Impact of Diabetes and Hypertension on Left Ventricular Structure and Function: The Jackson Heart Study.

Background Diabetes and hypertension have been associated with adverse left ventricular (LV) remodeling. While they often occur concurrently, their individual effects are understudied. We aimed to assess the independent effects of diabetes and hypertension on LV remodeling in Black adults. Methods and Results The JHS (Jackson Heart Study) participants (n=4143 Black adults) with echocardiographic measures from baseline exam were stratified into 4 groups: neither diabetes nor hypertension (n=1643), only diabetes (n=152), only hypertension (n=1669), or both diabetes and hypertension (n=679). Echocardiographic measures of LV structure and function among these groups were evaluated by multivariable regression adjusting for covariates. Mean age of the participants was 52±1 years, and 63.7% were women. LV mass index was not different in participants with only diabetes compared with participants with neither diabetes nor hypertension (P=0.8). LV mass index was 7.9% (6.0 g/m2) higher in participants with only hypertension and 10.8% (8.1 g/m2) higher in participants with both diabetes and hypertension compared with those with neither (P<0.001). LV wall thickness (relative, posterior, and septal) and brain natriuretic peptide levels in participants with only diabetes were not significantly higher than participants with neither (P>0.05). However, participants with both diabetes and hypertension demonstrated higher LV wall thickness and brain natriuretic peptide levels than participants with neither (P<0.05). Conclusions In this cross-sectional analysis, diabetes was not associated with altered LV structure or function in Black adults unless participants also had hypertension. Our findings suggest hypertension is the main contributor to cardiac structural and functional changes in Black adults with diabetes.

Community Informed Recruitment: A Promising Method to Enhance Clinical Trial Participation.

CONTEXT: Low recruitment rates in palliative care clinical trials amongst Black and rural individuals have been attributed to lack of trust and procedural barriers. Community engagement strategies have increased clinical trial participation of under-represented populations. OBJECTIVE: Describe a successful community-engaged recruitment strategy in an ongoing multi-site randomized clinical trial (RCT). STUDY DESIGN AND METHODS: Using community-based participatory research principles and input from a prior pilot study's community advisory group (CAG), we designed a novel recruitment strategy for Community Tele-Pal, a three-site, culturally based palliative care tele-consult RCT for Black and White seriously ill inpatients and their family caregivers. Local site CAGs helped design and implement a recruitment strategy in which a CAG member accompanied the study coordinators to introduce the study to eligible patients. Initially, CAG members could not accompany study coordinators in person due to pandemic restrictions. Hence, they created videos of themselves introducing the study, just as they would have done in person. We examined outcomes to date by the three recruitment methods and race. RESULTS: Of the 2879 patients screened, 228 were eligible and approached. Overall, the proportions of patients who consented 102 (44.7%) vs. not consented 126 (55.3%) were similar by race- White (consented= 75 [44.1%]) vs; Black (consented = 27 [46.6%]). Proportionally, consent rates favored CAG-involved methods: coordinator only- 47 approached and 13 (12.7%) consented vs. coordinator/CAG video-105 approached and 60 (58.8%) consented. CONCLUSION: A novel community-enhanced recruitment strategy demonstrated the potential to increase clinical trial participation from historically under-represented populations.

Epidemiology of Heart Failure Stages in Middle-Aged Black People in the Community: Prevalence and Prognosis in the Atherosclerosis Risk in Communities Study.

Background Black individuals have a higher burden of risk factors for heart failure (HF) and subclinical left ventricular remodeling. Methods and Results We evaluated 1871 Black participants in the Atherosclerosis Risk in Communities Study cohort who attended a routine examination (1993-1996, median age 58 years) when they underwent echocardiography. We estimated the prevalences of 4 HF stages: (1) Stage 0: no risk factors; (2) Stage A: presence of HF risk factors (hypertension, diabetes mellitus, obesity, smoking, dyslipidemia, coronary artery disease without clinical myocardial infarction), no cardiac structural/functional abnormality; (3) Stage B: presence of prior myocardial infarction, systolic dysfunction, left ventricular hypertrophy, regional wall motion abnormality, or left ventricular enlargement; and (4) Stage C/D: prevalent HF. We assessed the incidence of clinical HF, atherosclerotic cardiovascular disease events, and all-cause mortality on follow-up according to HF stage. The prevalence of HF Stages 0, A, B, and C/D were 3.8%, 20.6%, 67.0%, and 8.6%, respectively, at baseline. On follow-up (median 19.0 years), 309 participants developed overt HF, 390 incurred new-onset cardiovascular disease events, and 651 individuals died. Incidence rates per 1000 person-years for overt HF, cardiovascular disease events, and death, respectively, were Stage 0, 2.4, 0.8, and 7.6; Stage A, 7.4, 9.7, and 13.5; Stage B 13.6, 15.9, and 22.0. Stage B HF was associated with a 1.5- to 2-fold increased adjusted risk of HF, cardiovascular disease events and death compared with Stages 0/A. Conclusions In our large community-based sample of Black individuals, we observed a strikingly high prevalence of Stage B HF in middle age that was a marker of high cardiovascular morbidity and mortality.

Regional Adiposity and Risk of Heart Failure and Mortality: The Jackson Heart Study.

Background Visceral adipose tissue (VAT) is associated with incident heart failure (HF) and HF with preserved ejection fraction, yet it is unknown how pericardial and abdominal adiposity affect HF and mortality risks in Black individuals. We examined the associations of pericardial adipose tissue (PAT), VAT, and subcutaneous adipose tissue (SAT) with incident HF hospitalization and all-cause mortality in a large community cohort of Black participants. Methods and Results Among the 2882 Jackson Heart Study Exam 2 participants without prevalent HF who underwent body computed tomography, we used Cox proportional hazards models to examine associations between computed tomography-derived regional adiposity and incident HF hospitalization and all-cause mortality. Fully adjusted models included demographics and cardiovascular disease risk factors. Median follow-up was 10.6 years among participants with available VAT (n=2844), SAT (n=2843), and PAT (n=1386). Fully adjusted hazard ratios (95% CIs) of distinct computed tomography-derived adiposity measures (PAT per 10 cm3, VAT or SAT per 100 cm3) were as follows: for incident HF, PAT 1.08 (95% CI, 1.02-1.14) and VAT 1.04 (95% CI, 1.01-1.08); for HF with preserved ejection fraction, PAT 1.13 (95% CI, 1.04-1.21) and VAT 1.07 (95% CI, 1.01-1.13); for mortality, PAT 1.07 (95% CI, 1.03-1.12) and VAT 1.01 (95% CI, 0.98-1.04). SAT was not associated with either outcome. Conclusions High PAT and VAT, but not SAT, were associated with incident HF and HF with preserved ejection fraction, and only PAT was associated with mortality in the fully adjusted models in a longitudinal community cohort of Black participants. Future studies may help understand whether changes in regional adiposity improves HF, particularly HF with preserved ejection fraction, risk predictions. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT00005485.

Genetic Testing and Surveillance of Young Breast Cancer Survivors and Blood Relatives: A Cluster Randomized Trial.

We compared a tailored and a targeted intervention designed to increase genetic testing, clinical breast exam (CBE), and mammography in young breast cancer survivors (YBCS) (diagnosed <45 years old) and their blood relatives. A two-arm cluster randomized trial recruited a random sample of YBCS from the Michigan cancer registry and up to two of their blood relatives. Participants were stratified according to race and randomly assigned as family units to the tailored (n = 637) or the targeted (n = 595) intervention. Approximately 40% of participants were Black. Based on intention-to-treat analyses, YBCS in the tailored arm reported higher self-efficacy for genetic services (p = 0.0205) at 8-months follow-up. Genetic testing increased approximately 5% for YBCS in the tailored and the targeted arm (p ≤ 0.001; p < 0.001) and for Black and White/Other YBCS (p < 0.001; p < 0.001). CBEs and mammograms increased significantly in both arms, 5% for YBCS and 10% for relatives and were similar for Blacks and White/Others. YBCS and relatives needing less support from providers reported significantly higher self-efficacy and intention for genetic testing and surveillance. Black participants reported significantly higher satisfaction and acceptability. Effects of these two low-resource interventions were comparable to previous studies. Materials are suitable for Black women at risk for hereditary breast/ovarian cancer (HBOC).

Assistência a negros e não negros nos centros de atenção psicossocial em álcool e outras drogas nos estados do Amapá, Minas Gerais e São Paulo: um estudo comparativo / Assistence to black and non-black people users of the Psychosocial Care Center for Alcohol and Drugs in the states of Amapa, Minas Gerais and Sao Paulo: a comparative study

O movimento de Reforma Psiquiátrica trouxe a necessidade de reestruturar os serviços de assistência em saúde mental e para tal a avaliação torna-se prioritária para prestar uma assistência integral e humanizada. Diante desse contexto e considerando que a população brasileira é constituída em sua maioria por negros (pretos e pardos), é fundamental que todas as pesquisas em saúde tenham um recorte racial, a começar pela inserção do quesito raça cor. Desta forma identificando o perfil e as peculiaridades dessa população, garantindo assim a qualidade da assistência com a utilização dos dados encontrados no processo de avaliação. Estudo de caráter descritivo, exploratório e transversal, teve como objetivo: comparar variáveis sociodemográficas relacionadas ao cuidado recebido dos usuários atendidos em CAPSad nos estados AP, MG e SP quanto ao quesito raça/cor. Foram entrevistados 707 usuários atendidos em CAPSad nos estados AP, MG e SP Para o presente estudo foram utilizados: os seguintes instrumentos um questionário de dados sociodemográficos, a Escala de Satisfação SATIS-BR e a Escala de Avaliação da Percepção de Mudança (EMP). Este estudo constatou as seguintes características de variáveis sociodemográficas: predominância da população masculina (57,3%), que se autodeclararam negros (59,4%), solteiros (59,0%), com faixa etária média de 44 anos, sendo o emprego a principal fonte de renda (31,7%) e com renda familiar de até 2 salários mínimos (71,1%). Quanto à escolaridade, apesar de 94,3% saberem ler, a maioria (38,8%) tinham apenas o ensino fundamental incompleto, e somente 5,1% da amostra deste estudo apresentavam nível superior completo ou acima. Os resultados apontaram que sobre o tempo de permanência no serviço os não negros tem 1,7 mais chances de ficarem mais de 6 meses no CAPSad que os negros, controlado os efeitos de alfabetização, escolaridade e renda. Sobre internação os não negros tem 1,6 mais chances de terem sido internados antes do tratamento no CAPS ad que os negros, controlado os efeitos de alfabetização, escolaridade e renda, sobre a visita domiciliar os negros tem 2,4 mais chances de receberem visita que os não negros, controlados os efeitos de alfabetização, escolaridade e renda. Identificou também que negros e não negros estão igualmente satisfeitos e com a mesma percepção de mudança.

The psychiatric reform movement resulted in the restructuring process of metal health services, which aims to provide integral and humanized assistance, prioritizing the evaluation. Given this context and considering that the population in Brazil is made up mostly of black and pardo people, it is essential that every health research consider all the racial aspects, starting with race color. Therefore, it is possible to identify the profile and peculiarities of a certain population, guaranteeing the quality of assistance services offered through the data obtained in the evaluation process. The study made with descriptive, explanatory and transversal aspects, had as a goal to compare sociodemographic variants related to the care offered to the user of Psychosocial Care Center for Alcohol and Drugs (CAPSad), in the states of Amapa (AP), Minas Gerais (MG) and Sao Paulo (SP), considering race/color. 707 users of CAPSad were interviewed in the states of AP, MG and SP. In the study the following instruments were used: a socio demographic questionnaire, the Satisfaction Scale (SATIS-BR), the Scale of Perceived Change (EMP). The sociodemographic variants were characterized by: a larger male population (57,3%), which (59,4%) is self-denominated black, (59,0%) single, with the majority being in the 44 years old range, with the job as main source of income (31,7%), and with a family income equivalent to two times the value of the Brazilian minimum wage (71,1%). As for schooling, while 94,3% can read, the majority (38,8%) didnt complete their basic education, and only 5,1% graduated from college. The results revealed that 1,7 of non-black participants are more likely to be more than 6 months in the CAPSad than the black participants, where the effects of literacy, schooling and income are under control. About hospitalization, non-black participants have 1,6 more chances of being hospitalized before the treatment at the CAPSad than the black participants, where the effects of literacy, schooling and income are under control. About homecare visits (VD), the black participants have 2,4 more change to receive VD than the non-black participants, where the effects of literacy, schooling and income are under control. It was determined that black participants and non-black participants are equally satisfied and have the same perception of change.