Treadmill running and mechanical overloading improved the strength of the plantaris muscle in the dystrophin-desmin double knockout (DKO) mouse.

Limited knowledge exists regarding the chronic effect of muscular exercise on muscle function in a murine model of severe Duchenne muscular dystrophy (DMD). Here we determined the effects of 1 month of voluntary wheel running (WR), 1 month of enforced treadmill running (TR) and 1 month of mechanical overloading resulting from the removal of the synergic muscles (OVL) in mice lacking both dystrophin and desmin (DKO). Additionally, we examined the effect of activin receptor administration (AR). DKO mice, displaying severe muscle weakness, atrophy and greater susceptibility to contraction-induced functional loss, were exercised or treated with AR at 1 month of age and in situ force production of lower leg muscle was measured at the age of 2 months. We found that TR and OVL increased absolute maximal force and the rate of force development of the plantaris muscle in DKO mice. In contrast, those of the tibialis anterior (TA) muscle remained unaffected by TR and WR. Furthermore, the effects of TR and OVL on plantaris muscle function in DKO mice closely resembled those in mdx mice, a less severe murine DMD model. AR also improved absolute maximal force and the rate of force development of the TA muscle in DKO mice. In conclusion, exercise training improved plantaris muscle weakness in severely affected dystrophic mice. Consequently, these preclinical results may contribute to fostering further investigations aimed at assessing the potential benefits of exercise for DMD patients, particularly resistance training involving a low number of intense muscle contractions. KEY POINTS: Very little is known about the effects of exercise training in a murine model of severe Duchenne muscular dystrophy (DMD). One reason is that it is feared that chronic muscular exercise, particularly that involving intense muscle contractions, could exacerbate the disease. In DKO mice lacking both dystrophin and desmin, characterized by severe lower leg muscle weakness, atrophy and fragility in comparison to the less severe DMD mdx model, we found that enforced treadmill running improved absolute maximal force of the plantaris muscle, while that of tibialis anterior muscle remained unaffected by both enforced treadmill and voluntary wheel running. Furthermore, mechanical overloading, a non-physiological model of chronic resistance exercise, reversed plantaris muscle weakness. Consequently, our findings may have the potential to alleviate concerns and pave the way for exploring the prescription of endurance and resistance training as a viable therapeutic approach for the treatment of dystrophic patients. Additionally, such interventions may serve in mitigating the pathophysiological mechanisms induced by physical inactivity.

Mathematical modeling of exercise fatigability in the severe domain: A unifying integrative framework in isokinetic condition.

Muscle fatigue is the decay in the ability of muscles to generate force, and results from neural and metabolic perturbations. This article presents an integrative mathematical model that describes the decrease in maximal force capacity (i.e. fatigue) over exercises performed at intensities above the critical force Fc (i.e. severe domain). The model unifies the previous Critical Power Model and All-Out Model and can be applied to any exercise described by a changing force F over time. The assumptions of the model are (i) isokinetic conditions, an intensity domain of Fc

VEGFA rs2010963 GG genotype is associated with superior adaptations to resistance versus endurance training in the same group of healthy, young men.

PURPOSE: We used a within-subject, cross-over study to determine the relationship between the intra-individual adaptations to four weeks' resistance (RT) versus four weeks' endurance (END) training, and we investigated whether three single nucleotide polymorphisms (SNPs) were associated with these adaptations. METHODS: Thirty untrained, healthy, young men completed a cycling test to exhaustion to determine peak oxygen uptake (V̇O2peak), and a knee extension (KE) maximum voluntary isometric contraction (MVIC) of the right leg before and after four weeks' supervised RT (four sets of 10 repetitions at 80% single repetition maximum unilateral KE exercise, three times weekly) and four weeks' supervised END (30 min combined continuous/interval cycling, three times weekly), separated by a three-week washout phase. Participants were genotyped for the ACTN3 rs1815739, NOS3 rs2070744 and VEGFA rs2010963 SNPs. RESULTS: The intra-individual adaptations regarding percentage changes in MVIC force and V̇O2peak following RT and END, respectively, were unrelated (r2 = 0.003; P = 0.79). However, a VEGFA genotype × training modality interaction (P = 0.007) demonstrated that VEGFA GG homozygotes increased their MVIC force after RT (+ 20.9 ± 13.2%) more than they increased their V̇O2peak after END (+ 8.4 ± 9.1%, P = 0.005), and more than VEGFA C-allele carriers increased their MVIC force after RT (+ 12.2 ± 8.1%, P = 0.04). There were no genotype × training modality interactions for the ACTN3 or NOS3 SNPs. CONCLUSION: High/low responders to RT were not consequently high/low responders to END or vice versa. However, preferential adaptation of VEGFA rs2010963 GG homozygotes to RT over END, and their greater adaptation to RT compared to VEGFA C-allele carriers, indicate a novel genetic predisposition for superior RT adaptation.

What are the best isometric exercises of muscle potentiation?

PURPOSE: The aim of this study was to follow post-activation potentiation (PAP), low-frequency fatigue (LFF), metabolic-induced fatigue and post-contractile depression (PCD) in response to different isometric muscle contraction modalities. METHODS: Young healthy men (N = 120) were randomly assigned to one of ten exercise modality groups which differed in contraction duration (5-60 s), activation pattern (intermittent or continuous contractions), activation mode (voluntary or stimulated), and intensity [maximal or submaximal (50%)]. Isometric maximal voluntary contraction (MVC), and electrically induced knee extension torque were measured at baseline and at regular intervals for 60 min after exercise. RESULTS: Muscle contraction modalities involving 5 s MVC were the most effective for PAP, whereas the lowest PAP effectiveness was found after the 12 × 5-MVC modality. After all of the 5-15 s MVC and 6 × 5-MVC protocols, the potentiation of the twitch rate was significantly higher than that recorded after continuous 30-60 s protocols (P < 0.001). Tetanic maximal torque (100 Hz) potentiation occurred 5 min after 15-30 s repetitive MVC modalities and after modality involving 15 electrical stimuli (P < 0.05). CONCLUSIONS: The findings demonstrate that post-activation potentiation was most effective after brief duration continuous and repetitive MVC protocols. To understand the resultant warm-up of motor performance, it is necessary to recognize the coexistence of muscle PAP, tetanic maximal force potentiation, rapid recovery of metabolic muscle, and central muscle activation processes, as well as prolonged LFF and prolonged PCD.

Gonad-related factors promote muscle performance gain during postnatal development in male and female mice.

To better define the role of male and female gonad-related factors (MGRF, presumably testosterone, and FGRF, presumably estradiol, respectively) on mouse hindlimb skeletal muscle contractile performance/function gain during postnatal development, we analyzed the effect of castration initiated before puberty in male and female mice. We found that muscle absolute and specific (normalized to muscle weight) maximal forces were decreased in 6-mo-old male and female castrated mice compared with age- and sex-matched intact mice, without alteration in neuromuscular transmission. Moreover, castration decreased absolute and specific maximal powers, another important aspect of muscle performance, in 6-mo-old males, but not in females. Absolute maximal force was similarly reduced by castration in 3-mo-old muscle fiber androgen receptor (AR)-deficient and wild-type male mice, indicating that the effect of MGRF was muscle fiber AR independent. Castration reduced the muscle weight gain in 3-mo mice of both sexes and in 6-mo females but not in males. We also found that bone morphogenetic protein signaling through Smad1/5/9 was not altered by castration in atrophic muscle of 3-mo-old mice of both sexes. Moreover, castration decreased the sexual dimorphism regarding muscle performance. Together, these results demonstrated that in the long term, MGRF and FGRF promote muscle performance gain in mice during postnatal development, independently of muscle growth in males, largely via improving muscle contractile quality (force and power normalized), and that MGFR and FGRF also contribute to sexual dimorphism. However, the mechanisms underlying MGFR and FGRF actions remain to be determined.

Maximal force and tremor changes across the menstrual cycle.

PURPOSE: Sex hormones have profound effects on the nervous system in vitro and in vivo. The present study examines the effect of the menstrual cycle on maximal isometric force (MVC) and tremor during an endurance task. METHODS: Nine eumenorrheic females participated in five study visits across their menstrual cycle. In each menstrual phase, an MVC and an endurance task to failure were performed. Tremor across the endurance task was quantified as the coefficient of variation in force and was assessed in absolute time and relative percent time to task failure. RESULTS: MVC decreases 23% from ovulation to the mid luteal phase of the menstrual cycle. In absolute time, the mid luteal phase has the highest initial tremor, though the early follicular phase has substantially higher tremor than other phases after 150 s of task performance. In relative time, the mid luteal phase has the highest level of tremor throughout the endurance task. CONCLUSIONS: Both MVC and tremor during an endurance task are modified by the menstrual cycle. Performance of tasks and sports which require high force and steadiness to exhaustion may be decreased in the mid luteal phase compared to other menstrual phases.

Test-retest reliability of gastrocnemius medialis fascicle force-length relationship.

Fascicle force-length relationship is one major basic mechanical property of skeletal muscle, subsequently influencing movement mechanics. While force-length properties are increasingly described through ultrafast ultrasound imaging, their test-retest reliability remains unknown. Using ultrafast ultrasound, and electrically evoked contractions at various ankle angles, gastrocnemius medialis fascicle force-length relationship was assessed twice, few days apart, in sixteen participants. The test-retest reliability of the resulting fascicle force-length relationship key parameters - i.e., maximal force (Fmax), and optimal fascicle length (L0) - was evaluated considering (i) all the trials obtained at each ankle joint and (ii) the mean of the two trials obtained at each tested angle. Considering all trials, L0 indicated a 'high' test-retest reliability, with intra-class correlation coefficients (ICC) of 0.89 and Fmax a 'moderate' reliability (ICC = 0.71), while when averaging the two trials L0 reliability was 'very-high' (ICC = 0.91), and Fmax reliability 'moderate' (ICC = 0.73). All values of coefficient of variation and standard error of measurement were low, i.e., ≤7.7 % and ≤0.35 cm for L0 and ≤3.4 N for Fmax, respectively. Higher absolute reliability was reported for L0 than Fmax, with better reliability when averaging the two trials at each angle. All these parameters, in accordance with the limit of agreement, demonstrated that L0 and Fmax test-retest reliability is acceptable, particularly when averaging multiple points obtained at a given angle. Interestingly, the shape of the fascicle force-length relationship is more variable. Therefore, L0 and Fmax can be used to compare between days-effects following an intervention, while a comparison of fascicle operating lengths may require more precautions.

Construction and validation of the Wingate index model for elite athletes.

Objective: The gold standard for measuring anaerobic fitness is the power cycle ergometer test, but this method is expensive and time-consuming, and it has negative effects on pre-competition performance. This study aims to utilize the strong correlation between accessible body composition indices and less accessible anaerobic power bicycle indices to establish and verify a Wingate Index Model. Methods: A cohort of 993 male (age: 22.56 ± 3.30 years) and 450 female (age: 21.47 ± 2.70 years) athletes who participated in diverse sports were enrolled and completed the high-intensity power cycle test and body composition test, and the model formula was established based on these data. Totally, 283 participants were randomly selected to verify the formula using SPSS 22.0 and GraphPad Prism 9.4.1. Results: There was no significant difference between the value derived from the confirmed formula and the measured value of the instrument among the elite athletes (p > 0.05). The probabilities that the values obtained by the formula would fall within the 95 % confidence interval were as follows: Mpower(mean power): 94.7 %, Mpower/W(mean power/weight): 96.8 %, total work: 94.7 %, Ppower(peak power): 94.7 %, Ppower/W(peak power/weight): 95.8 %, and fatigue index: 93.6 %. Conclusion: By constructing and validating multiple regression equations for the anaerobic power cycle and body composition indices, this study showed that the probabilities of the values obtained from the equations falling within the 95 % confidence interval were 94.7 % for Mpower, 96.8 % for Mpower/W, 94.7 % for total work, 94.7 % for Ppower, 95.8 % for Ppower/W, and 93.6 % for fatigue index. Therefore, these equations may have some practical value in predicting the elite athlete population.

Biomechanical comparisons of F.E.R.I. techniques with different type of intramedullary screws fixation for Jones fractures.

Introduction: Jones fractures frequently fail to unite, and adequate fixation stability is crucial. This study aimed to elucidate the biomechanical stability of various intramedullary screw fixation constructs. Methods: Jones fracture model over the proximal 5th metatarsal of artificial bone was created in all specimens. Six groups were divided based on varied screw constructs with different screw lengths, either 30 or 40 mm, including cannulated screws-C30 and C40 groups, one high-resistance suture combined with intramedullary cannulated screws (F.E.R.I. technique)-CF30 and CF40 groups, and second-generation headless compression screws (SG-HCS) -HL30 and HL40 groups. Mechanical testing was conducted sequentially, and the maximal force (N) and stiffness (N/mm) of all constructs were recorded. Results: The maximal force (N) at 1.0 mm downward displacement in C30, C40, CF30, CF40, HL30, and HL40 groups were 0.56 ± 0.02, 0.49 ± 0.02, 0.65 ± 0.02, 0.49 ± 0.01, 0.68 ± 0.02, and 0.73 ± 0.02, respectively, and the stiffness (N/mm) in subgroups were 0.49 ± 0.01, 0.43 ± 0.01, 0.67 ± 0.01, 0.42 ± 0.01, 0.61 ± 0.01, and 0.58 ± 0.02, respectively. SG-HCS subgroups exhibited greater maximal force and stiffness than conventional cannulated screws. Screws of 30 mm in length demonstrated better stability than all 40 mm-length screws in each subgroup. In C30 fixation, the stiffness and maximum force endured increased by 1.16 and 1.12 times, respectively, compared with the C40 fixation method. There were no significant differences between CF30 and SG-HCS groups. Only the F.E.R.I technique combined with the 4.5 mm cannulated screw of 30 mm in length increased the biomechanical stability for Jones fractures. Discussion: These biomechanical findings help clinicians decide on better screw fixation options for greater stability in Jones fractures, especially when large-diameter screws are limited in use. However, this biomechanical testing of intramedullary screw fixation on Jones fracture model lacks clinical validation and no comparisons to extramedullary plate fixations. Moving forward, additional clinical and biomechanical research is necessary to validate our findings.

Effect of unilateral training and bilateral training on physical performance: A meta-analysis.

Background: In Unilateral (UNI) exercises are more effective than bilateral (BI) exercises in improving athletic performance is debatable. Objectives: this meta-analysis investigated the effects of UNI and BI exercises on different effect indicators of jump ability, sprint ability, maximal force, change of direction ability, and balance ability. Data Sources: PubMed, Google Scholar, Web of science, CNKI, Proquest, Wan Fang Data. Study Eligibility Criteria: To be eligible for inclusion in the meta-analysis, the study had to be: 1) athletes; 2) UNI training and BI training; 3) the intervention period had to be more than 6 weeks and the intervention frequency had to be more than 2 times/week; 4) the outcome indicators were jumping ability, sprinting ability, maximum strength, and change of direction and balance. Study Appraisal and Synthesis Method: We used the random-effects model for meta-analyses. Effect sizes (standardized mean difference), calculated from measures of horizontally oriented performance, were represented by the standardized mean difference and presented alongside 95% confidence intervals (CI). Results: A total of 28 papers met the inclusion criteria, and Meta-analysis showed that UNI training was more effective than BI training in improving jumping ability (ES = 0.61.0.23 to 0.09; Z = 3.12, p = 0.002 < 0.01), sprinting ability (ES = -0.02, -0.03 to -0.01; Z = 2.73, p = 0.006 < 0.01), maximum strength (ES = 8.95,2.30 to 15.61; Z = 2.64, p = 0.008 > 0.05), change of direction ability (ES = -0.03, -0.06 to 0.00; Z = 1.90, p = 0.06 > 0.01) and balance ability (ES = 1.41,-0.62 to 3.44; Z = 1.36, p = 0.17 > 0.01). The results of the analysis of moderating variables showed that intervention period, intervention frequency and intervention types all had different indicators of effect on exercise performance. Conclusion: UNI training has a more significant effect on jumping and strength quality for unilateral power patterns, and BI training has a more significant effect on jumping and strength quality for bilateral power patterns.

Anaerobic Speed Reserve, Sprint Force-Velocity Profile, Kinematic Characteristics, and Jump Ability among Elite Male Speed- and Endurance-Adapted Milers.

This study aimed to compare sprint, jump performance, and sprint mechanical variables between endurance-adapted milers (EAM, specialized in 1500-3000-m) and speed-adapted milers (SAM, specialized in 800-1500 m) and to examine the relationships between maximal sprint speed (MSS), anaerobic speed reserve (ASR), sprint, jump performance, and sprint mechanical characteristics of elite middle-distance runners. Fifteen participants (8 EAM; 7 SAM) were evaluated to obtain their maximal aerobic speed, sprint mechanical characteristics (force-velocity profile and kinematic variables), jump, and sprint performance. SAM displayed greater MSS, ASR, horizontal jump, sprint performance, and mechanical ability than EAM (p < 0.05). SAM also showed higher stiffness in the 40-m sprint (p = 0.026) and a higher ratio of horizontal-to-resultant force (RF) at 10 m (p = 0.003) and RFpeak (p = 0.024). MSS and ASR correlated with horizontal (r = 0.76) and vertical (r = 0.64) jumps, all sprint split times (r ≤ -0.85), stiffness (r = 0.86), and mechanical characteristics (r ≥ 0.56) during the 100-m sprint, and physical qualities during acceleration (r ≥ 0.66) and sprint mechanical effectiveness from the force-velocity profile (r ≥ 0.69). Season-best times in the 800 m were significantly correlated with MSS (r = -0.86). Sprint ability has a crucial relevance in middle-distance runners' performance, especially for SAM.

Methodological considerations for assessing whole-body strength capacity through isometric dynamometry.

The present study aimed to explore the possibility of comprehensively assessing whole-body muscle strength by testing as few muscle groups as possible, using a single testing method (isometric or isokinetic dynamometry) and a single variable (maximal force or rate of force development). Knee, hip, shoulder and elbow extensors and flexors were evaluated in males with high (n = 26) and low strength levels (n = 32). The principal component analysis revealed three factors that explained 62.5% of the total variance, while the main factors were loaded by the different testing methods and strength variables for the muscles acting on the knee (first component), hip (second component) and arm joints (third component). These results were confirmed by a three-way ANOVA which revealed a significant factor of group (P < 0.001) and the interaction test type × group (P = 0.002), but not of test type (P = 0.644), muscle group (P = 0.999), or their interactions (P > 0.205). The correlations of strength outcomes across the muscles ranged from trivial to very large (r range = -0.17, 0.84), being generally higher for the antagonistic muscles. Overall, a comprehensive assessment of whole-body muscle strength can be obtained using isometric dynamometry and maximal force, but it should consider at least one muscle group from the antagonistic pair.

Distinct Mechanisms for Increased Cardiac Contraction Through Selective Alteration of Either Myosin or Troponin Activity.

Modulation of sarcomere contractility represents a new therapeutic opportunity for the treatment of heart failure by directly targeting the thick and thin filament proteins of the sarcomere to increase cardiac muscle contraction. This study compared the effect of 2 small molecules (M and T) that selectively alter myosin thick filament (M) or troponin thin filament (T) activity on overall cardiac muscle mechanics. This study revealed key differences related to the mechanism utilized by M and T to increase contractile force generation and suggests that targeting different proteins within the sarcomere may result in differentiating therapeutic profiles.

Running patterns and force-velocity sprinting profiles in elite training young soccer players: A cross-sectional study.

The Volodalen® field method permits to classify runners into aerial or terrestrial, based on vertical oscillation, upper-body motion, pelvis and foot position at ground contact, and foot strike pattern. The present study aimed to compare the sprint running force-velocity profiles between aerial and terrestrial runners. Sixty-Four French National-Level young soccer players (28 females, 36 males) performed three trials of unloaded maximal 40 m sprints. External horizontal power-force-velocity relationships were computed using a validated biomechanical model and based on the velocity-time curve. Accordingly, the participants were classified into patterns in aerial and terrestrial runners. Terrestrial runners showed a higher maximal horizontal force (F0) (6.73 ± 1.03 vs 6.01 ± 0.94 N·kg-1), maximal horizontal power (Pmax) (14.04 ± 3.24 vs 12.51 ± 3.31W·kg-1), maximal acceleration (Acc) (6.83 ± 0.85 vs 6.26 ± 0.89 m·s-2), and maximal rate of horizontal force (RFmax) (57.41 ± 4.64 vs 52.81 ± 5.69%) compared to aerial runners. In contrast, terrestrial runners displayed a more negative rate of decrease of RF (DRF) (-11.65 ± 1.71 vs -10.23 ± 1.66%) and slope of the Force-Velocity relationship (F-V slope) (-0.83 ± 0.11 vs -0.77 ± 0.10 N·s·m-1·kg-1) than aerial runners. The results indicate that terrestrial runners displayed more efficient force production in the forward direction and displayed more "force-oriented" F-V profiles. Nevertheless, aerial runners were more effective in maintaining a net horizontal force production with increasing speed. Our results suggest that terrestrial runners could be more adapted to the specific short distance and high acceleration sprints running.

Preferred Music Genre Benefits During Strength Tests: Increased Maximal Strength and Strength-Endurance and Reduced Perceived Exertion.

The ability to increase muscle strength seems to be influenced by extrinsic factors such as the characteristics of an exercise environment. Given that many people train while listening to music, the music environment is an important research topic. However, no studies have investigated whether a preferred music genre differentially affects strength production when compared to a non-preferred music genre. This study evaluated the influence of listening to varied conditions of musical genre preference on maximal strength and strength-endurance testing, and on ratings of perceived exertion (RPE). We submitted 20 young men to three different listening conditions during strength testing: (a) preferred music genre (PMG), (b) non-preferred music genre (NPMG), and (c) no music (NM), with the order of these conditions randomized. We measured maximal strength with a handgrip dynamometer, strength-endurance through the participant's maximal repetition execution in the lat-pulldown exercise, and RPE by participant-completed Borg's scales at the end of the strength tests. Using three-way analyses of variances (ANOVAs) and a significance level of p < 0.05, we found that participants produced higher maximal strength, performed more repetitions of the lat-pulldown exercise, and reported decreased RPE in the PMG condition, compared to the NPMG (maximal strength p < 0.01, strength-endurance p < 0.01, RPE p = 0.016) and NM (maximal strength p < 0.01, strength-endurance p < 0.01, RPE p = 0.023) conditions. Individually determined PMG appears to improve maximal strength and strength-endurance performance during exercise, and to decrease RPE in the PMG condition.

A Single Bout of Foam Rolling Increases Flexibility of the Hip Adductor Muscles without Compromising Strength.

Foam rolling (FR) is a method of self-myofascial release (SMR) implemented to reduce tension in underlying soft tissue, leading to increased range of motion (ROM). The hip adductor muscles of the groin are commonly less flexible and often a site for soft tissue injuries. Limited research has been done to determine the most effective flexibility exercises to increase ROM in the groin muscles prior to exercise without comprising strength. The purpose was to determine the effect of an acute bout of FR on passive groin flexibility and strength. Randomized crossover study with 3 × 2 (Condition × Time) repeated measures ANOVA statistical design. 40 volunteers (n = 20 males; n = 20 females) with limited flexibility in groin ROM participated. Following warm-up, maximal voluntary isometric contraction (MVC) and static ROM were measured pre and postintervention. Conditions included 60 seconds of FR, SS, and CON. The Condition × Time interaction was not significant for MVC or ROM. A main effect of time showed a significant increase in ROM from pre to post for FR (1.2°, p < 0.001), SS (1.0°, p < 0.001), and CON (0.5°, p = 0.039). No significant changes in MVC were observed for FR from pre to post (p > 0.05), whereas SS and CON both increased (p < 0.05). An increase in passive groin ROM after acute bouts of SMR or SS without compromising MVC was observed. This suggests that 60 seconds of FR may be employed before exercise to improve flexibility without strength decrement.

Differences in Sprint Mechanical Force-Velocity Profile Between Trained Soccer and Futsal Players.

PURPOSE: To compare the sprint mechanical force-velocity (F-V) profile between soccer and futsal players. A secondary aim was, within each sport, to study the differences in sprint mechanical F-V profile between sexes and players of different levels. METHODS: A total of 102 soccer players (63 men) and 77 futsal players (49 men) who were competing from the elite to amateur levels in the Spanish league participated in this investigation. The testing procedure consisted of 3 unloaded maximal 40-m sprints. The velocity-time data recorded by a radar device were used to calculate the variables of the sprint acceleration F-V profile (maximal theoretical force [F0], maximal theoretical velocity [V0], maximal power [Pmax], decrease in the ratio of horizontal to resultant force [DRF], and maximal ratio of horizontal to resultant force [RFpeak]). RESULTS: Futsal players showed a higher F0 than soccer players (effect size [ES] range: 0.11-0.74), while V0 (ES range: -0.48 to -1.15) and DRF (ES range: -0.75 to -1.45) was higher for soccer players. No significant differences were observed between soccer and futsal players for Pmax (ES range: -0.43 to 0.19) and RFpeak (ES range: -0.49 to 0.30). Men and high-level players presented an overall enhanced F-V profile compared with women and their lower-level counterparts, respectively. CONCLUSIONS: The higher F0 and lower V0 of futsal players could be caused by the game's specific demands (larger number of accelerations but over shorter distances than in soccer). These results show that the sprint mechanical F-V profile is able to distinguish between soccer and futsal players.

Acute effect of taping on plantar pressure characteristics in athletes with exercise-induced leg pain: a description and comparison of groups.

OBJECTIVES: Foot pronation is considered as a potential risk factor of lower leg overuse injury. This study aimed to identify plantar pressure characteristics of elite athletes with exercise-induced leg pain in throwing athletic disciplines, and to verify the acute effect of taping for restricting foot pronation by analyzing the plantar pressure characteristics. METHODS: This study was designed as a description and comparison of throwing athletic athletes. Participants were divided into exercise-induced leg pain (ELP group, n = 17) and control groups (CON group, n = 14). Plantar pressure variables (contact area, maximum force, and peak pressure) at eight-foot regions in athletes' supporting leg were recorded during standing on one leg and a natural walk before and after applying anti-pronation or sham taping techniques. RESULTS: There are significant difference of contact area, maximal force, and peak pressure in some regions of their foot between the ELP and CON groups. But the anti-pronation taping decreased only the peak pressure in lateral midfoot of CON group during a natural walk (p = 0.002). CONCLUSION: The anti-pronation taping technique may not be effective preventive strategy from the exercise-induced leg pain, such as shin splints.

Differences between human septal and alar cartilage with respect to biomechanical features and biochemical composition.

Cartilage grafts have become popular in facial plastic surgery to reconstruct defects or to improve aesthetic outcomes in various applications. But there is a considerable rate of graft failure like resorption or deformation. To improve graft survival and function, accurate understanding of the properties of the recipient site is indispensable. Therefore 10 noses of human cadavers were meticulously dissected and specimens of alar and septal cartilage subjected to confined compression and tensile tests. Furthermore, cell number, glycosaminoglycan and hydroxyproline content were measured. RESULTS: showed a significant difference (p < 0.05) of alar and septal cartilage regarding Equilibrium Modulus, cell number and glycosaminoglycan but not hydroxyproline content. Tensile tests showed a significant difference (p < 0.001) between alar and septal cartilage (vertical vector of force) for E-modulus, maximal force and maximal strain but not for horizontal vector of force. There was a significant difference (p < 0.05) within septal cartilage samples depending on vector of force (vertical vs. horizontal). Finally multifactorial linear regression allowed an estimation of Equilibrium Modulus depending on compression, glycosaminoglycan content and cell number with statistical significance (p < 0.05). In conclusion, nasal cartilage differs in function and composition depending on anatomical location and the prevalent forces. Therefore further research will be necessary to evaluate if graft failure depends on a mismatch of functional properties and if grafts can be adapted to the recipient site.

The Influence of Verbal Instruction on Measurement Reliability and Explosive Neuromuscular Performance of the Knee Extensors.

The current study aimed to examine the effect of verbal instruction on explosive force production and between-session measurement reliability during maximal voluntary contractions of knee extensors. Following familiarization, 20 healthy males performed 3 maximal contractions with a "hard-and-fast" instruction and 3 maximal contractions with a "fast" instruction during 2 test-retest sessions. Knee extension maximal voluntary force (Fmax) and the maximal rate of force development (RFDmax) were measured. Maximal electromechanical delay (EMDmax), and the maximal rate of muscle activation (RMAmax) of quadriceps muscles were determined. No significant effect of instruction was observed on Fmax (p > 0.05). The RFDmax and RMAmax were significantly higher with the "fast" compared to the "hard-and-fast" instruction (36.07%, ES = 1.99 and 37.24%, ES = 0.92, respectively), whereas EMDmax was significantly lower with the "fast" instruction compared to the "hard-and-fast" instruction (-3.79%, ES = - 0.29). No significant differences between test and retest measurements were found (p < 0.05). However, the reliability of the RFDmax was higher with the fast instruction compared to the hard-and-fast instruction (CV: 7.3 vs. 16.2%; ICC: 0.84 vs. 0.56). Besides, the RFDmax was associated with the RMAmax and EMDmax with a significant effect of instruction. Data showed that the instruction given prior contracting muscle affected explosive force production and associated neuromuscular variables. As a result, the "fast" instruction may be preferred in the assessment of explosive force capacity of skeletal muscle during maximal efforts.