Replication-restricted vaccinia as a cytokine gene therapy vector in cancer: persistent transgene expression despite antibody generation.

Mukherjee, S; Haenel, T; Himbeck, R; Scott, B; Ramshaw, I; Lake, R A; Harnett, G; Phillips, P; Morey, S; Smith, D; Davidson, J A; Musk, A W; Robinson, B

Mukherjee, S; Haenel, T; Himbeck, R; Scott, B; Ramshaw, I; Lake, R A; Harnett, G; Phillips, P; Morey, S; Smith, D; Davidson, J A; Musk, A W; Robinson, B.

Affiliation

Mukherjee S; Department of Medicine, University of Western Australia, Queen Elizabeth II Medical Center, Nedlands, Australia.

Cancer Gene Ther ; 7(5): 663-70, 2000 May.

Article in En | MEDLINE | ID: mdl-10830713

Subject(s)

Genetic Therapy/methods; Genetic Vectors; Lung Neoplasms/therapy; Mesothelioma/therapy; Transgenes; Vaccinia virus/genetics; Adult; Female; Genetic Vectors/toxicity; Humans; Immunoglobulin G/metabolism; Immunohistochemistry; Interleukin-2/biosynthesis; Interleukin-2/blood; Interleukin-2/genetics; Interleukin-2/urine; Lung Neoplasms/metabolism; Male; Mesothelioma/metabolism; Middle Aged; Pilot Projects; RNA, Messenger/metabolism; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes/metabolism; Thymidine Kinase/genetics; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Vaccinia virus / Genetic Therapy / Transgenes / Genetic Vectors / Lung Neoplasms / Mesothelioma Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Cancer Gene Ther Journal subject: GENETICA MEDICA / NEOPLASIAS / TERAPEUTICA Year: 2000 Type: Article Affiliation country: Australia

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