Pesquisa | BVS Violência e Saúde

1.

Of mice and men: From hematopoiesis in mouse models to curative gene therapy for sickle cell disease.

Makani, Julie; Luzzatto, Lucio.

Cell ; 185(8): 1261-1265, 2022 04 14.

Artigo em Inglês | MEDLINE | ID: mdl-35385685

2.

Blocking HbS Polymerization in SCD.

Lettre, Guillaume.

Cell ; 180(5): 819, 2020 03 05.

Artigo em Inglês | MEDLINE | ID: mdl-32142671

3.

The Gut Microbiome Regulates Psychological-Stress-Induced Inflammation.

Xu, Chunliang; Lee, Sung Kyun; Zhang, Dachuan; Frenette, Paul S.

Immunity ; 53(2): 417-428.e4, 2020 08 18.

Artigo em Inglês | MEDLINE | ID: mdl-32735844

4.

Exagamglogene Autotemcel for Severe Sickle Cell Disease.

Frangoul, Haydar; Locatelli, Franco; Sharma, Akshay; Bhatia, Monica; Mapara, Markus; Molinari, Lyndsay; Wall, Donna; Liem, Robert I; Telfer, Paul; Shah, Ami J; Cavazzana, Marina; Corbacioglu, Selim; Rondelli, Damiano; Meisel, Roland; Dedeken, Laurence; Lobitz, Stephan; de Montalembert, Mariane; Steinberg, Martin H; Walters, Mark C; Eckrich, Michael J; Imren, Suzan; Bower, Laura; Simard, Christopher; Zhou, Weiyu; Xuan, Fengjuan; Morrow, Phuong Khanh; Hobbs, William E; Grupp, Stephan A.

N Engl J Med ; 390(18): 1649-1662, 2024 May 09.

Artigo em Inglês | MEDLINE | ID: mdl-38661449

5.

Base editing of haematopoietic stem cells rescues sickle cell disease in mice.

Newby, Gregory A; Yen, Jonathan S; Woodard, Kaitly J; Mayuranathan, Thiyagaraj; Lazzarotto, Cicera R; Li, Yichao; Sheppard-Tillman, Heather; Porter, Shaina N; Yao, Yu; Mayberry, Kalin; Everette, Kelcee A; Jang, Yoonjeong; Podracky, Christopher J; Thaman, Elizabeth; Lechauve, Christophe; Sharma, Akshay; Henderson, Jordana M; Richter, Michelle F; Zhao, Kevin T; Miller, Shannon M; Wang, Tina; Koblan, Luke W; McCaffrey, Anton P; Tisdale, John F; Kalfa, Theodosia A; Pruett-Miller, Shondra M; Tsai, Shengdar Q; Weiss, Mitchell J; Liu, David R.

Nature ; 595(7866): 295-302, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-34079130

6.

Neutrophils as drivers of vascular injury in sickle cell disease.

Torres, Lidiane S; Hidalgo, Andrés.

Immunol Rev ; 314(1): 302-312, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36251624

7.

The genetic dissection of fetal haemoglobin persistence in sickle cell disease in Nigeria.

Ojewunmi, Oyesola O; Adeyemo, Titilope A; Oyetunji, Ajoke I; Inyang, Bassey; Akinrindoye, Afolashade; Mkumbe, Baraka S; Gardner, Kate; Rooks, Helen; Brewin, John; Patel, Hamel; Lee, Sang Hyuck; Chung, Raymond; Rashkin, Sara; Kang, Guolian; Chianumba, Reuben; Sangeda, Raphael; Mwita, Liberata; Isa, Hezekiah; Agumadu, Uche-Nnebe; Ekong, Rosemary; Faruk, Jamilu A; Jamoh, Bello Y; Adebiyi, Niyi M; Umar, Ismail A; Hassan, Abdulaziz; Grace, Christopher; Goel, Anuj; Inusa, Baba P D; Falchi, Mario; Nkya, Siana; Makani, Julie; Ahmad, Hafsat R; Nnodu, Obiageli; Strouboulis, John; Menzel, Stephan.

Hum Mol Genet ; 33(10): 919-929, 2024 May 04.

Artigo em Inglês | MEDLINE | ID: mdl-38339995

8.

Sickle Cell Disease: From Genetics to Curative Approaches.

Hardouin, Giulia; Magrin, Elisa; Corsia, Alice; Cavazzana, Marina; Miccio, Annarita; Semeraro, Michaela.

Annu Rev Genomics Hum Genet ; 24: 255-275, 2023 08 25.

Artigo em Inglês | MEDLINE | ID: mdl-37624668

9.

CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease.

Sharma, Akshay; Boelens, Jaap-Jan; Cancio, Maria; Hankins, Jane S; Bhad, Prafulla; Azizy, Marjohn; Lewandowski, Andrew; Zhao, Xiaojun; Chitnis, Shripad; Peddinti, Radhika; Zheng, Yan; Kapoor, Neena; Ciceri, Fabio; Maclachlan, Timothy; Yang, Yi; Liu, Yi; Yuan, Jianping; Naumann, Ulrike; Yu, Vionnie W C; Stevenson, Susan C; De Vita, Serena; LaBelle, James L.

N Engl J Med ; 389(9): 820-832, 2023 Aug 31.

Artigo em Inglês | MEDLINE | ID: mdl-37646679

10.

"Treatment with curative intent": the emergence of genetic therapies for sickle cell anemia.

Benz, Edward J; Silberstein, Leslie E; Panepinto, Julie.

Blood ; 143(11): 967-970, 2024 Mar 14.

Artigo em Inglês | MEDLINE | ID: mdl-38289232

11.

How I treat sickle cell disease in pregnancy.

James, Andra H; Strouse, John Joseph.

Blood ; 143(9): 769-776, 2024 Feb 29.

Artigo em Inglês | MEDLINE | ID: mdl-37979134

12.

Recent developments in the use of pyruvate kinase activators as a new approach for treating sickle cell disease.

Parekh, Dina S; Eaton, William A; Thein, Swee Lay.

Blood ; 143(10): 866-871, 2024 Mar 07.

Artigo em Inglês | MEDLINE | ID: mdl-38118071

13.

Platelets mediate the clearance of senescent red blood cells by forming prophagocytic platelet-cell complexes.

Ningtyas, Dian C; Leitner, Florentina; Sohail, Huma; Thong, Yee Lin; Hicks, Sarah M; Ali, Sidra; Drew, Megan; Javed, Kiran; Lee, Jiwon; Kenangalem, Enny; Poespoprodjo, Jeanne R; Anstey, Nicholas M; Rug, Melanie; Choi, Philip Y-I; Kho, Steven; Gardiner, Elizabeth E; McMorran, Brendan J.

Blood ; 143(6): 535-547, 2024 Feb 08.

Artigo em Inglês | MEDLINE | ID: mdl-37992231

14.

Clearance of VWF by hepatic macrophages is critical for the protective effect of ADAMTS13 in sickle cell anemia mice.

Shi, Huiping; Gao, Liang; Kirby, Nicole; Shao, Bojing; Shan, Xindi; Kudo, Mariko; Silasi, Robert; McDaniel, John Michael; Zhou, Meixiang; McGee, Samuel; Jing, Wei; Lupu, Florea; Cleuren, Audrey; George, James N; Xia, Lijun.

Blood ; 143(13): 1293-1309, 2024 Mar 28.

Artigo em Inglês | MEDLINE | ID: mdl-38142410

15.

Hydroxyurea reduces infections in children with sickle cell anemia in Uganda.

Namazzi, Ruth; Bond, Caitlin; Conroy, Andrea L; Datta, Dibyadyuti; Tagoola, Abner; Goings, Michael J; Jang, Jeong Hoon; Ware, Russell E; Opoka, Robert; John, Chandy C.

Blood ; 143(14): 1425-1428, 2024 Apr 04.

Artigo em Inglês | MEDLINE | ID: mdl-38169476

16.

Sickle cell disease iPSC-derived sensory neurons exhibit increased excitability and sensitization to patient plasma.

Allison, Reilly L; Welby, Emily; Ehlers, Vanessa; Burand, Anthony; Isaeva, Olena; Nieves Torres, Damaris; Highland, Janelle; Brandow, Amanda M; Stucky, Cheryl L; Ebert, Allison D.

Blood ; 143(20): 2037-2052, 2024 May 16.

Artigo em Inglês | MEDLINE | ID: mdl-38427938

17.

The influence of voxelotor on cerebral blood flow and oxygen extraction in pediatric sickle cell disease.

Brothers, Rowan O; Turrentine, Katherine B; Akbar, Mariam; Triplett, Sydney; Zhao, Hongting; Urner, Tara M; Goldman-Yassen, Adam; Jones, Richard A; Knight-Scott, Jack; Milla, Sarah S; Bai, Shasha; Tang, Amy; Brown, R Clark; Buckley, Erin M.

Blood ; 143(21): 2145-2151, 2024 May 23.

Artigo em Inglês | MEDLINE | ID: mdl-38364110

18.

Hemolysis-driven IFNα production impairs erythropoiesis by negatively regulating EPO signaling in sickle cell disease.

Han, Yongshuai; Gao, Chengjie; Liu, Yunfeng; Zhang, Huan; Wang, Shihui; Zhao, Huizhi; Bao, Weili; Guo, Xinhua; Vinchi, Francesca; Lobo, Cheryl; Shi, Patricia; Mendelson, Avital; Luchsinger, Larry; Zhong, Hui; Yazdanbakhsh, Karina; An, Xiuli.

Blood ; 143(11): 1018-1031, 2024 Mar 14.

Artigo em Inglês | MEDLINE | ID: mdl-38127913

19.

The promise and challenge of therapeutic genome editing.

Doudna, Jennifer A.

Nature ; 578(7794): 229-236, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-32051598

20.

Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease.

Qiang, Yuhao; Sissoko, Abdoulaye; Liu, Zixiang L; Dong, Ting; Zheng, Fuyin; Kong, Fang; Higgins, John M; Karniadakis, George E; Buffet, Pierre A; Suresh, Subra; Dao, Ming.

Proc Natl Acad Sci U S A ; 120(6): e2217607120, 2023 02 07.

Artigo em Inglês | MEDLINE | ID: mdl-36730189

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