Raloxifene acutely relaxes rabbit coronary arteries in vitro by an estrogen receptor-dependent and nitric oxide-dependent mechanism.

Figtree, G A; Lu, Y; Webb, C M; Collins, P

Figtree, G A; Lu, Y; Webb, C M; Collins, P.

Affiliation

Figtree GA; Cardiac Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK.

Circulation ; 100(10): 1095-101, 1999 Sep 07.

Article in En | MEDLINE | ID: mdl-10477535

Subject(s)

Coronary Vessels/drug effects; Nitric Oxide/physiology; Raloxifene Hydrochloride/pharmacology; Receptors, Estrogen/physiology; Selective Estrogen Receptor Modulators/pharmacology; Vasodilation; Animals; Arteries/drug effects; Arteries/physiology; Calcium/metabolism; Calcium/physiology; Coronary Vessels/physiology; Endothelium, Vascular/physiology; Enzyme Inhibitors/pharmacology; Female; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester/pharmacology; Rabbits; Time Factors; Vasoconstriction/drug effects; Vasoconstriction/physiology; Vasodilation/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Vasodilation / Receptors, Estrogen / Coronary Vessels / Raloxifene Hydrochloride / Selective Estrogen Receptor Modulators / Nitric Oxide Limits: Animals Language: En Journal: Circulation Year: 1999 Type: Article Affiliation country: United kingdom

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