CDR substitutions of a humanized monoclonal antibody (CC49): contributions of individual CDRs to antigen binding and immunogenicity.

Iwahashi, M; Milenic, D E; Padlan, E A; Bei, R; Schlom, J; Kashmiri, S V

Iwahashi, M; Milenic, D E; Padlan, E A; Bei, R; Schlom, J; Kashmiri, S V.

Affiliation

Iwahashi M; Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Mol Immunol ; 36(15-16): 1079-91, 1999.

Article in En | MEDLINE | ID: mdl-10698310

Subject(s)

Antibodies, Monoclonal/genetics; Antibodies, Monoclonal/metabolism; Immunoglobulin Variable Region/genetics; Immunoglobulin Variable Region/metabolism; Amino Acid Sequence; Amino Acid Substitution; Animals; Antibodies, Anti-Idiotypic/biosynthesis; Antibodies, Monoclonal/immunology; Antibody Affinity; Antigen-Antibody Reactions; Baculoviridae/genetics; Binding Sites/genetics; Binding, Competitive; Cell Line; Humans; Immunoglobulin Variable Region/immunology; Kinetics; Mice; Molecular Sequence Data; Recombinant Proteins/genetics; Recombinant Proteins/immunology; Recombinant Proteins/metabolism; Spodoptera

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Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Variable Region / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Immunol Year: 1999 Type: Article Affiliation country: United States

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