RESUMO
A visible-light-promoted chloramination of olefins is reported. N-Chlorosulfonamides serve as both nitrogen and chlorine sources. These reactions provide a simple, efficient, regioselective, and atom-economical method for the preparation of vicinal haloamine derivatives under mild reaction conditions. A variety of olefins were tolerated, and chloramination products were obtained in good yields.
Assuntos
Alcenos/química , Cloraminas/síntese química , Cloro/química , Luz , Nitrogênio/química , Sulfonamidas/química , Aminação/efeitos da radiação , Cloraminas/química , Estrutura MolecularRESUMO
An efficient protocol for the amination of 6-chloropurine derivatives through nucleophilic aromatic substitution under microwave irradiation was developed and applied to the synthesis in two steps of a series of new acyclic nucleosides (acyclovir analogues) starting from commercially available compounds.
Assuntos
Micro-Ondas , Nucleosídeos/síntese química , Purinas/efeitos da radiação , Aminação/efeitos da radiação , Química Orgânica/métodos , Compostos Clorados/química , Compostos Clorados/efeitos da radiação , Hidrocarbonetos Acíclicos/síntese química , Modelos Biológicos , Purinas/químicaRESUMO
The activity of aspartate aminotransferase, glutamate dehydrogenase in the liver of rats in 1, 7 and 15 days after gamma irradiation effect of the dose of 0.5 Gy on the background of consumption by animals of sodium nitrate, sodium nitrite and nitrosodiethylamine was studied. The combined influence of chemical agents and gamma irradiation modified the effects of nitro compounds-xenobiotics on processes of the synthesis and dissociation of the glutamic acid as well as the intensity of transamination of the reamination by aspartate aminotransferase.