Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats.

Song, X M; Kawano, Y; Krook, A; Ryder, J W; Efendic, S; Roth, R A; Wallberg-Henriksson, H; Zierath, J R

Song, X M; Kawano, Y; Krook, A; Ryder, J W; Efendic, S; Roth, R A; Wallberg-Henriksson, H; Zierath, J R.

Affiliation

Song XM; Department of Clinical Physiology, Karolinska Hospital, Stockholm, Sweden.

Diabetes ; 48(3): 664-70, 1999 Mar.

Article in En | MEDLINE | ID: mdl-10078575

Subject(s)

Diabetes Mellitus, Type 2/physiopathology; Gene Expression Regulation; Glucose/metabolism; Insulin/physiology; Muscle Fibers, Skeletal/metabolism; Muscle Proteins; Muscle, Skeletal/metabolism; Protein Serine-Threonine Kinases; Signal Transduction/physiology; 3-O-Methylglucose/pharmacokinetics; Animals; Biological Transport/drug effects; Body Weight; Diabetes Mellitus, Type 2/genetics; Gene Expression Regulation/drug effects; Glucose Transporter Type 4; Glycogen Synthase/genetics; Insulin Receptor Substrate Proteins; Monosaccharide Transport Proteins/genetics; Muscle Fibers, Skeletal/drug effects; Muscle, Skeletal/drug effects; Phlorhizin/pharmacology; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/metabolism; Phosphoproteins/genetics; Phosphoproteins/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred Strains; Rats, Wistar; Species Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Gene Expression Regulation / Protein Serine-Threonine Kinases / Muscle, Skeletal / Muscle Fibers, Skeletal / Diabetes Mellitus, Type 2 / Glucose / Insulin / Muscle Proteins Limits: Animals Language: En Journal: Diabetes Year: 1999 Type: Article Affiliation country: Sweden

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