Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis.

Horwitz, M; Benson, K F; Person, R E; Aprikyan, A G; Dale, D C

Horwitz, M; Benson, K F; Person, R E; Aprikyan, A G; Dale, D C.

Affiliation

Horwitz M; Division of Medical Genetics, University of Washington School of Medicine, Seattle, Washington, USA. horwitz@u.washington.edu

Nat Genet ; 23(4): 433-6, 1999 Dec.

Article in En | MEDLINE | ID: mdl-10581030

Subject(s)

Biological Clocks/genetics; Hematopoiesis/genetics; Leukocyte Elastase/genetics; Mutation; Neutropenia/enzymology; Neutropenia/genetics; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 19/genetics; DNA Mutational Analysis; DNA Primers/genetics; DNA, Complementary/genetics; Female; Genes, Dominant; Humans; Leukocyte Elastase/chemistry; Male; Models, Molecular; Molecular Sequence Data; Neutropenia/blood; Pedigree; Periodicity; Protein Structure, Tertiary

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Collection: 01-internacional Database: MEDLINE Main subject: Biological Clocks / Leukocyte Elastase / Hematopoiesis / Mutation / Neutropenia Limits: Female / Humans / Male Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 1999 Type: Article Affiliation country: United States

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