Design, synthesis, and evaluation of conformationally constrained tongs, new inhibitors of HIV-1 protease dimerization.

Bouras, A; Boggetto, N; Benatalah, Z; de Rosny, E; Sicsic, S; Reboud-Ravaux, M

Bouras, A; Boggetto, N; Benatalah, Z; de Rosny, E; Sicsic, S; Reboud-Ravaux, M.

Affiliation

Bouras A; BIOCIS, URA-CNRS 1843, Faculté de Pharmacie, Université de Paris-sud, 5 rue J. B. Clément, F-92296 Châtenay-Malabry Cedex, France.

J Med Chem ; 42(6): 957-62, 1999 Mar 25.

Article in En | MEDLINE | ID: mdl-10090778

Subject(s)

Anti-HIV Agents/chemical synthesis; HIV Protease Inhibitors/chemical synthesis; HIV Protease/metabolism; Naphthalenes/chemical synthesis; Oligopeptides/chemical synthesis; Pyridines/chemical synthesis; Anti-HIV Agents/chemistry; Dimerization; Drug Design; HIV Protease Inhibitors/chemistry; Kinetics; Models, Molecular; Molecular Conformation; Naphthalenes/chemistry; Oligopeptides/chemistry; Protein Structure, Secondary; Pyridines/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Pyridines / HIV Protease / HIV Protease Inhibitors / Anti-HIV Agents / Naphthalenes Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1999 Type: Article Affiliation country: France

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