Molecular mechanism of the short-term cardiotoxicity caused by 2',3'-dideoxycytidine (ddC): modulation of reactive oxygen species levels and ADP-ribosylation reactions.

Skuta, G; Fischer, G M; Janaky, T; Kele, Z; Szabo, P; Tozser, J; Sumegi, B

Skuta, G; Fischer, G M; Janaky, T; Kele, Z; Szabo, P; Tozser, J; Sumegi, B.

Affiliation

Skuta G; Department of Biochemistry, University Medical School, Pecs, Hungary.

Biochem Pharmacol ; 58(12): 1915-25, 1999 Dec 15.

Article in En | MEDLINE | ID: mdl-10591146

Subject(s)

Adenosine Diphosphate Ribose/metabolism; Anti-HIV Agents/toxicity; Cardiomyopathies/chemically induced; Heart/drug effects; Reactive Oxygen Species/metabolism; Zalcitabine/toxicity; Animals; Cardiomyopathies/metabolism; DNA/drug effects; DNA/metabolism; Electrocardiography/drug effects; Energy Metabolism/drug effects; Heart/physiology; Heat-Shock Proteins/drug effects; Heat-Shock Proteins/metabolism; Mass Spectrometry; Mitochondria/drug effects; Mitochondria/enzymology; Muscle, Skeletal/drug effects; Muscle, Skeletal/metabolism; Oxidation-Reduction; Rats; Rats, Wistar; Reverse Transcriptase Inhibitors/toxicity; Sequence Analysis

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Collection: 01-internacional Database: MEDLINE Main subject: Adenosine Diphosphate Ribose / Reactive Oxygen Species / Zalcitabine / Anti-HIV Agents / Heart / Cardiomyopathies Limits: Animals Language: En Journal: Biochem Pharmacol Year: 1999 Type: Article Affiliation country: Hungary

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