RESUMO
AIMS: Monitoring current of injury (COI) during left bundle branch area pacing (LBBAP) implantation is useful to evaluate lead depth. Technical aspects for recording COI amplitude have not been well studied. Our aims were to evaluate the impact of high-pass filter settings on electrogram recordings during LBBAP implantation. METHODS AND RESULTS: Consecutive patients with successful LBBAP implantation had unipolar recordings of COI at final lead position at different high-pass filter settings (0.01-1â Hz) from the tip electrode during sensing and pacing, and from the ring electrode during sensing. Duration of saturation-induced signal loss was also measured at each filter setting. COI amplitudes were compared between lumenless and stylet-driven leads. A total of 156 patients (96 males, aged 81.4 ± 9.6 years) were included. Higher filter settings led to significantly lower COI amplitudes. In 50 patients with COI amplitude < 10â mV, the magnitude of the drop was on average 1-1.5â mV (and up to 4â mV) between 0.05 and 0.5â Hz, meaning that cut-offs may not be used interchangeably. Saturation-induced signal loss was on average 10â s at 0.05â Hz and only 2â s with 0.5â Hz. When pacing was interrupted, the sensed COI amplitude varied (either higher or lower) by up to 4â mV, implying that it is advisable to periodically interrupt pacing to evaluate the sensed COI when reaching levels of â¼10â mV. Lead type did not impact COI amplitude. CONCLUSION: High-pass filters have a significant impact on electrogram characteristics at LBBAP implantation, with the 0.5â Hz settings having the most favourable profile.
Assuntos
Estimulação Cardíaca Artificial , Humanos , Masculino , Feminino , Idoso de 80 Anos ou mais , Idoso , Estimulação Cardíaca Artificial/métodos , Eletrodos Implantados , Técnicas Eletrofisiológicas Cardíacas , Fascículo Atrioventricular/fisiopatologia , Marca-Passo Artificial , Desenho de Equipamento , Resultado do Tratamento , Potenciais de AçãoRESUMO
AIMS: A three-dimensional electroanatomic mapping system-guided transseptal puncture (3D-TSP), without fluoroscopy or echocardiography, has been only minimally reported. Indications for 3D-TSP remain unclear. Against this background, this study aims to establish a precise technique and create a workflow for validating and selecting eligible patients for fluoroless 3D-TSP. METHODS AND RESULTS: We developed a new methodology for 3D-TSP based on a unipolar electrogram derived from a transseptal needle tip (UEGM tip) in 102 patients (the derivation cohort) with intracardiac echocardiography (ICE) from March 2018 to February 2019. The apparent current of injury (COI) was recorded at the muscular limbus of the foramen ovalis (FO) on the UEGM tip (sinus rhythm: 2.57 ± 0.95â mV, atrial fibrillation: 1.92 ± 0.77â mV), which then disappeared or significantly reduced at the central FO. Changes in the COI, serving as a major criterion to establish a 3D-TSP workflow, proved to be the most valuable indicator for identifying the FO in 99% (101/102) of patients compared with three previous techniques (three minor criteria) of reduction in atrial unipolar or bipolar potential and FO protrusion. A total of 99.9% (1042/1043) patients in the validation cohort underwent successful 3D-TSP through the workflow from March 2019 to July 2023. Intracardiac echocardiography guidance was required for 6.6% (69/1042) of patients. All four criteria were met in 740 patients, resulting in a 100% pure fluoroless 3D-TSP success rate. CONCLUSION: In most patients, fluoroless 3D-TSP was successfully achieved using changes in the COI on the UEGM tip. Patients who met all four criteria were considered suitable for 3D-TSP, while those who met none required ICE guidance.
Assuntos
Fibrilação Atrial , Técnicas Eletrofisiológicas Cardíacas , Imageamento Tridimensional , Punções , Humanos , Masculino , Feminino , Fibrilação Atrial/cirurgia , Fibrilação Atrial/fisiopatologia , Fibrilação Atrial/diagnóstico , Técnicas Eletrofisiológicas Cardíacas/métodos , Idoso , Pessoa de Meia-Idade , Ablação por Cateter/métodos , Ablação por Cateter/instrumentação , Agulhas , Septos Cardíacos/cirurgia , Septos Cardíacos/diagnóstico por imagem , Fluxo de Trabalho , EcocardiografiaRESUMO
A larger left bundle branch (LBB) potential or LBB current of injury (COI) indicates a low LBB capture threshold in LBB pacing. During LBB pacing in an 85-year-old woman, achieving a low LBB capture threshold did not initially present with a larger LBB potential or LBB COI, but rather with a new initial negative deflection in a ventricular electrogram. LBB COI gradually developed over 7 min thereafter, which suggested that the lead tip had reached the left ventricular subendocardium. Therefore, this negative deflection may be the first sign to avoid further lead rotation.
RESUMO
BACKGROUND: Precordial Bipolar Leads (PBLs), Weighted Unipolar Leads (WUL), and Regional Vectorcardiograms (RVCGs) are constructed using the same data recorded by a standard 12lead ECG, but they provide additional information not visible in the standard 12lead ECG (ECG) tracings. OBJECTIVES: In previous studies during balloon occlusion of the LAD and RCA, we observed a complete ischemic inversion of the QRS waves, with folding of the loop and ST segment shift. In the present study, we aim to investigate this abnormality using new ECG methods. We hypothesize that utilizing PBL, WUL, and RVCG in patients with ischemia caused by total acute coronary artery occlusion enables the detection of specific abnormalities-such as changes in waveform time/amplitude, the presence of the omega sign, distortion and folding of RVCG loops, and alterations in loop direction in both the transverse and frontal planes-that are not easily discernible with a standard 12lead ECG. This enhanced detection aids in understanding the mechanisms underlying electrocardiographic changes and may assist in managing patients when diagnostic uncertainties arise. METHODS: Thirty-three patients undergoing elective PTCA were studied before and after acute LAD (16 patients) or RCA (17 patients) occlusion, and their data were processed with new methods based on PBLs, WULs, and RVCGs. RESULTS: 1. In acute ischemia due to occlusion of the LAD and RCA, the most important current of injury occurs in the right to left axis. This axis is underestimated by the standard 12lead ECG and only partially complemented by leads V3R and V4R. 2. The two-dimensional presentation detects a new sign (the omega sign), not detectable in the classic ECG, but almost always present in ischemia. It also allows for an accurate identification of the J point. 3. Ischemic R wave peak delay results in distortion and folding of the RVCG loop and causes displacement of the J point and the ST segment. 4. Wave inversion changes the loop direction in the transverse and frontal plane. CONCLUSIONS: Precordial bipolar leads, weighted unipolar leads, and regional vectorcardiograms provide essential information omitted by the standard 12lead ECG.
RESUMO
BACKGROUND: Precordial Bipolar Leads (PBLs) provide new electrocardiographic information derived from standard 12lead ECG recordings. OBJECTIVES: To explore the usefulness of PBLs in patients with acute circumflex coronary artery (CxCA) occlusion. METHODS: Twelve patients undergoing elective percutaneous transluminal coronary angioplasty (PTCA) were studied before and after acute CxCA occlusion and their data were processed with new methods based on PBLs. RESULTS: The findings were: 1. In right PBL V2-V1, a strong systolic current of injury moving in the left-to-right direction coexists with a strong right-to-left current of injury displayed in left standard unipolar precordial leads (V4, V5 and V6). 2. Ischemic changes lead to a significant increase (approximately 10 ms) in the QRS duration in different leads, although changes in the QRS loop rotation and folding were absent. 3. In the transverse, sagittal, and frontal planes, superimposing two PBLs and the corresponding Regional VCG facilitates the location of the J-point. 4. In the Regional VCGs of this group of patients, J-point and ST segment shifts produced an image that reminds the Greek letter omega (Ω). 5. The currents of injury flowing in opposite directions could result in electrical cancellation that minimizes ECG changes in the standard 12lead recordings. CONCLUSIONS: Computerized processing of digital, standard 12lead ECG recordings, provides new valuable diagnostic data in patients with acute CxCA occlusion. The loops revealed important information related to systolic currents of injury. Because these methods use routine 12lead ECG data, the procedure is based only in software applications. CONDENSED ABSTRACT: Twelve patients undergoing PTCA were studied before and after acute CxCA occlusion and their data were processed with the new methods based on Precordial Bipolar Leads (PBLs) to explore their usefulness. The results showed strong systolic currents of injury in different and sometimes opposite directions in the right-to-left axis and ischemic alterations in the time and amplitude of the QRS waves. The superimposition of two-dimensional coordinates planes (x-y, x-z or z-y) helped to locate the J-point and to display the Regional VCG omega sign (Ω) of myocardial injury. In conclusion, computerized processing of digital ECG data provides new diagnostic information in patients with acute CxCA occlusion.
Assuntos
Vetorcardiografia , Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Vetorcardiografia/métodos , Reprodutibilidade dos Testes , Idoso , Sensibilidade e Especificidade , Ventrículos do Coração/fisiopatologia , Eletrodos , Eletrocardiografia , Diagnóstico por Computador/métodosRESUMO
BACKGROUND: Precordial Bipolar Leads (PBL) provide new electrocardiographic information derived from standard 12lead ECG recordings. OBJECTIVES: To explore the usefulness of PBL in patients with acute right coronary artery (RCA) occlusion. METHODS: Sixteen patients undergoing elective percutaneous transluminal coronary angioplasty (PTCA) were studied before and after RCA occlusion and their data were processed with new methods based on PBL. RESULTS: The findings were: 1. In PBL V2-V1, strong systolic currents of injury moving in the left to right direction coexist with those directed towards leads II, III and aVF. 2. Changes in the time of the peaks of the QRS waves do not alter the duration of the QRS. 3. The QRS loops of the surrogate VCG generated show that, during ischemia, the time changes in the peak of the QRS waves displayed in one axis are the consequence of an increase in the amplitude of the waves observed in the perpendicular axis. 4. The use of two simultaneous dimensions (transverse and frontal planes) facilitates the location of the J-point. 5. In the surrogate VCGs of this group of patients, J-point and ST segment shifts produced an image that reminded the Greek letter omega (Ω). 6. The QRS wave changes, in time and amplitude, explained the rotational changes and the ischemic distortions of the surrogate VCG loops. CONCLUSIONS: Computerized processing of ECG data appears to provide new and valuable diagnostic data in patients with acute RCA occlusion. The loops revealed important information related to systolic currents of injury. Because these methods use routine 12lead ECG data, the procedure is based only in software applications.
Assuntos
Angioplastia Coronária com Balão , Oclusão Coronária , Humanos , Eletrocardiografia/métodos , Ventrículos do Coração , Oclusão Coronária/complicações , Oclusão Coronária/diagnóstico , Arritmias CardíacasRESUMO
AIMS: Current electrophysiology signal recording and mapping systems have limited dynamic range (DR) and bandwidth, which causes loss of valuable information during acquisition of cardiac signals. We evaluated a novel advanced signal processing platform with the objective to obtain and assess additional information of clinical importance. METHODS AND RESULTS: Over 10 canines, we compared intracardiac recordings within all cardiac chambers, in various rhythms, in pacing and during radiofrequency (RF) ablation across two platforms; a conventional system and the PURE EP™ [(PEP); Bio Sig Technologies, Inc., Los Angeles, CA, USA]. Recording cardiac signals with varying amplitudes were consistently and reproducibly observed, without loss of detail or introduction of artefact. Further the amplitude of current of injury (COI) on the unipolar signals correlated with the instantaneous contact force (CF) recorded on the sensing catheter in all the animals (r2 = 0.94 in ventricle). The maximum change in the unipolar COI correlated with the change in local electrogram amplitude during non-irrigated RF ablation (r2 = 0.61 in atrium). Reduction in artefact attributable to pacing (20 sites) and noise during ablation (48 sites) was present on the PEP system. Within the PEP system, simultaneous display of identical signals, filtered differently, aided the visualization of discrete conduction tissue signals. CONCLUSION: Compared to current system, the PEP system provided incremental information including identifying conduction tissue signals, estimates of CF and a surrogate for lesion formation. This novel signal processing platform with increased DR and minimal front-end filtering may be useful in clinical practice.
Assuntos
Ablação por Cateter , Animais , Catéteres , Cães , Átrios do Coração/cirurgia , Ventrículos do CoraçãoRESUMO
BACKGROUND: Left bundle branch pacing (LBBP) is emerging as a novel option for physiological ventricular pacing. The impact of current of injury (COI) at left bundle branch (LBB) has not been previously evaluated. METHODS: Consecutive patients with QRS duration less than 120 milliseconds referred for LBBP in whom LBB potentials were recorded were included from August 2018 to March 2019. We recorded LBB COI during LBBP and assessed its impact on the pacing parameters and complications during implantation and at short term follow-up. RESULTS: A total of 115 patients with an identifiable LBB potential at implant were included. LBB COI was confirmed in 77 (67.0%) of these patients. Three types of LBB COI were observed. LBB was captured in all patients at a pacing threshold less than 1.5 V/0.5 ms in COI(+) patients, while present in only 29 patients without an LBB COI(-) (100% vs 76.3%; P < .001). There was no significant difference between COI(+) and COI(-) patients in LBB bundle capture threshold (0.64 ± 0.24 vs 0.74 ± 0.26 V/0.5 ms). Selective LBBP was more common in COI(+) group than COI(-) group (54.5% vs 0%; P < .001). Pacing parameters were stable and no lead perforation or dislodgements were observed during follow-up. CONCLUSIONS: LBB COI is commonly observed during LBBP in cases with an identifiable LBB potential and can be associated with a low LBB capture threshold and demonstrable selective capture of the LBB acutely and during follow-up. A COI does not preclude safe and stable LBBP pacing.
Assuntos
Arritmias Cardíacas/terapia , Fascículo Atrioventricular/lesões , Estimulação Cardíaca Artificial/efeitos adversos , Insuficiência Cardíaca/terapia , Traumatismos Cardíacos/etiologia , Potenciais de Ação , Idoso , Idoso de 80 Anos ou mais , Arritmias Cardíacas/diagnóstico , Arritmias Cardíacas/fisiopatologia , Fascículo Atrioventricular/fisiopatologia , Feminino , Insuficiência Cardíaca/diagnóstico , Insuficiência Cardíaca/fisiopatologia , Traumatismos Cardíacos/diagnóstico , Traumatismos Cardíacos/fisiopatologia , Frequência Cardíaca , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Tempo , Resultado do TratamentoRESUMO
BACKGROUND: The implantation of leads in the right atrial septum (RAS) or the right ventricular septum (RVS) is technically challenging, and dislodgement occurs occasionally. This study aims to determine a predictor for the dislodgement of leads implanted in the RAS or RVS. METHODS: This retrospective cohort study enrolled 137 consecutive patients who underwent the cardiac implantable electronic devices implantation, using active fixation leads in the RAS and RVS. We compared the pacing threshold, R- or P-wave amplitude, slew rate, and presence of the current of injury (COI) between dislodged and nondislodged leads. RESULTS: We performed lead fixation for 74 and 125 times in the RAS and RVS, respectively. Atrial lead dislodgement occurred five times (6.8%) intraoperatively and five times (6.8%) postoperatively, whereas ventricular lead dislodgement occurred eight times (6.4%) intraoperatively and three times (2.4%) postoperatively. Although there were no lead parameters that showed a significant difference common to RAS lead and RVS lead, the presence of the COI was significantly different between nondislodged and dislodged leads in both the RAS and RVS (atrial leads: 57.8% vs 0%, P < 0.001; ventricular leads: 67.5% vs 9.1%, P < 0.001). The positive predictive value of COI presence for predicting no lead dislodgement was 100% and 98.7% in the RAS and RVS, respectively. CONCLUSION: Lead dislodgement is more likely when the COI is absent; documentation of COI should be pursued during lead implantation in challenging sites as the RAS and RVS.
Assuntos
Septo Interatrial , Bloqueio Atrioventricular/terapia , Eletrodos Implantados , Falha de Equipamento , Marca-Passo Artificial , Síndrome do Nó Sinusal/terapia , Septo Interventricular , Idoso , Técnicas Eletrofisiológicas Cardíacas , Feminino , Fluoroscopia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos RetrospectivosRESUMO
BACKGROUND: There are only limited prospective data on the clinical relevance of current of injury (COI) as a predictor of the midterm performance of active-fixation leads. This study sought to investigate whether it is possible to predict the midterm performance of active-fixation leads using COI recorded at the time of implantation. METHODS AND RESULTS: One hundred fifty patients (78 men; mean age, 63 ± 19 years) who received active-fixation pacing (n = 201) and defibrillator (n = 51) leads were studied. COI was measured from the intracardiac bipolar electrogram recorded at the time of lead implantation. The study outcome was good lead performance at 6 months, defined as P wave ≥ 1.5 mV, threshold <1.5 V for atrial lead, R-wave ≥ 5 mV, and threshold <1 V for ventricular lead. A total of 102 active-fixation atrial and 150 ventricular leads were implanted. During a 6-month follow-up, invasive intervention was required for seven atrial and seven ventricular leads. In multivariate analysis, COI was the only independent predictor of good outcome for the active-fixation atrial (odds ratio [OR]: 5.67, 95% confidence interval [CI]: 2.18-14.76, P = 0.001) and ventricular leads (OR: 3.99, 95% CI: 1.08-21.26, P = 0.002). Receiver-operating characteristic analysis identified ST-segment elevation ≥2.0 mV for the atrial leads (sensitivity, 75%; specificity, 89%) and ≥10.0 mV for the ventricular leads (sensitivity, 70%; specificity, 87%) as optimal cutoffs for good midterm performance. CONCLUSIONS: Midterm performance of active-fixation leads is predictable using COI recorded at the time of lead implantation. A ST-segment elevation ≥2.0 mV in the atrial leads and ≥10.0 mV in the ventricular leads are recommended to improve the lead performance at 6 months.
Assuntos
Fibrilação Atrial/terapia , Eletrodos Implantados , Marca-Passo Artificial , Disfunção Ventricular Esquerda/terapia , Fibrilação Atrial/complicações , Fibrilação Atrial/diagnóstico , Desenho de Equipamento , Análise de Falha de Equipamento , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento , Disfunção Ventricular Esquerda/diagnóstico , Disfunção Ventricular Esquerda/etiologiaRESUMO
Electrical stimulation as a mode of external enhancement factor in wound healing has been explored widely. It has proven to have multidimensional effects in wound healing including antibacterial, galvanotaxis, growth factor secretion, proliferation, transdifferentiation, angiogenesis, etc. Despite such vast exploration, this modality has not yet been established as an accepted method for treatment. This article reviews and analyzes the approaches of using electrical stimulation to modulate wound healing and discusses the incoherence in approaches towards reporting the effect of stimulation on the healing process. The analysis starts by discussing various processes adapted in in vitro, in vivo, and clinical practices. Later it is focused on in vitro approaches directed to various stages of wound healing. Based on the analysis, a protocol is put forward for reporting in vitro works in such a way that the outcomes of the experiment are replicable and scalable in other setups. This work proposes a ground of unification for all the in vitro approaches in a more sensible manner, which can be further explored for translating in vitro approaches to complex tissue stimulation to establish electrical stimulation as a controlled clinical method for modulating wound healing.
Assuntos
Terapia por Estimulação Elétrica , Cicatrização , Cicatrização/fisiologia , Estimulação Elétrica/métodos , Terapia por Estimulação Elétrica/métodos , Peptídeos e Proteínas de Sinalização IntercelularRESUMO
BACKGROUND: Monitoring of lead depth is crucial to achieve left bundle branch pacing (LBBP) with a low capture threshold and avoid septal perforation, but lacks informative approach. OBJECTIVE: We aimed to prospectively assess the predictive value of current of injury on the occurrence of inadequate left bundle branch (LBB) capture threshold and acute septal perforation. METHODS: Consecutive patients who received LBBP were enrolled. ST-segment elevation ≥ 25% of intrinsic R-wave amplitude on the unipolar intracardiac electrogram was defined as a sign of distinct current of injury. An LBB capture threshold of <1.5 V/0.5 ms was considered acceptable. RESULTS: LBBP was attempted 513 times in 212 patients. The LBB capture threshold was more likely to improve to an acceptable level after 10 minutes in leads with initial (33 of 47 vs 0 of 8, with vs without) and residual (29 of 33 vs 4 of 14, with vs without) current of injury recorded on the tip electrode (P < .0001). Lead perforation during the procedure has occurred in 11 patients who had no current of injury noted on the tip electrode. The ratio of current of injury recorded on the tip electrode to that on the ring electrode was correlated to the lead depth determined by sheath angiography (Spearman correlation coefficient -0.624; P < .0001), and microperforation is highly possible when the ratio is decreased to <1 (sensitivity 100%; specificity 96.6%). CONCLUSION: Current of injury is a useful tool in forecasting LBBP lead depth and septal perforation, and it could facilitate the decision-making process when the initial LBB capture threshold is undesirable.
Assuntos
Fascículo Atrioventricular , Estimulação Cardíaca Artificial , Bloqueio de Ramo/terapia , Estimulação Cardíaca Artificial/efeitos adversos , Estimulação Cardíaca Artificial/métodos , Eletrocardiografia/métodos , Sistema de Condução Cardíaco , HumanosRESUMO
BACKGROUND: Left bundle branch pacing (LBBP) provides a low and stable threshold by direct capture of left bundle fibers on the left ventricular subendocardium. As the procedure involves the deployment of the pacing lead deep inside the septum, septal perforation is a potential complication. OBJECTIVES: The purpose of this study was to analyze the morphology of intracardiac electrograms and unipolar pacing parameters to identify septal perforation in patients undergoing LBBP. METHODS: Patients who had undergone successful LBBP between January 2020 to November 2021 were retrospectively included in the study. RESULTS: LBBP was attempted in 219 patients and was successful in 212 (96.8% success rate). Septal perforation during lead deployment was identified in 30 patients (14.1%). Peak troponin release was 188 ± 162 pg/mL. Mean unipolar impedance during septal perforation was 404.6 ± 19.9 Ω (400-450 Ω in 16 patients [53.3%]; <400 Ω in 14 patients [46.7%]). A cutoff <450 Ω for diagnosing septal perforation had high sensitivity (100%) and specificity (96.6%). Current of injury amplitude reduced from 15.4 ± 11.6 mV just before perforation to 0.9 ± 0.6 mV after perforation. Based on morphology, unfiltered unipolar electrograms were classified into 2 patterns: (1) type I (QS) seen in 20 patients (67%) due to complete perforation (mean unipolar impedance 402.5 ± 20.4 Ω); and (2) type II (RS/rS) seen in 10 patients (33%) due to partial perforation, with 80% showing capture (mean impedance 411 ± 21.3 Ω). All 30 patients underwent successful reimplantation at a new site. No patient developed lead dislodgment during mean follow-up of 9.9 ± 6.7 months. CONCLUSION: Although considered one of the concerns of LBBP, septal perforation, when recognized promptly during implantation by unipolar parameters and treated by reimplantation, would be benign and not associated with an unfavorable outcome.
Assuntos
Fascículo Atrioventricular , Estimulação Cardíaca Artificial , Estimulação Cardíaca Artificial/efeitos adversos , Estimulação Cardíaca Artificial/métodos , Eletrocardiografia/métodos , Sistema de Condução Cardíaco , Humanos , Estudos RetrospectivosRESUMO
RATIONALE: Skin breakdown, as in wounds, leads to an electric potential, defined as current of injury with the intent of wound closure. Burn wounds are defined by different zones of perfusion having a direct influence on further therapy (e.g. conservative management or skin grafting). We studied immediate, quantifiable effects of electric stimulation on skin perfusion in burn wounds. METHOD: Wireless Microcurrent Stimulation (WMCS) was utilised as an adjunct therapeutic modality in 10 patients with partial thickness burn wounds. Microcirculation in the skin was quantified with a Laser Doppler (LDI) before and after WMCS treatment. We included a control group of 10 healthy individuals. RESULTS: A single application of WMCS significantly increased mean flow, velocity and subsequently, haemoglobin and oxygen saturation in partial thickness burn wounds. In healthy skin these parameters increased, but were far less pronounced than in thermally injured skin. CONCLUSION: This study revealed, for the first time that non-contact WMCS improves blood flow in critically perfused partial thickness burn wounds without disturbing the wound or systemically affecting the patient and may represent a promising adjunct tool in burn treatment, with the potential of faster healing by enhanced perfusion of burn wounds and reduction of the zone of stasis. LEVEL OF EVIDENCE: III.
Assuntos
Queimaduras , Queimaduras/cirurgia , Humanos , Microcirculação , Pele/irrigação sanguínea , Transplante de Pele , Cicatrização/fisiologiaRESUMO
Background: Left bundle branch (LBB) pacing (LBBP) has recently emerged as a physiological pacing mode. Current of injury (COI) can be used as the basis for electrode fixation position and detection of perforation. However, because the intermittent pacing method cannot monitor the changes in COI in real time, it cannot obtain information about the entire COI change process during implantation. Case summary: Left bundle branch pacing was achieved for treatment of atrioventricular block in a 76-year-old female. Uninterrupted electrocardiogram and electrogram were recorded on an electrophysiology system. In contrast to the interrupted pacing method, this continuous pacing and recording technique enables real-time monitoring of the change in ventricular COI and the paced QRS complex as the lead advances into the interventricular septum. During the entire screw-in process, the COI amplitude increased and then decreased gradually after reaching the peak, followed by a small but significant, rather than dramatic, decrease. Conclusion: This case report aims to demonstrate the clinical significance of changes in COI and QRS morphology for LBBP using real-time electrocardiographic monitoring and filtered and unfiltered electrograms when the lead is deployed using a continuous pacing technique. The technique could be used to confirm LBB capture and avoid perforation.
RESUMO
BACKGROUND: Currents of injury (COI) have been associated with improved lead performance during perioperative measurements in pacemaker and ICD implants. Their relevance on long term lead stability remains unclear. METHODS: Unipolar signals were recorded immediately after active fixation ICD lead positioning, blinded to the implanting surgeon. Signals were assigned to prespecified COI types by two independent investigators. Sensing, pacing as well as changes requiring surgical intervention were prospectively investigated for 3 months. RESULTS: 105 consecutive ICD lead implants were studied. All could be assigned to a particular COI with 48 type 1, 43 type 2 and 14 type 3 signals. Pacing impedance at implant was 703.8+/-151.6 Ohm with a significant COI independent drop within the first week. Sensing was 10.6mV+/- 3.7mV and pacing threshold at implant was 0.8+/-0.3mV at 0.5ms at implant. There was no significant difference between COI groups at implant and during a 3 months follow up regarding sensing, pacing nor surgical revisions. CONCLUSIONS: Three distinct patterns of unipolar endocardial potentials were observed in active fixation ICD lead implant, but COI morphology did not predict lead performance after 3 months.
RESUMO
BACKGROUND: Pacing parameters may influence pacing lead life and pacemaker life. This study sought to determine whether different right atrial active-fixation lead implantation parameters are associated with chronic pacing performance. METHODS: A retrospective observational study was conducted on all consecutive patients implanted with an active-fixation atrial lead at our institution from July 2014 to October 2016. Atrial leads with a P-wave sensing of ≥2.0 mV, a pacing threshold of ≤1.0 V, and a lead impedance of 300-1,000 ohms were assigned as the optimized group, while atrial leads that did not meet these specifications were assigned as the conventional group. A total of 98 patients who received active-fixation atrial leads (55 patients were male, mean age was 63±12 years old) were studied, and the lead performance of 67 of these patients were optimized in 3 months. RESULTS: In the multivariate analysis, current of injury [COI; COI10min, odds ratio (OR): 0.296, 95% confidence interval (CI): 0.093-0.939, P=0.039] and P-wave sensing (P10min, OR: 0.449, 95% CI: 0.265-0.762, P=0.003) were recorded at 10 minutes after lead fixation, and were considered predictors of lead optimized performance. The cut-off value of COI10min and P10min was 1.04 mV (sensitivity: 0.58 and specificity: 0.77) and 3.3 mV (sensitivity: 0.67 and specificity: 0.74), respectively, for predicting lead optimized performance after 3 months. COI10min ≥1.04 mV and P10min ≥3.3 mV were combined and considered as the predictable criteria, and the area under the ROC curve was 0.806 (sensitivity =0.70 and specificity =0.77). CONCLUSIONS: Optimized atrial lead performance at 3 months was predictable from COI10min ≥1.04 mV and P10min ≥3.3 mV.