RESUMO
Dinitrogen tetroxide is often used as an oxidant in rocket propellant and has strong irritant and corrosive properties. This paper analyzes the clinical data of a patient with dinitrogen tetroxide poisoning admitted in the 63710 Army Hospital of Chinese People's Liberation Army, so as to further explore the poisoning mechanism, clinical characteristics and key points of acute inhaled dinitrogen tetroxide poisoning.
Assuntos
Exposição por Inalação , Óxidos de Nitrogênio , Adulto , Humanos , Masculino , Exposição por Inalação/efeitos adversos , Óxidos de Nitrogênio/intoxicaçãoAssuntos
Poluição Ambiental , Hidrogênio/metabolismo , Áreas de Pobreza , Cidades/estatística & dados numéricos , Poluição Ambiental/efeitos adversos , Poluição Ambiental/análise , Poluição Ambiental/economia , Humanos , Óxidos de Nitrogênio/metabolismo , Óxidos de Nitrogênio/intoxicação , Reino Unido/epidemiologia , População Urbana/estatística & dados numéricosAssuntos
Poluentes Atmosféricos/intoxicação , Poluição do Ar/efeitos adversos , Saúde Global/estatística & dados numéricos , Pesquisa Interdisciplinar , Internacionalidade , Material Particulado/intoxicação , Poluentes Atmosféricos/análise , Poluentes Atmosféricos/química , Poluentes Atmosféricos/toxicidade , Poluição do Ar/legislação & jurisprudência , Poluição do Ar/prevenção & controle , China , Exposição Ambiental/efeitos adversos , Exposição Ambiental/legislação & jurisprudência , Exposição Ambiental/prevenção & controle , Humanos , Índia , Mortalidade , Óxidos de Nitrogênio/análise , Óxidos de Nitrogênio/química , Óxidos de Nitrogênio/intoxicação , Óxidos de Nitrogênio/toxicidade , Ozônio/análise , Ozônio/química , Material Particulado/análise , Material Particulado/química , Material Particulado/toxicidade , Compostos Orgânicos Voláteis/química , Recursos HumanosRESUMO
OBJECTIVE: Several studies have shown that underground salt miners may have an increased incidence of chest symptoms and sometimes decreased lung function. Miners of two salt mines were investigated to evaluate relationships between the lung function and the workplace exposure. The effect of nitrogen monoxide (NO) and nitrogen dioxide (NO(2)) was investigated in view of the recent debate on European occupational exposure limits. METHODS: A total of 410/463 miners (mine A/mine B) were examined cross-sectional and 75/64% of the first cohort were examined after a 5-year period. Exposure was measured by personal sampling. Personal lifetime exposure doses of salt dust, diesel exhaust, NO(2) and NO were calculated for all miners. Dose-response relationships were calculated by multiple regression analysis. Each exposure component acted as an indicator for the complex exposure. RESULTS: Exposure response relationships were shown in the cross-sectional and longitudinal investigations in both mines. In the 5-year period, the adjusted (age, smoking, etc.) effect of the exposure indicators resulted in a mean decrease of FEV(1) between -18 ml/year (mine A) and -10 ml/year (mine B). The personal concentrations related to this effect were 12.6/7.1 mg/m(3) inhalable dust, 2.4/0.8 mg/m(3) respirable dust, 0.09/0.09 mg/m(3) diesel exhaust, 0.4/0.5 ppm NO(2) and 1.7/1.4 ppm NO (mine A/B). Exposure was related to symptoms of chronic bronchitis only in mine B. CONCLUSION: The effects found in both mines indicate that the mixed exposure can cause lung function disorders in salt miners exposed over a long time. Because of the high correlation of the concentrations it was not possible to determine the effects of a single exposure component separately or to recommend a specific occupational exposure limit. However, possible maximum effects associated with the mixed exposure can be evaluated in the ranges of concentrations of the individual substances in the mines.
Assuntos
Pneumopatias/induzido quimicamente , Pulmão/efeitos dos fármacos , Óxidos de Nitrogênio/análise , Exposição Ocupacional/análise , Emissões de Veículos/análise , Adulto , Biomarcadores/análise , Misturas Complexas/análise , Misturas Complexas/intoxicação , Estudos Transversais , Relação Dose-Resposta a Droga , Seguimentos , Alemanha , Humanos , Exposição por Inalação/efeitos adversos , Exposição por Inalação/análise , Pulmão/fisiopatologia , Pessoa de Meia-Idade , Mineração/estatística & dados numéricos , Óxidos de Nitrogênio/intoxicação , Exposição Ocupacional/efeitos adversos , Testes de Função Respiratória , SaisRESUMO
A case of accidental occupational intoxication by fumes of nitrogen oxides and the application of an indirect method for the analysis of nitrate, nitrite, and nitro groups to establish the origin of the intoxication are presented. The method is based on the formation of a copper neocuproine complex, and extraction of the complex with methyl isobutyl ketone. The amount of copper in the organic phase is directly proportional to the nitrate content. This copper complex is determined by atomic absorption spectrophotometry. The results, which showed that samples from the contaminated workroom contained 0.1-0.2% nitrate, while blanks contained less than 0.02%, strongly support the hypothesis proposed for the course of the accident.
Assuntos
Laticínios/análise , Nitratos/análise , Óxidos de Nitrogênio/intoxicação , Doenças Profissionais/induzido quimicamente , Edema Pulmonar/induzido quimicamente , Acidentes de Trabalho , Humanos , Masculino , Pessoa de Meia-Idade , Nitritos/análise , Nitrocompostos/análise , Espectrofotometria AtômicaRESUMO
Using disk electrophoresis in the polyacrylamide gel, blood serum proteins were studied in miners working under conditions of the combine (the control group) and drilling-and-blasting (the contact with carbon oxide, nitrogen oxides) driving technique under normal temperature conditions. 26--27 protein fractions characterized by mobility, thermolability under definite conditions of the experiment and the contitative content were obtained. It is shown that the contact with carbon oxide and nitrogen oxides causes changes in the rpoperties of certain proteins (II3, globulins--2 alpha 1, 3 alpha 1, 2 beta, 2 alpha 2, 5 alpha 2, 6 alpha 2, 7 alpha 2) of miners blood serum. Some of these proteins are supposed to participate in the adaptation reactions of the organism.
Assuntos
Proteínas Sanguíneas/análise , Minas de Carvão , Intoxicação por Monóxido de Carbono/sangue , Eletroforese Descontínua , Humanos , Óxidos de Nitrogênio/intoxicação , Soroglobulinas/análiseRESUMO
To review the progress in the major assignment, the organization and implementation of protection against liquid rocket propellent. The safety detection methods of the rocket [correction of rocked] propellent in the launching field were also discussed. Three steps of the sanitation and protection of the liquid propellent, the toxicity and the toxicology of hydrazine on central nervous system, blood circulatory system, assimilation system, respiratory system, immune system, liver, kidney, eye, skin and its hereditary toxicology were described. In addition, the clinical types of poisoning, the current principle and the common ways of the prevention and treatment of hydrazine and nitrogen oxides poisoning were summarized.
Assuntos
Medicina Aeroespacial , Hidrazinas/efeitos adversos , Óxidos de Nitrogênio/efeitos adversos , Exposição Ocupacional/prevenção & controle , Saúde Ocupacional , Substâncias Perigosas/efeitos adversos , Substâncias Perigosas/intoxicação , Substâncias Perigosas/toxicidade , Humanos , Hidrazinas/intoxicação , Hidrazinas/toxicidade , Óxidos de Nitrogênio/intoxicação , Óxidos de Nitrogênio/toxicidade , Roupa de Proteção , Voo EspacialRESUMO
The content of lipids and fatty acids was measured in lung tissue of intact rats and animals with lung edema caused by nitrogen oxide or adrenaline. Lung edema was found to involve disagreement between the phospholipid and fatty acid spectra and to increase the permeability of membranes. The toxic and adrenaline-induced edemas were found identical as regards the type of changes in the ratio of fractions of neutral lipids, phospholipids, and fatty acid spectrum, that is, these shifts represent a nonspecific reaction of lung tissue to aggression.
Assuntos
Epinefrina/intoxicação , Lipídeos/análise , Pulmão/efeitos dos fármacos , Óxidos de Nitrogênio/intoxicação , Doença Aguda , Animais , Cromatografia em Camada Fina/métodos , Pulmão/química , Intoxicação/metabolismo , Ratos , Ratos Wistar , Fatores de TempoRESUMO
We report a case of a worker who developed ALI requiring mechanical ventilatory support after attempting to melt ice condensate by applying the flame of an oxy-acetylene torch to refrigeration coils charged with a halocarbon refrigerant in a closed environment. A discussion of possible etiologies are discussed, including phosgene, carbonyl fluoride, and nitrogen oxides. Primary prevention with adequate respiratory protection is recommended whenever deicing is performed in a closed space environment.