A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor.

Lu, D C; Rabizadeh, S; Chandra, S; Shayya, R F; Ellerby, L M; Ye, X; Salvesen, G S; Koo, E H; Bredesen, D E

Lu, D C; Rabizadeh, S; Chandra, S; Shayya, R F; Ellerby, L M; Ye, X; Salvesen, G S; Koo, E H; Bredesen, D E.

Affiliation

Lu DC; Program on Aging, The Burnham Institute, La Jolla, California 92037, USA.

Nat Med ; 6(4): 397-404, 2000 Apr.

Article in En | MEDLINE | ID: mdl-10742146

Subject(s)

Amyloid beta-Protein Precursor/metabolism; Caspases/metabolism; Peptides/metabolism; Alzheimer Disease/metabolism; Alzheimer Disease/pathology; Amyloid beta-Protein Precursor/genetics; Animals; Apoptosis; Brain/enzymology; Brain/pathology; Caspase 9; Caspases/genetics; Cell Line, Transformed; Enzyme Activation; Humans; Mice; Peptide Fragments/metabolism; Peptides/physiology; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Amyloid beta-Protein Precursor / Caspases Limits: Animals / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2000 Type: Article Affiliation country: United States

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