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1.
Ann Pharm Fr ; 73(3): 180-9, 2015 May.
Artigo em Francês | MEDLINE | ID: mdl-25592653

RESUMO

A product of the arms race during the Cold War, the Russian VX, or VR, is an organophosphorus compound that is a structural isomer of the western VX compound (or A4), with which it shares a very high toxicity. It is much less studied and known than VX because the knowledge of its existence is relatively recent. A very low volatility and high resistance in the environment make it a persistent agent. Poisoning occurs mainly following penetration through skin and mucosa but vapour inhalation is a credible risk in some circumstances. The clinical presentation may be differed by several hours and despite the absence of signs and symptoms, the casualty should not be considered as contamination or intoxication-free. This agent has a long residence time in blood, a characteristics that clearly differentiates it from other compounds such as sarin. The protocols for antidote administration may thus have to be changed accordingly. The fact that VR poisoned individuals will less respond to the current oxime therapy used in France, the 2-PAM and that VR represents a higher threat than VX, being probably possessed by some proliferating states, justify the interest for this toxic product.


Assuntos
Agentes Neurotóxicos/toxicidade , Compostos Organotiofosforados/toxicidade , Animais , Inibidores da Colinesterase/química , Inibidores da Colinesterase/toxicidade , Humanos , Agentes Neurotóxicos/química , Compostos Organotiofosforados/química , Intoxicação/terapia , Federação Russa
2.
Rev Mal Respir ; 40(2): 156-168, 2023 Feb.
Artigo em Francês | MEDLINE | ID: mdl-36690507

RESUMO

INTRODUCTION: Recent news points to the eventuality of an armed conflict on the national territory. STATE OF THE ART: In this situation, pulmonologists will in all likelihood have a major role to assume in caring for the injured, especially insofar as chest damage is a major cause of patient death. PERSPECTIVES: The main injuries that pulmonologists may be called upon to treat stem not only from explosions, but also from chemical, biological and nuclear hazards. In this article, relevant organizational and pedagogical aspects are addressed. Since exhaustiveness on this subject is unattainable, we are proposing training on specific subjects for interested practitioners. CONCLUSION: The resilience of the French health system in a situation of armed conflict depends on the active participation of all concerned parties. With this in mind, it is of prime importance that the pneumological community be sensitized to the potential predictable severity of war-related injuries.


Assuntos
Conflitos Armados , Pneumologistas , Humanos
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