Retrovirus-mediated gene transfer of the human multidrug resistance-associated protein into hematopoietic cells protects mice from chemotherapy-induced leukopenia.

Machiels, J P; Govaerts, A S; Guillaume, T; Bayat, B; Feyens, A M; Lenoir, E; Goeminne, J C; Cole, S; Deeley, R; Caruso, M; Bank, A; Symann, M; D'Hondt, V

Machiels, J P; Govaerts, A S; Guillaume, T; Bayat, B; Feyens, A M; Lenoir, E; Goeminne, J C; Cole, S; Deeley, R; Caruso, M; Bank, A; Symann, M; D'Hondt, V.

Affiliation

Machiels JP; Laboratory of Experimental Hematology and Oncology, Université Catholique de Louvain, Brussels, Belgium.

Hum Gene Ther ; 10(5): 801-11, 1999 Mar 20.

Article in En | MEDLINE | ID: mdl-10210147

Subject(s)

ATP-Binding Cassette Transporters/genetics; Antineoplastic Agents/adverse effects; Gene Transfer Techniques; Hematopoietic Stem Cells/metabolism; Leukopenia/chemically induced; Animals; Blotting, Southern; Bone Marrow Cells/metabolism; Dose-Response Relationship, Drug; Doxorubicin/adverse effects; Flow Cytometry; Humans; Leukocytes/drug effects; Male; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Retroviridae/genetics; Reverse Transcriptase Polymerase Chain Reaction; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / Gene Transfer Techniques / ATP-Binding Cassette Transporters / Leukopenia / Antineoplastic Agents Type of study: Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: Hum Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 1999 Type: Article Affiliation country: Belgium

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