Pesquisa | BVS Violência e Saúde

1.

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities.

Martens, Arne; Priem, Dario; Hoste, Esther; Vetters, Jessica; Rennen, Sofie; Catrysse, Leen; Voet, Sofie; Deelen, Laura; Sze, Mozes; Vikkula, Hanna; Slowicka, Karolina; Hochepied, Tino; Iliaki, Kalliopi; Wullaert, Andy; Janssens, Sophie; Lamkanfi, Mohamed; Beyaert, Rudi; Armaka, Marietta; Bertrand, Mathieu J M; van Loo, Geert.

Nat Immunol ; 21(4): 381-387, 2020 04.

Artigo em Inglês | MEDLINE | ID: mdl-32205881

2.

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation.

de Reuver, Richard; Verdonck, Simon; Dierick, Evelien; Nemegeer, Josephine; Hessmann, Eline; Ahmad, Sadeem; Jans, Maude; Blancke, Gillian; Van Nieuwerburgh, Filip; Botzki, Alexander; Vereecke, Lars; van Loo, Geert; Declercq, Wim; Hur, Sun; Vandenabeele, Peter; Maelfait, Jonathan.

Nature ; 607(7920): 784-789, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35859175

3.

Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes.

Maschalidi, Sophia; Mehrotra, Parul; Keçeli, Burcu N; De Cleene, Hannah K L; Lecomte, Kim; Van der Cruyssen, Renée; Janssen, Pauline; Pinney, Jonathan; van Loo, Geert; Elewaut, Dirk; Massie, Ann; Hoste, Esther; Ravichandran, Kodi S.

Nature ; 606(7915): 776-784, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35614212

4.

Microbes exploit death-induced nutrient release by gut epithelial cells.

Anderson, Christopher J; Medina, Christopher B; Barron, Brady J; Karvelyte, Laura; Aaes, Tania Løve; Lambertz, Irina; Perry, Justin S A; Mehrotra, Parul; Gonçalves, Amanda; Lemeire, Kelly; Blancke, Gillian; Andries, Vanessa; Ghazavi, Farzaneh; Martens, Arne; van Loo, Geert; Vereecke, Lars; Vandenabeele, Peter; Ravichandran, Kodi S.

Nature ; 596(7871): 262-267, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34349263

5.

A20 phosphorylation controls A20 function.

Martens, Arne; van Loo, Geert.

Nat Immunol ; 20(10): 1261-1262, 2019 10.

Artigo em Inglês | MEDLINE | ID: mdl-31534239

6.

Author Correction: Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.

Masuda, Takahiro; Sankowski, Roman; Staszewski, Ori; Böttcher, Chotima; Amann, Lukas; Scheiwe, Christian; Nessler, Stefan; Kunz, Patrik; van Loo, Geert; Coenen, Volker Arnd; Reinacher, Peter Christoph; Michel, Anna; Sure, Ulrich; Gold, Ralf; Grün, Dominic; Priller, Josef; Stadelmann, Christine; Prinz, Marco.

Nature ; 568(7751): E4, 2019 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-30918409

7.

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.

Masuda, Takahiro; Sankowski, Roman; Staszewski, Ori; Böttcher, Chotima; Amann, Lukas; Scheiwe, Christian; Nessler, Stefan; Kunz, Patrik; van Loo, Geert; Coenen, Volker Arnd; Reinacher, Peter Christoph; Michel, Anna; Sure, Ulrich; Gold, Ralf; Grün, Dominic; Priller, Josef; Stadelmann, Christine; Prinz, Marco.

Nature ; 566(7744): 388-392, 2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-30760929

8.

Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8-mediated apoptosis of macrophages to promote lethal anthrax.

Van Hauwermeiren, Filip; Van Opdenbosch, Nina; Van Gorp, Hanne; de Vasconcelos, Nathalia; van Loo, Geert; Vandenabeele, Peter; Kanneganti, Thirumala-Devi; Lamkanfi, Mohamed.

Proc Natl Acad Sci U S A ; 119(2)2022 01 11.

Artigo em Inglês | MEDLINE | ID: mdl-34996874

9.

OTULIN in NF-κB signaling, cell death, and disease.

Verboom, Lien; Hoste, Esther; van Loo, Geert.

Trends Immunol ; 42(7): 590-603, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-34074601

10.

Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice.

Frising, Ulrika C; Ribo, Silvia; Doglio, M Giulia; Malissen, Bernard; van Loo, Geert; Wullaert, Andy.

EMBO Rep ; 23(7): e54339, 2022 07 05.

Artigo em Inglês | MEDLINE | ID: mdl-35574994

11.

A20 controls RANK-dependent osteoclast formation and bone physiology.

Martens, Arne; Hertens, Pieter; Priem, Dario; Rinotas, Vagelis; Meletakos, Theodore; Gennadi, Meropi; Van Hove, Lisette; Louagie, Els; Coudenys, Julie; De Muynck, Amélie; Gaublomme, Djoere; Sze, Mozes; van Hengel, Jolanda; Catrysse, Leen; Hoste, Esther; Zajac, Jeffrey D; Davey, Rachel A; Van Hoorebeke, Luc; Hochepied, Tino; Bertrand, Mathieu J M; Armaka, Marietta; Elewaut, Dirk; van Loo, Geert.

EMBO Rep ; 23(12): e55233, 2022 12 06.

Artigo em Inglês | MEDLINE | ID: mdl-36194667

12.

A20 and Cell Death-driven Inflammation.

Priem, Dario; van Loo, Geert; Bertrand, Mathieu J M.

Trends Immunol ; 41(5): 421-435, 2020 05.

Artigo em Inglês | MEDLINE | ID: mdl-32241683

13.

Fibrotic enzymes modulate wound-induced skin tumorigenesis.

Van Hove, Lisette; Lecomte, Kim; Roels, Jana; Vandamme, Niels; Vikkula, Hanna-Kaisa; Hoorens, Isabelle; Ongenae, Katia; Hochepied, Tino; Donati, Giacomo; Saeys, Yvan; Quist, Sven R; Watt, Fiona M; van Loo, Geert; Hoste, Esther.

EMBO Rep ; 22(5): e51573, 2021 05 05.

Artigo em Inglês | MEDLINE | ID: mdl-33780134

14.

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.

Imai, Yumiko; Kuba, Keiji; Neely, G Greg; Yaghubian-Malhami, Rubina; Perkmann, Thomas; van Loo, Geert; Ermolaeva, Maria; Veldhuizen, Ruud; Leung, Y H Connie; Wang, Hongliang; Liu, Haolin; Sun, Yang; Pasparakis, Manolis; Kopf, Manfred; Mech, Christin; Bavari, Sina; Peiris, J S Malik; Slutsky, Arthur S; Akira, Shizuo; Hultqvist, Malin; Holmdahl, Rikard; Nicholls, John; Jiang, Chengyu; Binder, Christoph J; Penninger, Josef M.

Cell ; 133(2): 235-49, 2008 Apr 18.

Artigo em Inglês | MEDLINE | ID: mdl-18423196

15.

Author Correction: Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes.

Maschalidi, Sophia; Mehrotra, Parul; Keçeli, Burcu N; De Cleene, Hannah K L; Lecomte, Kim; Van der Cruyssen, Renée; Janssen, Pauline; Pinney, Jonathan; van Loo, Geert; Elewaut, Dirk; Massie, Ann; Hoste, Esther; Ravichandran, Kodi S.

Nature ; 608(7923): E29, 2022 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-35896752

16.

Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.

Prabakaran, Thaneas; Bodda, Chiranjeevi; Krapp, Christian; Zhang, Bao-Cun; Christensen, Maria H; Sun, Chenglong; Reinert, Line; Cai, Yujia; Jensen, Søren B; Skouboe, Morten K; Nyengaard, Jens R; Thompson, Craig B; Lebbink, Robert Jan; Sen, Ganes C; van Loo, Geert; Nielsen, Rikke; Komatsu, Masaaki; Nejsum, Lene N; Jakobsen, Martin R; Gyrd-Hansen, Mads; Paludan, Søren R.

EMBO J ; 37(8)2018 04 13.

Artigo em Inglês | MEDLINE | ID: mdl-29496741

17.

Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection.

Dubois, Hanne; Sorgeloos, Frederic; Sarvestani, Soroush T; Martens, Liesbet; Saeys, Yvan; Mackenzie, Jason M; Lamkanfi, Mohamed; van Loo, Geert; Goodfellow, Ian; Wullaert, Andy.

PLoS Pathog ; 15(4): e1007709, 2019 04.

Artigo em Inglês | MEDLINE | ID: mdl-31017981

18.

Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.

Derudder, Emmanuel; Cadera, Emily J; Vahl, J Christoph; Wang, Jing; Fox, Casey J; Zha, Shan; van Loo, Geert; Pasparakis, Manolis; Schlissel, Mark S; Schmidt-Supprian, Marc; Rajewsky, Klaus.

Nat Immunol ; 10(6): 647-54, 2009 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-19412180

19.

Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice.

van Uden, Denise; Koudstaal, Thomas; van Hulst, Jennifer A C; Bergen, Ingrid M; Gootjes, Chelsea; Morrell, Nicholas W; van Loo, Geert; von der Thüsen, Jan H; van den Bosch, Thierry P P; Ghigna, Maria-Rosa; Perros, Frédéric; Montani, David; Kool, Mirjam; Boomars, Karin A; Hendriks, Rudi W.

Int J Mol Sci ; 22(4)2021 Feb 10.

Artigo em Inglês | MEDLINE | ID: mdl-33578743

20.

DNGR1-Cre-mediated Deletion of Tnfaip3/A20 in Conventional Dendritic Cells Induces Pulmonary Hypertension in Mice.

Koudstaal, Thomas; van Hulst, Jennifer A C; Das, Tridib; Neys, Stefan F H; Merkus, Daphne; Bergen, Ingrid M; de Raaf, Michiel A; Bogaard, Harm Jan; Boon, Louis; van Loo, Geert; Aerts, Joachim G J V; Boomars, Karin A; Kool, Mirjam; Hendriks, Rudi W.

Am J Respir Cell Mol Biol ; 63(5): 665-680, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32755457

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