Resultados de profilaxis con itraconazol 800 mg/día vía oral en adultos con leucemia aguda y neutropenia de alto riesgo: Hospital del Salvador 2006-2008 / Itraconazole 800 mg for the prophylaxis of fungal infections in patients with acute leukemia and severe neutropenia
Rev. méd. Chile
; 139(9): 1128-1134, set. 2011. tab
Article
in Es
| LILACS
| ID: lil-612235
Responsible library:
BR1.1
ABSTRACT
Background:
Systemic fungal infections and specifically invasive aspergillosis (IA) are associated with a high morbi-mortality rate in patients with hematologic malignancies. Itraconazole kinetic studies show that plasma levels are not satisfactory, even though there is a reduction of the severity in clinical cases.Aim:
To evaluate the results of oral prophylaxis with high dose itraconazole, 400 mg bid, among patients with adult acute leukemia. Material andMethods:
Prospective analysis of 93 high risk febrile episodes (with an absolute neutrophil count of less than 500 x mm3 for more 10 days), that occurred in 76 patients.Results:
Seventy five percent of episodes occurred in patients with acute myeloid leukemia and 25 percent in patients with acute lymphoblastic leukemia. Fifty two percent occurred during the induction of chemotherapy. Median duration of severe neutropenia was 21 days (range 10-48). Median duration of itraconazole prophylaxis was 17 days (range 6-34). A low frequency of invasive fungal infections was observed (17 percent). According to diagnostic criteria, 5 percent of episodes corresponded to persistent fever , 1 percent and 11 percent of episodes, to probable or possible IA, respectively. No confirmed or proven IA was observed. Mortality of IA was 18 percent. No serious adverse events due to itraconazole were observed.Conclusions:
The use of high dose itraconazole prophylaxis in adult patients with acute leukemia and severe neutropenia was associated to low incidence and mortality of invasive mycoses.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Leukemia, Myeloid, Acute
/
Itraconazole
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
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Mycoses
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Antifungal Agents
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Neutropenia
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
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Aged
/
Aged80
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Female
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Humans
/
Male
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2011
Type:
Article
Affiliation country:
Chile