Effects of local alendronate administration on bone defect healing. Histomorphometric and radiological evaluation in a rabbit model
Acta cir. bras
; 32(9): 781-795, Sept. 2017. graf
Article
in En
| LILACS
| ID: biblio-886237
Responsible library:
BR1.1
ABSTRACT
Abstract Purpose:
To performed a histomorphometric and radiological study to evaluate the effects of alendronate sodium administered locally in mandibular bone defects created in rabbits.Methods:
Two circular defects 5 mm in diameter were created bilaterally in the mandibular corpus of 20 New Zealand rabbits (i.e., four defects per animal). Each defect received one of four treatments no treatment (EC group), alendronate irrigation (AL group), autogenous bone grafting (AG group), or alendronate irrigation with autogenous bone grafting (AL+AG group). Histomorphometric and radiological assessments were conducted at 4 and 8 weeks after surgery.Results:
Between-group comparisons of the new bone area, the value of the AL+AG group was significantly lower thanthe remaining three groups at 4 weeks postoperatively. In all groups, the new bone area was significantly larger at 8 weeks than at 4 weeks. The residual graft area at 4 and 8 weeks was significantly higher in the AL+AG group than in the AG group, although it was significantly smaller at 8 weeks than at 4 weeks in both these groups.Conclusion:
The use of alendronate sodium in conjunction with autogenous bone grafting improves the osteoconductive properties of the graft, enhances graft retention in the defect, and improves ossification.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Bone Regeneration
/
Fracture Healing
/
Alendronate
/
Fractures, Bone
/
Bone Density Conservation Agents
Limits:
Animals
Language:
En
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2017
Type:
Article
Affiliation country:
Turkey