Pedestrian dynamics at the running of the bulls evidence an inaccessible region in the fundamental diagram.

We characterize the dynamics of runners in the famous "Running of the Bulls" Festival by computing the individual and global velocities and densities, as well as the crowd pressure. In contrast with all previously studied pedestrian systems, we unveil a unique regime in which speed increases with density that can be understood in terms of a time-dependent desired velocity of the runners. Also, we discover the existence of an inaccessible region in the speed-density state diagram that is explained by falls of runners. With all these ingredients, we propose a generalization of the pedestrian fundamental diagram for a scenario in which people with different desired speeds coexist.

Anchoring Effect of an Obstacle in the Silo Unclogging Process.

Contrary to the proven beneficial role that placing an obstacle above a silo exit has in clogging prevention, we demonstrate that, when the system is gently shaken, this passive element has a twofold effect in the clogging destruction process. On one side, the obstacle eases the destruction of weak arches, a phenomenon that can be explained by the pressure screening that it causes in the outlet proximities. But on the other side, we discover that the obstacle presence leads to the development of a few very strong arches. These arches, which dominate in the heavy tailed distributions of unclogging times, correlate with configurations where the number of particles contacting the obstacle from below are higher than the average; hence suggesting that the obstacle acts as an anchoring point for the granular packing. This finding may help one to understand the ambiguous effect of obstacles in the bottleneck flow of other systems, such as pedestrians evacuating a room or active matter in general.

Steering self-organisation through confinement.

Self-organisation is the spontaneous emergence of spatio-temporal structures and patterns from the interaction of smaller individual units. Examples are found across many scales in very different systems and scientific disciplines, from physics, materials science and robotics to biology, geophysics and astronomy. Recent research has highlighted how self-organisation can be both mediated and controlled by confinement. Confinement is an action over a system that limits its units' translational and rotational degrees of freedom, thus also influencing the system's phase space probability density; it can function as either a catalyst or inhibitor of self-organisation. Confinement can then become a means to actively steer the emergence or suppression of collective phenomena in space and time. Here, to provide a common framework and perspective for future research, we examine the role of confinement in the self-organisation of soft-matter systems and identify overarching scientific challenges that need to be addressed to harness its full scientific and technological potential in soft matter and related fields. By drawing analogies with other disciplines, this framework will accelerate a common deeper understanding of self-organisation and trigger the development of innovative strategies to steer it using confinement, with impact on, e.g., the design of smarter materials, tissue engineering for biomedicine and in guiding active matter.

E46K α-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation.

α-Synuclein (aSyn) is the main driver of neurodegenerative diseases known as "synucleinopathies," but the mechanisms underlying this toxicity remain poorly understood. To investigate aSyn toxic mechanisms, we have developed a primary neuronal model in which a longitudinal survival analysis can be performed by following the overexpression of fluorescently tagged WT or pathologically mutant aSyn constructs. Most aSyn mutations linked to neurodegenerative disease hindered neuronal survival in this model; of these mutations, the E46K mutation proved to be the most toxic. While E46K induced robust PLK2-dependent aSyn phosphorylation at serine 129, inhibiting this phosphorylation did not alleviate aSyn toxicity, strongly suggesting that this pathological hallmark of synucleinopathies is an epiphenomenon. Optical pulse-chase experiments with Dendra2-tagged aSyn versions indicated that the E46K mutation does not alter aSyn protein turnover. Moreover, since the mutation did not promote overt aSyn aggregation, we conclude that E46K toxicity was driven by soluble species. Finally, we developed an assay to assess whether neurons expressing E46K aSyn affect the survival of neighboring control neurons. Although we identified a minor non-cell-autonomous component spatially restricted to proximal neurons, most E46K aSyn toxicity was cell autonomous. Thus, we have been able to recapitulate the toxicity of soluble aSyn species at a stage preceding aggregation, detecting non-cell-autonomous toxicity and evaluating how some of the main aSyn hallmarks are related to neuronal survival.

Trap Model for Clogging and Unclogging in Granular Hopper Flows.

Granular flows through narrow outlets may be interrupted by the formation of arches or vaults that clog the exit. These clogs may be destroyed by vibrations. A feature which remains elusive is the broad distribution p(τ) of clog lifetimes τ measured under constant vibrations. Here, we propose a simple model for arch breaking, in which the vibrations are formally equivalent to thermal fluctuations in a Langevin equation; the rupture of an arch corresponds to the escape from an energy trap. We infer the distribution of trap depths from experiments made in two-dimensional hoppers. Using this distribution, we show that the model captures the empirically observed heavy tails in p(τ). These heavy tails flatten at large τ, consistently with experimental observations under weak vibrations. But, here, we find that this flattening is systematic, which casts doubt on the ability of gentle vibrations to restore a finite outflow forever. The trap model also replicates recent results on the effect of increasing gravity on the statistics of clog formation in a static silo. Therefore, the proposed framework points to a common physical underpinning to the processes of clogging and unclogging, despite their different statistics.

Clogging of granular materials in silos: effect of gravity and outlet size.

By means of extensive numerical simulations we disclose the role of the driving force in the clogging of inert particles passing through a constriction. We uncover the effect of gravity and outlet size on the flow rate and kinetic energy within the system, and use these quantities to deepen our understanding of the blocking process. First, we confirm the existence of a finite avalanche size when the driving force tends to zero. The magnitude of this limit avalanche size grows with the outlet size, as expected due to geometrical reasons. In addition, there is an augment of the avalanche size when the driving force is increased, an effect that is enhanced by the outlet size. This phenomenology is explained by assuming that in order to get a stable clog developed, two conditions must be fulfilled: (1) an arch spanning the outlet size should be formed; (2) the arch should resist until the complete dissipation of the kinetic energy within the system. From these assumptions, we are able to obtain the probability that an arch gets destabilized, which is shown to primarily depend on the square root of the kinetic energy. A minor additional dependence of the outlet size is also observed which is explained in the light of recent results of the arch resistance in vibrated silos.

Elongated particles discharged with a conveyor belt in a two-dimensional silo.

The flow of elliptical particles out of a two-dimensional silo when extracted with a conveyor belt is analyzed experimentally. The conveyor belt-placed directly below the silo outlet-reduces the flow rate, increases the size of the stagnant zone, and it has a very strong influence on the relative velocity fluctuations as they strongly increase everywhere in the silo with decreasing belt speed. In other words, instead of slower but smooth flow, flow reduction by belt leads to intermittent flow. Interestingly, we show that this intermittency correlates with a strong reduction of the orientational order of the particles at the orifice region. Moreover, we observe that the average orientation of the grains passing through the outlet is modified when they are extracted with the belt, a feature that becomes more evident for large orifices.

Flow rate of particles through apertures obtained from self-similar density and velocity profiles.

"Beverloo's law" is considered as the standard expression to estimate the flow rate of particles through apertures. This relation was obtained by simple dimensional analysis and includes empirical parameters whose physical meaning is poorly justified. In this Letter, we study the density and velocity profiles in the flow of particles through an aperture. We find that, for the whole range of apertures studied, both profiles are self-similar. Hence, by means of the functionality obtained for them the mass flow rate is calculated. The comparison of this expression with the Beverloo's one reveals some differences which are crucial to understanding the mechanism that governs the flow of particles through orifices.

Breaking arches with vibrations: the role of defects.

We present experimental and numerical results regarding the stability of arches against external vibrations. Two-dimensional strings of mutually stabilizing grains are geometrically analyzed and subsequently submitted to a periodic forcing at fixed frequency and increasing amplitude. The main factor that determines the granular arch resistance against vibrations is the maximum angle among those formed between any particle of the arch and its two neighbors: the higher the maximum angle is, the easier it is to break the arch. On the basis of an analysis of the forces, a simple explanation is given for this dependence. From this, interesting information can be extracted about the expected magnitudes of normal forces and friction coefficients of the particles composing the arches.

Pedestrian bottleneck flow when keeping a prescribed physical distance.

We present experimental results of pedestrian evacuations through a narrow door under a prescribed safety distancing of either 1.5 or 2 meters. In this situation, flow rate augments with pedestrian velocity due to a complete absence of flow interruptions or clogs. Accordingly, the evacuation improves when the prescribed physical distance is reduced, as this implies shortening the time lapses between the exit of consecutive pedestrians. In addition, the analysis of pedestrian trajectories reveals that the distance to the first neighbor in the evacuation process is rather similar to the one obtained when pedestrians were just roaming within the arena, hence suggesting that this magnitude depends more on the crowd state (desired speed, prescribed safety distance, etc.) than on the geometry where the pedestrian flow takes place. Also, an important difference in pedestrian behavior is observed when people are asked to walk at different speeds: whereas slow pedestrians evidence a clear preference for stop-and-go motion, fast walkers display detouring and stop-and-go behavior roughly in the same proportion.

Spontaneous emergence of counterclockwise vortex motion in assemblies of pedestrians roaming within an enclosure.

The emergence of coherent vortices has been observed in a wide variety of many-body systems such as animal flocks, bacteria, colloids, vibrated granular materials or human crowds. Here, we experimentally demonstrate that pedestrians roaming within an enclosure also form vortex-like patterns which, intriguingly, only rotate counterclockwise. By implementing simple numerical simulations, we evidence that the development of swirls in many-particle systems can be described as a phase transition in which both the density of agents and their dissipative interactions with the boundaries play a determinant role. Also, for the specific case of pedestrians, we show that the preference of right-handed people (the majority in our experiments) to turn leftwards when facing a wall is the symmetry breaking mechanism needed to trigger the global counterclockwise rotation observed.

Silo clogging reduction by the presence of an obstacle.

We present experimental results on the effect that inserting an obstacle just above the outlet of a silo has on the clogging process. We find that, if the obstacle position is properly selected, the probability that the granular flow is arrested can be reduced by a factor of 100. This dramatic effect occurs without any remarkable modification of the flow rate or the packing fraction above the outlet, which are discarded as the cause of the change in the clogging probability. Hence, inspired by previous results of pedestrian crowd dynamics, we propose that the physical mechanism behind the clogging reduction is a pressure decrease in the region of arch formation.

Transition from clogging to continuous flow in constricted particle suspensions.

When suspended particles are pushed by liquid flow through a constricted channel, they might either pass the bottleneck without trouble or encounter a permanent clog that will stop them forever. However, they may also flow intermittently with great sensitivity to the neck-to-particle size ratio D/d. In this Rapid Communication, we experimentally explore the limits of the intermittent regime for a dense suspension through a single bottleneck as a function of this parameter. To this end, we make use of high time- and space-resolution experiments to obtain the distributions of arrest times (T) between successive bursts, which display power-law tails (∝T^{-α}) with characteristic exponents. These exponents compare well with the ones found for as disparate situations as the evacuation of pedestrians from a room, the entry of a flock of sheep into a shed, or the discharge of particles from a silo. Nevertheless, the intrinsic properties of our system (i.e., channel geometry, driving and interaction forces, particle size distribution) seem to introduce a sharp transition from a clogged state (α≤2) to a continuous flow, where clogs do not develop at all. This contrasts with the results obtained in other systems where intermittent flow, with power-law exponents above two, were obtained.

Systematic experimental investigation of the obstacle effect during non-competitive and extremely competitive evacuations.

Although some experimental evidence showed that an obstacle placed in front of a door allows making people's evacuations faster, the efficacy of such a solution has been debated for over 15 years. Researchers are split between those who found the obstacle beneficial and those who could not find a significant difference without it. One of the reasons for the several conclusions lies in the variety of the experiments performed so far, both in terms of competitiveness among participants, geometrical configuration and number of participants. In this work, two unique datasets relative to evacuations with/without obstacle and comprising low and high competitiveness are analyzed using state-of-the-art definitions for crowd dynamics. In particular, the so-called congestion level is employed to measure the smoothness of collective motion. Results for extreme conditions show that, on the overall, the obstacle does not reduce density and congestion level and it could rather slightly increase it. From this perspective, the obstacle was found simply shifting the dangerous spots from the area in front of the exit to the regions between the obstacle and the wall. On the other side, it was however confirmed, that the obstacle can stabilize longitudinal crowd waves, thus reducing the risk of trampling, which could be as important (in terms of safety) as improving the evacuation time. However, under urgent, competitive, but non-extreme conditions, the obstacle generally had a positive effect, helping channeling the flow of pedestrians through the exit while facilitating their interactions.

Clogging-jamming connection in narrow vertical pipes.

We report experimental evidence of clogging due to the spontaneous development of hanging arches when a granular sample composed of spherical particles flows down a narrow vertical pipe. These arches, akin to the ones responsible for silo clogging, can only be possible due to the role of frictional forces; otherwise they will be unstable. We find that, contrary to the silo case, the probability of clogging in vertical narrow tubes does not decrease monotonically with the ratio of the pipe-to-particle diameters. This behavior is related to the clogging prevention caused by the spontaneous ordering of particles apparent in certain aspect ratios. More importantly, by means of numerical simulations, we discover that the interparticle normal force distributions broaden in systems with higher probability of clogging. This feature, which has been proposed before as a distinctive feature of jamming in sheared granular samples, suggests that clogging and jamming are connected in pipe flow.

Role of vibrations in the jamming and unjamming of grains discharging from a silo.

We present experimental results of the jamming of noncohesive particles discharged from a flat bottomed silo subjected to vertical vibration. When the exit orifice is only a few grain diameters wide, the flow can be arrested due to the formation of blocking arches. Hence, an external excitation is needed to resume the flow. The use of a continuous gentle vibration is a usual technique to ease the flow in such situations. Even though jamming is less frequent, it is still an issue in vibrated silos. There are, in principle, two possible mechanisms through which vibrations may facilitate the flow: (i) a decrease in the probability of the formation of blocking arches and (ii) the breakage of blocking arches once they have been formed. By measuring the time intervals inside an avalanche during which no particles flow through the outlet, we are able to estimate the probability of breaking a blocking arch by vibrations. The result agrees with the prediction of a bivariate probabilistic model in which the formation of blocking arches is equally probable in vibrated and nonvibrated silos. This indicates that the second aforementioned mechanism is mainly responsible for improving the flowability in gently vibrated silos.

Effect of hopper angle on granular clogging.

We present experimental results of the effect of the hopper angle on the clogging of grains discharged from a two-dimensional silo under gravity action. We observe that the probability of clogging can be reduced by three orders of magnitude by increasing the hopper angle. In addition, we find that for very large hopper angles, the avalanche size (〈s〉) grows with the outlet size (D) stepwise, in contrast to the case of a flat-bottom silo for which 〈s〉 grows smoothly with D. This surprising effect is originated from the static equilibrium requirement imposed by the hopper geometry to the arch that arrests the flow. The hopper angle sets the bounds of the possible angles of the vectors connecting consecutive beads in the arch. As a consequence, only a small and specific portion of the arches that jam a flat-bottom silo can survive in hoppers.

Active particles with desired orientation flowing through a bottleneck.

We report extensive numerical simulations of the flow of anisotropic self-propelled particles through a constriction. In particular, we explore the role of the particles' desired orientation with respect to the moving direction on the system flowability. We observe that when particles propel along the direction of their long axis (longitudinal orientation) the flow-rate notably reduces compared with the case of propulsion along the short axis (transversal orientation). And this is so even when the effective section (measured as the number of particles that are necessary to span the whole outlet) is larger for the case of longitudinal propulsion. This counterintuitive result is explained in terms of the formation of clogging structures at the outlet, which are revealed to have higher stability when the particles align along the long axis. This generic result might be applied to many different systems flowing through bottlenecks such as microbial populations or different kind of cells. Indeed, it has already a straightforward connection with recent results of pedestrian (which self-propel transversally oriented) and mice or sheep (which self-propel longitudinally oriented).

Role of particle size in the kinematic properties of silo flow.

We experimentally analyze the effect that particle size has on the mass flow rate of a quasi two-dimensional silo discharged by gravity. In a previous work, Janda et al. [Phys. Rev. Lett. 108, 248001 (2012)PRLTAO0031-900710.1103/PhysRevLett.108.248001] introduced a new expression for the mass flow rate based on a detailed experimental analysis of the flow for 1-mm diameter beads. Here, we aim to extend these results by using particles of larger sizes and a variable that was not explicitly included in the proposed expression. We show that the velocity and density profiles at the outlet are self-similar and scale with the outlet size with the same functionalities as in the case of 1-mm particles. Nevertheless, some discrepancies are evidenced in the values of the fitting parameters. In particular, we observe that larger particles lead to higher velocities and lower packing fractions at the orifice. Intriguingly, both magnitudes seem to compensate giving rise to very similar flow rates. In order to shed light on the origin of this behavior we have computed fields of a solid fraction, velocity, and a kinetic-stress like variable in the region above the orifice.

Effect of obstacle position in the flow of sheep through a narrow door.

In a recent work [Phys. Rev. E 91, 022808 (2015)PLEEE81539-375510.1103/PhysRevE.91.022808] it was reported that placing an obstacle in front of a gate has a beneficial effect in the flow of sheep through it. Here, we extend such results by implementing three different obstacle positions. We have observed that the flow is improved in two cases, while it worsens in the other one; the last instance happens when the obstacle is too close to the door. In this situation, the outcomes suggest that clogging develops between the doorjamb and the obstacle, contrary to the cases when the obstacle is farther, in which case clogging always occurs at the very door. The effectiveness of the obstacle (a strategy put forward to alleviate clogging in emergency exits) is therefore quite sensitive to its location. In addition, the study of the temporal evolution of the flow rate as the test develops makes evident a steady behavior during the entire duration of the entrance. This result is at odds with recent findings in human evacuation tests where the flow rate varies over time, therefore challenging the fairness of straightforward comparisons between pedestrian behavior and animal experimental observations.