Dose-dependent inhibition of platelet cyclooxygenase-1 and monocyte cyclooxygenase-2 by meloxicam in healthy subjects.

Panara, M R; Renda, G; Sciulli, M G; Santini, G; Di Giamberardino, M; Rotondo, M T; Tacconelli, S; Seta, F; Patrono, C; Patrignani, P

Panara, M R; Renda, G; Sciulli, M G; Santini, G; Di Giamberardino, M; Rotondo, M T; Tacconelli, S; Seta, F; Patrono, C; Patrignani, P.

Affiliation

Panara MR; Department of Medicine and Aging, Division of Pharmacology, University of Chieti "G. D'Annunzio" School of Medicine, Chieti, Italy.

J Pharmacol Exp Ther ; 290(1): 276-80, 1999 Jul.

Article in En | MEDLINE | ID: mdl-10381787

Subject(s)

Blood Platelets/enzymology; Cyclooxygenase Inhibitors/pharmacology; Isoenzymes/metabolism; Monocytes/enzymology; Prostaglandin-Endoperoxide Synthases/metabolism; Thiazines/pharmacology; Thiazoles/pharmacology; Adult; Blood Platelets/drug effects; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors/blood; Dinoprostone/blood; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; In Vitro Techniques; Isoenzymes/blood; Male; Meloxicam; Membrane Proteins; Monocytes/drug effects; Prostaglandin-Endoperoxide Synthases/blood; Thiazines/blood; Thiazoles/blood; Thromboxane B2/blood

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Collection: 01-internacional Database: MEDLINE Main subject: Thiazines / Thiazoles / Blood Platelets / Monocytes / Cyclooxygenase Inhibitors / Prostaglandin-Endoperoxide Synthases / Isoenzymes Type of study: Clinical_trials Limits: Adult / Female / Humans / Male Language: En Journal: J Pharmacol Exp Ther Year: 1999 Type: Article Affiliation country: Italy

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