PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells.

Marx, N; Sukhova, G K; Collins, T; Libby, P; Plutzky, J

Marx, N; Sukhova, G K; Collins, T; Libby, P; Plutzky, J.

Affiliation

Marx N; Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division and the Vascular Research Division, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Circulation ; 99(24): 3125-31, 1999 Jun 22.

Article in En | MEDLINE | ID: mdl-10377075

Subject(s)

Endothelium, Vascular/chemistry; Receptors, Cytoplasmic and Nuclear/genetics; Transcription Factors/genetics; Tumor Necrosis Factor-alpha/pharmacology; Vascular Cell Adhesion Molecule-1/genetics; Anticholesteremic Agents/pharmacology; Arteriosclerosis/genetics; Arteriosclerosis/metabolism; Carotid Arteries/chemistry; Carotid Arteries/cytology; Cell Adhesion/drug effects; Cell Adhesion/physiology; Dose-Response Relationship, Drug; Endothelium, Vascular/cytology; Endothelium, Vascular/physiology; Fenofibrate/pharmacology; Gene Expression/drug effects; Gene Expression/physiology; Humans; Hypolipidemic Agents/pharmacology; Monocytes/cytology; Monocytes/physiology; NF-kappa B/metabolism; Promoter Regions, Genetic/physiology; Pyrimidines/pharmacology; RNA, Messenger/analysis; Receptors, Cytoplasmic and Nuclear/metabolism; Saphenous Vein/cytology; Transcription Factors/metabolism; Transfection; U937 Cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Endothelium, Vascular / Tumor Necrosis Factor-alpha / Receptors, Cytoplasmic and Nuclear / Vascular Cell Adhesion Molecule-1 Limits: Humans Language: En Journal: Circulation Year: 1999 Type: Article Affiliation country: United States

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