The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells.

Eckenberg, R; Rose, T; Moreau, J L; Weil, R; Gesbert, F; Dubois, S; Tello, D; Bossus, M; Gras, H; Tartar, A; Bertoglio, J; Chouaïb, S; Goldberg, M; Jacques, Y; Alzari, P M; Thèze, J

Eckenberg, R; Rose, T; Moreau, J L; Weil, R; Gesbert, F; Dubois, S; Tello, D; Bossus, M; Gras, H; Tartar, A; Bertoglio, J; Chouaïb, S; Goldberg, M; Jacques, Y; Alzari, P M; Thèze, J.

Affiliation

Eckenberg R; Unité d'Immunogénétique Cellulaire, Institut Pasteur, 75015 Paris, France.

J Exp Med ; 191(3): 529-40, 2000 Feb 07.

Article in En | MEDLINE | ID: mdl-10662798

Subject(s)

Interleukin-2/pharmacology; Killer Cells, Lymphokine-Activated/metabolism; Receptors, Interleukin-2/agonists; Amino Acid Sequence; Animals; Binding Sites; CD8-Positive T-Lymphocytes/metabolism; Cell Line; Enzyme Activation/drug effects; Humans; Interferon-gamma/analysis; Interleukin-2/chemistry; Interleukin-2/genetics; Lymphocyte Activation/drug effects; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism; Lymphocyte Subsets/metabolism; Mice; Molecular Sequence Data; Monocytes/drug effects; Peptide Fragments/chemistry; Peptide Fragments/pharmacology; Protein Folding; Receptors, Interleukin-2/antagonists & inhibitors; Receptors, Interleukin-2/metabolism; Signal Transduction; src Homology Domains

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Interleukin-2 / Killer Cells, Lymphokine-Activated / Interleukin-2 Limits: Animals / Humans Language: En Journal: J Exp Med Year: 2000 Type: Article Affiliation country: France

Fulltext

XML

PubMed Links

Search on Google