Pesquisa | BVS Violência e Saúde

1.

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer.

Ott, Patrick A; Hu-Lieskovan, Siwen; Chmielowski, Bartosz; Govindan, Ramaswamy; Naing, Aung; Bhardwaj, Nina; Margolin, Kim; Awad, Mark M; Hellmann, Matthew D; Lin, Jessica J; Friedlander, Terence; Bushway, Meghan E; Balogh, Kristen N; Sciuto, Tracey E; Kohler, Victoria; Turnbull, Samantha J; Besada, Rana; Curran, Riley R; Trapp, Benjamin; Scherer, Julian; Poran, Asaf; Harjanto, Dewi; Barthelme, Dominik; Ting, Ying Sonia; Dong, Jesse Z; Ware, Yvonne; Huang, Yuting; Huang, Zhengping; Wanamaker, Amy; Cleary, Lisa D; Moles, Melissa A; Manson, Kelledy; Greshock, Joel; Khondker, Zakaria S; Fritsch, Ed; Rooney, Michael S; DeMario, Mark; Gaynor, Richard B; Srinivasan, Lakshmi.

Cell ; 183(2): 347-362.e24, 2020 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-33064988

2.

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold.

Vredevoogd, David W; Kuilman, Thomas; Ligtenberg, Maarten A; Boshuizen, Julia; Stecker, Kelly E; de Bruijn, Beaunelle; Krijgsman, Oscar; Huang, Xinyao; Kenski, Juliana C N; Lacroix, Ruben; Mezzadra, Riccardo; Gomez-Eerland, Raquel; Yildiz, Mete; Dagidir, Ilknur; Apriamashvili, Georgi; Zandhuis, Nordin; van der Noort, Vincent; Visser, Nils L; Blank, Christian U; Altelaar, Maarten; Schumacher, Ton N; Peeper, Daniel S.

Cell ; 178(3): 585-599.e15, 2019 07 25.

Artigo em Inglês | MEDLINE | ID: mdl-31303383

3.

Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome Prediction.

Kurtz, David M; Esfahani, Mohammad S; Scherer, Florian; Soo, Joanne; Jin, Michael C; Liu, Chih Long; Newman, Aaron M; Dührsen, Ulrich; Hüttmann, Andreas; Casasnovas, Olivier; Westin, Jason R; Ritgen, Matthais; Böttcher, Sebastian; Langerak, Anton W; Roschewski, Mark; Wilson, Wyndham H; Gaidano, Gianluca; Rossi, Davide; Bahlo, Jasmin; Hallek, Michael; Tibshirani, Robert; Diehn, Maximilian; Alizadeh, Ash A.

Cell ; 178(3): 699-713.e19, 2019 07 25.

Artigo em Inglês | MEDLINE | ID: mdl-31280963

4.

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.

Lignitto, Luca; LeBoeuf, Sarah E; Homer, Harrison; Jiang, Shaowen; Askenazi, Manor; Karakousi, Triantafyllia R; Pass, Harvey I; Bhutkar, Arjun J; Tsirigos, Aristotelis; Ueberheide, Beatrix; Sayin, Volkan I; Papagiannakopoulos, Thales; Pagano, Michele.

Cell ; 178(2): 316-329.e18, 2019 07 11.

Artigo em Inglês | MEDLINE | ID: mdl-31257023

5.

Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.

Ponzetta, Andrea; Carriero, Roberta; Carnevale, Silvia; Barbagallo, Marialuisa; Molgora, Martina; Perucchini, Chiara; Magrini, Elena; Gianni, Francesca; Kunderfranco, Paolo; Polentarutti, Nadia; Pasqualini, Fabio; Di Marco, Sabrina; Supino, Domenico; Peano, Clelia; Cananzi, Ferdinando; Colombo, Piergiuseppe; Pilotti, Silvana; Alomar, Suliman Yousef; Bonavita, Eduardo; Galdiero, Maria Rosaria; Garlanda, Cecilia; Mantovani, Alberto; Jaillon, Sebastien.

Cell ; 178(2): 346-360.e24, 2019 07 11.

Artigo em Inglês | MEDLINE | ID: mdl-31257026

6.

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis.

Wiel, Clotilde; Le Gal, Kristell; Ibrahim, Mohamed X; Jahangir, Chowdhury Arif; Kashif, Muhammad; Yao, Haidong; Ziegler, Dorian V; Xu, Xiufeng; Ghosh, Tanushree; Mondal, Tanmoy; Kanduri, Chandrasekhar; Lindahl, Per; Sayin, Volkan I; Bergo, Martin O.

Cell ; 178(2): 330-345.e22, 2019 07 11.

Artigo em Inglês | MEDLINE | ID: mdl-31257027

7.

Clonally expanded EOMES⁺ Tr1-like cells in primary and metastatic tumors are associated with disease progression.

Bonnal, Raoul J P; Rossetti, Grazisa; Lugli, Enrico; De Simone, Marco; Gruarin, Paola; Brummelman, Jolanda; Drufuca, Lorenzo; Passaro, Marco; Bason, Ramona; Gervasoni, Federica; Della Chiara, Giulia; D'Oria, Claudia; Martinovic, Martina; Curti, Serena; Ranzani, Valeria; Cordiglieri, Chiara; Alvisi, Giorgia; Mazza, Emilia Maria Cristina; Oliveto, Stefania; Silvestri, Ylenia; Carelli, Elena; Mazzara, Saveria; Bosotti, Roberto; Sarnicola, Maria Lucia; Godano, Chiara; Bevilacqua, Valeria; Lorenzo, Mariangela; Siena, Salvatore; Bonoldi, Emanuela; Sartore-Bianchi, Andrea; Amatu, Alessio; Veronesi, Giulia; Novellis, Pierluigi; Alloisio, Marco; Giani, Alessandro; Zucchini, Nicola; Opocher, Enrico; Ceretti, Andrea Pisani; Mariani, Nicolò; Biffo, Stefano; Prati, Daniele; Bardelli, Alberto; Geginat, Jens; Lanzavecchia, Antonio; Abrignani, Sergio; Pagani, Massimiliano.

Nat Immunol ; 22(6): 735-745, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-34017124

8.

Heme catabolism by tumor-associated macrophages controls metastasis formation.

Consonni, Francesca Maria; Bleve, Augusto; Totaro, Maria Grazia; Storto, Mariangela; Kunderfranco, Paolo; Termanini, Alberto; Pasqualini, Fabio; Alì, Chiara; Pandolfo, Chiara; Sgambelluri, Francesco; Grazia, Giulia; Santinami, Mario; Maurichi, Andrea; Milione, Massimo; Erreni, Marco; Doni, Andrea; Fabbri, Marco; Gribaldo, Laura; Rulli, Eliana; Soares, Miguel Parreira; Torri, Valter; Mortarini, Roberta; Anichini, Andrea; Sica, Antonio.

Nat Immunol ; 22(5): 595-606, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33903766

9.

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics.

Liu, Jianfang; Lichtenberg, Tara; Hoadley, Katherine A; Poisson, Laila M; Lazar, Alexander J; Cherniack, Andrew D; Kovatich, Albert J; Benz, Christopher C; Levine, Douglas A; Lee, Adrian V; Omberg, Larsson; Wolf, Denise M; Shriver, Craig D; Thorsson, Vesteinn; Hu, Hai.

Cell ; 173(2): 400-416.e11, 2018 04 05.

Artigo em Inglês | MEDLINE | ID: mdl-29625055

10.

A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging.

Keren, Leeat; Bosse, Marc; Marquez, Diana; Angoshtari, Roshan; Jain, Samir; Varma, Sushama; Yang, Soo-Ryum; Kurian, Allison; Van Valen, David; West, Robert; Bendall, Sean C; Angelo, Michael.

Cell ; 174(6): 1373-1387.e19, 2018 09 06.

Artigo em Inglês | MEDLINE | ID: mdl-30193111

11.

Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer.

Coscia, Fabian; Lengyel, Ernst; Duraiswamy, Jaikumar; Ashcroft, Bradley; Bassani-Sternberg, Michal; Wierer, Michael; Johnson, Alyssa; Wroblewski, Kristen; Montag, Anthony; Yamada, S Diane; López-Méndez, Blanca; Nilsson, Jakob; Mund, Andreas; Mann, Matthias; Curtis, Marion.

Cell ; 175(1): 159-170.e16, 2018 09 20.

Artigo em Inglês | MEDLINE | ID: mdl-30241606

12.

A Milieu Molecule for TGF-ß Required for Microglia Function in the Nervous System.

Qin, Yan; Garrison, Brian S; Ma, Wenjiang; Wang, Rui; Jiang, Aiping; Li, Jing; Mistry, Meeta; Bronson, Roderick T; Santoro, Daria; Franco, Charlotte; Robinton, Daisy A; Stevens, Beth; Rossi, Derrick J; Lu, Chafen; Springer, Timothy A.

Cell ; 174(1): 156-171.e16, 2018 06 28.

Artigo em Inglês | MEDLINE | ID: mdl-29909984

13.

N⁶-methyladenine DNA Modification in Glioblastoma.

Xie, Qi; Wu, Tao P; Gimple, Ryan C; Li, Zheng; Prager, Briana C; Wu, Qiulian; Yu, Yang; Wang, Pengcheng; Wang, Yinsheng; Gorkin, David U; Zhang, Cheng; Dowiak, Alexis V; Lin, Kaixuan; Zeng, Chun; Sui, Yinghui; Kim, Leo J Y; Miller, Tyler E; Jiang, Li; Lee, Christine H; Huang, Zhi; Fang, Xiaoguang; Zhai, Kui; Mack, Stephen C; Sander, Maike; Bao, Shideng; Kerstetter-Fogle, Amber E; Sloan, Andrew E; Xiao, Andrew Z; Rich, Jeremy N.

Cell ; 175(5): 1228-1243.e20, 2018 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-30392959

14.

CBFß-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.

Pulikkan, John Anto; Hegde, Mahesh; Ahmad, Hafiz Mohd; Belaghzal, Houda; Illendula, Anuradha; Yu, Jun; O'Hagan, Kelsey; Ou, Jianhong; Muller-Tidow, Carsten; Wolfe, Scot A; Zhu, Lihua Julie; Dekker, Job; Bushweller, John Hackett; Castilla, Lucio Hernán.

Cell ; 174(1): 172-186.e21, 2018 06 28.

Artigo em Inglês | MEDLINE | ID: mdl-29958106

15.

A multi-omic single-cell landscape of human gynecologic malignancies.

Regner, Matthew J; Wisniewska, Kamila; Garcia-Recio, Susana; Thennavan, Aatish; Mendez-Giraldez, Raul; Malladi, Venkat S; Hawkins, Gabrielle; Parker, Joel S; Perou, Charles M; Bae-Jump, Victoria L; Franco, Hector L.

Mol Cell ; 81(23): 4924-4941.e10, 2021 12 02.

Artigo em Inglês | MEDLINE | ID: mdl-34739872

16.

MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota.

Koyama, Motoko; Mukhopadhyay, Pamela; Schuster, Iona S; Henden, Andrea S; Hülsdünker, Jan; Varelias, Antiopi; Vetizou, Marie; Kuns, Rachel D; Robb, Renee J; Zhang, Ping; Blazar, Bruce R; Thomas, Ranjeny; Begun, Jakob; Waddell, Nicola; Trinchieri, Giorgio; Zeiser, Robert; Clouston, Andrew D; Degli-Esposti, Mariapia A; Hill, Geoffrey R.

Immunity ; 51(5): 885-898.e7, 2019 11 19.

Artigo em Inglês | MEDLINE | ID: mdl-31542340

17.

ctDNA guiding adjuvant immunotherapy in urothelial carcinoma.

Powles, Thomas; Assaf, Zoe June; Davarpanah, Nicole; Banchereau, Romain; Szabados, Bernadett E; Yuen, Kobe C; Grivas, Petros; Hussain, Maha; Oudard, Stephane; Gschwend, Jürgen E; Albers, Peter; Castellano, Daniel; Nishiyama, Hiroyuki; Daneshmand, Siamak; Sharma, Shruti; Zimmermann, Bernhard G; Sethi, Himanshu; Aleshin, Alexey; Perdicchio, Maurizio; Zhang, Jingbin; Shames, David S; Degaonkar, Viraj; Shen, Xiaodong; Carter, Corey; Bais, Carlos; Bellmunt, Joaquim; Mariathasan, Sanjeev.

Nature ; 595(7867): 432-437, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-34135506

18.

Behavioural nudges increase COVID-19 vaccinations.

Dai, Hengchen; Saccardo, Silvia; Han, Maria A; Roh, Lily; Raja, Naveen; Vangala, Sitaram; Modi, Hardikkumar; Pandya, Shital; Sloyan, Michael; Croymans, Daniel M.

Nature ; 597(7876): 404-409, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34340242

19.

Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.

Glodde, Nicole; Bald, Tobias; van den Boorn-Konijnenberg, Debby; Nakamura, Kyohei; O'Donnell, Jake S; Szczepanski, Sabrina; Brandes, Maria; Eickhoff, Sarah; Das, Indrajit; Shridhar, Naveen; Hinze, Daniel; Rogava, Meri; van der Sluis, Tetje C; Ruotsalainen, Janne J; Gaffal, Evelyn; Landsberg, Jennifer; Ludwig, Kerstin U; Wilhelm, Christoph; Riek-Burchardt, Monika; Müller, Andreas J; Gebhardt, Christoffer; Scolyer, Richard A; Long, Georgina V; Janzen, Viktor; Teng, Michele W L; Kastenmüller, Wolfgang; Mazzone, Massimiliano; Smyth, Mark J; Tüting, Thomas; Hölzel, Michael.

Immunity ; 47(4): 789-802.e9, 2017 10 17.

Artigo em Inglês | MEDLINE | ID: mdl-29045907

20.

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.

Arce Vargas, Frederick; Furness, Andrew J S; Solomon, Isabelle; Joshi, Kroopa; Mekkaoui, Leila; Lesko, Marta H; Miranda Rota, Enrique; Dahan, Rony; Georgiou, Andrew; Sledzinska, Anna; Ben Aissa, Assma; Franz, Dafne; Werner Sunderland, Mariana; Wong, Yien Ning Sophia; Henry, Jake Y; O'Brien, Tim; Nicol, David; Challacombe, Ben; Beers, Stephen A; Turajlic, Samra; Gore, Martin; Larkin, James; Swanton, Charles; Chester, Kerry A; Pule, Martin; Ravetch, Jeffrey V; Marafioti, Teresa; Peggs, Karl S; Quezada, Sergio A.

Immunity ; 46(4): 577-586, 2017 04 18.

Artigo em Inglês | MEDLINE | ID: mdl-28410988

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