The end of an era.

These volumes conclude a series initiated in 1974, marking almost fifty years of effort by a huge cohort of scholars. This review is thus a valedictory for the whole series as well as an account of what we have learned from the most recent volumes about Darwin's final years (1879-82). The project was begun by Frederick Burckhardt, who shared the editorial role for the early volumes with Sydney Smith and a rolling sequence of assistant editors and advisers who eventually comprised a significant fraction of the leading members of what used to be called the 'Darwin industry'. Smith passed away in 1988 (volume 7 notes his legacy). Burkardt too left this world in 2007 - volume 16, part 1 includes an obituary, but his name has been retained and Cambridge University Press still ask that the series be cited as 'Burkhardt et al.' Duncan Porter took over for volumes 8-15, again with a sequence of fellow editors and assistants, after which James Secord became head of the project through its final years. The dedications of successive volumes record the efforts of individual scholars who have aided the teams and the involvement of the many institutions and foundations that have leant moral and material support over the years. For those of us with Cambridge connections, the University Library will not seem the same without the presence of the team it supported.

Fast news or fake news?: The advantages and the pitfalls of rapid publication through pre-print servers during a pandemic.

Pre-print servers have helped to rapidly publish important information during the COVID-19 pandemic. The downside is the risk of spreading false information or fake news though.

Statistical Analysis Must Improve to Address the Reproducibility Crisis: The ACcess to Transparent Statistics (ACTS) Call to Action.

The ACcess to Transparent Statistics (ACTS) call to action assembles four measures that are rapidly achievable by journals and funding agencies to enhance the quality of statistical reporting. The ACTS call to action is an appeal for concrete actions from institutions that should spearhead the battle for reproducibility.

Sex bias and omission in neuroscience research is influenced by research model and journal, but not reported NIH funding.

Neuroscience research has historically demonstrated sex bias that favors male over female research subjects, as well as sex omission, which is the lack of reporting sex. Here we analyzed the status of sex bias and omission in neuroscience research published across six different journals in 2017. Regarding sex omission, 16% of articles did not report sex. Regarding sex bias, 52% of neuroscience articles reported using both males and females, albeit only 15% of articles using both males and females reported assessing sex as an experimental variable. Overrepresentation of the sole use of males compared to females persisted (26% versus 5%, respectively). Sex bias and omission differed across research models, but not by reported NIH funding status. Sex omission differed across journals. These findings represent the latest information regarding the complex status of sex in neuroscience research and illustrate the continued need for thoughtful and informed action to enhance scientific discovery.

Toward assessing clinical trial publications for reporting transparency.

OBJECTIVE: To annotate a corpus of randomized controlled trial (RCT) publications with the checklist items of CONSORT reporting guidelines and using the corpus to develop text mining methods for RCT appraisal. METHODS: We annotated a corpus of 50 RCT articles at the sentence level using 37 fine-grained CONSORT checklist items. A subset (31 articles) was double-annotated and adjudicated, while 19 were annotated by a single annotator and reconciled by another. We calculated inter-annotator agreement at the article and section level using MASI (Measuring Agreement on Set-Valued Items) and at the CONSORT item level using Krippendorff's α. We experimented with two rule-based methods (phrase-based and section header-based) and two supervised learning approaches (support vector machine and BioBERT-based neural network classifiers), for recognizing 17 methodology-related items in the RCT Methods sections. RESULTS: We created CONSORT-TM consisting of 10,709 sentences, 4,845 (45%) of which were annotated with 5,246 labels. A median of 28 CONSORT items (out of possible 37) were annotated per article. Agreement was moderate at the article and section levels (average MASI: 0.60 and 0.64, respectively). Agreement varied considerably among individual checklist items (Krippendorff's α= 0.06-0.96). The model based on BioBERT performed best overall for recognizing methodology-related items (micro-precision: 0.82, micro-recall: 0.63, micro-F1: 0.71). Combining models using majority vote and label aggregation further improved precision and recall, respectively. CONCLUSION: Our annotated corpus, CONSORT-TM, contains more fine-grained information than earlier RCT corpora. Low frequency of some CONSORT items made it difficult to train effective text mining models to recognize them. For the items commonly reported, CONSORT-TM can serve as a testbed for text mining methods that assess RCT transparency, rigor, and reliability, and support methods for peer review and authoring assistance. Minor modifications to the annotation scheme and a larger corpus could facilitate improved text mining models. CONSORT-TM is publicly available at https://github.com/kilicogluh/CONSORT-TM.

Hallmarks of a new era in mitochondrial biochemistry.

Stemming from the pioneering studies of bioenergetics in the 1950s, 1960s, and 1970s, mitochondria have become ingrained in the collective psyche of scientists as the "powerhouses" of the cell. While this remains a worthy moniker, more recent efforts have revealed that these organelles are home to a vast array of metabolic and signaling processes and possess a proteomic landscape that is both highly varied and largely uncharted. As mitochondrial dysfunction is increasingly being implicated in a spectrum of human diseases, it is imperative that we construct a more complete framework of these organelles by systematically defining the functions of their component parts. Powerful new approaches in biochemistry and systems biology are helping to fill in the gaps.

Female Authorship in Radiology: Trends in the Past Decade in CARJ.

PURPOSE: To identify trends in female authorship in the Canadian Association of Radiologists Journal (CARJ) from 2010 to 2019. METHODS: We retrieved papers published in the CARJ over a 10-year period, and retrospectively reviewed 602 articles. All articles except editorials and advertisements were included. We categorized the names of the first and last position authors as female or male and excluded articles that had at least one author of which gender was not known. We compared the trends in the first and last position authors of the articles from 2010 to 2019. For statistical analysis, logistic regression was performed with reported odds ratios (ORs), and a P value of <.05 was defined as statistically significant. RESULTS: Five hundred thirteen articles met inclusion criteria. Among them, 23 articles with a single author were classified as having only a first author. 39.8% (204/513) of first authors were female and 26.9% (132/490) of last authors were female. There has been an overall temporal increase in the odds of both the first and last author being female in CARJ publications (OR: 1.11, P = .034). Similarly, the odds a CARJ publication's first author being female increased over time (OR: 1.07, P = .033). Female last author did not predict female first author (OR: 1.48, P = .056). There was no association identified between female last author and year of publication (OR: 1.04, P = .225). CONCLUSION: There has been an overall increase in engagement of female authorship in CARJ.

Mind the gap: Gendered publication trends in oncology.

BACKGROUND: Investigating scientific publication trends in the field of oncology may highlight opportunities for improved representation, mentorship, collaboration, and advancement for women. METHODS: We conducted a bibliometric analysis of Annals of Surgical Oncology; Cancer; International Journal of Radiation Oncology, Biology, Physics (IJROBP); JAMA Oncology; and Journal of Clinical Oncology in 1990, 2000, 2010, and 2017. Full name and degree credentials per author role (ie, first or senior author), article type, publication year, and citation metrics were collected. First names were used to identify author gender. RESULTS: Across 9189 articles, female representation rose between 1990 and 2017 (first authors: 17.7% in 1990, 36.6% in 2017; senior authors: 11.7% in 1990, 28.5% in 2017). For the 50 most cited articles per year, women comprised a smaller percent of first (26.5%) and senior (19.9%) authors. The average citation count was higher for male first (44.8 per article) and senior (47.1) authors compared to female first (39.7) and senior (44.1) authors. With male senior authors, the first author was more likely male (71.4% male; 25.0% female); with female senior authors, first authors were 50.2% male and 47.6% female. IJROBP had the lowest total female representation among first (25.1%) and senior (16.7%) authors. Women had more MDs with Masters degrees, whereas men held more MDs only and more MDs with PhDs. CONCLUSION: Despite positive trends, substantial gendered differences in oncology publications persist. Fostering more women in oncology research will benefit female representation at many levels of academia and improve productivity, collaboration, and recruitment, especially in technical fields such as radiation and surgical oncology.

The need for a worldwide consensus for cell line authentication: Experience implementing a mandatory requirement at the International Journal of Cancer.

Cell lines are used in life science research worldwide as biological surrogates. All cell lines are subject to major limitations when used as research tools, including (i) cross-contamination with other cells cultured in the same laboratory environment and (ii) evolution in vitro that renders a given cell line inappropriate as a surrogate for a specific biological hypothesis. There is ample evidence that cross-contamination or phenotypic drift of cells in culture can generate irreproducible or misleading data. A small number of scientific journals-the International Journal of Cancer being at the forefront-and funding agencies have recently moved forward to ask for obligatory cell line authentication data. The history of implementing such rules by the International Journal of Cancer exemplifies the difficulties encountered when installing mandatory quality measures in life sciences.

A revolutionary joins the establishment: Reproductive Biomedicine Online turns 20.

This commentary highlights the publishing revolution achieved by Robert Edwards in founding Reproductive Biomedicine Online. It corrects some inaccuracies in the account given by Roger Gosden in his recently published book Let There Be Life: An Intimate Portrait of Robert Edwards and His IVF Revolution.

Europe PMC in 2017.

Europe PMC (https://europepmc.org) is a comprehensive resource of biomedical research publications that offers advanced tools for search, retrieval, and interaction with the scientific literature. This article outlines new developments since 2014. In addition to delivering the core database and services, Europe PMC focuses on three areas of development: individual user services, data integration, and infrastructure to support text and data mining. Europe PMC now provides user accounts to save search queries and claim publications to ORCIDs, as well as open access profiles for authors based on public ORCID records. We continue to foster connections between scientific data and literature in a number of ways. All the data behind the paper - whether in structured archives, generic archives or as supplemental files - are now available via links to the BioStudies database. Text-mined biological concepts, including database accession numbers and data DOIs, are highlighted in the text and linked to the appropriate data resources. The SciLite community annotation platform accepts text-mining results from various contributors and overlays them on research articles as licence allows. In addition, text miners and developers can access all open content via APIs or via the FTP site.

A century of Hereditas: from local publication to international journal.

BACKGROUND: The Mendelian Society of Lund launched Hereditas in 1920. The purpose of this article is to give an overview of Hereditas's hundred-year existence, focusing on the conditions for a learned society to publish a scientific journal, and the journal's importance for the publication and dissemination of genetic research. The article focuses on the historical development of the journal and analyses how the content and orientation of research published in Hereditas have changed over the years. METHODS: The historical study is based on the collation and interpretation of archival material, mainly held in the Mendelian Society's archive, which includes the Hereditas archive. The bibliometric analyses are based on bibliographic metadata from Web of Science (WoS). Together with descriptive statistics, co-citation analyses were performed by using BibExcel, in combination with the clustering and visualisation tool VOSviewer. Journals with articles citing Hereditas articles were identified as a complement to the co-citation analyses. RESULTS: The history of the journal falls into three main periods: a local period, 1920-1959, when Hereditas was primarily intended for Swedish geneticists; a Scandinavian period, 1960-1988, when Hereditas was the official journal of the Scandinavian Association of Geneticists; and an international period from 1989 onwards. The original decision that Hereditas should cover genetic research with no particular specialisation was retained throughout. Its publications demonstrate the continuing presence of genetic research on plants and animals, albeit with a shifting focus, while human genetics emerged slowly and reached its peak in the period 1960-1988. CONCLUSION: In the hundred years of Hereditas's existence, the publishing landscape has changed dramatically, including a far greater number of specialist journals, changes to the academic merit system, new commercial models for publishing, and digitalisation. Over the years, the journal's survival has therefore been dependent on the strong commitment of its owners and an ability to adapt to changing conditions.

Health Research Titles and Guidelines Improve Impact and Article Acceptance Rates.

The peer-reviewed publication of Arthroscopy, Arthroscopy Techniques, and Arthroscopy, Sports Medicine, and Rehabilitation is the result of a team effort. Our assistant editors-in-chief are a notable part of this team who are specifically credited for, among other contributions, leadership in organizing, creating, and publishing a series of pearls, templates, and checklists for health research authors as well as reviewers, editors, and readers. These articles and tools are available under drop-down menus on the Arthroscopy journal home page. Our series of research pearls concludes with 2 articles on the weighty impact of journal article titles and on instruments to improve research publication quality.

Systematic mapping of organophosphate contaminant (OPC) research trends between 1990 and 2018.

Since the addition of polybrominated diphenyls and organochlorine pesticides (OCPs) to the world banned list, toxic organophosphate contaminants (OPCs) such as organophosphate flame retardants and organophosphate pesticides have been, respectively, used as substitutes. These chemicals are reported to be more toxic than their halogenated counterparts. It is rare to find a study that focuses on visualising the publication trends of these chemical classes. In this study, we employed a bibliometric model to systematically map research activities between 1990 and 2018 using OPC articles retrieved from the WoS and Scopus databases. A total of 1090 articles were retrieved from the hybrid databases with an article/author and author/article ratio of 0.33 and 3.02, respectively. Articles on OPC studies were positively correlated with the number of years (r2 = 0.96; y = 0.23x2 - 3.82x + 27.90) suggesting an increase in the number of articles on this subject in future. The USA ranked first in terms of articles (n = 245) and citations (n = 12,922) followed by China and India (203 and 89 articles, respectively). Articles from China and the USA had strong collaboration with other countries. Research priorities and top author keywords included pesticides (n = 112), organophosphate (n = 83) and acetylcholinesterase (n = 60) and were also well represented in keywords-plus. Developed countries had higher outputs compared to developing countries. It was observed that from our thematic literature classifications, human toxicity, ecotoxicological impacts, and environmental monitoring of OPCs were of greater importance to scholars, thus indicating the direction of future research. Futuristic studies need to foster partnership with policymakers, journalists, consultants, farmers, artisans and community workers on OPC research. This will not only enhance scientific communication and community engagement but will also increase the awareness of these pollutants to the general public.

Badges to Acknowledge Open Practices: A Simple, Low-Cost, Effective Method for Increasing Transparency.

Beginning January 2014, Psychological Science gave authors the opportunity to signal open data and materials if they qualified for badges that accompanied published articles. Before badges, less than 3% of Psychological Science articles reported open data. After badges, 23% reported open data, with an accelerating trend; 39% reported open data in the first half of 2015, an increase of more than an order of magnitude from baseline. There was no change over time in the low rates of data sharing among comparison journals. Moreover, reporting openness does not guarantee openness. When badges were earned, reportedly available data were more likely to be actually available, correct, usable, and complete than when badges were not earned. Open materials also increased to a weaker degree, and there was more variability among comparison journals. Badges are simple, effective signals to promote open practices and improve preservation of data and materials by using independent repositories.

Credit and Priority in Scientific Discovery: A Scientist's Perspective.

Credit for scientific discovery plays a central role in the reward structure of science. As the "currency of the realm," it powerfully influences the norms and institutional practices of the research ecosystem. Though most scientists enter the field for reasons other than desiring credit, once in the field they desire credit for their work. In addition to being a source of pleasure, credit and recognition are necessary for successful careers. The consensus among sociologists, philosophers, and economists is that pursuit of credit increases the efficiency of the scientific enterprise. Publishing results in a scholarly journal is the core approach to obtaining credit and priority, and the publishing landscape is undergoing dramatic change. As research groups get larger and more interdisciplinary, and scholarly journals proliferate, allocating credit has become more difficult. Awards and prizes further contribute to credit by recognizing prior attributions and articulating new credit attributions through their decisions. Patents can have a complex relationship to credit, and disputes over authorship and credit are common and difficult to adjudicate. Pathologic pursuit of credit adversely affects the scientific enterprise. Academic institutions assess credit in appointment and promotion decisions, and are best positioned to assume responsibility for addressing problems with the credit ecosystem. Several possible remedies are presented.

Assessments of Metals in Coastal Environments: State of Art.

This study is an overview of the assessments of metal contamination in coastal environments for the past five decades. Research articles with evaluations in sediments and biota were quantified and had their content visited for the registry of (1) the source of metals (anthropogenic or natural), (2) assessed country/territory, (3) groups of organisms assessed, (4) trophic transfer evaluation, (5) spatio-temporal variations, and (6) metals evaluated. We found an increase in the number of assessments over the years, mainly from 2014. The majority of the assessments pointed to anthropogenic sources of metals. The United States, the United Kingdom, and China were the most assessed countries. "Mollusks" was the most assessed group of organisms, and only 17% of all sampled studies identified any trophic relation, although there has been an increase since 2013. Spatial variations were more frequent than spatio-temporal and temporal variations alone. Cadmium, copper, zinc, and lead were the top metals evaluated in both sediment and biota. We believe that these are all valuable information for researchers and policy makers interested in the topic.

Taking the next steps: Promoting open science and expanding diversity in Law and Human Behavior.

In this editorial, the authors note that steady submission rate and a rejection rate that hovers at 80%, indicates the journal is flourishing and provides them with the fortunate opportunity to make an excellent journal even better. To that end, they describe three initiatives they are working on and explain the changes readers can expect as they begin to implement them in the journal. Specifically, these initiatives include: (1) promoting transparency, openness, and reproducibility in published research; (2) improving author-reviewer fit; and (3) expanding the diversity of journal content and decision makers. (PsycINFO Database Record (c) 2019 APA, all rights reserved).