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1.
BMC Public Health ; 23(1): 2418, 2023 12 05.
Artigo em Inglês | MEDLINE | ID: mdl-38053131

RESUMO

BACKGROUND: Despite major improvements in child survival over the past decade, many children in low and middle-income countries (LMICs) remain at risk of not reaching their developmental potential due to malnutrition, poor health, and a lack of stimulation. Maternal engagement and stimulation have been identified as some of the most critical inputs for healthy development of children. However, relatively little evidence exists on the links between maternal stimulation and child development exists in sub-Saharan Africa (SSA). This current paper aims to identify the associations between maternal stimulation and child development in Kenya and Zambia, as well as the activities that are most predictive of developmental outcomes in these settings. METHODS: We conducted a descriptive study using data from a prospective study in Kenya and Zambia. The study included three rounds of data collection. Children were on average 10 months old in round one, 25 months old in round two, and 36 months old in round three. The primary exposure variable of interest was maternal stimulation activities, which we grouped into cognitive, language, motor, and socio-emotional activities. The outcome of interest was child development measured through the Third Edition of the Ages and Stages Questionnaire (ASQ-3). Linear regression models were used to estimate the associations between overall maternal stimulation and domain-specific maternal stimulation and child development across the three rounds of the survey. RESULTS: Higher maternal stimulation scores were associated with higher ASQ scores (effect size = 0.25; 95% CI: 0.19, 0.31) after adjusting for other confounders. For domain specific and child development (ASQ scores), the largest effect size (ES) was found for language stimulation (ES = 0.15) while weakest associations were found for socio-emotional domain activities (ES= -0.05). Overall maternal stimulation was most strongly associated with gross motor development (ES = 0.21) and the least associated with problem-solving (ES = 0.16). CONCLUSION: Our study findings suggest a strong positive link between maternal stimulation activities and children's developmental outcomes among communities in poor rural settings. TRIAL REGISTRATION: NA (not a clinical trial).


Assuntos
Desenvolvimento Infantil , Família , Criança , Humanos , Lactente , Pré-Escolar , Desenvolvimento Infantil/fisiologia , Zâmbia/epidemiologia , Quênia/epidemiologia , Estudos Prospectivos
2.
J Sports Sci ; 40(21): 2371-2383, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36576089

RESUMO

Being and perceiving oneself as proficient in motor skills seems essential for an active lifestyle; conversely, being active and perceiving oneself as proficient may be associated with greater motor competence. By expanding the causal path view about the relationship between active and healthy developmental system elements, this study tested the mediation hypothesis of perceived motor competence in the relationship between motor competence and physical activity - in both ways - and moderation by developmental phase and sex. This cross-sectional study sampled healthy schoolchildren (n = 379; 8.2 ± 1.7 years; 54.9% boys). Physical activity (questionnaire), motor competence (tests included locomotor and object control skills) and perception of motor competence (a pictorial scale) were assessed. Maximum likelihood structural equation models with fit statistics confirmed the mediation in both ways. Unexpectedly, the relationship between motor competence and physical activity was inverse. Sex was a moderating variable (boys). In a systemic relational paradigm of human development, perceived motor competence, motor competence, and physical activity interact in an active and healthy behavioural system, but the complexities of understanding how these elements relate to one another across childhood point to the need for future longitudinal studies.


Assuntos
Exercício Físico , Destreza Motora , Masculino , Humanos , Criança , Feminino , Estudos Transversais , Estudos Longitudinais , Análise de Sistemas
3.
Cerebellum ; 15(3): 336-42, 2016 06.
Artigo em Inglês | MEDLINE | ID: mdl-26202671

RESUMO

We investigated how subjects with cerebellar ataxia (CA) adapt their postural stability and alignment to a slow and small tilt of the support surface allowing for online postural corrections. Eight subjects with CA and eight age- and gender-matched healthy control subjects participated in the study. Subjects stood eyes closed for 1 min after which the support surface was tilted 5° toes-up at a ramp velocity of 1°/s. The toes-up position was held for 2.5 min after which the surface rotated back down to level with identical tilt characteristics. As reflected by the large number of falls, subjects with CA had marked difficulty adapting their posture to the up-moving incline in contrast to control subjects. Subjects with CA who lost their balance had faster trunk velocity and excessive backward trunk reorientation beginning within the first second after onset of the tilting surface. In contrast, the down-moving tilt to level did not result in instability in CA subjects. These results suggest that instability and falls associated with CA derive from an inability to maintain trunk orientation to vertical while standing on a slow-moving or unstable surface. This study underscores the importance of the cerebellum in the online sensory control of the upper body orientation during small amplitude and slow velocity movements of the support surface.


Assuntos
Acidentes por Quedas , Ataxia Cerebelar , Equilíbrio Postural , Postura , Idoso , Fenômenos Biomecânicos , Ataxia Cerebelar/fisiopatologia , Feminino , Humanos , Perna (Membro)/fisiopatologia , Masculino , Pessoa de Meia-Idade , Tronco/fisiopatologia
4.
J Spinal Cord Med ; : 1-12, 2024 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-39172032

RESUMO

OBJECTIVE: The primary objective of this study was to quantify changes in performance of task-specific motor activities over 12 motor rehabilitation sessions with lumbosacral spinal cord stimulation (SCS) via either transcutaneous stimulation or epidural stimulation. Both stimulation modalities have been used in recent years to restore functions lost to spinal cord injury (SCI). Secondary outcomes examine participants' perspectives captured via the User Experience Questionnaire (UEQ) upon study completion to further understand their perception of SCS. METHODS: Six individuals with SCI completed 12 sessions with one modality of SCS during supine and/or side-lying, seated forward reaching, and standing activities. Changes in volitional lower extremity movement, the number of points of contact needed at hips and/or knees to facilitate standing, and changes in seated forward reaching distance were used to quantify performance. The UEQ was administered to gauge participants' perspectives following use of SCS to enable functions impaired due to SCI. RESULTS: For all participants, performance of motor activities improved with SCS compared to without stimulation. Responses for the UEQ showed an overall positive perception of trialing SCS with rehabilitation to enhance motor functions impaired by SCI. CONCLUSIONS: Regardless of injury severity, location of injury, time since SCI, or SCS modality, all participants experienced gains in motor function in the presence of SCS combined with a condensed rehabilitation program. However, no evidence of sustained motor functions was found in the absence of SCS. UEQ results highlight the positive perception of SCS with rehabilitation as well as the importance of consulting persons with lived experience of SCS during clinical trial design and protocol development.Trial registration: ClinicalTrials.gov identifier: NCT05095454.

5.
J Basic Clin Physiol Pharmacol ; 34(6): 791-795, 2023 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-36209355

RESUMO

OBJECTIVES: The present study was undertaken to observe the effectiveness of electrical vestibular stimulation on the range of motion (ROM) in patients with Parkinson's disease (PD). METHODS: The present study was a randomized controlled trial (ClinicalTrials.gov Identifier: NCT04450550). The study participants were assessed at three points of time. After recording baseline cognitive functions, electrical vestibular nerve stimulation was administered to the intervention group and placebo stimulation was administered to the control group for 12 weeks. Post-intervention parameters were recorded after 6 weeks and after 12 weeks after the intervention in both control and intervention groups. A total of 30 cases of PD, including both males and females were recruited in the study by convenient sampling after obtaining written informed consent. All ROM and flexibility measurements were recorded using a universal goniometer and standard protocol with help of an experienced physiotherapist at our hospital. RESULTS: There was a significant improvement in the hip internal and external rotation right and left sides. There was a significant improvement in the hip extension right and left. There was a significant improvement in the ankle plantarflexion left and ankle dorsiflexion right and left followed by the intervention. There was a significant decline in the hip internal rotation on right and left sides. There was a significant decline in the hip extension and ankle dorsiflexion on the left side. CONCLUSIONS: The study results confirm the improvement of motor activities of patients with PD followed by vestibular stimulation. Further detailed studies are recommended to support the application of vestibular stimulation as an alternative therapy in the management of motor functions in patients with PD.


Assuntos
Doença de Parkinson , Masculino , Feminino , Humanos , Doença de Parkinson/terapia , Nervo Vestibular , Amplitude de Movimento Articular/fisiologia
6.
Children (Basel) ; 10(12)2023 Nov 28.
Artigo em Inglês | MEDLINE | ID: mdl-38136066

RESUMO

The aim was to explore longitudinal motor development in children with cerebral palsy (CP) in Sweden with respect to the Gross Motor Function Classification System (GMFCS). In this national CP registry-based study, 2138 children aged 0.5-19 years participated (42% girls). The distribution with respect to GMFCS was I: 49%, II: 16%, III: 10%, IV: 14%, and V: 11%. In total, 5538 assessments (mean 2.7, min-max: 1-9) with the Gross Motor Function Measure-66 were included. Data were analysed using non-linear mixed-effects regression models, and the Stable Limit Model was selected to fit data. Five distinct curves of predicted gross motor development with respect to GMFCS levels were obtained. The achieved motor development was maintained over time. The estimated average GMFM-66 limit and the average age when 90% of the expected limits were reached were at GMFCS I: 88 at age 4.5; GMFCS II: 71 at age 4.2; GMFCS III: 54 at age 3.1; GMFCS IV: 38 at age 2.6, and at GMFCS V: 18 at age 0.9. In conclusion, this is the first national population-based study following motor development in CP. Five distinct curves reported in previous controlled research studies were confirmed. Our study adds knowledge about motor development captured in children's everyday context.

7.
AIMS Neurosci ; 9(4): 460-478, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36660078

RESUMO

Background: Piper guineense and honey contain antioxidative, anti-inflammatory, and antimicrobial properties that can help restore neuronal and other cell damage. To investigate the neuromodulatory roles of p. guineense and honey against lead toxicity on the hippocampus and cerebellum, impairing social behaviors and motor activities. Methodology: Thirty Wistar rats were separated into six groups of five rats each, marked with dye. Group A served as control; B was untreated lead; C was a medium dose of the extract (50 mg/kg) and honey (1000 mg/kg); D was a high dose of the extract (80 mg/kg) and honey (1500 mg/kg); E received extract (80 mg/kg), and F received honey (1500 mg/kg). All groups received 110 mg/kg of lead orally, except the control. Social interaction, antidepressant effects, and motor activities were studied using a sociability chamber (SC), Forced Swim Test (FST), and String methods. A blood sample was used to evaluate glutathione peroxidase (GPx) and glutathione oxide transaminase (GOT), while the lipid level was estimated using cerebellar homogenate. Neuronal damage, vacuolation, necrosis, cell degeneration, and alterations in both hippocampus and cerebellum marked untreated group, with decreased GPx and GOT activities followed by impaired motor activities, social behavior, memory, and motivation. Using SCT, group B spent significantly lesser time (47.60 ± 47.60) with stranger 1 compared to A (138.20 ± 34.05), while group C spent considerably more time with stranger 1 (86.80 ± 30.32) than group B at P ≥ 0.05. The treatment increased the enzyme level and restored histoarchitecture (Figures 1-12), improving motor activities, social behavior, memory, motivation, and social affiliation (Tables 3, 4, 2, and 6). The extract and honey may be helpful as neuromodulators in lead toxicity in a dose-dependent manner.

8.
JMIR Serious Games ; 10(4): e38972, 2022 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-36350683

RESUMO

BACKGROUND: The increasing number of children with cerebral palsy (CP) has a serious impact on individuals, families, and society. As a new technology, virtual reality (VR) has been used in the rehabilitation of children with CP. OBJECTIVE: This study aimed to systematically evaluate the effect of VR training on balance, gross motor function, and daily living ability in children with CP. METHODS: PubMed, Embase, The Cochrane Library, Web of Science, and China National Knowledge Infrastructure databases were searched by computer, with the search period being from the establishment of each database to December 25, 2021, to collect randomized controlled trials (RCTs) on the effects of VR training on balance, gross motor function, and daily living ability in children with CP. The Cochrane risk of bias assessment tool was used to conduct quality assessment on the included literature, and RevMan software (version 5.3) was used to analyze data. RESULTS: A total of 16 articles were included, involving 513 children with CP. VR training can improve the balance function (Pediatric Balance Scale: mean difference 2.06, 95% CI 1.15-2.97; P<.001; Berg Balance Scale: mean difference 3.66, 95% CI 0.29-7.02; P=.03) and gross motor function (standardized mean difference [SMD] 0.60, 95% CI 0.34-0.87; P<.001) of children with CP. However, there is still certain disagreement on the impact on daily living ability (SMD 0.37, 95% CI -0.04 to 0.78; P=.08); after removing the source literature with heterogeneity, VR training can improve the daily living ability of children with CP (SMD 0.55, 95% CI 0.30-0.81; P<.001). CONCLUSIONS: VR training can significantly improve the balance function and gross motor function of children with CP, but the effect on the daily living ability of children with CP remains controversial.

9.
Front Aging Neurosci ; 12: 539598, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33132893

RESUMO

Introduction: Motor and cognitive deficits were compared in aging, chronically treated human immunodeficiency virus (HIV) people, people with mild-to-moderate stage Parkinson's disease (PD), and healthy controls. Methods: Groups consisted of 36 people with PD, 28 with HIV infection, and 28 healthy controls. Motor function was assessed with the Unified Parkinson's Disease Rating Scale (MDS-UPDRS-III) and a rapid alternating finger tapping (RAFT) task on an engineered keyboard known as Quantitative Digitography (QDG). Executive function, verbal memory, and visuospatial processing were assessed using standard neuropsychological tests. Results: HIV demonstrated RAFT deficits similar to PD such as reduced amplitude (P = 0.023) and greater amplitude variability (P = 0.019) in the index finger when compared to controls. This fine motor disturbance correlated with HIV's immune health, measured by their CD4+ T cell count (P < 0.01). The UPDRS did not yield motor differences between HIV and controls. Executive function and verbal memory were impaired in HIV (P = 0.006, P = 0.016, respectively), but not in PD; visuospatial processing was similarly impaired in HIV and PD (P < 0.05) although motor deficits predominated in PD. Conclusions: Fine motor bradykinesia measured quantitatively by QDG RAFT holds promise as a marker of motor decline related to current immune health in aging HIV patients and may be useful in longitudinal studies regarding mechanisms of immunosenescence vs. potential toxicity of combination antiretroviral therapy (cART) in this population. Additionally, motor and cognitive networks in HIV may be affected differently as the disease progresses as observed in the differential patterns of impairment between HIV and PD, providing insight into the mechanisms of brain deterioration in HIV.

10.
Dev Neurorehabil ; 20(3): 149-159, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27019351

RESUMO

OBJECTIVE: This systematic review aimed to list the tools used by rehabilitation professionals to test motor abilities in children with cerebral palsy (CP), to determine if these tools have psychometric properties specifically measured for CP, and to identify the main characteristics of these tools. METHOD: Web of Science, PEDro, PubMed/MEDLINE, Science Direct, and SciELO databases were searched to identify the tools. PubMed/MEDLINE was then searched to identify the studies assessing those tools' psychometric properties. The agreement-based standards for the selection of health measurement tools and the Terwee criteria were used to assess the quality and the results of each included study, respectively. RESULTS: Eighteen tools were identified. The psychometric properties of many of the tools used with children with CP have not been evaluated for this population. CONCLUSION: The psychometric properties evaluated often have a poor methodological quality of measurement. Overall, we suggest the tools with most empirical support to evaluate children with CP.


Assuntos
Paralisia Cerebral/diagnóstico , Reabilitação Neurológica/métodos , Psicometria/instrumentação , Índice de Gravidade de Doença , Criança , Humanos
11.
J Spinal Cord Med ; 39(5): 527-34, 2016 09.
Artigo em Inglês | MEDLINE | ID: mdl-26781769

RESUMO

OBJECTIVE: To provide validation of functional ability levels for the Spinal Cord Injury - Functional Index (SCI-FI). DESIGN: Cross-sectional. SETTING: Inpatient rehabilitation hospital and community settings. PARTICIPANTS: A sample of 855 individuals with traumatic spinal cord injury enrolled in 6 rehabilitation centers participating in the National Spinal Cord Injury Model Systems Network. INTERVENTIONS: Not Applicable. MAIN OUTCOME MEASURES: Spinal Cord Injury-Functional Index (SCI-FI). RESULTS: Cluster analyses identified three distinct groups that represent low, mid-range and high SCI-FI functional ability levels. Comparison of clusters on personal and other injury characteristics suggested some significant differences between groups. CONCLUSIONS: These results strongly support the use of SCI-FI functional ability levels to document the perceived functional abilities of persons with SCI. Results of the cluster analysis suggest that the SCI-FI functional ability levels capture function by injury characteristics. Clinical implications regarding tracking functional activity trajectories during follow-up visits are discussed.


Assuntos
Escala de Gravidade do Ferimento , Exame Neurológico/normas , Traumatismos da Medula Espinal/patologia , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Exame Neurológico/métodos , Traumatismos da Medula Espinal/classificação
12.
Technol Health Care ; 24(5): 665-72, 2016 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-27198463

RESUMO

BACKGROUND: Obesity is one of the biggest drivers of preventable chronic diseases and healthcare costs in Worldwide. Different prevention activities are suggested. By monitoring daily energy expenditure (EE) could be possible make personalized diets and programming physical activity. In this, physical inactivity is one of the most important public health problems. Some studies refer the effort of the international community in promoting physical activities. Physical activity can be promoted only by increasing citizens' empowerment on taking care of their health, and it passes from the improving of individual information. Technology can offer solutions and metrics for monitoring and measuring daily activity by interacting with individuals, sharing information and feedbacks. OBJECTIVE: In this study we review indicators of total energy expenditure and weaknesses of available devices in assessing these parameters. METHODS: Literature review and technology testing EuNetHta core model. RESULTS: For the clinical aspects, it is fundamental to take into account all the factor that can influence the personal energy expenditure as: heart rate, blood pressure and thermoregulation (influenced by the body temperature). DISCUSSION: In this study we focused the attention on the importance of tools to encourage the physical activity. We made an analysis of the factor that can influence the right analysis of energy expenditure and at the same time the energy regime. A punctual monitoring of the exercise regime could be helpful in Telemedicine application as Telemonitorig. More study are needed to value the impact of physical activity tracker in Telemonitorig protocols. CONCLUSION: On the assessment of the energy expenditure, critical issues are related to the physiological data acquisition. Sensors connected with mobile devices could be important tools for disease prevention and interventions affecting health behaviors. New devices applications are potential useful for telemedicine assistance, but security of data and the related communication protocol limits should be taking into account.


Assuntos
Metabolismo Energético/fisiologia , Exercício Físico/fisiologia , Monitorização Ambulatorial/instrumentação , Telemedicina/instrumentação , Pressão Sanguínea , Regulação da Temperatura Corporal , Comportamentos Relacionados com a Saúde , Frequência Cardíaca , Humanos , Hipotálamo/metabolismo
13.
Cienc. act. fís. (Talca, En línea) ; 22(2): 32-43, 2021. graf, tab
Artigo em Espanhol | LILACS | ID: biblio-1361616

RESUMO

RESUMEN. El objetivo principal de esta investigación fue evaluar el efecto de un programa de educación física con actividades motrices en niños con discapacidad intelectual inscritos en el Centro de Atención Múltiple de la ciudad de Hermosillo, Sonora. Se realizó un estudio cuantitativo de diseño cuasi-experimental con medias repetidas pretest-postest no aleatorizado, siendo cada participante su propio control. La muestra por conveniencia estuvo conformada por 12 niños en un rango de edad de 7a 10 años (9 ±1.04). La evaluación se llevó a cabo por medio del Inventario de Desarrollo Battelle, el cual se aplicó al inicio y al final del programa, el cual tuvo una duración de tres meses. Se utilizó material didáctico reciclado para estimular los aspectos motrices que se deseaban. Los resultados muestran cambios significativos en la coordinación corporal y en locomoción (p=0.006). Se concluye que aplicar un programa de educación física con actividades motrices de manera regular, a niños con discapacidad, puede contribuir desarrollar de mejor manera las habilidades de motricidad superando su edad equivalente.


ABSTRACT. The main objective of this research was to evaluate the effect of a physical education program with motor activities in children with intellectual disabilities enrolled in the Multiple Attention Center of the city of Hermosillo, Sonora. A quantitative study of quasi-experimental design with repeated means pretest-posttest non-randomized, with each participant being his/her own control was carried out. The convenience sample consisted of 12 children in an age range of 7to 10 years (9 ±1.04). The evaluation was carried out by means of the Battelle Development Inventory, which was applied at the beginning and at the end of the three-month program. Recycled didactic material was used to stimulate the desired motor aspects. The results show significant changes in body coordination and locomotion (p=0.006). It is concluded that applying a physical education program with motor activities on a regular basis to children with disabilities can contribute to better develop motor skills beyond their age equivalent.


Assuntos
Humanos , Masculino , Feminino , Criança , Educação Física e Treinamento/métodos , Planos e Programas de Saúde , Deficiência Intelectual , Atividade Motora , Locomoção
14.
São Paulo med. j ; 138(6): 545-553, Nov.-Dec. 2020. tab
Artigo em Inglês | LILACS, SES-SP | ID: biblio-1145133

RESUMO

ABSTRACT BACKGROUND: Being active has been shown to have beneficial effects for the health of individuals with chronic diseases. However, data on the association between multimorbidity and physical activity are limited. OBJECTIVE: To investigate the association between chronic diseases, multimorbidity and insufficient physical activity among older adults in southern Brazil, according to sex. DESIGN AND SETTING: Cross-sectional population-based and household-based study derived from the second wave (2013-2014) of the EpiFloripa Aging Cohort Study. METHODS: Insufficiency of physical activity (outcome) was ascertained using the long version of the International Physical Activity Questionnaire (≤ 150 minutes/week). Eleven self-reported chronic diseases were identified. Multimorbidity was defined from the number of chronic diseases (none; 2 or 3; or 4 or more). The adjustment variables were age, schooling, marital status, income, smoking, alcohol consumption and cognition. Additionally, each chronic disease was adjusted for the others. Associations were tested using logistic regression (crude and adjusted). RESULTS: Among the 1197 participants (≥ 63 years), women (54.0%) were more likely than men (39.6%) to be insufficiently active. In the adjusted analysis, women and men with depressive symptoms, and men with diabetes, were more likely to be insufficiently active than those without symptoms. Multimorbid women were more likely to be insufficiently active, and the magnitude of the effect was strongest for 4 or more diseases. CONCLUSION: This study indicates that the associations were sex-specific. Depressive symptoms and multimorbidity were associated with insufficient physical activity among women, while diabetes was associated with insufficient physical activity among men.


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Doença Crônica/epidemiologia , Comportamento Sedentário , Multimorbidade , Brasil/epidemiologia , Estudos Transversais
15.
Res Dev Disabil ; 35(8): 1863-7, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24794321

RESUMO

The principle of this study was to use the finger-pressing position detection program (FPPDP) with a standard keyboard to improve the fine motor activities of disabled people through environmental stimulation. The FPPDP is a software solution which turns a standard keyboard into a finger-pressing position detector. By using this technique, this study tried to find out whether two students with developmental disabilities would be able to effectively perform fine motor activities through the triggering of environmental stimulation. This study was based on an ABAB design and the results showed that both participants demonstrated an obvious increase in terms of their willingness to perform target responses during the intervention phases. The practical and developmental implications of the findings are discussed.


Assuntos
Auxiliares de Comunicação para Pessoas com Deficiência , Periféricos de Computador , Deficiências do Desenvolvimento/reabilitação , Pessoas com Deficiência/reabilitação , Educação de Pessoa com Deficiência Intelectual/métodos , Dedos , Destreza Motora/fisiologia , Adolescente , Comunicação , Humanos , Masculino , Software
16.
Brain Res ; 1582: 227-36, 2014 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-25084038

RESUMO

Potentiation of GABAergic inhibition is a mechanism of action of many antiepileptic drugs. The potential use of an agonist of GABAA receptors, muscimol, as an antiepileptic drug was studied in immature rats by assessing anticonvulsant activity and side effects on motor activities. Anticonvulsant action was tested in two models of seizures (pentetrazol-induced convulsions and cortical epileptic afterdischarges). Off target effect on motor performance was assessed in a battery of tests and in the open field in three age groups (12-, 18- and 25-day-old rats). Muscimol was administered in doses from 0.1 to 1mg/kg i.p. Only the 1 mg/kg dose exhibited marked anticonvulsant effect against pentetrazol-induced convulsions in 12- and 18-day-old rats, proconvulsant effect was observed in the second model in 18- and 25-day-old rats as prolongation of afterdischarges. Even the 0.5 mg/kg dose suppressed spontaneous locomotion and heavily compromised motor performance. The effect on motor activity was marked in the youngest group and decreased with age. Due to the low anticonvulsant potency and serious side effects, systemic administration of a competitive agonist of GABAA receptors in immature animals is not a promising strategy for new anticonvulsants.


Assuntos
Anticonvulsivantes/farmacologia , Encéfalo/efeitos dos fármacos , Agonistas de Receptores de GABA-A/farmacologia , Atividade Motora/efeitos dos fármacos , Muscimol/farmacologia , Convulsões/tratamento farmacológico , Fatores Etários , Animais , Encéfalo/crescimento & desenvolvimento , Encéfalo/fisiopatologia , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Eletroencefalografia , Epilepsia/tratamento farmacológico , Epilepsia/fisiopatologia , Comportamento Exploratório/efeitos dos fármacos , Comportamento Exploratório/fisiologia , Masculino , Atividade Motora/fisiologia , Testes Neuropsicológicos , Pentilenotetrazol , Ratos Wistar , Convulsões/fisiopatologia , Índice de Gravidade de Doença
17.
Rev. bras. ativ. fís. saúde ; 24: 01-05, out. 2019.
Artigo em Inglês | LILACS | ID: biblio-1026741

RESUMO

The Academia da Cidade program (ACP), linked to the Health Secretariat of Recife, Pernambuco since 2002, is a component of health policy focused on Primary Care and aims to promote physical activities, healthy eating and health education. The study aimed to map the scientific production on the ACP. This is a mapping review study with the following steps: (1) clarifying the research question; (2) identifying relevant studies; (3) selecting studies; (4) mapping the studies; (5) summarizing and reporting the results. Searches were made in the Virtual Health Library, Pubmed, Scielo and LILACS databases. Were excluded articles that did not address PAC (n = 17), review articles (n = 2), and articles that analyzed other programs (n = 2) and 16 articles were excluded because they did not present the ACP as the focus of the analysis. Eight studies were identified on this theme. The study identified that most articles focus on types I and II of evidence and that only one article presented the theoretical contribution of policy science in its theoretical scope. We conclude that more research is needed to contribute with more reliable frameworks and methodologies, in line with the public policy analysis process


O Programa Academia da Cidade (PAC), vinculado à Secretaria de Saúde do Recife, Pernambuco, desde o ano de 2002, é um componente da política de saúde voltado à Atenção Primária e tem como objetivo a promoção da prática de atividades físicas, alimentação saudável e educação para a saúde. O objetivo deste estudo foi mapear a produção científica sobre o PAC. Trata-se de um estudo de revisão de mapeamento com as seguintes etapas: (1) esclarecer a pergunta da pesquisa; (2) identificar estudos relevantes; (3) selecionar estudos; (4) mapear os estudos; (5) resumir e reportar os resultados. Foram realizadas buscas nas bases de dados Biblioteca Virtual de Saúde, Pubmed, Scielo e LILACS. Foram excluídos artigos que não abordavam o PAC (n = 17), artigos de revisão (n = 2) e artigos que analisaram outros programas (n = 2) e 16 artigos foram excluídos por não apresentar o PAC como foco da análise. Foram identificados oito artigos científicos sobre o tema. Maior parte dos artigos se concentram nos tipos I e II de evidências e apenas um artigo apresentou aporte teórico da ciência política em seu escopo teórico. Conclui-se que mais investigações são necessárias para contribuir com frameworks e metodologias mais fidedignas e alinhadas com o processo de análise de políticas públicas


Assuntos
Política Pública , Política de Saúde , Promoção da Saúde , Atividade Motora
18.
Open Cardiovasc Med J ; 6: 156-62, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23346259

RESUMO

OBJECTIVES: Questionnaires on physical activity (PA) and physical capacity (PC) are valuable tools, as they are cost beneficial, and have high response rates. The validity of short versions of such questionnaires has not been examined satisfactorily. Therefore, we aimed at examining the validity of a set of questions coding for PA and PC. DESIGN: The questions were administered to 217 men and women attending a cardiac rehabilitation program. Participants also gave blood samples, measuring HDL cholesterol, triglycerides (TG), insulin, glucose, and microCRP. The relations between PA and PC and biological markers were examined by linear regression analyses. RESULTS: Measures for PC and for PA were identified by factor analysis, which proved internally consistent. TG, homeostatic model assessment (HOMA) score, and mCRP were all significantly associated with the measures of PC and PA. CONCLUSIONS: The measures of PA and PC are valid compared with biological markers, allowing cost-beneficial and time-efficient evaluation of important measures for cardiovascular health.

19.
Psicol. reflex. crit ; 27(4): 740-747, Oct-Dec/2014. tab, graf
Artigo em Inglês | LILACS, Index Psi Periódicos Técnico-Científicos | ID: lil-728847

RESUMO

The aim of the present study was to examine the effects of motor tasks through photos and videos in post-stroke patients. Participants were 12 patients and 10 control people. Five functional tasks were presented in four different sequences and participants had to indicate the ones which reached the goal correctly. By ANOVA it was found that the response time of the patients was greater than of the control group (photos = patients: 4833 ± 310 ms, control: 1112 ± 76 ms, p = .0001 and videos = patients: 3655 ± 242 ms, control: 2451 ± 270 ms, p = .0001). Patients performed better with videos (p = .001). These results may influence therapeutic strategies and enable a discussion about a possible impairment of the mirror neuron system. (AU)


O objetivo deste estudo foi analisar os efeitos da demonstração de tarefas motoras através de fotos e vídeos em pacientes pós-AVE (acidente vascular encefálico). Participaram 12 pacientes e 10 controles. Cinco tarefas funcionais foram apresentadas em quatro sequências diferentes e os participantes indicavam aquela que alcançava o objetivo corretamente. Pela ANOVA verificou-se que o tempo de resposta dos pacientes foi maior (fotos = pacientes: 4833 ± 310 ms, controle: 1112 ± 76 ms, p = 0,0001 e vídeos = pacientes: 3655 ± 242 ms; controle: 2451 ± 270 ms, p= 0,0001). Os pacientes apresentaram melhor desempenho com os vídeos (p= 0,001). Estes resultados podem influenciar as estratégias terapêuticas e permitir uma discussão a respeito de um possível impedimento do sistema de neurônios-espelho. (AU)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Atividades Cotidianas/psicologia , Reconhecimento Psicológico , Neurônios-Espelho , Reabilitação do Acidente Vascular Cerebral/métodos , Atividade Motora
20.
Rev. bras. med. esporte ; 15(1): 27-30, jan.-fev. 2009. tab
Artigo em Português | LILACS | ID: lil-507718

RESUMO

O objetivo deste trabalho foi avaliar a associação entre prática de atividade física na adolescência e osteoporose na vida adulta. Realizou-se um estudo de base populacional incluindo uma amostra aleatória de 1.016 indivíduos de 50 anos ou mais. Atividade física no lazer foi avaliada utilizando o Questionário Internacional de Atividade Física - IPAQ. Os indivíduos foram definidos como ativos se estiveram engajados em atividade física durante a sua adolescência (10-19 anos) pelo menos por seis meses consecutivos. Os indivíduos ativos na adolescência demonstraram probabilidade 67 por cento menor do que os inativos de apresentar osteoporose na vida adulta (p < 0,001). Esse resultado se manteve significativo após ajuste para os fatores de confusão (p = 0,005) e para o efeito mediador do nível de atividade física na idade adulta (p = 0,007). Conclui-se que a prática de atividade física na adolescência reduz o risco de osteoporose, independentemente do nível de atividade física na vida adulta. Desse modo, a adolescência é um importante período no desenvolvimento da saúde óssea.


The aim of the present study was to assess the association between physical activity practice in adolescence and the prevalence of osteoporosis in adulthood. A population-based study with a randomly-selected sample of 1.016 individuals, aged 50 years or older was carried out. Leisure physical activity was assessed using the International Physical Activity Questionnaire (IPAQ). Individuals were defined as active in adolescence (10-19 years) if had been engaged in physical activity for at least six consecutive months. Individuals classified as active in adolescence were 67% less likely to present osteoporosis in adulthood than inactive ones (p/

Assuntos
Humanos , Adolescente , Adulto , Envelhecimento , Densidade Óssea , Estudos Transversais , Exercício Físico , Probabilidade , Risco
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