUS images exhibited satisfactory performance in the binary and multiclass classification compared with the dermatologists. It may be a valuable tool for general dermatologists and primary care providers. Funding: This work was supported in part by the National Natural Science Foundation of China and the Clinical research project of Shanghai Skin Disease Hospital.