Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188.

Carmeliet, P; Ng, Y S; Nuyens, D; Theilmeier, G; Brusselmans, K; Cornelissen, I; Ehler, E; Kakkar, V V; Stalmans, I; Mattot, V; Perriard, J C; Dewerchin, M; Flameng, W; Nagy, A; Lupu, F; Moons, L; Collen, D; D'Amore, P A; Shima, D T

Carmeliet, P; Ng, Y S; Nuyens, D; Theilmeier, G; Brusselmans, K; Cornelissen, I; Ehler, E; Kakkar, V V; Stalmans, I; Mattot, V; Perriard, J C; Dewerchin, M; Flameng, W; Nagy, A; Lupu, F; Moons, L; Collen, D; D'Amore, P A; Shima, D T.

Affiliation

Carmeliet P; The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Belgium. peter.carmeliet@med.kuleuven.ac.be

Nat Med ; 5(5): 495-502, 1999 May.

Article in En | MEDLINE | ID: mdl-10229225

Subject(s)

Disease Models, Animal; Endothelial Growth Factors/deficiency; Lymphokines/deficiency; Mice, Mutant Strains; Myocardial Ischemia/pathology; Myocardium/pathology; Neovascularization, Physiologic/genetics; Alternative Splicing; Animals; Antigens, Differentiation; Endothelial Growth Factors/genetics; Endothelium, Vascular/chemistry; Gene Targeting; Heart Function Tests; Lymphokines/genetics; Mice; Muscle, Skeletal/blood supply; Protein Isoforms/deficiency; Protein Isoforms/genetics; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Endothelial Growth Factors / Lymphokines / Myocardial Ischemia / Neovascularization, Physiologic / Disease Models, Animal / Mice, Mutant Strains / Myocardium Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 1999 Type: Article Affiliation country: Belgium

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