Impaired prion replication in spleens of mice lacking functional follicular dendritic cells.

Montrasio, F; Frigg, R; Glatzel, M; Klein, M A; Mackay, F; Aguzzi, A; Weissmann, C

Montrasio, F; Frigg, R; Glatzel, M; Klein, M A; Mackay, F; Aguzzi, A; Weissmann, C.

Affiliation

Montrasio F; Institute of Neuropathology, Department of Pathology, University of Zürich, Schmelzbergstrasse 12, CH-8091 Zürich, Switzerland.

Science ; 288(5469): 1257-9, 2000 May 19.

Article in En | MEDLINE | ID: mdl-10818004

Subject(s)

Dendritic Cells, Follicular/pathology; Dendritic Cells, Follicular/virology; PrPSc Proteins/biosynthesis; Spleen/pathology; Spleen/virology; Virus Replication/immunology; Animals; Cell Differentiation/genetics; Cell Differentiation/immunology; Dendritic Cells, Follicular/metabolism; Immunoglobulins/genetics; Lymphotoxin beta Receptor; Lymphotoxin-alpha/antagonists & inhibitors; Lymphotoxin-alpha/genetics; Lymphotoxin-alpha/immunology; Mice; Mice, Inbred C57BL; Mice, SCID; PrPSc Proteins/administration & dosage; Receptors, Tumor Necrosis Factor/antagonists & inhibitors; Receptors, Tumor Necrosis Factor/genetics; Receptors, Tumor Necrosis Factor/immunology; Recombinant Fusion Proteins/administration & dosage; Scrapie/immunology; Scrapie/metabolism; Signal Transduction/genetics; Signal Transduction/immunology; Spleen/immunology; Spleen/metabolism; Virus Replication/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Spleen / Virus Replication / PrPSc Proteins / Dendritic Cells, Follicular Limits: Animals Language: En Journal: Science Year: 2000 Type: Article Affiliation country: Switzerland

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