Effect of novel CAAX peptidomimetic farnesyltransferase inhibitor on angiogenesis in vitro and in vivo.

Gu, W Z; Tahir, S K; Wang, Y C; Zhang, H C; Cherian, S P; O'Connor, S; Leal, J A; Rosenberg, S H; Ng, S C

Gu, W Z; Tahir, S K; Wang, Y C; Zhang, H C; Cherian, S P; O'Connor, S; Leal, J A; Rosenberg, S H; Ng, S C.

Affiliation

Gu WZ; Abbott Laboratories, Department 4N6 AP9/2, Abbott Park, Illinois, USA.

Eur J Cancer ; 35(9): 1394-401, 1999 Sep.

Article in En | MEDLINE | ID: mdl-10658533

Subject(s)

Alkyl and Aryl Transferases/antagonists & inhibitors; Colonic Neoplasms/drug therapy; Animals; Colonic Neoplasms/blood supply; Endothelial Growth Factors/metabolism; Endothelium, Vascular; Farnesyltranstransferase; Humans; Lymphokines/metabolism; Methionine/analogs & derivatives; Methionine/therapeutic use; Mice; Mice, Nude; Neovascularization, Pathologic/prevention & control; Pyridines/therapeutic use; Rats; Tumor Cells, Cultured; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Colonic Neoplasms / Alkyl and Aryl Transferases Limits: Animals / Humans Language: En Journal: Eur J Cancer Year: 1999 Type: Article Affiliation country: United States

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