RESUMO
The newly approved drug Diclegis(®), indicated for the treatment of nausea and vomiting associated with pregnancy, has a very interesting background story going back more than 50 years, in which science, celebrity individuals, the media, and the courts crossed paths. The story illustrates how concepts of truth, evidence, objectivity, and disinterested inquiry can become distorted in various ways, and this is especially relevant and prevalent in today's media environment of cable television, talk radio, and especially the Internet.
Assuntos
Antieméticos/efeitos adversos , Diciclomina/efeitos adversos , Doxilamina/efeitos adversos , Piridoxina/efeitos adversos , Anormalidades Induzidas por Medicamentos/etiologia , Anormalidades Induzidas por Medicamentos/história , Antieméticos/história , Diciclomina/história , Doxilamina/história , Combinação de Medicamentos , Feminino , História do Século XX , Humanos , Internet/normas , Gravidez , Piridoxina/história , Talidomida/efeitos adversos , Talidomida/história , Estados UnidosAssuntos
Antieméticos/uso terapêutico , Diciclomina/uso terapêutico , Doxilamina/uso terapêutico , Êmese Gravídica/tratamento farmacológico , Piridoxina/uso terapêutico , Anormalidades Congênitas , Diciclomina/efeitos adversos , Diciclomina/história , Doxilamina/efeitos adversos , Doxilamina/história , Aprovação de Drogas/história , Combinação de Medicamentos , Feminino , História do Século XX , Humanos , Gravidez , Piridoxina/efeitos adversos , Piridoxina/história , Estados Unidos , United States Food and Drug AdministrationRESUMO
The discovery of vitamins as essential factors in the diet was a scientific breakthrough that changed the world. Diseases such as scurvy, rickets, beriberi, and pellagra were recognized to be curable with an adequate diet. These diseases had been prevalent for thousands of years and had a dramatic impact on societies as well as on economic development. This Review highlights the key achievements in the development of industrial processes for the manufacture of eight of the 13 vitamins.